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There is increasing recognition of the mental health burden of climate change and the effects on general well-being, even in those who have not (yet) experienced direct impacts. Climate anxiety, which is prominent among young people in particular, describes a state of heightened distress about the (future) effects of climate change. Despite evidence of a link between engagement in climate change issues and heightened climate anxiety, there is a dearth of knowledge on how this affects emerging professionals preparing for careers in the environmental sector. Furthermore, there is a paucity of literature regarding the extent to which young adults are coping with their thoughts and feelings about climate change, and the extent to which they consider climate change in making future plans. The aim of this study was to understand the occurrence and personal management of climate anxiety in UK university students through an online questionnaire. This study was the first to investigate the association between climate anxiety, coping strategies and future planning in university students. Environmental degree students (n = 249) reported greater levels of climate anxiety, more frequent employment of all three examined coping strategies and in particular considered climate change as a factor in their career plans, as compared to their non-environmental degree counterparts (n = 224). Problem-focused coping was the most commonly endorsed strategy, although the prior literature on coping suggests that this may not be sustainable for individually intractable problems. Highly climate-anxious students were more likely to consider climate change in all five decision-making domains, including family planning, long-term habitation, career, financial and travel decisions. This study has identified a need to communicate effective climate anxiety coping strategies to environmental practitioners, university students and educators. Additional research is required to validate the study findings and investigate what motivates students to incorporate climate change into future plans.

Awareness of the threats of climate change is engendering distress in increasingly documented ways, with young people particularly affected. Experiences such as climate distress and eco-anxiety have implications for the health and wellbeing of societies, economies, and for climate action, including mental health, agency to address the crisis, and future planning. While multi-country studies suggest that eco-anxiety and related experiences of distress may vary with context, the hypothesis that exposure to climate-related impacts increases eco-anxiety and associated psychological impacts is underexplored in youth at the individual level. Here we show that in a large sample of US youth (aged 16–24, n = 2834), self-reported direct experience of climate-related events significantly increased eco-anxiety, climate distress and the impact of climate change on future planning, but also psychological adaptation, meaning-focused coping and climate agency. As the climate crisis accelerates and exposure to climate-related hazards increases, these findings have important implications for the mental health of populations, life choices that have socioeconomic impact, and climate behaviours of the growing group of young people experiencing these threats.

In this mixed methods study, which complements an earlier publication (https://doi.org/10.1016/S2542-5196(22)00172-3), we delve deeper into the experience of ‘climate distress’ among UK residents aged 16-24 (N=539). We report on data collected from an online survey assessing general mental health, subjective wellbeing, and climate distress using existing psychometric scales. We also included novel questions assessing positive and negative life impacts of climate change, open-ended questions on aspirations and priorities for the future, and engagement in pro-environmental and climate actions. In addition to quantitative results, we analysed free-text responses to two open-ended questions about respondents' hopes for the future, and their experience with climate change and actions in response to it.

Conservation science practitioners seek to pre-empt irreversible impacts on species, ecosystems, and social-ecological systems, requiring efficient and timely action even when data and understanding are unavailable, incomplete, dated, or biased. These challenges are exacerbated by the scientific community's capacity to consistently distinguish between reliable and unreliable evidence, including the recognition of questionable research practices (QRPs, or ‘questionable practices’), which may threaten the credibility of research, including harming trust in well-designed and reliable scientific research. In this paper, we propose a ‘toolkit’ for open and pluralistic conservation science, highlighting common questionable practices and sources of bias and indicating where remedies for these problems may be found. The toolkit provides an accessible resource for anyone conducting, reviewing, or using conservation research, to identify sources of false claims or misleading evidence that arise unintentionally, or through misunderstandings or carelessness in the application of scientific methods and analyses. We aim to influence editorial and review practices and hopefully to remedy problems before they are published or deployed in policy or conservation practice.

