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大空心率中空夹层钢管混凝土构件的抗撞击性能有其自身特点，利用有限元软件ABAQUS建立考虑初始几何缺陷的中空夹层钢管混凝土构件的侧向撞击模型，对比了不同初始几何缺陷组合下空心率范围为0.2~0.9构件的抗撞击性能；在此基础上讨论了初始几何缺陷对空心率为0.8构件撞击响应的影响，并对影响大空心率构件撞击响应的主要参数进行分析；最后基于参数分析结果和静态荷载作用下的荷载-局部压痕关系，给出大空心率中空夹层钢管混凝土构件在侧向撞击荷载作用下撞击力-局部变形简化预测公式。结果表明：与无几何缺陷构件相比，考虑初始几何缺陷时构件的撞击力平台值降低，局部变形增大，当空心率达到0.8时，几何缺陷的不利影响最显著，构件的撞击力平台值下降10.6%，跨中局部变形增大20.4%。提高名义含钢率和减小内钢管径厚比可有效减小初始几何缺陷对该类构件抗撞击性能的不利影响，而改变材料强度对该类构件抗撞性能影响相对较小。给出的简化计算公式可以较好地预测有无初始几何缺陷的大空心率构件在侧向撞击荷载下的撞击力-局部变形曲线。

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Objective To evalute the drug resistance characteristics of tuberculosis(TB) patients of all ages in Guangdong Province during 2014-2020, and provide prevention and treatment strategies of tuberculosis. Method We used 39, 048 clinical isolates of Mycobacterium tuberculosis (MTB) belonging to patients with confirmed TB from 2014 to 2020, from 32 TB drug-resistant surveillance sites in Guangdong Province, and we retrospectively analyzed the laboratories data of patients with drug-resistant TB, and grouped patients by age and region, to explore the trend of drug-resistance of MTB clinical isolates, the trend and incidence differences of multi-resistant TB (including monodrug-resistant TB (MR-TB), polydrug-resistant TB (PDR-TB), multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB)), and resistance characteristics of MTB clinical isolates to drugs in focus (rifampicin and ofloxacin). Result The differences in the resistance rates of MTB clinical isolates to nine antituberculosis drugs among patients at 32 TB drug resistance surveillance sites in Guangdong Province from 2014 to 2020 were not statistically significant (P > 0.05). The rates of MR-TB, PDR-TB, MDR-TB, XDR-TB, and total resistance isolates of MTB clinical isolates were 14.46%, 5.16%, 5.16%, 4.58%, and 1.29%, respectively. he pediatric group had a higher MR rate (15.4%) than the adult and geriatric groups, while the adult and geriatric groups had higher MDR rates (5.0% and 5.0%, respectively). The geriatric group also had a higher XDR rate (2.1%), with statistically significant differences (P < 0.001). The rates of MR-TB (14.8%), PDR-TB (5.3%), MDR-TB (4.7%), XDR-TB (1.4%), ofloxacin resistance (11.33%) and rifampicin resistance (6.92%) of MTB clinical isolates were higher in patients from the Pearl River Delta than in other regions of Guangdong Province, with statistically significant differences (P < 0.001). Conclusion According to the data from the surveillance sites, the epidemiological trend of drugresistant TB in Guangdong Province is leveling off during the period 2014-2020. However, the incidence of drug-resistant TB is higher in specific populations (e.g. children and the elderly), and the incidence of drug-resistant TB and the rate of drug resistance to drugs in focus are higher in the Pearl River Delta than in other regions of Guangdong Province, necessitating further investigation and the development of novel prevention and control strategies. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Computer-Aided Design & Computer Graphics / Jisuanji Fuzhu Sheji Yu Tuxingxue Xuebao is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective To observe and detect the changes of interleukin-10（IL-10）and miR-513c-5p in peripheral blood of patients with unexplained recurrent spontaneous abortion（URSA），and to discuss their roles in the pathogenesis of URSA. Methods Thirty cases of normal pregnant women and 30 cases of URSA patients were included in this study. Six mL fasting peripheral venous blood was extracted. Serum IL-10 protein was detected by ELISA，and miR-513c-5p in peripheral blood mononuclear cells（PBMCS）was detected by qPCR. Target Scan 7. 1 software was used to predict the binding site between miR-513c-5p and IL-10；besides，luciferase reporter assay was used to confirm the binding between them. In addition，wild-type and mutated IL-10 mRNA 3´UTR plasmids containing binding sites were constructed，respectively. 293T cells were divided into the overexpressed group，inhibited group，and control group，which were transfected with miR-513c-5p mimics，inhibitor and negative control，respectively. Then，IL-10 mRNA in 293T cells of each group was detected by qPCR，and IL-10 protein in the supernatant of cell culture was detected by ELISA. Results Serum IL- 10 protein of URSA group was lower than that of the normal pregnancy group（P<0. 05），while the level of miR-513c-5p was higher than that of the normal pregnancy group（P<0. 05）. Target Scan 7. 1 and luciferase reporter assay showed that miR-513c-5p bound with IL-10 3´UTR via the complementary bases. The expression of IL-10 mRNA in the cells and the level of IL-10 protein in the cell supernatant were as follows：inhibited group>control group>overexpressed group（all P< 0. 05）. Conclusions In URSA patients，IL-10 protein level decreases and the expression of miR-513c-5p increases. MiR-513c-5p inhibits the expression of IL-10 by binding to its 3´UTR directly. Thereby，it breaks the maternal-fetal immunotolerance and leads to URSA；miR-513c-5p/IL-10 axis may become a novel therapeutic target for URSA clinically. [ABSTRACT FROM AUTHOR]

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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Land surface temperature (LST) is one of the most important parameters in the physical processes of surface energy and water balance. Due to the payload limit and the technical bottleneck of the sensor， it is difficult to obtain land surface temperature products with both high spatial and high temporal resolutions，which restricts applications of land surface temperature products. Based on M〇DIS and ETM+ images，this paper combines the enhanced spatial and temporal adaptive reflectance fusion model(ESTARFM) with the non-linear disaggregation procedure for radiometric surface temperature (NL-DisTrad) to generate daily land surface temperature products of urban area at a resolution of 60m. We use the actual land surface temperature products in July 9 and October 1 3 of 2002 over Wuhan urban areas to verify the quality of fusion products. It is shown their R2 are as high as 0.80 and 0.86，respectively, and the RMSE are 2.65 K and 1.78 K，respectively. The results show that the proposed algorithm has fine prospects in the spatial and temporal land surface temperature fusion applications in urban areas. [ABSTRACT FROM AUTHOR]

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Copyright of Transactions of Beijing Institute of Technology is the property of Beijing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of Beijing Institute of Technology is the property of Beijing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The multi-objective optimization of vehicle bottom structure under landmine explosion is a mass computation, strong-nonlinearity and high dimension multi-objective optimization problem. The protective vehicle structure response is simulated based on combination of LAE and FSI methods. The thickness and geometry parameters of vehicle bottom structure are screened with sensitivity analysis. A response surface is built by employing the experimental design and regression analysis. Eventually, the Pareto optimality, normal boundary intersection and multi-objective optimization genetic algorithms are applied to get the Pareto optimal front and an ideal solution which could give a comprehensive consideration of the contradiction between lightweight and protection capability. [ABSTRACT FROM AUTHOR]