Author: "Allebes, Wil A." / Publication Year Range: Last 10 years - Searchworks@Jio Institute Digital Library Search Results

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1. Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival

Author: Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Kroesen, Bart Jan, Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Heidt, Sebastiaan, Otten, Henny G., Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Kroesen, Bart Jan, Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Heidt, Sebastiaan, and Otten, Henny G.
Abstract: In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In a large Dutch kidney transplant cohort, Ellipro scores of pretransplant donor antibodies that can be assigned to known eplets (donor epitope specific HLA antibodies [DESAs]) were compared between early graft failure and long surviving deceased donor transplants. We did not observe a significant Ellipro score difference between the two cohorts, nor significant differences in graft survival between transplants with DESAs having high versus low total Ellipro scores. We conclude that Ellipro scores cannot be used to identify DESAs associated with early versus late kidney graft loss in deceased donor transplants.
Published: 2024

2. Determination of the clinical relevance of donor epitope-specific HLA-antibodies in kidney transplantation

Author: Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Reteig, Leon, Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Senev, Aleksandar, Naesens, Maarten, Heidt, Sebastiaan, Otten, Henny G., Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Reteig, Leon, Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Senev, Aleksandar, Naesens, Maarten, Heidt, Sebastiaan, and Otten, Henny G.
Abstract: In kidney transplantation, survival rates are still partly impaired due to the deleterious effects of donor specific HLA antibodies (DSA). However, not all luminex-defined DSA appear to be clinically relevant. Further analysis of DSA recognizing polymorphic amino acid configurations, called eplets or functional epitopes, might improve the discrimination between clinically relevant vs. irrelevant HLA antibodies. To evaluate which donor epitope-specific HLA antibodies (DESAs) are clinically important in kidney graft survival, relevant and irrelevant DESAs were discerned in a Dutch cohort of 4690 patients using Kaplan–Meier analysis and tested in a cox proportional hazard (CPH) model including nonimmunological variables. Pre-transplant DESAs were detected in 439 patients (9.4%). The presence of certain clinically relevant DESAs was significantly associated with increased risk on graft loss in deceased donor transplantations (p < 0.0001). The antibodies recognized six epitopes of HLA Class I, 3 of HLA-DR, and 1 of HLA-DQ, and most antibodies were directed to HLA-B (47%). Fifty-three patients (69.7%) had DESA against one donor epitope (range 1–5). Long-term graft survival rate in patients with clinically relevant DESA was 32%, rendering DESA a superior parameter to classical DSA (60%). In the CPH model, the hazard ratio (95% CI) of clinically relevant DESAs was 2.45 (1.84–3.25) in deceased donation, and 2.22 (1.25–3.95) in living donation. In conclusion, the developed model shows the deleterious effect of clinically relevant DESAs on graft outcome which outperformed traditional DSA-based risk analysis on antigen level.
Published: 2024

3. Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival

Author: CTI Otten, CTI, CDL Cluster Speciële Diagnostiek, Cancer, Infection & Immunity, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CDL Unit SKIM, CTI CFF, Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Kroesen, Bart Jan, Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Heidt, Sebastiaan, Otten, Henny G., CTI Otten, CTI, CDL Cluster Speciële Diagnostiek, Cancer, Infection & Immunity, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CDL Unit SKIM, CTI CFF, Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Kroesen, Bart Jan, Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Heidt, Sebastiaan, and Otten, Henny G.
Published: 2024

4. Determination of the clinical relevance of donor epitope‐specific HLA‐antibodies in kidney transplantation

Author: Kardol‐Hoefnagel, Tineke, primary, Senejohnny, Danial Mohammadi, additional, Kamburova, Elena G., additional, Wisse, Bram W., additional, Reteig, Leon, additional, Gruijters, Maartje L., additional, Joosten, Irma, additional, Allebes, Wil A., additional, van der Meer, Arnold, additional, Hilbrands, Luuk B., additional, Baas, Marije C., additional, Spierings, Eric, additional, Hack, Cornelis E., additional, van Reekum, Franka E., additional, van Zuilen, Arjan D., additional, Verhaar, Marianne C., additional, Bots, Michiel L., additional, Drop, Adriaan C. A. D., additional, Plaisier, Loes, additional, Melchers, Rowena C. A., additional, Seelen, Marc A. J., additional, Sanders, Jan Stephan, additional, Hepkema, Bouke G., additional, Lambeck, Annechien J. A., additional, Bungener, Laura B., additional, Roozendaal, Caroline, additional, Tilanus, Marcel G. J., additional, Voorter, Christina E., additional, Wieten, Lotte, additional, van Duijnhoven, Elly M., additional, Gelens, Mariëlle A. C. J., additional, Christiaans, Maarten H. L., additional, van Ittersum, Frans J., additional, Nurmohamed, Shaikh A., additional, Lardy, Neubury M., additional, Swelsen, Wendy, additional, van der Pant, Karlijn A. M. I., additional, van der Weerd, Neelke C., additional, ten Berge, Ineke J. M., additional, Hoitsma, Andries, additional, van der Boog, Paul J. M., additional, de Fijter, Johan W., additional, Betjes, Michiel G. H., additional, Roelen, Dave L., additional, Claas, Frans H., additional, Bemelman, Frederike J., additional, Senev, Aleksandar, additional, Naesens, Maarten, additional, Heidt, Sebastiaan, additional, and Otten, Henny G., additional
Published: 2024
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5. Antibodies against ARHGDIB are associated with long-term kidney graft loss

Author: Kamburova, Elena G., Gruijters, Maartje L., Kardol-Hoefnagel, Tineke, Wisse, Bram W., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., and Otten, Henny G.
Published: 2019
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6. Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival.