The COVID-19 pandemic and climate change are both significant and pressing global challenges, posing threats to public health and wellbeing. Young people are particularly vulnerable to the distress both crises can cause, but understanding of the varied psychological responses to both issues is poor. We aimed to investigate these responses and their links with mental health conditions and feelings of agency.We conducted an online survey between Aug 5 and Oct 26, 2020, targeting a diverse sample of young people (aged 16-24 years, n=530) in the UK. The survey was distributed using a combination of a survey panel (panel sample) and direct approaches to youth groups and schools who shared the survey with young people in their networks (community sample). We collected data on respondents' psychological responses to both climate change and the COVID-19 pandemic, their sense of agency to respond to each crisis, and the range of impacts on their lives. We also collected demographics data and screened for mental health and wellbeing indicators. We used non-parametric tests for most statistical comparisons. For paired samples, we used Wilcoxon's signed-rank test, and used Mann-Whitney U-tests or Kruskal-Wallis tests for two or more independent samples. Summed scale scores were considered as interval-level data and analysed with Student's t tests and ANOVAs. Effect sizes are reported as Cohen's d and partial eta-squared (η·After excluding 18 suspected bots and 94 incomplete responses, 530 responses were retained for analysis. Of the 518 respondents who provided demographic data, 63% were female, 71·4% were White, and the mean family affluence score was 8·22 (SD 2·29). Most participants (n=343; 70%) did not report a history of diagnosis or treatment for a mental health disorder, but mental health scores indicated a common experience of (relatively mild) symptoms of anxiety, depression, and stress. Although UK youth reported more life disruption and concern for their future due to the COVID-19 pandemic, climate change was associated with significantly greater distress overall, particularly for individuals with low levels of generalised anxiety. The COVID-19 pandemic was more associated with feelings of anxiety, isolation, disconnection, and frustration; distress around loss and grief; and effects on quality of life. Climate change was more likely to evoke emotions such as interest and engagement, guilt, shame, anger, and disgust. The greater distress attributed to climate change overall was due, in particular, to higher levels of guilt, sense of personal responsibility, and greater distress triggered by upsetting media coverage. Agency to address climate change was associated with greater climate distress, but pandemic-related distress and agency were unrelated.The COVID-19 pandemic and climate change are affecting the wellbeing of UK young people in distinct ways, with implications for health service, policy, and research responses. There is a need for mental health practitioners, policy makers, and other societal actors to account for the complex relationship between climate agency, distress, and mental wellbeing in young people.Imperial College London.

