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In this study, the performance of an integrated desiccant air conditioning system (IDACS) activated by solar energy is evaluated by back propagation artificial neural network (BP-ANN). The IDACS consists of a liquid desiccant dehumidification cycle combined with a vapor compression refrigeration cycle. The integrated system performance is assessed utilizing the system coefficient of performance (COP), outlet dry air temperature (Tda-out), and specific moisture removal (SMR). The training of the BP-ANN is accomplished utilizing experimental results previously published. The results of the BP-ANN model revealed the high accuracy in predicting system performance parameters compared with experimental values. The BP-ANN model has shown relative errors in the trained mode for COP, Tda-out, and SMR within ±0.005%, ±0.006%, and ±0.05%, respectively. On the other side, the BP-ANN model is inspected in the predictive mode as well. The relative errors of the model for COP, Tda-out, and SMR in the predictive mode are within ±0.006%, ±0.006%, and ±0.004%, respectively. The influences of some selected parameters, namely regeneration temperature, desiccant solution temperature in the condenser and evaporator, and strong solution concentration on the system performance are examined and discussed as well. [ABSTRACT FROM AUTHOR]

In this study, a library of phthalimide Schiff base linked to 1,4-disubstituted-1,2,3-triazoles was designed, synthesised, and characterised by different spectral analyses. All analogues have been introduced for in vitro assay of their antiviral activity against COVID-19 virus using Vero cell as incubator with different concentrations. The data revealed most of these derivatives showed potent cellular anti-COVID-19 activity and prevent viral growth by more than 90% at two different concentrations with no or weak cytotoxic effect on Vero cells. Furthermore, in vitro assay was done against this enzyme for all analogues and the results showed two of them have IC50 data by 90 µM inhibitory activity. An extensive molecular docking simulation was run to analyse their antiviral mechanism that found the proper non-covalent interaction within the Mpro protease enzyme. Finally, we profiled two reversible inhibitors, COOH and F substituted analogues that might be promising drug candidates for further development have been discovered.

A novel derivative of ciprofloxacin (Cpx) was synthesized and characterized using various analytical techniques, including FT-IR spectroscopy, UV-Vis spectroscopy, TEM and SEM analysis, 1 H NMR, 13 C NMR, and HPLC analysis. The newly prepared Cpx derivative (Cpx-Drv) exhibited significantly enhanced antibacterial properties compared to Cpx itself. In particular, Cpx-Drv demonstrated a 51% increase in antibacterial activity against S. aureus and a 30% improvement against B. subtilis . It displayed potent inhibitory effects on topoisomerases II (DNA gyrase and topoisomerase IV) as potential molecular targets, with IC50 values of 6.754 and 1.913 µg/mL, respectively, in contrast to Cpx, which had IC50 values of 2.125 and 0.821 µg/mL, respectively. Docking studies further supported these findings, showing that Cpx-Drv exhibited stronger binding interactions with the gyrase enzyme (PDB ID: 2XCT) compared to the parent Cpx, with binding affinities of -10.3349 and -7.7506 kcal/mole, respectively.

There is concern for important adverse effects with use of second-generation antipsychotics in Parkinson's disease psychosis (PDP) and dementia-related psychosis. Pimavanserin is the only antipsychotic drug authorized for PDP and represents an inverse agonist of 5-HT 2A receptors (5-HT2AR) lacking affinity for dopamine receptors. Therefore, the development of serotonin 5-HT2AR inverse agonists without dopaminergic activity represents a challenge for different neuropsychiatric disorders. Using ligand-based drug design, we discovered a novel structure of pimavanserin analogues ( 2 , 3 , and 4 ). In vitro competition receptor binding and functional G protein coupling assays demonstrated that compounds 2 , 3 , and 4 showed higher potency than pimavanserin as 5-HT2AR inverse agonists in the human brain cortex and recombinant cells. To assess the effect of molecular substituents for selectivity and inverse agonism at 5-HT2ARs, molecular docking and in silico predicted physicochemical parameters were performed. Docking studies were in agreement with in vitro screenings and the results resembled pimavanserin.

