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5 results on '"Amann, Sabine"'

1. Identification of ALK in Thinness

Author

Orthofer, Michael, primary, Valsesia, Armand, additional, Mägi, Reedik, additional, Wang, Qiao-Ping, additional, Kaczanowska, Joanna, additional, Kozieradzki, Ivona, additional, Leopoldi, Alexandra, additional, Cikes, Domagoj, additional, Zopf, Lydia M., additional, Tretiakov, Evgenii O., additional, Demetz, Egon, additional, Hilbe, Richard, additional, Boehm, Anna, additional, Ticevic, Melita, additional, Nõukas, Margit, additional, Jais, Alexander, additional, Spirk, Katrin, additional, Clark, Teleri, additional, Amann, Sabine, additional, Lepamets, Maarja, additional, Neumayr, Christoph, additional, Arnold, Cosmas, additional, Dou, Zhengchao, additional, Kuhn, Volker, additional, Novatchkova, Maria, additional, Cronin, Shane J.F., additional, Tietge, Uwe J.F., additional, Müller, Simone, additional, Pospisilik, J. Andrew, additional, Nagy, Vanja, additional, Hui, Chi-Chung, additional, Lazovic, Jelena, additional, Esterbauer, Harald, additional, Hagelkruys, Astrid, additional, Tancevski, Ivan, additional, Kiefer, Florian W., additional, Harkany, Tibor, additional, Haubensak, Wulf, additional, Neely, G. Gregory, additional, Metspalu, Andres, additional, Hager, Jorg, additional, Gheldof, Nele, additional, and Penninger, Josef M., additional

Published
2020
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2. Erratum. Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition. Diabetes 2017;66:272–286

Author

Mueller, Kristina M., primary, Hartmann, Kerstin, additional, Kaltenecker, Doris, additional, Vettorazzi, Sabine, additional, Bauer, Mandy, additional, Mauser, Lea, additional, Amann, Sabine, additional, Jall, Sigrid, additional, Fischer, Katrin, additional, Esterbauer, Harald, additional, Müller, Timo D., additional, Tschöp, Matthias H., additional, Magnes, Christoph, additional, Haybaeck, Johannes, additional, Scherer, Thomas, additional, Bordag, Natalie, additional, Tuckermann, Jan P., additional, and Moriggl, Richard, additional

Published
2017
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3. Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition

Author

Mueller, Kristina M., primary, Hartmann, Kerstin, additional, Kaltenecker, Doris, additional, Vettorazzi, Sabine, additional, Bauer, Mandy, additional, Mauser, Lea, additional, Amann, Sabine, additional, Jall, Sigrid, additional, Fischer, Katrin, additional, Esterbauer, Harald, additional, Müller, Timo D., additional, Tschöp, Matthias H., additional, Magnes, Christoph, additional, Haybaeck, Johannes, additional, Scherer, Thomas, additional, Bordag, Natalie, additional, Tuckermann, Jan P., additional, and Moriggl, Richard, additional

Published
2016
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4. Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition.

Author

Mueller, Kristina M., Hartmann, Kerstin, Kaltenecker, Doris, Vettorazzi, Sabine, Bauer, Mandy, Mauser, Lea, Amann, Sabine, Jall, Sigrid, Fischer, Katrin, Esterbauer, Harald, Müller, Timo D., Tschöp, Matthias H., Magnes, Christoph, Haybaeck, Johannes, Scherer, Thomas, Bordag, Natalie, Tuckermann, Jan P., and Moriggl, Richard

Subjects
GLUCOCORTICOIDS, ENERGY metabolism, PATHOLOGICAL physiology, METABOLOMICS, OBESITY, FAT cells, ADIPOSE tissues, AGING, ANIMAL experimentation, BETA adrenoceptors, BIOCHEMISTRY, HUMAN body composition, CELL receptors, CELLULAR signal transduction, DIET, FASTING, FATTY liver, FOOD habits, GENETIC disorders, HYPERTROPHY, INSULIN, LIPID metabolism disorders, LIQUID chromatography, LIVER, MASS spectrometry, MICE, WESTERN immunoblotting
Abstract

Glucocorticoids (GCs) are important regulators of systemic energy metabolism, and aberrant GC action is linked to metabolic dysfunctions. Yet, the extent to which normal and pathophysiological energy metabolism depend on the GC receptor (GR) in adipocytes remains unclear. Here, we demonstrate that adipocyte GR deficiency in mice significantly impacts systemic metabolism in different energetic states. Plasma metabolomics and biochemical analyses revealed a marked global effect of GR deficiency on systemic metabolite abundance and, thus, substrate partitioning in fed and fasted states. This correlated with a decreased lipolytic capacity of GR-deficient adipocytes under postabsorptive and fasting conditions, resulting from impaired signal transduction from β-adrenergic receptors to adenylate cyclase. Upon prolonged fasting, the impaired lipolytic response resulted in abnormal substrate utilization and lean mass wasting. Conversely, GR deficiency attenuated aging-/diet-associated obesity, adipocyte hypertrophy, and liver steatosis. Systemic glucose tolerance was improved in obese GR-deficient mice, which was associated with increased insulin signaling in muscle and adipose tissue. We conclude that the GR in adipocytes exerts central but diverging roles in the regulation of metabolic homeostasis depending on the energetic state. The adipocyte GR is indispensable for the feeding-fasting transition but also promotes adiposity and associated metabolic disorders in fat-fed and aged mice. [ABSTRACT FROM AUTHOR]

Published
2017
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5. Erratum. Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition. Diabetes 2017;66:272-286.

Author

Mueller, Kristina M, Hartmann, Kerstin, Kaltenecker, Doris, Vettorazzi, Sabine, Bauer, Mandy, Mauser, Lea, Amann, Sabine, Jall, Sigrid, Fischer, Katrin, Esterbauer, Harald, Müller, Timo D, Tschöp, Matthias H, Magnes, Christoph, Haybaeck, Johannes, Scherer, Thomas, Bordag, Natalie, Tuckermann, Jan P, and Moriggl, Richard

Subjects
OBESITY treatment, GLUCOCORTICOID receptors
Abstract

A correction to the article "Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition" by M. Kristina et al. that was published in a 2017 issue of the journal "Diabetes" is presented.

Published
2018
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