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Objective: To observe the effect of ABCLOVE voice training on improving the pronunciation function of patients with early laryngeal cancer after vocal cord surgery. Methods: A total of 126 patients with early laryngeal cancer after vocal cord surgery admitted to our hospital from December 2020 to January 2023 were selected as the research objects. They were divided into control group and observation group by random number table method, with 63 cases in each group. The control group was treated with drug therapy and routine voice training, and the observation group was treated with ABCLOVE voice training on the basis of the control group for 6weeks. The electronic laryngoscopy, voice disorder assessment (VHI), aerodynamic analysis and dynamic laryngoscopy were compared between the two groups before and after intervention. Results: Electronic laryngoscopy showed that the effective rate of treatment in the observation group was better than that in the control group (P＜0.05) . After intervention, the VHI score of the observation group was significantly lower than that of the control group (P＜0.05) . After intervention, the longest pronunciation time (MPT), maximum pronunciation time (MLPT) and voice disorder index (DSI) were significantly higher than those in the control group, and the fundamental frequency perturbation (Jitter), amplitude perturbation (Shimmer) and mean airflow rate (MFR) were significantly lower than those in the control group (P＜0.05) . After intervention, the scores of vocal cord closure, vocal cord mucosal wave, vocal cord movement symmetry and vocal cord vibration regularity were significantly lower than those in the control group (P＜0.05) . Conclusion: ABCLOVE voice training method can effectively improve the dysphonia of patients with early laryngeal cancer after vocal cord surgery, improve their pronunciation ability, and help to further improve their clinical efficacy. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Chongqing University of Technology (Natural Science) is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Clean Coal Technology is the property of Clean Coal Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the angiogenesis changes caused by biodegradable material polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) through the regulation of macrophage polarization, and to provide a basis for its clinical application. Methods: The samples were prepared by 3D printing technology and characterized. In vivo experiments, SD rats were implanted in distal femur. Immunofluorescences taining was performed to detect the expression of angiogenesis marker CD31 and angiography was used to evaluate the vascular volume in the stent. Pro-inflammatory marker iNOS and anti-inflammatory marker Arg-1 in the scaffold were detected by immunofluorescences taining after implantation. PCL/β-TCP and its effect on angiogenesis through the regulation of macrophage polarization were detected by cellco-culture in vitro. The experiment was divided into two groups, the blank group (Control) and the PCL/β-TCP (PT5) group. Macrophage cell line Raw264.7 was inoculated on the surface of the material and the polarization and secretion changes were detected. The expression of the M1 macrophage marker iNOS and M2 macrophage marker Arg-1 were detected by immunofluorescences taining. The transcription of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF-BB), M1 macrophage marker CCR-7, and M2 macrophage marker CD206 were detected by RT-qPCR. The secretion of VEGF, TNF-α, PDGF-BB and IL-10 were detected by enzyme-linked immunosorbent assay (ELISA). Transwell migration experiment was used to detect the effect of macrophage secretion on HUVECs migration ability of human umbilical vein endothelial cells stimulated by PCL/β-TCP. Results: In vivo experiments, the volume and expression of CD31 were enhanced ( P <0.001,P<0.001). Expression of inflammatory marker iNOS decreased (P <0.001), while the anti-inflammatory marker Arg-1 increased (P <0.001). Invitrostudy, compared with Control, there was no significant difference in synthesis of inflammatory marker iNOS ( P >0.05), and the synthesis of anti-inflammatory marker Arg-1 increased in PT5( P <0.001). Transcription level of inflammatory marker CCR-7 and TNF-α was decreased ( P <0.01, P<0.01) in PT5, while the transcription of anti-inflammatory markers CD206 and IL-10 were up-regulated ( P <0.001, P<0.001). Transcription of VEGF was down-regulated (P <0.01) in PT5, and PDGF-BB transcription level was up-regulated (P <0.001). Treated with PT5, the secretion level of VEGF decreased ( P <0.01), while the secretion level of PDGF-BB was upregulated ( P <0.01) as well as IL-10 (P <0.001). Compared with Control, the secretion of TNF-α was impaired in PT5 (P <0.05). Under the action of macrophage secretion, HUVECs migration ability and expression of CD31 were enhanced (P <0.001). Conclusion: Bone repair material PCL/β-TCP can promote angiogenesis by regulating the polarization of macrophages towards M2, and can be one of the candidate materials for bone repair materials. [ABSTRACT FROM AUTHOR]

Copyright of Research of Environmental Sciences is the property of Research of Environmental Sciences Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)