Environmental decisions are often deferred to groups of experts, committees, or panels to develop climate policy, plan protected areas, or negotiate trade-offs for biodiversity conservation. There is, however, surprisingly little empirical research on the performance of group decision making related to the environment. We examined examples from a range of different disciplines, demonstrating the emergence of collective intelligence (CI) in the elicitation of quantitative estimates, crowdsourcing applications, and small-group problem solving. We explored the extent to which similar tools are used in environmental decision making. This revealed important gaps (e.g., a lack of integration of fundamental research in decision-making practice, absence of systematic evaluation frameworks) that obstruct mainstreaming of CI. By making judicious use of interdisciplinary learning opportunities, CI can be harnessed effectively to improve decision making in conservation and environmental management. To elicit reliable quantitative estimates an understanding of cognitive psychology and to optimize crowdsourcing artificial intelligence tools may need to be incorporated. The business literature offers insights into the importance of soft skills and diversity in team effectiveness. Environmental problems set a challenging and rich testing ground for collective-intelligence tools and frameworks. We argue this creates an opportunity for significant advancement in decision-making research and practice.Potencial No Explotado de la Inteligencia Colectiva en la Toma de Decisiones Ambientales y de Conservación Resumen Las decisiones ambientales comúnmente se difieren a grupos de expertos, comités, o paneles para desarrollar la política climática, planear las áreas protegidas o negociar compensaciones por la conservación de la biodiversidad. Aun así, sorprendentemente, existen pocas investigaciones empíricas sobre el desempeño de la toma grupal de decisiones en relación con el ambiente. Examinamos los ejemplos de una gama de disciplinas diferentes, demostrando el surgimiento de la inteligencia colectiva en la obtención de estimaciones cuantitativas, las aplicaciones de la colaboración masiva y la resolución de problemas en grupos pequeños. Exploramos el alcance que tienen las herramientas similares que se usan en la toma de decisiones ambientales. Esto último reveló vacíos importantes (p. ej.: la falta de integración de investigaciones fundamentales en la práctica de la toma de decisiones, la ausencia de marcos de trabajo de evaluación sistemática) que obstruyen la popularización de la inteligencia colectiva. Si hacemos un uso juicioso de las oportunidades de aprendizaje interdisciplinario, la inteligencia colectiva puede aprovecharse efectivamente para mejorar la toma de decisiones en el manejo ambiental y de conservación. La incorporación de un entendimiento de la psicología cognitiva y la optimización de las herramientas de IA para la colaboración masiva pueden ser necesarias para obtener estimados cuantitativos confiables. La literatura de los negocios ofrece conocimientos sobre la importancia de las habilidades blandas y la diversidad en la efectividad del equipo. Los problemas ambientales plantean un campo de pruebas rico y desafiante para las herramientas y los marcos de trabajo de inteligencia colectiva. Argumentamos que esto crea una oportunidad para el avance significativo en la investigación y la práctica de la toma de decisiones.在环境决策中, 通常由专家组、委员会或专门小组来制定气候政策、进行保护区规划或商讨生物多样性保护的利弊权衡。但令人惊讶的是, 很少有实证研究评估与环境相关的群体决策的成效。本研究利用不同学科的案例, 展示了在定量评估、众包应用和小群体问题解决等方面涌现的集体智慧。我们还分析了类似的工具在环境决策中的应用情况。研究结果揭示了一些阻碍集体智慧主流化的一些重要缺口, 如决策实践中缺乏基础研究的整合, 缺少系统的评价框架。而善用跨学科的学习机会, 则可以更有效地利用集体智慧来改善保护和环境管理方面的决策。为了获得可靠的定量评估, 可能需要结合对认知心理学的理解和对众包人工智能工具的优化。另外, 商业文献也有助于更好地了解软技能和多样的团队效能的重要性。环境问题为集体智慧的工具和框架提供了一个极具挑战又丰富多样的试验场, 这也为决策研究和实践取得重大进展创造了机会。【翻译: 胡怡思; 审校: 聂永刚】.

As replications of individual studies are resource intensive, techniques for predicting the replicability are required. We introduce the repliCATS (Collaborative Assessments for Trustworthy Science) process, a new method for eliciting expert predictions about the replicability of research. This process is a structured expert elicitation approach based on a modified Delphi technique applied to the evaluation of research claims in social and behavioural sciences. The utility of processes to predict replicability is their capacity to test scientific claims without the costs of full replication. Experimental data supports the validity of this process, with a validation study producing a classification accuracy of 84% and an Area Under the Curve of 0.94, meeting or exceeding the accuracy of other techniques used to predict replicability. The repliCATS process provides other benefits. It is highly scalable, able to be deployed for both rapid assessment of small numbers of claims, and assessment of high volumes of claims over an extended period through an online elicitation platform, having been used to assess 3000 research claims over an 18 month period. It is available to be implemented in a range of ways and we describe one such implementation. An important advantage of the repliCATS process is that it collects qualitative data that has the potential to provide insight in understanding the limits of generalizability of scientific claims. The primary limitation of the repliCATS process is its reliance on human-derived predictions with consequent costs in terms of participant fatigue although careful design can minimise these costs. The repliCATS process has potential applications in alternative peer review and in the allocation of effort for replication studies.

Background: The COVID-19 pandemic and climate change are both significant and pressing global challenges, posing threats to public health and wellbeing. Young people represent a particularly vulnerable group to the distress both crises appear to engender, but we currently lack an understanding of the varied psychological responses to both issues, and their links with mental health conditions and feelings of agency. Methods: We conducted an online survey in August - October 2020 targeting a diverse sample of young people (16–24 years, N=530) in the United Kingdom. Findings: While UK youth reported more life disruption and concern for their future due to the COVID-19 pandemic, climate change was associated with significantly greater distress overall, particularly for individuals with low levels of generalised anxiety. COVID-19 was more associated with feelings of anxiety, isolation, disconnection, and frustration; distress around loss and grief; and effects on quality of life. Climate change was more likely to evoke interest and engagement, guilt, shame, anger, and disgust; and distress associated with guilt, feeling responsible and media coverage. Agency to address climate change was associated with greater climate distress, but COVID-related distress and agency were unrelated. Interpretation: COVID-19 and climate change are affecting the wellbeing of young people in distinct ways, with implications for health service, policy and research responses. There is a need for mental health practitioners and policy makers to account for the complex relationship between climate agency, distress and mental wellbeing in young people. Funding: Institute of Global Health Innovation, Imperial College London. Declaration of Interests: We declare no conflicts of interest. Ethics Approval Statement: The study was reviewed and received approval from the Imperial College London Science, Engineering, & Technology Research Ethics Committee (SETREC; approval number 20IC6060).

