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Your search keyword '"Aguilar, Zoraida P."' showing total 186 results
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186 results on '"Aguilar, Zoraida P."'

18. Intravenous Administration of Functionalized Magnetic Iron Oxide Nanoparticles Does Not Induce CNS Injury in the Rat: Influence of Spinal Cord Trauma and Cerebrolysin Treatment

Author

Menon, Preeti K., primary, Sharma, Aruna, additional, Lafuente, José V., additional, Muresanu, Dafin F., additional, Aguilar, Zoraida P., additional, Wang, Y. Anderw, additional, Patnaik, Ranjana, additional, Mössler, Herbert, additional, and Sharma, Hari S., additional

Published
2017
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21. ZnO Nanoparticles Induced Male Reproductive Toxicity Based on the Effects on the Endoplasmic Reticulum Stress Signaling Pathway

Author

Tang, Yizhou, Chen, Bolu, Hong, Wuding, Chen, Ling, Yao, Liyang, Zhao, Yu, Aguilar, Zoraida P, and Xu, Hengyi

Subjects
Male, Sertoli Cells, Dose-Response Relationship, Drug, Sperm Count, male reproductive toxicity, zinc oxide nanoparticles, Leydig Cells, Metal Nanoparticles, Apoptosis, Endoplasmic Reticulum Stress, Mice, Zinc, Gene Expression Regulation, International Journal of Nanomedicine, Testis, Animals, Testosterone, Zinc Oxide, Original Research, Signal Transduction
Abstract

Yizhou Tang,1 Bolu Chen,1 Wuding Hong,1 Ling Chen,1,2 Liyang Yao,1 Yu Zhao,1 Zoraida P Aguilar,3 Hengyi Xu1 1State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, People’s Republic of China; 2The Second Affiliated Hospital of Nanchang University, Nanchang 330000, People’s Republic of China; 3Zystein, LLC., Fayetteville, AR 72704, USACorrespondence: Hengyi XuState Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang 330047, People’s Republic of ChinaTel +86-791-8830-4447 ext 9520Fax +86-791-8830-4400Email kidyxu@163.comPurpose: The aim of this study was to evaluate the adverse effects of ZnO NPs on male reproductive system and explore the possible mechanism.Methods: In this study, the effect of oral administration of 50, 150 and 450 mg/kg zinc oxide nanoparticles (ZnO NPs) in adult male mice was studied over a 14-day period.Results: The results showed that the number of sperms in the epididymis and the concentration of testosterone in serum were decreased with an increased dose of ZnO NPs. Testicular histopathological lesions like detachment, atrophy and vacuolization of germ cells were observed. The results showed that increased dosage of ZnO NPs correspondingly up-regulated the IRE1α, XBP1s, BIP, and CHOP (P

Published
2019

30. Cover Image

Author

Yao, Liyang, primary, Tang, Yizhou, additional, Chen, Bolu, additional, Hong, Wuding, additional, Xu, Xinyue, additional, Liu, Yang, additional, Aguilar, Zoraida P., additional, and Xu, Hengyi, additional

Published
2020
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44. Inhibition of testosterone synthesis induced by oral TiO2 NPs is associated with ROS-MAPK(ERK1/2)-StAR signaling pathway in SD rat.

Author

Shanji Liu, Yizhou Tang, Bolu Chen, Yu Zhao, Aguilar, Zoraida P., Xueying Tao, and Hengyi Xu

Subjects
TITANIUM dioxide nanoparticles, TESTOSTERONE, STEROIDOGENIC acute regulatory protein, RAT diseases, ANIMAL reproduction
Abstract

