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Your search keyword '"Aitken-Buck, Hamish M."' showing total 19 results
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19 results on '"Aitken-Buck, Hamish M."'

3. An arrhythmogenic metabolite in atrial fibrillation

Author

Krause, Julia, Nickel, Alexander, Madsen, Alexandra, Aitken-Buck, Hamish M., Stoter, A. M. Stella, Schrapers, Jessica, Ojeda, Francisco, Geiger, Kira, Kern, Melanie, Kohlhaas, Michael, Bertero, Edoardo, Hofmockel, Patrick, Hübner, Florian, Assum, Ines, Heinig, Matthias, Müller, Christian, Hansen, Arne, Krause, Tobias, Park, Deung-Dae, Just, Steffen, Aïssi, Dylan, Börnigen, Daniela, Lindner, Diana, Friedrich, Nele, Alhussini, Khaled, Bening, Constanze, Schnabel, Renate B., Karakas, Mahir, Iacoviello, Licia, Salomaa, Veikko, Linneberg, Allan, Tunstall-Pedoe, Hugh, Kuulasmaa, Kari, Kirchhof, Paulus, Blankenberg, Stefan, Christ, Torsten, Eschenhagen, Thomas, Lamberts, Regis R., Maack, Christoph, Stenzig, Justus, and Zeller, Tanja

Published
2023
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7. Study of amphipathic metabolites in cardiac pathophysiology: Insights gained from long‐chain acylcarnitines and calcium handling.

Author

Aitken‐Buck, Hamish M., Khaing, Ei Phyo, Lamberts, Regis R., and Jones, Peter P.

Subjects
RYANODINE receptors, ARRHYTHMIA, CALCIUM, INTRACELLULAR calcium, PATHOLOGICAL physiology
Abstract

This article discusses the role of long-chain acylcarnitines (LCACs) in cardiac pathophysiology. Metabolomics studies have identified associations between LCACs and cardiovascular diseases such as heart failure and cardiac arrhythmias. The article focuses on the effects of LCACs on the ryanodine receptor (RyR2), a calcium release channel in cardiomyocytes. The study found that LCACs promote spontaneous calcium release and intracellular calcium accumulation, potentially through increased cytosolic calcium levels. The article also highlights the importance of considering methodological limitations and membrane perturbation effects when studying LCACs. The findings have implications for future research on LCACs and their potential as therapeutic targets for cardiovascular diseases. [Extracted from the article]

Published
2023
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10. Long-chain acylcarnitine 18:1 acutely increases human atrial myocardial contractility and arrhythmia susceptibility

Author

Aitken-Buck, Hamish M., primary, Krause, Julia, additional, van Hout, Isabelle, additional, Davis, Philip J., additional, Bunton, Richard W., additional, Parry, Dominic J., additional, Williams, Michael J. A., additional, Coffey, Sean, additional, Zeller, Tanja, additional, Jones, Peter P., additional, and Lamberts, Regis R., additional

Published
2021
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14. Acute interaction between human epicardial adipose tissue and human atrial myocardium induces arrhythmic susceptibility

Author

Babakr, Aram A., primary, Fomison-Nurse, Ingrid C., additional, van Hout, Isabelle, additional, Aitken-Buck, Hamish M., additional, Sugunesegran, Ramanen, additional, Davis, Philip J., additional, Bunton, Richard W., additional, Williams, Michael J. A., additional, Coffey, Sean, additional, Stiles, Martin K., additional, Jones, Peter P., additional, and Lamberts, Regis R., additional

Published
2020
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15. To the heart of activation heat

Author

Aitken‐Buck, Hamish M. and Lamberts, Regis R.

Subjects
Male, Hot Temperature, Myocardium, Animals, Heart, Rats, Wistar, Heterocyclic Compounds, 4 or More Rings, Myocardial Contraction, Perspectives
Abstract

The heat of activation of cardiac muscle reflects the metabolic cost of restoring ionic homeostasis following a contraction. The accuracy of its measurement depends critically on the abolition of crossbridge cycling. We abolished crossbridge activity in isolated rat ventricular trabeculae by use of blebbistatin, an agent that selectively inhibits myosin II ATPase. We found cardiac activation heat to be muscle length independent and to account for 15-20% of total heat production at body temperature. We conclude that it can be accurately estimated at minimal muscle length.Activation heat arises from two sources during the contraction of striated muscle. It reflects the metabolic expenditure associated with Ca

Published
2017

16. Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index

Author

Aitken-Buck, Hamish M., primary, Moharram, Mohammed, additional, Babakr, Aram A, additional, Reijers, Robin, additional, Van Hout, Isabelle, additional, Fomison-Nurse, Ingrid C., additional, Sugunesegran, Ramanen, additional, Bhagwat, Krishna, additional, Davis, Phillip J, additional, Bunton, Richard W., additional, Williams, Michael J. A., additional, Stiles, Martin K., additional, Jones, Peter P., additional, Coffey, Sean, additional, and Lamberts, Regis R., additional

Published
2019
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19. Preparation of Human Atrial Trabeculae for Ex Vivo Analysis of Human Myocardial Function.

Author

Aitken-Buck HM, Bingham KT, and Lamberts RR

Subjects
Humans, Myocardial Contraction physiology, Atrial Function physiology, Dissection methods, Heart Atria metabolism, Heart Atria cytology, Myocardium metabolism, Myocardium cytology
Abstract

Human myocardial function can be investigated in the laboratory using human atrial trabeculae. These multicellular preparations provide a translatable model for assessing the ex vivo contractility, electrophysiology, and ionic and metabolic underpinnings of human cardiac muscle. Here, we detail the materials and methods required to determine the baseline function of a human atrial trabecula, from dissection to stimulation. This method is also adaptable for additional non-human myocardial applications., (© 2025. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2025
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