1. Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections
- Author
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Chao Tian, Suzanne M. Noble, Bethann S. Hromatka, Nicholas Eriksson, David A. Hinds, Joyce Y. Tung, and Amy K. Kiefer
- Subjects
0301 basic medicine ,Male ,Mononucleosis ,General Physics and Astronomy ,Common Cold ,Chickenpox ,HLA Antigens ,lcsh:Science ,Multidisciplinary ,Hepatitis A ,Pharyngitis ,Hepatitis B ,3. Good health ,Tonsillitis ,Urinary Tract Infections ,Rheumatic fever ,Female ,Rheumatic Fever ,Warts ,Scarlet Fever ,Strep throat ,Science ,Ear infection ,Infections ,Rubella ,Herpes Zoster ,General Biochemistry, Genetics and Molecular Biology ,White People ,Article ,Meningitis, Bacterial ,03 medical and health sciences ,Streptococcal Infections ,medicine ,Humans ,Tuberculosis ,Genetic Predisposition to Disease ,Infectious Mononucleosis ,Sinusitis ,Mumps ,Candidiasis, Vulvovaginal ,Tonsillectomy ,business.industry ,Tuberculin Test ,General Chemistry ,Pneumonia ,medicine.disease ,Middle Ear Ventilation ,Otitis Media ,030104 developmental biology ,Case-Control Studies ,Immunology ,Chronic Disease ,Scarlet fever ,lcsh:Q ,Herpes Labialis ,business ,Genome-Wide Association Study ,Measles - Abstract
Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry. We detect 59 genome-wide significant (P, Susceptibility to infectious diseases is, among others, influenced by the genetic landscape of the host. Here, Tian and colleagues perform genome-wide association studies for 23 common infections and find 59 risk loci for 17 of these, both within the HLA region and non-HLA loci.
- Published
- 2017