A series of amphiphilic arborescent copolymers of generations G1 and G2 with an arborescent poly(γ-benzyl L-glutamate) (PBG) core and poly(ethylene oxide) (PEO) chain segments in the shell, PBG- g -PEO, were synthesized and evaluated as drug delivery nanocarriers. The PBG building blocks were generated by ring-opening polymerization of γ-benzyl L-glutamic acid N- carboxyanhydride (Glu-NCA) initiated with n -hexylamine. Partial or full deprotection of the benzyl ester groups followed by coupling with PBG chains yielded a comb-branched (arborescent polymer generation zero or G0) PBG structure. Additional cycles of deprotection and grafting provided G1 and G2 arborescent polypeptides. Side chains of poly(ethylene oxide) were then randomly grafted onto the arborescent PBG substrates to produce amphiphilic arborescent copolymers. Control over the branching density of G0PBG was investigated by varying the length and the deprotection level of the linear PBG substrates used in their synthesis. Three G0PBG cores with different branching densities, varying from a compact and dense to a loose and more porous structure, were thus synthesized. These amphiphilic copolymers behaved similar to unimolecular micelles in aqueous solutions, with a unimodal number- and volume-weighted size distributions in dynamic light scattering measurements. It was demonstrated that these biocompatible copolymers can encapsulate hydrophobic drugs such as doxorubicin (DOX) within their hydrophobic core with drug loading efficiencies of 42-65%. Sustained and pH-responsive DOX release was observed from the unimolecular micelles, which suggests that they could be useful as drug nanocarriers for cancer therapy.

The solar stills can solve the problem of freshwater shortage for the people living in remote areas. Through this work, the performance of hybrid solar desalination arrangement was investigated. The system comprised of parabolic trough solar collector, automatic solar tracking system, separation room, modified solar still, two condensation units, feed water tank, and supplementary and measuring tools. The effect of using various water flow rates on the effectiveness of parabolic trough solar collector was tested. Also, the influences of integrating condenser to the modified solar still with and without phase change material were studied. The experimental results revealed that the best flow rate for parabolic trough solar collector was obtained as 10 L/h (100 L/day), where its effectivity was 61%. Under this condition, the obtained freshwater was around 61 L/day from a total saline water of 100 L/day. In addition, integrating a condenser to the modified solar still improved its productivity. So, the total yields of conventional and modified solar stills were 2500 and 5145 mL/m 2 .day, respectively. Therefore, the distillate of modified solar still was improved by 105.8% as compared to that of the conventional solar still due to using the hot feed water and external condenser. Moreover, using phase change material enhanced the modified solar still yield. The total yield of conventional solar still and modified solar still with hot feed water, condenser, and phase change material was 2575 and 6150 mL/m 2 .day, respectively. Consequently, the productivity of the modified solar still with hot feed water, condenser, and phase change material was improved by around 138.83% over that of the conventional solar still. Finally, the conventional solar still had an average efficiency of 31.5%. Also, when using the hot feed water and external condenser with the modified solar still, the thermal efficiency was reported as 49.7%. Also, the modified solar still with hot water, condenser, and phase change material had a thermal efficiency of 56.5%. Finally, the water costs of 1 L from the CSS and MSS are 0.063 $ and 0.050 $, respectively., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Polymer colloids have remarkable features and are gaining importance in many areas of research including medicinal science. Presently, the innovation of cancer drugs is at the top in the world. Polymer colloids have been used as drug delivery and diagnosis agents in cancer treatment. The polymer colloids may be of different types such as micelles, liposomes, emulsions, cationic carriers, and hydrogels. The current article describes the state-of-the-art polymer colloids for the treatment of cancer. The contents of this article are about the role of polymeric nanomaterials with special emphasis on the different types of colloidal materials and their applications in targeted cancer therapy including cancer diagnoses. In addition, attempts are made to discuss future perspectives. This article will be useful for academics, researchers, and regulatory authorities.