Introduction: Efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) targeting the temporo-parietal junction (TPJ) for the treatment of auditory verbal hallucinations (AVH) remains under debate. We assessed the influence of a 1 Hz rTMS treatment on neural networks involved in a cognitive mechanism proposed to subserve AVH.Methods: Patients with schizophrenia (N = 24) experiencing medication-resistant AVH completed a 10-day 1 Hz rTMS treatment. Participants were randomized to active stimulation of the left or bilateral TPJ, or sham stimulation. The effects of rTMS on neural networks were investigated with an inner speech task during fMRI. Changes within and between neural networks were analyzed using Independent Component Analysis.Results: rTMS of the left and bilateral TPJ areas resulted in a weaker network contribution of the left supramarginal gyro to the bilateral fronto-temporal network. Left-sided rTMS resulted in stronger network contributions of the right superior temporal gyrus to the auditory-sensorimotor network, right inferior gyrus to the left fronto-parietal network, and left middle frontal gyrus to the default mode network. Bilateral rTMS was associated with a predominant inhibitory effect on network contribution. Sham stimulation showed different patterns of change compared to active rTMS.Conclusion: rTMS of the left temporo-parietal region decreased the contribution of the left supramarginal gyros to the bilateral fronto-temporal network, which may reduce the likelihood of speech intrusions. On the other hand, left rTMS appeared to increase the contribution of functionally connected regions involved in perception, cognitive control and self-referential processing. These findings hint to potential neural mechanisms underlying rTMS for hallucinations but need corroboration in larger samples.

Aim Mega-diverse coral reef ecosystems are declining globally, necessitating conservation prioritizations to protect biodiversity and ecosystem services of sites with high functional integrity to promote persistence. In practice however, the design of marine-protected area (MPA) systems often relies on broad classifications of habitat class and size, making the tacit assumption that all reefs are of comparable condition. We explored the impact of this assumption through a novel, pragmatic approach for incorporating variability in coral cover in a large-scale regional spatial prioritization plan. Location The Coral Triangle. Methods We developed a spatially explicit predictive model of hard coral cover based on freely available macro-ecological data to generate a complete regional map of coral cover as a proxy for reef condition. We then incorporate this information in spatial conservation prioritization software Marxan to design an MPA system that meets specific conservation objectives. Results We discover prioritizations using area-based representation of reef habitat alone may overestimate the conservation benefit, defined as the amount of hard coral cover protected, by up to 64%. We find substantial differences in conservation priorities and an overall increase in habitat quality metrics when accounting for predicted coral cover. Main conclusions This study shows that including habitat condition in a large-scale marine spatial prioritization is feasible within time and resource constraints, and calls for increased implementation, and evaluation, of such ecologically relevant planning approaches to enhance potential conservation effectiveness.

In the wake of 9/11 and the assessment of Iraq's WMD, several inquiries placed the blame primarily on the Intelligence Community. Part of the reform that followed was a codification of analytic tradecraft standards into Intelligence Community Directive (ICD) 203 and the appointment of an analytic ombudsman in the newly created Office of the Director of National Intelligence charged with monitoring the quality of analytic products from across the intelligence community. In this paper we identify three assumptions behind ICD203: (1) tradecraft standards can be employed consistently; (2) tradecraft standards sufficiently capture the key elements of good reasoning; (3) good reasoning leads to more accurate judgments. We then report on two controlled experiments that uncover operational constraints in the reliable application of the ICD203 criteria for the assessment of intelligence products. Despite criticisms of the post-9/11 and post-Iraq reform, our results highlight that ICD203, properly applied, holds potential to improve precision and accountability of intelligence processes and products.

