7 results on '"Annalisa Pedini"'
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2. Bartter Syndrome Type 1 Presenting as Nephrogenic Diabetes Insipidus
- Author
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Gianluca Vergine, Elena Fabbri, Annalisa Pedini, Silvana Tedeschi, and Niccolò Borsa
- Subjects
Pediatrics ,RJ1-570 - Abstract
Bartter syndrome (BS) type 1 (OMIM #601678) is a hereditary salt-losing renal tubular disorder characterized by hypokalemic metabolic alkalosis, hypercalciuria, nephrocalcinosis, polyuria, recurrent vomiting, and growth retardation. It is caused by loss-of-function mutations of the SLC12A1 gene, encoding the furosemide-sensitive Na-K-Cl cotransporter. Recently, a phenotypic variability has been observed in patients with genetically determined BS, including absence of nephrocalcinosis, hypokalemia, and/or metabolic alkalosis in the first year of life as well as persistent metabolic acidosis mimicking distal renal tubular acidosis. We report the case of a child with a genetically determined diagnosis of Bartter syndrome type 1 who presented with a phenotype of nephrogenic diabetes insipidus, with severe hypernatremia and urinary concentrating defect. In these atypical cases, molecular analysis is mandatory to define the diagnosis, in order to establish the correct clinical and therapeutic management.
- Published
- 2018
- Full Text
- View/download PDF
3. Differences between Transient Neonatal Diabetes Mellitus Subtypes can Guide Diagnosis and Therapy
- Author
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Riccardo Bonfanti, Dario Iafusco, Ivana Rabbone, Giacomo Diedenhofen, Carla Bizzarri, Patrizia Ippolita Patera, Petra Reinstadler, Francesco Costantino, Valeria Calcaterra, Lorenzo Iughetti, Silvia Savastio, Anna Favia, Francesca Cardella, Donatella Lo Presti, Ylenia Girtler, Sarah Rabbiosi, Giuseppe D’Annunzio, Angela Zanfardino, Alessia Piscopo, Francesca Casaburo, Letizia Pintomalli, Lucia Russo, Valeria Grasso, Nicola Minuto, Mafalda Mucciolo, Antonio Novelli, Antonella Marucci, Barbara Piccini, Sonia Toni, Francesca Silvestri, Paola Carrera, Andrea Rigamonti, Giulio Frontino, Michela Trada, Davide Tinti, Maurizio Delvecchio, Novella Rapini, Riccardo Schiaffini, Corrado Mammì, Fabrizio Barbetti, Monica Aloe, Simona Amadeo, Claudia Arnaldi, Marta Bassi, Luciano Beccaria, Marzia Benelli, Giulia Maria Berioloi, Enrica Bertelli, Martina Biagioni, Adriana Bobbio, Stefano Boccato, Oriana Bologna, Franco Bontempi, Clara Bonura, Giulia Bracciolini, Claudia Brufani, Patrizia Bruzzi, Pietro Buono, Roberta Cardani, Giuliana Cardinale, Alberto Casertano, Maria Cristina Castiglione, Vittoria Cauvin, Valentino Cherubini, Franco Chiarelli, Giovanni Chiari, Stefano Cianfarani, Dante Cirillo, Felice Citriniti, Susanna Coccioli, Anna Cogliardi, Santino