In this study, an efficient multistep synthesis of novel aromatic tricyclic hybrids incorporating different biological active moieties, such as 1,3,4-thiadiazole and 1,2,4-triazole, was reported. These target scaffolds are characterized by having terminal lipophilic or hydrophilic parts, and their structures are confirmed by different spectroscopic methods. Further, the cytotoxic activities of the newly synthesized compounds were evaluated using in vitro MTT cytotoxicity screening assay against three different cell lines, including HepG-2, MCF-7, and HCT-116, compared with the reference drug Taxol. The results showed variable performance against cancer cell lines, exhibiting MCF-7 and HepG-2 selectivities by active analogs. Among these derivatives, 1,2,4-triazoles 11 and 13 and 1,3,4-thiadiazole 18 were found to be the most potent compounds against MCF-7 and HepG-2 cancer cells. Moreover, structure-activity relationship (SAR) studies led to the identification of some potent LSD1 inhibitors. The tested compounds showed good LSD1 inhibitory activities, with an IC 50 range of 0.04-1.5 μM. Compounds 27 , 23 , and 22 were found to be the most active analogs with IC 50 values of 0.046, 0.065, and 0.074 μM, respectively. In addition, they exhibited prominent selectivity against a MAO target with apparent cancer cell apoptosis, resulting in DNA fragmentation. This research provides some new aromatic-centered 1,2,4-triazole-3-thione and 1,3,4-thiadiazole analogs as highly effective anticancer agents with good LSD1 target selectivity.

Polymer-based nanocomposites are being considered as replacements for conventional materials in medium to high-temperature applications. This article aims to discover the synergistic effects of reinforcements on the developed polymer-based nanocomposite. An epoxy-based polymer composite was manufactured by reinforcing graphene nanoplatelets (GNP) and h-boron nitride (h-BN) nanofillers. The composites were prepared by varying the reinforcements with the step of 0.1 from 0.1 to 0.6%. Ultrasonication was carried out to ensure the homogenous dispersion of reinforcements. Mechanical, thermal, functional, and scanning electron microscopy (SEM) analysis was carried out on the novel manufactured composites. The evaluation revealed that the polymer composite with GNP 0.2 by wt % has shown an increase in load-bearing capacity by 265% and flexural strength by 165% compared with the pristine form, and the polymer composite with GNP and h-BN 0.6 by wt % showed an increase in load-bearing capacity by 219% and flexural strength by 114% when compared with the pristine form. Furthermore, the evaluation showed that the novel prepared nanocomposite reinforced with GNP and h-BN withstands a higher temperature, around 340 °C, which is validated by thermogravimetric analysis (TGA) trials. The numerical simulation model is implemented to gather the synthesised nanocomposite's best composition and mechanical properties. The minor error between the simulation and experimental data endorses the model's validity. To demonstrate the industrial applicability of the presented material, a case study is proposed to predict the temperature range for compressor blades of gas turbine engines containing nanocomposite material as the substrate and graphene/h-BN as reinforcement particles.

Polyethylene glycol (PEG) is a multifunctional polymer that has many uses in medical and biological applications. Recently, PEG has been mainly used in developing nanomaterial-based drug delivery systems (DDS). PEG is characterized by its high solubility, biological inertness, and ability to escape from immune cells (stealthiness) after systemic injection. The most challenging problem for PEGylated nanomaterials is their rapid elimination from the bloodstream after repeated doses of systemic injection, called accelerated blood clearance (ABC). Therefore, in this study, the effect of PEGylated nanomaterial dose concentration on ABC induction will be investigated using quantitative, histological, and immunohistochemical analyses. A higher dose concentration (2 mg/kg) of PEGylated gold nanoparticles (PEG-coated AuNPs) reduced the ABC phenomenon when intravenously injected into mice preinjected with the same dose. In contrast, a lower dose concentration (< 1 mg/kg) significantly induced the ABC phenomenon by the rapid elimination of the second dose of PEG-coated AuNPs from the bloodstream. To explain the relationship between the dose concentration (from PEG and AuNPs) and the induction of ABC, the biodistribution of PEG-coated AuNPs in liver and spleen [reticuloendothelial systems (RES)-rich organs] was investigated. The injected dose of PEG-coated AuNPs accumulated mainly in the hepatic Kupffer cells and hepatocytes. Similarly, spleen red pulp received a higher amount of the injected dose of PEG-coated AuNPs. However, the biodistriution profiles of PEG-coated AuNPs after the first and second dose for different dose concentrations varied in RES-rich organs. Additionally, the number of B lymphocytes, which have an important role in producing anti-PEG immunoglobulin (Ig)M, was affected by the repeated dose of PEG-coated AuNPs in the spleen. Therefore, for effective nanomaterial-based DDS development, dose optimization of PEG molecules that express PEGylated nanomaterials is important to reduce the ABC phenomenon effect. The ideal concentration of PEG molecules used to coat nanomaterials and the role of RES-rich organs must be determined to control the ABC phenomenon effect of PEGylated nanomaterials., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