Author: Kardol‐Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Drop, Adriaan C. A. D., Plaisier, Loes, Melchers, Rowena C. A., Seelen, Marc A. J., and Sanders, Jan Stephan
Subjects: IMMUNOGLOBULINS, GRAFT survival, KIDNEYS, KIDNEY transplantation
Abstract: In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In a large Dutch kidney transplant cohort, Ellipro scores of pretransplant donor antibodies that can be assigned to known eplets (donor epitope specific HLA antibodies [DESAs]) were compared between early graft failure and long surviving deceased donor transplants. We did not observe a significant Ellipro score difference between the two cohorts, nor significant differences in graft survival between transplants with DESAs having high versus low total Ellipro scores. We conclude that Ellipro scores cannot be used to identify DESAs associated with early versus late kidney graft loss in deceased donor transplants. [ABSTRACT FROM AUTHOR]
Published: 2024
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7. Toward a sensible single antigen bead cut-off based on kidney graft survival

Author: Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J. A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Junior N.M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., and Otten, Henny G.
Published: 2018
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8. T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

Author: Peereboom, Emma T. M., primary, Matern, Benedict M., additional, Tomosugi, Toshihide, additional, Niemann, Matthias, additional, Drylewicz, Julia, additional, Joosten, Irma, additional, Allebes, Wil A., additional, van der Meer, Arnold, additional, Hilbrands, Luuk B., additional, Baas, Marije C., additional, van Reekum, Franka E., additional, Verhaar, Marianne C., additional, Kamburova, Elena G., additional, Seelen, Marc A. J., additional, Sanders, Jan Stephan, additional, Hepkema, Bouke G., additional, Lambeck, Annechien J., additional, Bungener, Laura B., additional, Roozendaal, Caroline, additional, Tilanus, Marcel G. J., additional, Voorter, Christien E., additional, Wieten, Lotte, additional, van Duijnhoven, Elly M., additional, Gelens, Mariëlle A. C. J., additional, Christiaans, Maarten H. L., additional, van Ittersum, Frans J., additional, Nurmohamed, Azam, additional, Lardy, Neubury M., additional, Swelsen, Wendy, additional, van der Pant, Karlijn A., additional, van der Weerd, Neelke C., additional, ten Berge, Ineke J. M., additional, Bemelman, Fréderike J., additional, de Vries, Aiko P. J., additional, de Fijter, Johan W., additional, Betjes, Michiel G. H., additional, Roelen, Dave L., additional, Claas, Frans H., additional, Otten, Henny G., additional, Heidt, Sebastiaan, additional, van Zuilen, Arjan D., additional, Kobayashi, Takaaki, additional, Geneugelijk, Kirsten, additional, and Spierings, Eric, additional
Published: 2021
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9. T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

Author: Peereboom, Emma T.M., Matern, Benedict M., Tomosugi, Toshihide, Niemann, Matthias, Drylewicz, Julia, Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., van Reekum, Franka E., Verhaar, Marianne C., Kamburova, Elena G., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Azam, Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Fréderike J., de Vries, Aiko P.J., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Otten, Henny G., Heidt, Sebastiaan, van Zuilen, Arjan D., Kobayashi, Takaaki, Geneugelijk, Kirsten, Spierings, Eric, Peereboom, Emma T.M., Matern, Benedict M., Tomosugi, Toshihide, Niemann, Matthias, Drylewicz, Julia, Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., van Reekum, Franka E., Verhaar, Marianne C., Kamburova, Elena G., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Azam, Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Fréderike J., de Vries, Aiko P.J., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Otten, Henny G., Heidt, Sebastiaan, van Zuilen, Arjan D., Kobayashi, Takaaki, Geneugelijk, Kirsten, and Spierings, Eric
Abstract: CD4+ T-helper cells play an important role in alloimmune reactions following transplantation by stimulating humoral as well as cellular responses, which might lead to failure of the allograft. CD4+ memory T-helper cells from a previous immunizing event can potentially be reactivated by exposure to HLA mismatches that share T-cell epitopes with the initial immunizing HLA. Consequently, reactivity of CD4+ memory T-helper cells toward T-cell epitopes that are shared between immunizing HLA and donor HLA could increase the risk of alloimmunity following transplantation, thus affecting transplant outcome. In this study, the amount of T-cell epitopes shared between immunizing and donor HLA was used as a surrogate marker to evaluate the effect of donor-reactive CD4+ memory T-helper cells on the 10-year risk of death-censored kidney graft failure in 190 donor/recipient combinations using the PIRCHE-II algorithm. The T-cell epitopes of the initial theoretical immunizing HLA and the donor HLA were estimated and the number of shared PIRCHE-II epitopes was calculated. We show that the natural logarithm-transformed PIRCHE-II overlap score, or Shared T-cell EPitopes (STEP) score, significantly associates with the 10-year risk of death-censored kidney graft failure, suggesting that the presence of pre-transplant donor-reactive CD4+ memory T-helper cells might be a strong indicator for the risk of graft failure following kidney transplantation.
Published: 2021

10. T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

Author: CTI Spierings, CTI Computational Immunology Core, Infection & Immunity, CTI Borghans, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, Cancer, Peereboom, Emma T M, Matern, Benedict M, Tomosugi, Toshihide, Niemann, Matthias, Drylewicz, Julia, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, van Reekum, Franka E, Verhaar, Marianne C, Kamburova, Elena G, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Azam, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Fréderike J, de Vries, Aiko P J, de Fijter, Johan W, Betjes, Michiel G H, Roelen, Dave L, Claas, Frans H, Otten, Henny G, Heidt, Sebastiaan, van Zuilen, Arjan D, Kobayashi, Takaaki, Geneugelijk, Kirsten, Spierings, Eric, CTI Spierings, CTI Computational Immunology Core, Infection & Immunity, CTI Borghans, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, Cancer, Peereboom, Emma T M, Matern, Benedict M, Tomosugi, Toshihide, Niemann, Matthias, Drylewicz, Julia, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, van Reekum, Franka E, Verhaar, Marianne C, Kamburova, Elena G, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Azam, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Fréderike J, de Vries, Aiko P J, de Fijter, Johan W, Betjes, Michiel G H, Roelen, Dave L, Claas, Frans H, Otten, Henny G, Heidt, Sebastiaan, van Zuilen, Arjan D, Kobayashi, Takaaki, Geneugelijk, Kirsten, and Spierings, Eric
Published: 2021

11. Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients

Author: Heidt, Sebastiaan, Haasnoot, Geert W., Witvliet, Marian D., van der Linden-van Oevelen, Marissa J.H., Kamburova, Elena G., Wisse, Bram W., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan-Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Marielle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Otten, Henny G., Roelen, Dave L., and Claas, Frans H.J.
Published: 2019
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12. Antibodies against ARHGDIB are associated with long-term kidney graft loss

Author: Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, Otten, Henny G, Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, and Otten, Henny G
Published: 2019

13. Effect of initial immunosuppression on long-term kidney transplant outcome in immunological low-risk patients

Author: Michielsen, Laura A., van Zuilen, Arjan D., Verhaar, Marianne C., Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan F., Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elizabeth M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henderikus G., Hilbrands, Luuk B., Michielsen, Laura A., van Zuilen, Arjan D., Verhaar, Marianne C., Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan F., Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elizabeth M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henderikus G., and Hilbrands, Luuk B.
Published: 2019