Confetto, Giovanna Contreas, Anna Corò, Elisa Corsini, Nicoletta Cresta, Fiorella De Berardinis, Valeria De Donno, Giampaolo De Filippo, Rosaria De Marco, Annalisa Deodati, Elena Faleschini, Valentina Fattorusso, Valeria Favalli, Barbara Felappi, Lucia Ferrito, Graziella Fichera, Franco Fontana, Elena Fornari, Roberto Franceschi, Francesca Franco, Adriana Franzese, Anna Paola Frongia, Alberto Gaiero, Francesco Gallo, Luigi Gargantini, Elisa Giani, Chiara Giorgetti, Giulia Bianchi, Vanna Graziani, Antonella Gualtieri, Monica Guasti, Gennaro Iannicelli, Antonio Iannilli, Ignaccolo Giovanna, Dario Ingletto, Stefania Innaurato, Elena Inzaghi, Brunella Iovane, Peter Kaufmann, Alfonso La Loggia, Rosa Lapolla, Anna Lasagni, Nicola Lazzaro, Lorenzo Lenzi, Riccardo Lera, Gabriella Levantini, Fortunato Lombardo, Antonella Lonero, Silvia Longhi, Sonia Lucchesi, Lucia Paola Guerraggio, Sergio Lucieri, Patrizia Macellaro, Claudio Maffeis, Bendetta Mainetti, Giulio Maltoni, Chiara Mameli, Francesco Mammì, Maria Luisa Manca-Bitti, Melania Manco, Monica Marino, Matteo Mariano, Marco Marigliano, Alberto Marsciani, Costanzo Mastrangelo, Maria Cristina Matteoli, Elena Mazzali, Franco Meschi, Antonella MIgliaccio, Anita Morandi, Gianfranco Morganti, Enza Mozzillo, Gianluca Musolino, Rosa Nugnes, Federica Ortolani, Daniela Pardi, Filomena Pascarella, Stefano Passanisi, Annalisa Pedini, Cristina Pennati, Angelo Perrotta, Sonia Peruzzi, Paola Peverelli, Giulia Pezzino, Anita Claudia Piona, Gavina Piredda, Carmelo Pistone, Elena Prandi, Barbara Pedieri, Procolo Di Bonito, Anna Pulcina, Maria Quinci, Emioli Randazzo, Rossella Ricciardi, Carlo Ripoli, Rosanna Roppolo, Irene Rutigliano, Alberto Sabbio, Silvana salardi, Alessandro Salvatoni, Anna Saporiti, Rita Sardi, Mariapiera Scanu, Andrea Scaramuzza, Eleonardo Schiven, Andrea Secco, Linda Sessa, Paola Sogno Valin, Silvia Sordelli, Luisa Spallino, Stefano Stagi, Filomena Stamati, Tosca Suprani, Valentina Talarico, Tiziana Timapanaro, Antonella Tirendi, Letizia Tomaselli, Gianluca Tornese, Adolfo Andrea Trettene, Stefano Tumini, Giuliana Valerio, Claudia Ventrici, Matteo Viscardi, Silvana Zaffani, Maria Zampolli, Giorgio Zanette, Clara Zecchino, Maria Antonietta Zedda, Silvia Zonca, Stefano Zucchini, Bonfanti, R., Iafusco, D., Rabbone, I., Diedenhofen, G., Bizzarri, C., Patera, P. I., Reinstadler, P., Costantino, F., Calcaterra, V., Iughetti, L., Savastio, S., Favia, A., Cardella, F., Presti, D. L., Girtler, Y., Rabbiosi, S., D'Annunzio, G., Zanfardino, A., Piscopo, A., Casaburo, F., Pintomalli, L., Russo, L., Grasso, V., Minuto, N., Mucciolo, M., Novelli, A., Marucci, A., Piccini, B., Toni, S., Silvestri, F., Carrera, P., Rigamonti, A., Frontino, G., Trada, M., Tinti, D., Delvecchio, M., Rapini, N., Schiaffini, R., Mammi, C., and Barbetti, F.