The problem of potable water shortage all over the world made the scientists seek for solutions to overcome this problem. Solar distiller is one of the introduced solutions, but it demerited by the low freshwater output. In this proposed paper, a design modification includes the use of a convex dish absorber instead of the flat absorber liner. The modified solar distiller is nominated by dish solar distiller. The base of dish solar distiller was circular. In addition, a cotton wick was used as a wetting material for facilitating the evaporation process inside the distiller. Besides, the effect of different water heights in the clearance around the dish dome was investigated for 1, 3, 5, 7, 9, and 12 cm. Finally, the space under the dish absorber is filled with a phase change material of paraffin wax mixed with aluminum oxide nanoparticles. Experimental results revealed that the best dish height that provided the highest freshwater productivity was 9 cm, where the average daily yields of dish solar distiller (at 9 cm) and conventional distillers were reported as 4500 and 3000 mL/m 2 .day, respectively. Then, the productivity of dish solar distiller was improved by around 50% over that of the conventional distiller. In addition, when using the phase change material, the average daily distillate of dish solar distiller was improved by approximately 95% compared to that of the conventional solar still, where the distillate of conventional still and dish solar distiller with phase change material at 9 cm water depth was 3580 and 6980 mL/m 2 .day, respectively. Besides, the maximum thermal efficiency of dish solar distiller was obtained when using phase change material at 9 cm water depth, where it was 62.4% compared to 30% for the conventional distiller., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Environmental concerns have initiated the search for greener measures to mitigate pollution issues. Bio Nano CaO was synthesized by reducing CaO extracted from chicken egg shell using tea decoction. The synthesized material was characterized by physico-chemical techniques such as XRD, TGA, BET surface area analyser, TGA and SEM techniques. XRD studied confirmed the crystalline nature of material. The prepared material was found to be stable till 450 ο C from TGA study. The SEM pictures displayed uniform and discrete particles which portrays the high probable sites that maximises the catalytic activity. The optimization of microwave assisted Biodiesel synthesis from chicken feather oil through Transesterification process using the bio-synthesized catalytic material was the main aim of the study. A 500 W microwave irradiation of Chicken feather meal oil using 8:1 Methanol:Oil input, 1% Bio Nano CaO concentration, 5 min of reaction time resulted in 95% conversion of chicken feather meal oil into chicken feather meal methyl esters. The Biodiesel was showed low viscosity (4.15 mm 2 /s), high heating value (50 MJ/kg), high flash point (153 ο C), reasonable pour point (12 ο C) and good cetane number (50 min). The future works will be concentrated on the engine studies related to Torque, fuel consumption, emission data by using the synthesized Biodiesel., (Copyright © 2021 Elsevier Inc. All rights reserved.)

Nanotechnology provides the means to design and fabricate delivery vehicles capable of overcoming physiologically imposed obstacles and undesirable side effects of systemic drug delivery. This protocol allows maximal targeting effectiveness and therefore enhances therapeutic efficiency. In recent years, Mesoporous Silica Nanoparticles (MSNPs) have sparked interest in nanomedicine research community, particularly for their promising applications in cancer treatment. The intrinsic physio-chemical stability, facile functionalization, high surface area, low toxicity, and great loading capacity for a wide range of chemotherapeutic agents make MSNPs very appealing candidates for controllable drug delivery systems. Importantly, the peculiar nanostructures of MSNPs enabled them to serve as an effective drug, gene, protein and antigen delivery vehicle for a variety of therapeutic regimens. For these reasons, in this review article, we underscore the recent progress in the design and synthesis of MSNPs along with the parameters influencing their characteristic features and activities. In addition, the process of absorption, dissemination and secretion by injection or oral management of MSNPs are also discussed, as they are key directions for potential utilization of MSNPs. Factors influencing the in vivo fate of MSNPs will also be highlighted, with a main focus on particle size, morphology, porosity, surface functionality and oxidation. Given that combining other functional materials with MSNPs may increase their biological compatibility, monitor drug discharge, or improve absorption by tumor cells coated MSNPs; these aspects are also covered and discussed herein., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