14. Toward a sensible single antigen bead cut-off based on kidney graft survival

Author: Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Stephan Sanders, Jan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henny G., Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Stephan Sanders, Jan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., and Otten, Henny G.
Published: 2019

15. A paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival

Author: Michielsen, Laura A, Wisse, Bram W, Kamburova, Elena G, Verhaar, Marianne C, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Erik, van Reekum, Franka E, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elizabeth M, Gelens, Mariëlle, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Frederike J, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Otten, Henderikus G, van Zuilen, Arjan D, Michielsen, Laura A, Wisse, Bram W, Kamburova, Elena G, Verhaar, Marianne C, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Erik, van Reekum, Franka E, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elizabeth M, Gelens, Mariëlle, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Frederike J, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Otten, Henderikus G, and van Zuilen, Arjan D
Published: 2019

16. A paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival

Author: MS Nefrologie, Infection & Immunity, CTI Otten, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, CDL Celdiagnostiek, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CTI, CDL unit Immunoserologie, Michielsen, Laura A, Wisse, Bram W, Kamburova, Elena G, Verhaar, Marianne C, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Erik, van Reekum, Franka E, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elizabeth M, Gelens, Mariëlle, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Frederike J, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Otten, Henderikus G, van Zuilen, Arjan D, MS Nefrologie, Infection & Immunity, CTI Otten, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, CDL Celdiagnostiek, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CTI, CDL unit Immunoserologie, Michielsen, Laura A, Wisse, Bram W, Kamburova, Elena G, Verhaar, Marianne C, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Erik, van Reekum, Franka E, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elizabeth M, Gelens, Mariëlle, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Frederike J, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Otten, Henderikus G, and van Zuilen, Arjan D
Published: 2019

17. Toward a sensible single antigen bead cut-off based on kidney graft survival

Author: Infection & Immunity, CTI Otten, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Mondziekten/Kaakchirurgie, CDL Celdiagnostiek, UMC Utrecht, Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Stephan Sanders, Jan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henny G., Infection & Immunity, CTI Otten, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Mondziekten/Kaakchirurgie, CDL Celdiagnostiek, UMC Utrecht, Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Stephan Sanders, Jan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., and Otten, Henny G.
Published: 2019

18. Antibodies against ARHGDIB are associated with long-term kidney graft loss

Author: CTI Otten, Infection & Immunity, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Celdiagnostiek, CDL unit Immunoserologie, Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, Otten, Henny G, CTI Otten, Infection & Immunity, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Celdiagnostiek, CDL unit Immunoserologie, Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, and Otten, Henny G
Published: 2019

19. Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients

Author: UMC Utrecht, CTI Otten, Infection & Immunity, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Mondziekten/Kaakchirurgie, CDL Celdiagnostiek, Heidt, Sebastiaan, Haasnoot, Geert W., Witvliet, Marian D., van der Linden-van Oevelen, Marissa J.H., Kamburova, Elena G., Wisse, Bram W., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Marielle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Otten, Henny G., Roelen, Dave L., Claas, Frans H.J., UMC Utrecht, CTI Otten, Infection & Immunity, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Mondziekten/Kaakchirurgie, CDL Celdiagnostiek, Heidt, Sebastiaan, Haasnoot, Geert W., Witvliet, Marian D., van der Linden-van Oevelen, Marissa J.H., Kamburova, Elena G., Wisse, Bram W., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Marielle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Otten, Henny G., Roelen, Dave L., and Claas, Frans H.J.
Published: 2019

20. Effect of initial immunosuppression on long-term kidney transplant outcome in immunological low-risk patients

Author: Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, Infection & Immunity, CDL Patiëntenzorg MI, CTI, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL unit Immunoserologie, MS Mondziekten/Kaakchirurgie, CDL Celdiagnostiek, Michielsen, Laura A., van Zuilen, Arjan D., Verhaar, Marianne C., Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan F., Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elizabeth M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henderikus G., Hilbrands, Luuk B., Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, Infection & Immunity, CDL Patiëntenzorg MI, CTI, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL unit Immunoserologie, MS Mondziekten/Kaakchirurgie, CDL Celdiagnostiek, Michielsen, Laura A., van Zuilen, Arjan D., Verhaar, Marianne C., Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan F., Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elizabeth M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henderikus G., and Hilbrands, Luuk B.
Published: 2019

21. Toward a Sensible Single-antigen Bead Cutoff Based on Kidney Graft Survival

Author: Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., Van Der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., Van Reekum, Franka E., Van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Stephan Sanders, Jan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, Van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., Van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, Van Der Pant, Karlijn A.M.I., Van Der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., Van Der Boog, Paul J.M., De Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henny G., Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., Van Der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., Van Reekum, Franka E., Van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Stephan Sanders, Jan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, Van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., Van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, Van Der Pant, Karlijn A.M.I., Van Der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., Van Der Boog, Paul J.M., De Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., and Otten, Henny G.
Abstract: Background:There is no consensus in the literature on the interpretation of single-antigen bead positive for a specific HLA antibody. Methods:To inform the debate, we studied the relationship between various single-antigen bead positivity algorithms and the impact of resulting donor-specific HLA antibody (DSA) positivity on long-term kidney graft survival in 3237 deceased-donor transplants. Results:First, we showed that the interassay variability can be greatly reduced when working with signal-to-background ratios instead of absolute median fluorescence intensities (MFIs). Next, we determined pretransplant DSA using various MFI cutoffs, signal-to-background ratios, and combinations thereof. The impact of the various cutoffs was studied by comparing the graft survival between the DSA-positive and DSA-negative groups. We did not observe a strong impact of various cutoff levels on 10-year graft survival. A stronger relationship between the cutoff level and 1-year graft survival for DSA-positive transplants was found when using signal-to-background ratios, most pronounced for the bead of the same HLA locus with lowest MFI taken as background. Conclusions:With respect to pretransplant risk stratification, we propose a signal-to-background ratio-6 (using the bead of the same HLA-locus with lowest MFI as background) cutoff of 15 combined with an MFI cutoff of 500, resulting in 8% and 21% lower 1- A nd 10-year graft survivals, respectively, for 8% DSA-positive transplants.
Published: 2019