- Subjects
Proband ,Male ,Pediatrics ,Potassium Channels ,Endocrinology, Diabetes and Metabolism ,Datasets as Topic ,Diagnosis, Differential ,Diagnostic Techniques, Endocrine ,Female ,Humans ,Infant ,Infant, Newborn ,Italy ,Mutation ,Potassium Channels, Inwardly Rectifying ,Remission Induction ,Retrospective Studies ,Sulfonylurea Receptors ,Diabetes Mellitus ,Infant, Newborn, Diseases ,Diseases ,Gastroenterology ,Diabetes mellitus genetics ,Endocrinology ,Settore MED/13 ,Retrospective Studie ,Diagnosis ,Medicine ,Endocrine pancreas, Transient Neonatal Diabetes Mellitus, 6q24 TNDM, KATP TNDM, Sulfonylureas ,Sulfonylureas ,Sulfonylurea Receptor ,biology ,Diabetes Mellitu ,General Medicine ,Metformin ,Inwardly Rectifying ,Settore MED/03 ,6q24 TNDM ,medicine.symptom ,Endocrine ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug ,Human ,endocrine system ,medicine.medical_specialty ,KATP TNDM ,ABCC8 ,Transient Neonatal Diabetes Mellitus ,Internal medicine ,Diabetes mellitus ,Macroglossia ,Endocrine pancreas ,business.industry ,medicine.disease ,Newborn ,Diagnostic Techniques ,Transient neonatal diabetes mellitus ,Differential ,biology.protein ,Sulfonylurea receptor ,business - Abstract
Objective Transient neonatal diabetes mellitus (TNDM) is caused by activating mutations in ABCC8 and KCNJ11 genes (KATP/TNDM) or by chromosome 6q24 abnormalities (6q24/TNDM). We wanted to assess whether these different genetic aetiologies result in distinct clinical features. Design Retrospective analysis of the Italian data set of patients with TNDM. Methods Clinical features and treatment of 22 KATP/TNDM patients and 12 6q24/TNDM patients were compared. Results Fourteen KATP/TNDM probands had a carrier parent with abnormal glucose values, four patients with 6q24 showed macroglossia and/or umbilical hernia. Median age at diabetes onset and birth weight were lower in patients with 6q24 (1 week; −2.27 SD) than those with KATP mutations (4.0 weeks; −1.04 SD) (P = 0.009 and P = 0.007, respectively). Median time to remission was longer in KATP/TNDM than 6q24/TNDM (21.5 weeks vs 12 weeks) (P = 0.002). Two KATP/TNDM patients entered diabetes remission without pharmacological therapy. A proband with the ABCC8/L225P variant previously associated with permanent neonatal diabetes entered 7-year long remission after 1 year of sulfonylurea therapy. Seven diabetic individuals with KATP mutations were successfully treated with sulfonylurea monotherapy; four cases with relapsing 6q24/TNDM were treated with insulin, metformin or combination therapy. Conclusions If TNDM is suspected, KATP genes should be analyzed first with the exception of patients with macroglossia and/or umbilical hernia. Remission of diabetes without pharmacological therapy should not preclude genetic analysis. Early treatment with sulfonylurea may induce long-lasting remission of diabetes in patients with KATP mutations associated with PNDM. Adult patients carrying KATP/TNDM mutations respond favourably to sulfonylurea monotherapy.
- Published
- 2021
4. RACCOMANDAZIONI SULL’UTILIZZO DELLA TECNOLOGIA IN DIABETOLOGIA PEDIATRICA 2019
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Stefano Cianfarani, Riccardo Bonfanti, Martina Biagioni, Patrizia Bruzzi, Pietro Buono, Valentino Cherubini, Lucia Ferrito, Giulio Frontino, Roberto Franceschi, Dario Iafusco, Fortunato Lombardo, Giulio Maltoni, Marco Marigliano, Enza Mozzillo, Gianluca Musolino, Annalisa Pedini, Giulia Pezzino, Barbara Piccini, Ivana Rabbone, Andrea Rigamonti, Rosanna Roppolo, Andrea Scaramuzza, Riccardo Schiaffini, Davide Tini, Claudia Ventrici, Angela Zanfardino, Cianfarani, Stefano, Bonfanti, Riccardo, Biagioni, Martina, Bruzzi, Patrizia, Buono, Pietro, Cherubini, Valentino, Ferrito, Lucia, Frontino, Giulio, Franceschi, Roberto, Iafusco, Dario, Lombardo, Fortunato, Maltoni, Giulio, Marigliano, Marco, Mozzillo, Enza, Musolino, Gianluca, Pedini, Annalisa, Pezzino, Giulia, Piccini, Barbara, Rabbone, Ivana, Rigamonti, Andrea, Roppolo, Rosanna, Scaramuzza, Andrea, Schiaffini, Riccardo, Tini, Davide, Ventrici, Claudia, and Zanfardino, Angela
- Published
- 2019
5. Patent ductus arteriosus in preterm infants born before 30 weeks' gestation: high rate of spontaneous closure after hospital discharge
- Author
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Vittorio Romagnoli, Annalisa Pedini, Monica Santoni, Grazia Scutti, Massimo Colaneri, Marco Pozzi, Paola E. Cogo, and Virgilio P. Carnielli