Spatial conservation prioritization is used globally to guide decision making with the aim of delivering the best conservation gain per unit investment. However, despite many publications on the topic, the extent to which this approach is used by decision makers has been unclear. To investigate the degree to which prioritization has been adopted by practitioners to guide conservation implementation, we conducted an online survey, collecting data on the approaches used to develop prioritizations and the reported extent of translation to on-the-ground action. Using a cluster analysis, we identified two categories of prioritizations, those developed to advance the field (42% of responses) and those intended for implementation (58% of responses). Respondents reported 74% of the prioritizations intended for implementation had translated to on-the-ground action. Additionally, we identified strong collaboration between academics and practitioners in prioritization development, suggesting a bridging of the theory-practice gap. We recommend continued collaboration and research into the effectiveness of prioritizations in delivering conservation impacts.

Growing evidence suggests that testosterone may play a role in the pathophysiology of schizophrenia given that testosterone has been linked to cognition and negative symptoms in schizophrenia. Here, we determine the extent to which serum testosterone levels are related to neural activity in affective processing circuitry in men with schizophrenia. Functional magnetic resonance imaging was used to measure blood-oxygen-level-dependent signal changes as 32 healthy controls and 26 people with schizophrenia performed a facial emotion identification task. Whole brain analyses were performed to determine regions of differential activity between groups during processing of angry versus non-threatening faces. A follow-up ROI analysis using a regression model in a subset of 16 healthy men and 16 men with schizophrenia was used to determine the extent to which serum testosterone levels were related to neural activity. Healthy controls displayed significantly greater activation than people with schizophrenia in the left inferior frontal gyrus (IFG). There was no significant difference in circulating testosterone levels between healthy men and men with schizophrenia. Regression analyses between activation in the IFG and circulating testosterone levels revealed a significant positive correlation in men with schizophrenia (r=.63, p=.01) and no significant relationship in healthy men. This study provides the first evidence that circulating serum testosterone levels are related to IFG activation during emotion face processing in men with schizophrenia but not in healthy men, which suggests that testosterone levels modulate neural processes relevant to facial emotion processing that may interfere with social functioning in men with schizophrenia.

There is increasing clinical and molecular evidence for the role of hormones and specifically estrogen and its receptor in schizophrenia. A selective estrogen receptor modulator, raloxifene, stimulates estrogen-like activity in brain and can improve cognition in older adults. The present study tested the extent to which adjunctive raloxifene treatment improved cognition and reduced symptoms in young to middle-age men and women with schizophrenia. Ninety-eight patients with a diagnosis of schizophrenia or schizoaffective disorder were recruited into a dual-site, thirteen-week, randomized, double-blind, placebo-controlled, crossover trial of adjunctive raloxifene treatment in addition to their usual antipsychotic medications. Symptom severity and cognition in the domains of working memory, attention/processing speed, language and verbal memory were assessed at baseline, 6 and 13 weeks. Analyses of the initial 6-week phase of the study using a parallel groups design (with 39 patients receiving placebo and 40 receiving raloxifene) revealed that participants receiving adjunctive raloxifene treatment showed significant improvement relative to placebo in memory and attention/processing speed. There was no reduction in symptom severity with treatment compared with placebo. There were significant carryover effects, suggesting some cognitive benefits are sustained even after raloxifene withdrawal. Analysis of the 13-week crossover data revealed significant improvement with raloxifene only in attention/processing speed. This is the first study to show that daily, oral adjunctive raloxifene treatment at 120 mg per day has beneficial effects on attention/processing speed and memory for both men and women with schizophrenia. Thus, raloxifene may be useful as an adjunctive treatment for cognitive deficits associated with schizophrenia.