22. Toward a Sensible Single-antigen Bead Cutoff Based on Kidney Graft Survival

Author: Wisse, Bram W., primary, Kamburova, Elena G., additional, Joosten, Irma, additional, Allebes, Wil A., additional, van der Meer, Arnold, additional, Hilbrands, Luuk B., additional, Baas, Marije C., additional, Spierings, Eric, additional, Hack, Cornelis E., additional, van Reekum, Franka E., additional, van Zuilen, Arjan D., additional, Verhaar, Marianne C., additional, Bots, Michiel L., additional, Drop, Adriaan C.A.D., additional, Plaisier, Loes, additional, Seelen, Marc A.J., additional, Stephan Sanders, Jan, additional, Hepkema, Bouke G., additional, Lambeck, Annechien J.A., additional, Bungener, Laura B., additional, Roozendaal, Caroline, additional, Tilanus, Marcel G.J., additional, Voorter, Christina E., additional, Wieten, Lotte, additional, van Duijnhoven, Elly M., additional, Gelens, Mariëlle A.C.J., additional, Christiaans, Maarten H.L., additional, van Ittersum, Frans J., additional, Nurmohamed, Shaikh A., additional, Lardy, Neubury M., additional, Swelsen, Wendy, additional, van der Pant, Karlijn A.M.I., additional, van der Weerd, Neelke C., additional, ten Berge, Ineke J.M., additional, Bemelman, Frederike J., additional, Hoitsma, Andries J., additional, van der Boog, Paul J.M., additional, de Fijter, Johan W., additional, Betjes, Michiel G.H., additional, Heidt, Sebastiaan, additional, Roelen, Dave L., additional, Claas, Frans H., additional, and Otten, Henny G., additional
Published: 2019
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23. Development and Validation of a Multiplex Non-HLA Antibody Assay for the Screening of Kidney Transplant Recipients

Author: Kamburova, Elena G., primary, Kardol-Hoefnagel, Tineke, additional, Wisse, Bram W., additional, Joosten, Irma, additional, Allebes, Wil A., additional, van der Meer, Arnold, additional, Hilbrands, Luuk B., additional, Baas, Marije C., additional, Spierings, Eric, additional, Hack, Cornelis E., additional, van Reekum, Franka E., additional, van Zuilen, Arjan D., additional, Verhaar, Marianne C., additional, Bots, Michiel L., additional, Drop, Adriaan C. A. D., additional, Plaisier, Loes, additional, Meeldijk, Jan, additional, Bovenschen, Niels, additional, Seelen, Marc A. J., additional, Sanders, Jan Stephan, additional, Hepkema, Bouke G., additional, Lambeck, Annechien J. A., additional, Bungener, Laura B., additional, Roozendaal, Caroline, additional, Tilanus, Marcel G. J., additional, Voorter, Christina E., additional, Wieten, Lotte, additional, van Duijnhoven, Elly M., additional, Gelens, Mariëlle A. C. J., additional, Christiaans, Maarten H. L., additional, van Ittersum, Frans J., additional, Nurmohamed, Shaikh A., additional, Lardy, Neubury M., additional, Swelsen, Wendy, additional, van der Pant, Karlijn A. M. I., additional, van der Weerd, Neelke C., additional, ten Berge, Ineke J. M., additional, Bemelman, Frederike J., additional, van der Boog, Paul J. M., additional, de Fijter, Johan W., additional, Betjes, Michiel G. H., additional, Heidt, Sebastiaan, additional, Roelen, Dave L., additional, Claas, Frans H., additional, and Otten, Henny G., additional
Published: 2018
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24. Effect of initial immunosuppression on long-term kidney transplant outcome in immunological low-risk patients

Author: Michielsen, Laura A, primary, van Zuilen, Arjan D, additional, Verhaar, Marianne C, additional, Wisse, Bram W, additional, Kamburova, Elena G, additional, Joosten, Irma, additional, Allebes, Wil A, additional, van der Meer, Arnold, additional, Baas, Marije C, additional, Spierings, Eric, additional, Hack, Cornelis E, additional, van Reekum, Franka E, additional, Bots, Michiel L, additional, Drop, Adriaan C A D, additional, Plaisier, Loes, additional, Seelen, Marc A J, additional, Sanders, Jan-Stephan F, additional, Hepkema, Bouke G, additional, Lambeck, Annechien J, additional, Bungener, Laura B, additional, Roozendaal, Caroline, additional, Tilanus, Marcel G J, additional, Voorter, Christien E, additional, Wieten, Lotte, additional, van Duijnhoven, Elizabeth M, additional, Gelens, Mariëlle A C J, additional, Christiaans, Maarten H L, additional, van Ittersum, Frans J, additional, Nurmohamed, Shaikh A, additional, Lardy, Neubury M, additional, Swelsen, Wendy, additional, van der Pant, Karlijn A, additional, van der Weerd, Neelke C, additional, ten Berge, Ineke J M, additional, Bemelman, Frederike J, additional, Hoitsma, Andries, additional, van der Boog, Paul J M, additional, de Fijter, Johan W, additional, Betjes, Michiel G H, additional, Heidt, Sebastiaan, additional, Roelen, Dave L, additional, Claas, Frans H, additional, Otten, Henderikus G, additional, and Hilbrands, Luuk B, additional
Published: 2018
Full Text: View/download PDF

25. Development and Validation of a Multiplex Non-HLA Antibody Assay for the Screening of Kidney Transplant Recipients

Author: Kamburova, Elena G., Kardol-Hoefnagel, Tineke, Wisse, Bram W., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Meeldijk, Jan, Bovenschen, Niels, Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henny G., Kamburova, Elena G., Kardol-Hoefnagel, Tineke, Wisse, Bram W., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Meeldijk, Jan, Bovenschen, Niels, Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., and Otten, Henny G.
Published: 2018

26. Pretransplant C3D-fixing donor-specific anti-HLA antibodies are not associated with increased risk for kidney graft failure

Author: Kamburova, Elena G., Wisse, Bram W., Joosten, Irma, Allebes, Wil A., Van Der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., Van Reekum, Franka E., Van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, Van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., Van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, Van Der Pant, Karlijn A.M.I., Van Der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., Van Der Boog, Paul J.M., De Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henny G., Kamburova, Elena G., Wisse, Bram W., Joosten, Irma, Allebes, Wil A., Van Der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., Van Reekum, Franka E., Van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, Van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., Van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, Van Der Pant, Karlijn A.M.I., Van Der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., Van Der Boog, Paul J.M., De Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., and Otten, Henny G.
Published: 2018