The present research work reports the biosynthesis of hydroxyapatite (HAp) from eggshells and green synthesis of HAp from eggshells with incorporation of Piper betel leaf extract (PBL-HAp) using microwave conversion method. Although there are several works on synthesis of HAp from eggshells and other calcium and phosphorus rich substrates, the incorporation of herbal extract with HAp to promote antimicrobial and antibiofilm activity is less explored and reported. This research work highlights a simple and cost-effective method for development of antimicrobial biomaterials by combining the concepts of waste management, biomaterial science, and herbal medicine. In the present study, characterization of synthesized HAp was applied by X-ray Diffraction (XRD), Fourier Transform Infrared (FTIR) spectroscopy, Proton Nuclear Magnetic Resonance ( 1 H NMR) spectroscopy, and morphological analysis using Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). The characterization results indicated that the prepared HAp and PBL-HAp were pure b-type carbonated HAp. The PBL-HAp was checked for its antibacterial activity using the well diffusion method and biofilm inhibitory activity by crystal violet assay against some common pathogens. The antibacterial activities against Staphylococcus aureus and biofilm inhibitory activities against Escherichia coli, Vibrio harveyi, Pseudomonas aeruginosa, and Staphylococcus aureus of Piper betel leaf extract coated HAp (PBL-HAp) were showed to be significant and offered a promising role for the development of potent dental biomaterials., (Copyright © 2021 Elsevier Inc. All rights reserved.)

The frequent applications of synthetic chemical insecticides and drugs create resistance among insects and microbes, creating a new threat to human and environmental welfare. This investigation focused on evaluating the possibilities of fabricating and characterizing the titanium dioxide nanoparticles (TiO 2 NPs) from titanium dioxide (TiO 2 ) through the aqueous leaf extract of Coleus aromaticus. Their biological applications were studied against the larvae of Aedes aegypti human pathogenic bacteria, and cancer cell line. The results revealed that the aqueous leaf extract had the metal reducing proficiency to produce nanoparticles from TiO 2 . The synthesized TiO 2 NPs were initially confirmed by visible color changes and Ultraviolet-Visible Spectrophotometer analysis that showed a predominant peak at 332 nm. Furthermore, the nanocrystals, structural alignment, functional groups and elemental compositions were studied by following standard operating protocol in XRD (X-ray Powder Diffraction), FTIR (Fourier Transform Infrared Spectroscopy), TEM (Transmission Electron Microscopy), and EDX (Energy-Dispersive X-ray Spectroscopy) techniques, respectively. The results attained from these techniques confirmed that the plant mediated and fabricated particles were in the nanoscale range (12-33 nm) with a hexagonal shape. The synthesized TiO 2 NPs had an outstanding (1000 μg mL -1 ) larvicidal activity against the four stages of instars larvae of Ae. aegypti at 1000 μg mL -1 . It also had an excellent antibacterial potential against E. faecalis (33 mm), followed by S. boydii (30 mm) at 30 mg L -1 concentration. The green fabricated TiO 2 NPs had a fabulous (92.37%) cytotoxic activity on the HeLa cell line at 100 μg mL -1 dosage within one day of exposure. The entire results concluded that the C. aromaticus mediated TiO 2 NPs have excellent biological applications and thus, could be considered for the welfare of human beings., (Copyright © 2021 Elsevier Inc. All rights reserved.)

The frequent application of synthetic insecticides creates resistance among insects, including mosquitoes, and causes environmental pollution and health issues. The current work aim at assessing the possibilities to produce and characterize the titanium dioxide (TiO 2 ) nanoparticles (TiO 2 NPs) mediated through the aqueous leaf extract of Pouteria campechiana, and their larvicidal and pupicidal activities against Aedes aegypti. The attained results showed that the aqueous leaf extract of P. campechiana had the efficiency to fabricate TiO 2 NPs from TiO 2 . Under the UV-vis spectrum analysis, a sharp peak was recorded at 320 nm, which indicated the production of TiO 2 NPs by the plant extract. The SEM analysis revealed that the synthesized TiO 2 NPs were spherical, and 5 dissimilar diffractions were detected in the XRD spectrum analysis related to the TiO 2 NPs. In FTIR analysis, a prominent peak was found at 1052.41 cm -1 , corresponding to alcohol, and confirmed metal reduction. In the EDX analysis, there was a signal of around 58.44%, confirming the decrease in Ti from TiO 2 NPs, and the remaining percentages were Ca, Al, and Mg. About 900 μg mL -1 of TiO 2 NPs had excellent lethal activity against various larvae and pupa stages of Ae. aegypti. The attained results showed that the P. campechiana aqueous leaf extract could reduce TiO 2 into TiO 2 NPs and could be considered a mosquito control agent. Furthermore, this is the initial report about the aqueous leaf extract of P. campechiana effectively synthesizing the TiO 2 NPs with anti-mosquito activity., (Copyright © 2021 Elsevier Inc. All rights reserved.)