Most transcranial Direct Current Stimulation (tDCS) trials of schizophrenia administer few sessions and do not assess transfer effects to other cognitive domains. In a randomized, double-blind, sham-controlled, parallel groups trial, we determined the extent to which 4-weeks of 2 mA tDCS at 20 min/day totalling 20 tDCS sessions administered during a spatial working memory test, with anodal right dorsolateral prefrontal cortex (DLPFC) and cathodal left tempo-parietal junction (TPJ) placement, as an adjunct to antipsychotics reduced auditory hallucinations and improved cognition in 12 outpatients with schizophrenia. Anodal tDCS significantly improved language-based working memory after 2 weeks and verbal fluency after 2 and 4 weeks. Thus, four weeks of tDCS appears to be safe and elicits transfer benefits to other prefrontal-dependent cognitive abilities in schizophrenia.

BACKGROUND: Repetitive transcranial magnetic stimulation of the left temporo-parietal junction area has been studied as a treatment option for auditory verbal hallucinations. Although the right temporo-parietal junction area has also shown involvement in the genesis of auditory verbal hallucinations, no studies have used bilateral stimulation. Moreover, little is known about durability effects. We studied the short and long term effects of 1 Hz treatment of the left temporo-parietal junction area in schizophrenia patients with persistent auditory verbal hallucinations, compared to sham stimulation, and added an extra treatment arm of bilateral TPJ area stimulation. METHODS: In this randomized controlled trial, 51 patients diagnosed with schizophrenia and persistent auditory verbal hallucinations were randomly allocated to treatment of the left or bilateral temporo-parietal junction area or sham treatment. Patients were treated for six days, twice daily for 20 minutes. Short term efficacy was measured with the Positive and Negative Syndrome Scale (PANSS), the Auditory Hallucinations Rating Scale (AHRS), and the Positive and Negative Affect Scale (PANAS). We included follow-up measures with the AHRS and PANAS at four weeks and three months. RESULTS: The interaction between time and treatment for Hallucination item P3 of the PANSS showed a trend for significance, caused by a small reduction of scores in the left group. Although self-reported hallucination scores, as measured with the AHRS and PANAS, decreased significantly during the trial period, there were no differences between the three treatment groups. CONCLUSION: We did not find convincing evidence for the efficacy of left-sided rTMS, compared to sham rTMS. Moreover, bilateral rTMS was not superior over left rTMS or sham in improving AVH. Optimizing treatment parameters may result in stronger evidence for the efficacy of rTMS treatment of AVH. Moreover, future research should consider investigating factors predicting individual response. TRIAL REGISTRATION: Dutch Trial Register NTR1813.

The authors regret an error in Fig. 2 of this manuscript. The figure shows the PANSS scores for the hallucination item (P3) for the rTMS groups, aggregating the left and the bilateral treatment group, compared to the placebo group. The X axis plots the time points at which measurements were available: before the start of the treatment and immediately following the 6-day treatment protocol. The Y axis shows the score on the P3 item. Bubble sizes represent the number of subjects with a particular score on the Y axis.

Estrogen has been implicated in the development and course of schizophrenia with most evidence suggesting a neuroprotective effect. Treatment with raloxifene, a selective estrogen receptor modulator, can reduce symptom severity, improve cognition and normalize brain activity during learning in schizophrenia. People with schizophrenia are especially impaired in the identification of negative facial emotions. The present study was designed to determine the extent to which adjunctive raloxifene treatment would alter abnormal neural activity during angry facial emotion recognition in schizophrenia. Twenty people with schizophrenia (12 men, 8 women) participated in a 13-week, randomized, double-blind, placebo-controlled, crossover trial of adjunctive raloxifene treatment (120 mg per day orally) and performed a facial emotion recognition task during functional magnetic resonance imaging after each treatment phase. Two-sample t-tests in regions of interest selected a priori were performed to assess activation differences between raloxifene and placebo conditions during the recognition of angry faces. Adjunctive raloxifene significantly increased activation in the right hippocampus and left inferior frontal gyrus compared with the placebo condition (family-wise error, P<0.05). There was no significant difference in performance accuracy or reaction time between active and placebo conditions. To the best of our knowledge, this study provides the first evidence suggesting that adjunctive raloxifene treatment changes neural activity in brain regions associated with facial emotion recognition in schizophrenia. These findings support the hypothesis that estrogen plays a modifying role in schizophrenia and shows that adjunctive raloxifene treatment may reverse abnormal neural activity during facial emotion recognition, which is relevant to impaired social functioning in men and women with schizophrenia.