27. PIRCHE-II is related to graft failure after kidney transplantation

Author: Geneugelijk, Kirsten, Niemann, Matthias, Drylewicz, Julia, van Zuilen, Arjan D., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Erik Hack, C., van Reekum, Franka E., Verhaar, Marianne C., Kamburova, Elena G., Bots, Michiel L., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Vanderlocht, Joris, Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle, Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Azam, Lardy, Junior N.M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Fréderike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henny G., Spierings, Eric, Geneugelijk, Kirsten, Niemann, Matthias, Drylewicz, Julia, van Zuilen, Arjan D., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Erik Hack, C., van Reekum, Franka E., Verhaar, Marianne C., Kamburova, Elena G., Bots, Michiel L., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Vanderlocht, Joris, Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle, Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Azam, Lardy, Junior N.M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Fréderike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henny G., and Spierings, Eric
Published: 2018

28. Development and Validation of a Multiplex Non-HLA Antibody Assay for the Screening of Kidney Transplant Recipients

Author: CDL Patiëntenzorg MI, Infection & Immunity, CTI Otten, CTI, CDL Celdiagnostiek, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, UMC Utrecht, Pathologie Groep Bovenschen, Cancer, MS Mondziekten/Kaakchirurgie, Kamburova, Elena G., Kardol-Hoefnagel, Tineke, Wisse, Bram W., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Meeldijk, Jan, Bovenschen, Niels, Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henny G., CDL Patiëntenzorg MI, Infection & Immunity, CTI Otten, CTI, CDL Celdiagnostiek, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, UMC Utrecht, Pathologie Groep Bovenschen, Cancer, MS Mondziekten/Kaakchirurgie, Kamburova, Elena G., Kardol-Hoefnagel, Tineke, Wisse, Bram W., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Meeldijk, Jan, Bovenschen, Niels, Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., and Otten, Henny G.
Published: 2018

29. Pretransplant C3D-fixing donor-specific anti-HLA antibodies are not associated with increased risk for kidney graft failure

Author: CTI Otten, Infection & Immunity, CDL Patiëntenzorg MI, CDL Celdiagnostiek, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Kamburova, Elena G., Wisse, Bram W., Joosten, Irma, Allebes, Wil A., Van Der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., Van Reekum, Franka E., Van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, Van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., Van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, Van Der Pant, Karlijn A.M.I., Van Der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., Van Der Boog, Paul J.M., De Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henny G., CTI Otten, Infection & Immunity, CDL Patiëntenzorg MI, CDL Celdiagnostiek, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Kamburova, Elena G., Wisse, Bram W., Joosten, Irma, Allebes, Wil A., Van Der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., Van Reekum, Franka E., Van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, Van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., Van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, Van Der Pant, Karlijn A.M.I., Van Der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., Van Der Boog, Paul J.M., De Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., and Otten, Henny G.
Published: 2018

30. PIRCHE-II is related to graft failure after kidney transplantation

Author: CDL HLA, CTI Kuball, CTI Borghans, Infection & Immunity, MS Nefrologie, Circulatory Health, CTI, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CTI Otten, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Celdiagnostiek, Geneugelijk, Kirsten, Niemann, Matthias, Drylewicz, Julia, van Zuilen, Arjan D., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Erik Hack, C., van Reekum, Franka E., Verhaar, Marianne C., Kamburova, Elena G., Bots, Michiel L., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Vanderlocht, Joris, Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle, Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Azam, Lardy, Junior N.M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Fréderike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henny G., Spierings, Eric, CDL HLA, CTI Kuball, CTI Borghans, Infection & Immunity, MS Nefrologie, Circulatory Health, CTI, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CTI Otten, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Celdiagnostiek, Geneugelijk, Kirsten, Niemann, Matthias, Drylewicz, Julia, van Zuilen, Arjan D., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Erik Hack, C., van Reekum, Franka E., Verhaar, Marianne C., Kamburova, Elena G., Bots, Michiel L., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Vanderlocht, Joris, Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle, Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Azam, Lardy, Junior N.M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Fréderike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henny G., and Spierings, Eric
Published: 2018

31. Allostimulatory capacity of conditionally immortalized proximal tubule cell lines for bioartificial kidney application

Author: Mihajlovic, Milos, van den Heuvel, Lambertus W P J, Hoenderop, Joost G J, Jansen, Jitske, Wilmer, Martijn J, Westheim, Annemarie J F, Allebes, Wil A, Stamatialis, Dimitrios, Hilbrands, Luuk B, Masereeuw, Rosalinde, Afd Pharmacology, Pharmacology, Pharmaceutical and Pharmacological Sciences, Afd Pharmacology, Pharmacology, and Biomaterials Science and Technology
Subjects: 0301 basic medicine, Science, Gene Expression, Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0], Biology, Kidney, Peripheral blood mononuclear cell, Article, Proinflammatory cytokine, Kidney Tubules, Proximal, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Cells, Cultured, Cell Line, Transformed, Multidisciplinary, Tight junction, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Kidney metabolism, Immunohistochemistry, Kidney Transplantation, Coculture Techniques, Epithelium, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], 030104 developmental biology, medicine.anatomical_structure, Cell culture, 030220 oncology & carcinogenesis, Immunology, Leukocytes, Mononuclear, Cancer research, Cytokines, Medicine, Inflammation Mediators, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], Biomarkers, CD80
Abstract: Contains fulltext : 177234.pdf (Publisher’s version ) (Open Access) Novel renal replacement therapies, such as a bioartificial kidney (BAK), are needed to improve current hemodialysis treatment of end-stage renal disease (ESRD) patients. As BAK applications may reveal safety concerns, we assessed the alloimmunization and related safety aspects of readily available conditionally immortalized human proximal tubule epithelial cell (ciPTEC) lines to be used in BAK. Two ciPTEC lines, originally derived from urine and kidney tissue, were characterized for the expression and secretion of relevant molecules involved in alloimmunization and inflammatory responses, such as HLA class-I, HLA-DR, CD40, CD80, CD86, as wells as soluble HLA class I and proinflammatory cytokines (IL-6, IL-8 and TNF-alpha). A lack of direct immunogenic effect of ciPTEC was shown in co-culture experiments with peripheral blood mononuclear cells (PBMC), after appropriate stimulation of ciPTEC. Tight epithelial cell monolayer formation on polyethersulfone flat membranes was confirmed by zonula occludens-1 (ZO-1) expression in the ciPTEC tight junctions, and by restricted inulin-FITC diffusion. Co-culture with (activated) PBMC did not jeopardize the transepithelial barrier function of ciPTEC. In conclusion, the absence of allostimulatory effects and the stability of ciPTEC monolayers show that these unique cells could represent a safe option for BAK engineering application.
Published: 2017