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Male ,congenital, hereditary, and neonatal diseases and abnormalities ,Pediatrics ,medicine.medical_specialty ,Indomethacin ,Remission, Spontaneous ,Gestational Age ,Ibuprofen ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Ductus arteriosus ,Medicine ,Humans ,Cyclooxygenase Inhibitors ,030212 general & internal medicine ,Ductus Arteriosus, Patent ,Ligation ,Retrospective Studies ,Respiratory distress ,business.industry ,Remission Induction ,Infant, Newborn ,Gestational age ,Infant ,General Medicine ,Odds ratio ,medicine.disease ,Patient Discharge ,medicine.anatomical_structure ,Bronchopulmonary dysplasia ,Italy ,Dysplasia ,Infant, Extremely Low Birth Weight ,Anesthesia ,Infant, Extremely Premature ,Pediatrics, Perinatology and Child Health ,cardiovascular system ,Apgar score ,Administration, Intravenous ,Female ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug ,Follow-Up Studies - Abstract
AimThe aim of this study was to determine the spontaneous closure rate of patent ductus arteriosus at a 2-year follow-up, following failed medical therapy and beyond initial hospital discharge, and to evaluate in-hospital spontaneous or pharmacological closure rates.Materials and methodsA retrospective evaluation was conducted in a cohort of preterm infants admitted to the Neonatal ICU of Ancona between January, 2004 and June, 2013. Inclusion criteria were gestational age between 24+0 and 29+6 weeks or birth weight 1.5 mm, a left atrium-to-aorta ratio >1.4, and/or reversal of end-diastolic flow in the aorta >30% of the anterograde. First-line treatment was intravenous ibuprofen. Intravenous indomethacin was used if ibuprofen failed. Surgical ligation was considered in haemodynamically significant patent ductus arteriosus after medical treatment.ResultsA total of 593 infants met the inclusion criteria, and patent ductus arteriosus was diagnosed in 317 (53.4%). Among them, 283 (89.3%) infants had haemodynamically significant patent ductus arteriosus, with pharmacological closure achieved in 228 (80.6%) infants and surgical ligation performed in 20 (7.1%). Follow-up at 24 months was available for 39 (81.3%) of 48 infants with patent ductus arteriosus at the hospital discharge: 36 (92.3%) underwent spontaneous closure, two (5.1%) underwent surgical ligation, and one (2.6%) had a patent ductus arteriosus.DiscussionA significant number of patent ductus arteriosus that fail pharmacological closure undergo spontaneous closure by the age of 2 years. This information should be taken into account when considering surgery or additional attempts of pharmacological closure.
- Published
- 2018
6. Bartter Syndrome Type 1 Presenting as Nephrogenic Diabetes Insipidus
- Author
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Niccolò Borsa, Gianluca Vergine, Elena Fabbri, Silvana Tedeschi, and Annalisa Pedini
- Subjects
0301 basic medicine ,medicine.medical_specialty ,endocrine system diseases ,030232 urology & nephrology ,Metabolic alkalosis ,Case Report ,Bartter syndrome ,urologic and male genital diseases ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Renal tubular dysfunction ,Polyuria ,Distal renal tubular acidosis ,Internal medicine ,medicine ,Hypercalciuria ,business.industry ,lcsh:RJ1-570 ,lcsh:Pediatrics ,General Medicine ,medicine.disease ,Nephrogenic diabetes insipidus ,030104 developmental biology ,Nephrocalcinosis ,medicine.symptom ,business - Abstract
Bartter syndrome (BS) type 1 (OMIM #601678) is a hereditary salt-losing renal tubular disorder characterized by hypokalemic metabolic alkalosis, hypercalciuria, nephrocalcinosis, polyuria, recurrent vomiting, and growth retardation. It is caused by loss-of-function mutations of the SLC12A1 gene, encoding the furosemide-sensitive Na-K-Cl cotransporter. Recently, a phenotypic variability has been observed in patients with genetically determined BS, including absence of nephrocalcinosis, hypokalemia, and/or metabolic alkalosis in the first year of life as well as persistent metabolic acidosis mimicking distal renal tubular acidosis. We report the case of a child with a genetically determined diagnosis of Bartter syndrome type 1 who presented with a phenotype of nephrogenic diabetes insipidus, with severe hypernatremia and urinary concentrating defect. In these atypical cases, molecular analysis is mandatory to define the diagnosis, in order to establish the correct clinical and therapeutic management.