Cancer is a life-threatening disease killing millions of people globally. Among various medical treatments, nano-medicines are gaining importance continuously. Many nanocarriers have been developed for treatment, but polymerically-based ones are acquiring importance due to their targeting capabilities, biodegradability, biocompatibility, capacity for drug loading and long blood circulation time. The present article describes progress in polymeric nano-medicines for theranostic cancer treatment, which includes cancer diagnosis and treatment in a single dosage form. The article covers the applications of natural and synthetic polymers in cancer diagnosis and treatment. Efforts were also made to discuss the merits and demerits of such polymers; the status of approved nano-medicines; and future perspectives.

In the last decade, considerable attention has been devoted to the use of biodegradable polymeric materials as potential drug delivery carriers. However, bioavailability and drug release at the disease site remain uncontrollable even with the use of polymeric nanocarriers. To address this issue, successful methodologies have been developed to synthesize polymeric nanocarriers incorporated with regions exhibiting a response to stimuli such as redox potential, temperature, pH, and light. The resultant stimuli-responsive polymeric nanocarriers have shown tremendous promise in drug delivery applications, owing to their ability to enhance the bioavailability of drugs at the disease site. In such systems, drug release is controlled in response to specific stimuli, either exogenous or endogenous. This review reports recent advances in the design of stimuli-responsive nanocarriers for drug delivery in cancer therapy. In particular, the synthetic methodologies investigated to date to introduce different types of stimuli-responsive elements within the biomaterials are described. The sufficient understanding of these stimuli-responsive nanocarriers will allow the development of a better drug delivery system that will allow us to solve the challenges encountered in targeted cancer therapy., (© 2020 The Author(s).)

This report presents the development of a novel and primary model of sulfonamide compounds encompassing a chromene azo motif with the intent of becoming applicable for drug candidates in the cases of drug-resistant pathogens. The novel molecules (7a-n) have been synthesized via a two-step reaction. First, 4-((2, 4-dihydroxyphenyl)diazenyl)benzenesulfonamide (3a-e) were obtained through the reaction of their corresponding diazotized 4-aminobenzenesulfonamides (1a-e) with resorcinol, followed by the heterocyclization of 3a-e with arylidenemalononitriles (6a-d). Upon structural identification, the newly synthesized compounds were evaluated for their antibacterial and antifungal activities. Moreover, their cytotoxic screening was performed against three cancer cell lines: HCT-116, HepG-2, and MCF-7. Further examinations were comprised of the inhibitory effect analyses of the novel sulfonamide/chromene derivatives against the HDAC classes and the Tubulin polymerization in order to discern the prime antitumor drug candidates., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Chitosan biguanidine hydrochloride (CBg) was prepared as a novel multifunctional biodegradable polymer with antimicrobial and excellent water-solubility properties, and used as a crosslinker to prepare carboxymethyl cellulose (CMC)/alginate (A)/CBg edible coating. FTIR confirmed the successful preparation of CBg and CMC/A/CBg films. Wide-angle X-ray diffraction showed that the amorphous structure of CMC/A had some degree of order after CBg addition. The film thickness and solubility were decreased after CBg addition due to the formation of a dense crosslinked structure. CBg addition significantly improved the thermal properties of the films as detected from the calculated IPDT values from TGA curves. Water vapor permeability was reduced to 54% of the value of CMC/A when CBg was added by15 wt%. The addition of CBg didn't change the transparency of CMC/A films. The mechanical properties and antibacterial properties were significantly enhanced after the addition of CBg. CMC/A/CBg were coated on tomato fruits, and the shelf-life studies showed that the storage weight loss was significantly reduced, and the spoilage was inhibited after coating. These results suggest that CMC/A/CBg edible coating might be a promising candidate in food preservation industries., (Copyright © 2019 Elsevier B.V. All rights reserved.)