32. A paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival

Author: Michielsen, Laura A, primary, Wisse, Bram W, additional, Kamburova, Elena G, additional, Verhaar, Marianne C, additional, Joosten, Irma, additional, Allebes, Wil A, additional, van der Meer, Arnold, additional, Hilbrands, Luuk B, additional, Baas, Marije C, additional, Spierings, Eric, additional, Hack, Cornelis E, additional, van Reekum, Franka E, additional, Bots, Michiel L, additional, Drop, Adriaan C A D, additional, Plaisier, Loes, additional, Seelen, Marc A J, additional, Sanders, Jan-Stephan F, additional, Hepkema, Bouke G, additional, Lambeck, Annechien J, additional, Bungener, Laura B, additional, Roozendaal, Caroline, additional, Tilanus, Marcel G J, additional, Voorter, Christien E, additional, Wieten, Lotte, additional, van Duijnhoven, Elizabeth M, additional, Gelens, Mariëlle, additional, Christiaans, Maarten H L, additional, van Ittersum, Frans J, additional, Nurmohamed, Shaikh A, additional, Lardy, Neubury M, additional, Swelsen, Wendy, additional, van der Pant, Karlijn A, additional, van der Weerd, Neelke C, additional, ten Berge, Ineke J M, additional, Bemelman, Frederike J, additional, Hoitsma, Andries, additional, van der Boog, Paul J M, additional, de Fijter, Johan W, additional, Betjes, Michiel G H, additional, Heidt, Sebastiaan, additional, Roelen, Dave L, additional, Claas, Frans H, additional, Otten, Henderikus G, additional, and van Zuilen, Arjan D, additional
Published: 2018
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33. Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure

Author: Kamburova, Elena G., primary, Wisse, Bram W., additional, Joosten, Irma, additional, Allebes, Wil A., additional, van der Meer, Arnold, additional, Hilbrands, Luuk B., additional, Baas, Marije C., additional, Spierings, Eric, additional, Hack, Cornelis E., additional, van Reekum, Franka E., additional, van Zuilen, Arjan D., additional, Verhaar, Marianne C., additional, Bots, Michiel L., additional, Drop, Adriaan C.A.D., additional, Plaisier, Loes, additional, Seelen, Marc A.J., additional, Sanders, Jan Stephan, additional, Hepkema, Bouke G., additional, Lambeck, Annechien J.A., additional, Bungener, Laura B., additional, Roozendaal, Caroline, additional, Tilanus, Marcel G.J., additional, Voorter, Christina E., additional, Wieten, Lotte, additional, van Duijnhoven, Elly M., additional, Gelens, Mariëlle A.C.J., additional, Christiaans, Maarten H.L., additional, van Ittersum, Frans J., additional, Nurmohamed, Shaikh A., additional, Lardy, Neubury M., additional, Swelsen, Wendy, additional, van der Pant, Karlijn A.M.I., additional, van der Weerd, Neelke C., additional, ten Berge, Ineke J.M., additional, Bemelman, Frederike J., additional, Hoitsma, Andries J., additional, van der Boog, Paul J.M., additional, de Fijter, Johan W., additional, Betjes, Michiel G.H., additional, Heidt, Sebastiaan, additional, Roelen, Dave L., additional, Claas, Frans H., additional, and Otten, Henny G., additional
Published: 2018
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34. PIRCHE-II Is Related to Graft Failure after Kidney Transplantation

Author: Geneugelijk, Kirsten, primary, Niemann, Matthias, additional, Drylewicz, Julia, additional, van Zuilen, Arjan D., additional, Joosten, Irma, additional, Allebes, Wil A., additional, van der Meer, Arnold, additional, Hilbrands, Luuk B., additional, Baas, Marije C., additional, Hack, C. Erik, additional, van Reekum, Franka E., additional, Verhaar, Marianne C., additional, Kamburova, Elena G., additional, Bots, Michiel L., additional, Seelen, Marc A. J., additional, Sanders, Jan Stephan, additional, Hepkema, Bouke G., additional, Lambeck, Annechien J., additional, Bungener, Laura B., additional, Roozendaal, Caroline, additional, Tilanus, Marcel G. J., additional, Vanderlocht, Joris, additional, Voorter, Christien E., additional, Wieten, Lotte, additional, van Duijnhoven, Elly M., additional, Gelens, Mariëlle, additional, Christiaans, Maarten H. L., additional, van Ittersum, Frans J., additional, Nurmohamed, Azam, additional, Lardy, Junior N. M., additional, Swelsen, Wendy, additional, van der Pant, Karlijn A., additional, van der Weerd, Neelke C., additional, ten Berge, Ineke J. M., additional, Bemelman, Fréderike J., additional, Hoitsma, Andries, additional, van der Boog, Paul J. M., additional, de Fijter, Johan W., additional, Betjes, Michiel G. H., additional, Heidt, Sebastiaan, additional, Roelen, Dave L., additional, Claas, Frans H., additional, Otten, Henny G., additional, and Spierings, Eric, additional
Published: 2018
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35. Allostimulatory capacity of conditionally immortalized proximal tubule cell lines for bioartificial kidney application

Author: Afd Pharmacology, Pharmacology, Mihajlovic, Milos, van den Heuvel, Lambertus W P J, Hoenderop, Joost G J, Jansen, Jitske, Wilmer, Martijn J, Westheim, Annemarie J F, Allebes, Wil A, Stamatialis, Dimitrios, Hilbrands, Luuk B, Masereeuw, Rosalinde, Afd Pharmacology, Pharmacology, Mihajlovic, Milos, van den Heuvel, Lambertus W P J, Hoenderop, Joost G J, Jansen, Jitske, Wilmer, Martijn J, Westheim, Annemarie J F, Allebes, Wil A, Stamatialis, Dimitrios, Hilbrands, Luuk B, and Masereeuw, Rosalinde
Published: 2017