- Published
- 2018
7. Erratum to: Organization and regional distribution of centers for the management of children and adolescents with diabetes in Italy
- Author
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A. Scaramazza, Maurizio Delvecchio, F. Mammì, G. Santoro, E. De Nitto, Silvia Pietrosanti, E. Montani, F. Cardella, V. De Donno, Chiara Giorgetti, Federica Ortolani, L. Beccaria, G. Fichera, A. Francese, Annalisa Pedini, Dario Iafusco, Santino Confetto, Sonia Toni, Barbara Predieri, C. Arnaldi, L. Tomaselli, M. Frongia, Fortunato Lombardo, F. De Berardinis, Gianluca Tornese, C. Ripoli, E. Piccino, Riccardo Schiaffini, Antonio Iannilli, Maria Luisa Manca Bitti, G. Ignaccolo, B. Pasquino, Giovanni Federico, A. Marsciani, Angela Zanfardino, Anna Maria Marinaro, N. Lazzaro, Federica Zallocco, A. La Loggia, Ippolita Patrizia Patera, Stefano Zucchini, M. Trada, P. Pusceddu, G. Zanette, A. Gaiero, Lorenzo Iughetti, G. Cardinale, C. Monciotti, F. Citriniti, R. Cardani, G. Piredda, V. Rapisarda, Claudio Maffeis, M. Bruzzese, T. Soprani, Marco Marigliano, B. Kienberger, L. Guerraggio, L. De Luna, Elena Faleschini, Vittoria Cauvin, E. Prandi, Maria Ferrari, G. Morganti, Lorenzo Lenzi, Roberta Lidano, Giuseppe d'Annunzio, U. Marongiu, G. Meloni, A. Correddu, Nicola Minuto, Alessandro Salvatoni, Valentino Cherubini, A. Milia, A. Gualtieri, R. Maccioni, A. Pipia, Ivana Rabbone, Riccardo Bonfanti, Claudia Ventrici, Giulio Maltoni, V. Zattoni, F. Cadario, G. Ponzi, D. Pardi, Mohamad Maghnie, M. Soro, P. Scanu, F. Gallo, Francesco Prisco, P. Reinstadler, P. Bulciolu, R. Lera, M. G. Berioli, Stefano Tumini, L. Mereu, Andrea Rigamonti, M. S. Coccioli, C. Zecchino, B. Mainetti, Roberto Franceschi, P. Banin, Giovanni Chiari, I. Rabbone, A. Sabbion, and L. Ferrito
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Male ,Gerontology ,Adolescent ,Distribution (economics) ,Regional Medical Programs ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,030225 pediatrics ,Diabetes mellitus ,Prevalence ,Humans ,Medicine ,030212 general & internal medicine ,Practice Patterns, Physicians' ,Child ,business.industry ,Incidence ,Disease Management ,medicine.disease ,Diabetes Mellitus, Type 1 ,Italy ,Female ,Erratum ,business ,Delivery of Health Care - Abstract
The incidence of type 1 diabetes in childhood is increasing by 3 % per year, placing growing demands on healthcare professionals and medical expenditures. Aim of this study wars to assess the organization of care to children with diabetes in Italy.During 2012 a structured questionnaire was sent to all of the members of Italian Society of Paediatric Endocrinology and Diabetology (ISPED). Questions examined organizational structure of Centers, personnel dedicated to the care of children with diabetes, number of subjects followed, local legal legislation supporting centres.A total of 68 centers taking care to 15,563 children and adolescents with diabetes under 18 years of age were identified with a prevalence of 1.4 per 1,000 people. A wide variation in the organizational background was also reported. Fourty-four centers were organized as outpatient departments, 17 as simple units, 5 as complex units and 2 as simple departmental structures. Most centers had a multidisciplinary team. Ten out of twenty Italian regions had introduced supportive regional legislation, but it was fully applied only in six of them.Great differences between regions were found in organizational structures, staffing levels and supportive legislation. The national legislation on diabetes was broadly implemented throughout the country regions. Further efforts are needed to improve standards and consistency of pediatric diabetes care in Italy.
- Published
- 2016
- Full Text
- View/download PDF
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