Titanium dioxide nanoparticles (TiO2 NPs) have been widely used in food, medical, and other fields; their reproductive toxicity has been reported in numerous studies. However, the relevant toxicity mechanism still requires further exploration. In this paper, the effect of oral exposure to 500 mg/kg TiO2 NPs (anatase and rutile) in adult male SD rats was studied over 3 and 7 days. Results showed that the total sperm count and testosterone level of 7 days of exposure in serum decreased in the experimental group. Testicular tissue lesions, such as disappearance of Leydig cells, disorder of arrangement of spermatogenic cells in the lumen of convoluted seminiferous tubules, and disorder of arrangement of germ cells, were observed. Meanwhile, the expression of steroidogenic acute regulatory (StAR; the key factors of testosterone synthesis), MAPK (ERK1/2), and phosphorylated ERK1/2 in testes of SD rats after exposure to TiO2 NPs for 7 days decreased, while the malondialdehyde content increased and superoxide dismutase activity decreased in serum. The present study showed that TiO2 NPs could cause reproductive toxicity. Notably, anatase is more toxic than rutile. In addition, exposure to 500 mg/kg TiO2 NPs for 7 days inhibited testosterone synthesis in male rat, which may be related to the reactive oxygen species (ROS)-MAPK (ERK1/2)-StAR signal pathway. Warning that the use of TiO2 NPs should be regulated. [ABSTRACT FROM AUTHOR]

Published
2021
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45. The effect of reproductive toxicity induced by ZnO NPs in mice during early pregnancy through mitochondrial apoptotic pathway.

Author

Chen, Ling, Wu, Haifang, Hong, Wuding, Aguilar, Zoraida P., Fu, Fen, and Xu, Hengyi

Subjects
ZINC oxide, MITOCHONDRIA, FETAL development, PREGNANCY, MICE, FETUS
Abstract

The potential toxicity of Zinc oxide nanoparticles (ZnO NPs) to human beings has become a widespread concern. This study explored the reproductive toxicity and the mechanism of toxicity of ZnO NPs in early pregnant mice. The results showed that abnormal weight changes, induced inflammation, reduced level of serum sex hormones, damaged uterus, increased abortion, and abnormal development of fetus. In the uterus, the transcription levels of ZnT‐1, HO‐1, Bax, Bax/Bcl‐2, JNK, and Caspase‐3 were significantly up‐regulated while Bcl‐2, ER‐1 and PR were significantly down‐regulated. The TUNEL‐positive cells increased that were exposed to high levels of ZnO NPs. In summary, those results indicated that Zn from high levels of exposure to ZnO NPs accumulated in the uterus that could have caused the formation of ROS that led to oxidative stress, which might have activated the mitochondrial apoptotic pathway that could have caused the uterine injury which induced the observed reproductive toxicity. [ABSTRACT FROM AUTHOR]

Published
2021
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46. Reproductive organ dysfunction and gene expression after orally administration of ZnO nanoparticles in murine.

Author

Kuang, Huijuan, Zhang, Wanyi, Yang, Lin, Aguilar, Zoraida P., and Xu, Hengyi

Subjects
GENITALIA, ZINC oxide, FEMALE reproductive organs, GONADS, MALE reproductive organs, GENE expression, MULLERIAN ducts
Abstract

ZnO nanoparticles (NPs) are among the most manufactured nanoparticles in the consumer products, industries, and researches. An increasing body of evidence indicated that ZnO NPs show toxicological effects in vivo. Sex differences in the toxicity of ZnO NPs are not clear, thus the aim of this study was to investigate the effects of ZnO NPs on the female and male reproductive organs (uterus, ovary and testes). ZnO NPs were orally administered to female and male mice at dosages level of 0 and 100 mg/kg body weight. The biological material was sampled 3 days after tube feeding. The results demonstrated that Zinc contents were accumulated in the reproductive organs of treated mice. Furthermore, ZnO NPs administration induced significant decrease in the testes weight, an imbalance of hematological and serum biochemical parameters in male mice. The histopathological examinations showed that structural disorder and the appearance of cell apoptosis and death in the ZnO NPs‐exposed mice. Additionally, the RT‐qPCR data indicated ZnO NPs can activate mitochondrial‐mediated signaling pathway and induce caspase depend damage that ultimately injured the uterus. In the ovary, ZnO NPs induce cell apoptosis in Shh pathway activated ovary cells, and affect the synthesis of steroidogenesis. In the testes, ZnO NPs effectively changed the expression level of genes related to oxidant stress, detox/metabolic process, and apoptosis. It was found that ZnO NPs caused more serious reproductive toxicity in the male mice than female mice. Overall, these findings indicated that ZnO NPs could induce exposure‐related risks to reproductive health, especially in those who are at the occupational level. [ABSTRACT FROM AUTHOR]

Published
2021
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