36. OR41 PIRCHE-II: A novel tool to identify permissible HLA mismatches in kidney transplantation

Author: Geneugelijk, Kirsten, primary, Niemann, Matthias, additional, Drylewicz, Julia, additional, van Zuilen, Arjan, additional, Joosten, Irma, additional, Allebes, Wil, additional, van der Meer, Arnold, additional, Hilbrands, Luuk, additional, Baas, Marije, additional, Hack, Erik, additional, van Reekum, Franka, additional, Verhaar, Marianne, additional, Kamburova, Elena, additional, Bots, Michiel, additional, Seelen, Marc, additional, Sanders, Jan-Stefan, additional, Hepkema, Bouke, additional, Lambeck, Annechien, additional, Bungener, Laura, additional, Tilanus, Marcel, additional, Voorter, Christien, additional, Vanderlocht, Joris, additional, Wieten, Lotte, additional, Duijnhoven, Elly, additional, Gelens, Marielle, additional, Christiaans, Maarten, additional, van Ittersum, Frans, additional, Nurmohamed, Azam, additional, Lardy, Neubury, additional, Swelsen, Wendy, additional, van der Pant, Karlijn, additional, van der Weerd, Neelke, additional, Berge, Ineke ten, additional, Bemelman, Frederike, additional, Hoitsma, Andries, additional, van der Boog, Paul, additional, de Fijter, Johan, additional, Betjes, Michiel, additional, Heidt, Sebastiaan, additional, Roelen, Dave, additional, Claas, Frans, additional, Otten, Henny, additional, and Spierings, Eric, additional
Published: 2017
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37. Antibodies against ARHGDIBare associated with long‐term kidney graft loss

Author: Kamburova, Elena G., Gruijters, Maartje L., Kardol‐Hoefnagel, Tineke, Wisse, Bram W., Joosten, Irma, Allebes, Wil A., Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., Reekum, Franka E., Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C. A. D., Plaisier, Loes, Melchers, Rowena C. A., Seelen, Marc A. J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J. A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G. J., Voorter, Christina E., Wieten, Lotte, Duijnhoven, Elly M., Gelens, Mariëlle A. C. J., Christiaans, Maarten H. L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, Pant, Karlijn A. M. I., Weerd, Neelke C., Berge, Ineke J. M., Hoitsma, Andries, Boog, Paul J. M., de Fijter, Johan W., Betjes, Michiel G. H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., and Otten, Henny G.
Abstract: The clinical significance of non‐HLAantibodies on renal allograft survival is a matter of debate, due to differences in reported results and lack of large‐scale studies incorporating analysis of multiple non‐HLAantibodies simultaneously. We developed a multiplex non‐HLAantibody assay against 14 proteins highly expressed in the kidney. In this study, the presence of pretransplant non‐HLAantibodies was correlated to renal allograft survival in a nationwide cohort of 4770 recipients transplanted between 1995 and 2006. Autoantibodies against Rho GDP‐dissociation inhibitor 2 (ARHGDIB) were significantly associated with graft loss in recipients transplanted with a deceased‐donor kidney (N = 3276) but not in recipients of a living‐donor kidney (N = 1496). At 10 years after deceased‐donor transplantation, recipients with anti‐ARHGDIBantibodies (94/3276 = 2.9%) had a 13% lower death‐censored covariate‐adjusted graft survival compared to the anti‐ARHGDIB‐negative (3182/3276 = 97.1%) population (hazard ratio 1.82; 95% confidence interval, 1.32‐2.53; P= .0003). These antibodies occur independently from donor‐specific anti‐HLA antibodies (DSA) or other non‐HLAantibodies investigated. No significant relations with graft loss were found for the other 13 non‐HLAantibodies. We suggest that pretransplant risk assessment can be improved by measuring anti‐ARHGDIBantibodies in all patients awaiting deceased‐donor transplantation. From a multicenter evaluation of kidney transplants, the authors report that the pretransplant presence of autoantibodies against ARHGDIB are associated with long‐term graft loss in recipients transplanted with a deceased donor kidney, independent from donor‐specific HLA antibodies.
Published: 2019
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38. Effect of initial immunosuppression on long-term kidney transplant outcome in immunological low-risk patients.

Author: Michielsen, Laura A, Zuilen, Arjan D van, Verhaar, Marianne C, Wisse, Bram W, Kamburova, Elena G, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, Reekum, Franka E van, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, and Bungener, Laura B
Subjects: KIDNEY transplantation
Abstract: Background Few studies have evaluated the effect of different immunosuppressive strategies on long-term kidney transplant outcomes. Moreover, as they were usually based on historical data, it was not possible to account for the presence of pretransplant donor-specific human-leukocyte antigen antibodies (DSA), a currently recognized risk marker for impaired graft survival. The aim of this study was to evaluate to what extent frequently used initial immunosuppressive therapies increase graft survival in immunological low-risk patients. Methods We performed an analysis on the PROCARE cohort, a Dutch multicentre study including all transplantations performed in the Netherlands between 1995 and 2005 with available pretransplant serum (n = 4724). All sera were assessed for the presence of DSA by a luminex single-antigen bead assay. Patients with a previous kidney transplantation, pretransplant DSA or receiving induction therapy were excluded from the analysis. Results Three regimes were used in over 200 patients: cyclosporine (CsA)/prednisolone (Pred) (n = 542), CsA/mycophenolate mofetil (MMF)/Pred (n = 857) and tacrolimus (TAC)/MMF/Pred (n = 811). Covariate-adjusted analysis revealed no significant differences in 10-year death-censored graft survival between patients on TAC/MMF/Pred therapy (79%) compared with patients on CsA/MMF/Pred (82%, P = 0.88) or CsA/Pred (79%, P = 0.21). However, 1-year rejection-free survival censored for death and failure unrelated to rejection was significantly higher for TAC/MMF/Pred (81%) when compared with CsA/MMF/Pred (67%, P < 0.0001) and CsA/Pred (64%, P < 0.0001). Conclusion These results suggest that in immunological low-risk patients excellent long-term kidney graft survival can be achieved irrespective of the type of initial immunosuppressive therapy (CsA or TAC; with or without MMF), despite differences in 1-year rejection-free survival. [ABSTRACT FROM AUTHOR]
Published: 2019
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39. paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival.

Author: Michielsen, Laura A, Wisse, Bram W, Kamburova, Elena G, Verhaar, Marianne C, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, Reekum, Franka E van, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, and Bungener, Laura B
Subjects: IMMUNOGLOBULINS, KIDNEYS, KIDNEY transplantation
Abstract: Background Pre-transplant donor-specific anti–human leucocyte antigen (HLA) antibodies (DSAs) are associated with impaired kidney graft survival while the clinical relevance of non-donor-specific anti-HLA antibodies (nDSAs) is more controversial. The aim of the present paired kidney graft study was to compare the clinical relevance of DSAs and nDSAs. Methods To eliminate donor and era-dependent factors, a post hoc paired kidney graft analysis was performed as part of a Dutch multicentre study evaluating all transplantations between 1995 and 2005 with available pre-transplant serum samples. Anti-HLA antibodies were detected with a Luminex single-antigen bead assay. Results Among 3237 deceased donor transplantations, we identified 115 recipient pairs receiving a kidney from the same donor with one recipient being DSA positive and the other without anti-HLA antibodies. Patients with pre-transplant DSAs had a significantly lower 10-year death-censored graft survival (55% versus 82%, P=0.0001). We identified 192 pairs with one recipient as nDSA positive (against Class I and/or II) and the other without anti-HLA antibodies. For the patients with nDSAs against either Class I or II, graft survival did not significantly differ compared with patients without anti-HLA antibodies (74% versus 77%, P = 0.79). Only in patients with both nDSAs Class I and II was there a trend towards a lower graft survival (58%, P = 0.06). Lastly, in a small group of 42 recipient pairs, 10-year graft survival in recipients with DSAs was 49% compared with 68% in recipients with nDSAs (P=0.11). Conclusion This paired kidney analysis confirms that the presence of pre-transplant DSAs in deceased donor transplantations is a risk marker for graft loss, whereas nDSAs in general are not associated with a lower graft survival. Subgroup analysis indicated that only in broadly sensitized patients with nDSAs against Class I and II, nDSAs may be a risk marker for graft loss in the long term. [ABSTRACT FROM AUTHOR]
Published: 2019
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40. A paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival.

Author: Michielsen LA, Wisse BW, Kamburova EG, Verhaar MC, Joosten I, Allebes WA, van der Meer A, Hilbrands LB, Baas MC, Spierings E, Hack CE, van Reekum FE, Bots ML, Drop ACAD, Plaisier L, Seelen MAJ, Sanders JF, Hepkema BG, Lambeck AJ, Bungener LB, Roozendaal C, Tilanus MGJ, Voorter CE, Wieten L, van Duijnhoven EM, Gelens M, Christiaans MHL, van Ittersum FJ, Nurmohamed SA, Lardy NM, Swelsen W, van der Pant KA, van der Weerd NC, Ten Berge IJM, Bemelman FJ, Hoitsma A, van der Boog PJM, de Fijter JW, Betjes MGH, Heidt S, Roelen DL, Claas FH, Otten HG, and van Zuilen AD
Subjects: Adult, Female, Histocompatibility Antigens Class I, Humans, Kidney Transplantation mortality, Male, Middle Aged, Netherlands, Risk, Tissue Donors, Young Adult, Graft Rejection immunology, Graft Survival immunology, HLA Antigens immunology, Isoantibodies blood
Abstract: Background: Pre-transplant donor-specific anti-human leucocyte antigen (HLA) antibodies (DSAs) are associated with impaired kidney graft survival while the clinical relevance of non-donor-specific anti-HLA antibodies (nDSAs) is more controversial. The aim of the present paired kidney graft study was to compare the clinical relevance of DSAs and nDSAs., Methods: To eliminate donor and era-dependent factors, a post hoc paired kidney graft analysis was performed as part of a Dutch multicentre study evaluating all transplantations between 1995 and 2005 with available pre-transplant serum samples. Anti-HLA antibodies were detected with a Luminex single-antigen bead assay., Results: Among 3237 deceased donor transplantations, we identified 115 recipient pairs receiving a kidney from the same donor with one recipient being DSA positive and the other without anti-HLA antibodies. Patients with pre-transplant DSAs had a significantly lower 10-year death-censored graft survival (55% versus 82%, P=0.0001). We identified 192 pairs with one recipient as nDSA positive (against Class I and/or II) and the other without anti-HLA antibodies. For the patients with nDSAs against either Class I or II, graft survival did not significantly differ compared with patients without anti-HLA antibodies (74% versus 77%, P = 0.79). Only in patients with both nDSAs Class I and II was there a trend towards a lower graft survival (58%, P = 0.06). Lastly, in a small group of 42 recipient pairs, 10-year graft survival in recipients with DSAs was 49% compared with 68% in recipients with nDSAs (P=0.11)., Conclusion: This paired kidney analysis confirms that the presence of pre-transplant DSAs in deceased donor transplantations is a risk marker for graft loss, whereas nDSAs in general are not associated with a lower graft survival. Subgroup analysis indicated that only in broadly sensitized patients with nDSAs against Class I and II, nDSAs may be a risk marker for graft loss in the long term., (© The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.)
Published: 2019
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41. Allostimulatory capacity of conditionally immortalized proximal tubule cell lines for bioartificial kidney application.

Author: Mihajlovic M, van den Heuvel LP, Hoenderop JG, Jansen J, Wilmer MJ, Westheim AJF, Allebes WA, Stamatialis D, Hilbrands LB, and Masereeuw R
Subjects: Biomarkers, Cells, Cultured, Coculture Techniques, Cytokines metabolism, Gene Expression, Histocompatibility Antigens Class I genetics, Histocompatibility Antigens Class I immunology, Histocompatibility Antigens Class I metabolism, Histocompatibility Antigens Class II genetics, Histocompatibility Antigens Class II immunology, Histocompatibility Antigens Class II metabolism, Humans, Immunohistochemistry, Inflammation Mediators metabolism, Kidney metabolism, Kidney Transplantation, Leukocytes, Mononuclear immunology, Leukocytes, Mononuclear metabolism, Cell Line, Transformed, Kidney Tubules, Proximal cytology
Abstract: Novel renal replacement therapies, such as a bioartificial kidney (BAK), are needed to improve current hemodialysis treatment of end-stage renal disease (ESRD) patients. As BAK applications may reveal safety concerns, we assessed the alloimmunization and related safety aspects of readily available conditionally immortalized human proximal tubule epithelial cell (ciPTEC) lines to be used in BAK. Two ciPTEC lines, originally derived from urine and kidney tissue, were characterized for the expression and secretion of relevant molecules involved in alloimmunization and inflammatory responses, such as HLA class-I, HLA-DR, CD40, CD80, CD86, as wells as soluble HLA class I and proinflammatory cytokines (IL-6, IL-8 and TNF-α). A lack of direct immunogenic effect of ciPTEC was shown in co-culture experiments with peripheral blood mononuclear cells (PBMC), after appropriate stimulation of ciPTEC. Tight epithelial cell monolayer formation on polyethersulfone flat membranes was confirmed by zonula occludens-1 (ZO-1) expression in the ciPTEC tight junctions, and by restricted inulin-FITC diffusion. Co-culture with (activated) PBMC did not jeopardize the transepithelial barrier function of ciPTEC. In conclusion, the absence of allostimulatory effects and the stability of ciPTEC monolayers show that these unique cells could represent a safe option for BAK engineering application.
Published: 2017
Full Text: View/download PDF

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