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A case of umbilical pemphigus vulgaris is reported. A 37-year-old female presented with a half-year history of repeated oral blood blisters and periumbilical itchy blisters. Dermatological examination revealed a demarcated annular irregular erosive surface covered with odorless white secretions on the umbilical area. But neither blisters nor erosions were observed in the oral mucosa. PDAI activity scores were 2 points. Pathological examination of skin lesion showed blisters in the basal layer and acantholytic cells in the epidermis, and lymphocytic infiltrations in the superficial dermis. Direct immunofluorescence revealed reticular deposition of IgG and C3 in the intercellular space of the spinous layer, without IgM and IgA depostion. The diagnosis was pemphigus vulgaris. Patient was treated with intramuscular injection of Methotrexate (10 mg) once, and oral methylprednisolone tablets at a dose of 24 mg once daily, in addition to calcium supplementation and topical applications of Halometasone and Sodium Fusidate Ointment. After the skin lesion was improved, the patient was discharged. No new lesions occurred during 6-month phone follow-up. [ABSTRACT FROM AUTHOR]

This paper summarized the treatment and nursing management for a type 2 diabetic patient with bullous pemphigoid. Based on Traditional Chinese Medicine syndrome differentiation, integrative nursing was carried out in various ways including daily care, skin care, dietary care, medication guidance and emotion care. Patient’s herpes was rapidly dried, and began to scab as well as fall out. The integrative nursing interventions were effective to improve the healing of herpes and reduce the pain caused by bullous pemphigoid. (本文总结1例高龄2型糖尿病合并大疱性类天疱疮患者的治疗和护理经验。通过中西医结合护理干预, 从生活起居、皮肤护理、饮食调护、用药护理、情志护理等多方面进行辨证施护, 促进患者疱疹迅速干燥、结痂、脱落, 有效改善患者临床症状, 减轻患者痛苦。)

This paper summarized the nursing management for a patient with bullous pemphigoid complicated with hydrocephalus and respiratory disorders. Based on the nursing risk assessment, comprehensive nursing measures of integrated traditional Chinese and western medicine were carried out to enhance the nutrition status, skin care, psychological health of the patient, in order to relieve the symptoms of bullous pemphigoid and improve the outcomes of the patient. (本文总结1例大疱性类天疱疮合并脑积水并发呼吸障碍患者的护理经验。通过科学的护理评估, 明确护理目标, 开展中西医结合护理, 同时做好皮肤护理, 加强饮食和心理干预, 促进患者疱疹好转, 改善预后。)

A case of herpetiform pemphigus is reported・ A 76-year-old man suffered from erythema, blisters and pruritus on the trunk and extremities for 10 months. Dermatological examination revealed a large number of erythemas, papules, hyperpigmented spots and isolated pinpoint-to-green bean-sized blisters over the erythemas on the trunk and limbs・ The blisters appeared hemispheric, with thick walls and clear fluid・ Nikolsky sign was negative・ Some blisters were ruptured, with erosive surface・ Skin histopathology showed epidermal blisters containing eosinophils and neutrophils, and perivascular infiltrates of lymphohistiocytes and eosinophils in the superficial dermis・ Direct immunofluorescence showed reticular deposition of IgG and C3 in the epidermis・ Diagnosis was herpetiform pemphigus・ The patient was treated with methylprednisolone, cycl phosphamide, rupatadine, ketotifen, and topical compound clobetasol propionate ointment・ Nine days later, most of the blisters dried up, and the patient was discharged, without recurrence during 6 - month telephone follow-up. [ABSTRACT FROM AUTHOR]

Objective To investigate the relationship between bullous pemphigoid (BP) and vascular dementia (VD), and antibody expression. Methods A total of 63 BP patients from January 2021 to January 2023 were included in the BP group (n=63). Additionally, 83 VD patients during the same period were included in the VD group (n=83). A control group (n=90) consisted of 90 healthy individuals who underwent examinations at medical center during the same time. General patient's data and laboratory test results were collected. Fasting venous blood samples were obtained from all participants, and the concentration and presence of anti-BP180 antibodies were measured using an ELISA assay, Afterward, propensity score matching was performed to balance the three groups, and differences in the collected data were analyzed to assess the relationship between BP and VD. Results In the BP group, the rates of eosinophils (EOS) and BP180 antibody positivity were higher, while albumin levels were lower compared to the other two groups (P<0.05). In the VD group, the BP180 antibody positivity rate and concentration were higher than those in the control group (P< 0.05). There were no significant differences in EOS and albumin levels between the VD and control groups (P>0.05). VD patients had higher levels of triglycerides (TG), total cholesterol (TC), D-dimer, and homocysteine (Hey) com- pared to the other two groups (P<0.05). BP patients had higher levels of D-dimer and Hey compared to the control group (P<0.05), but there was no significant differences in TG and TC between the BP and control groups (P>0.05). D-dimer, Hey, BP180 antibody concentration, and BP180 antibody positivity were identified as independent risk factors for VD (P<0.05). BP180 antibody concentration and BP180 antibody positivity were identified as independent risk factors for BP (P<0.05). Conclusion The expression of BP180 in BP and VD patients shows similar variations, sugges ting that BP180 may be a key factor influencing the interaction between these two conditions. [ABSTRACT FROM AUTHOR]

目的 探讨早期定量营养干预方式对寻常型天疱疮患者疾病发展情况的影响。方法 选取 2022 年 1-12月该院皮肤科 2 个病区各 30 例寻常型天疱疮患者分为试验组和对照组。对照组患者给予常规 营养指导, 试验组患者入院时即对其进行营养风险评估, 并根据评估结果给予定量饮食指导, 比较两组患者血 清清蛋白水平、住院时间、皮损干涸时间、无水疱新发时间等指标差异。结果 试验组患者 2 周后血清清蛋白 水平为(43. 63±4. 65)g/L, 高于对照组的 (35. 18±3. 54)g/L, 差异有统计学意义 (P=0. 026); 试验组患者血清 清蛋白恢复正常水平比例为 84. 62%, 高于对照组的 (26. 67%), 差异有统计学意义 (P=0. 021); 试验组患者皮 损完全干涸时间为 (13. 55±6. 27)d, 低于对照组的 (17. 93±9. 61)d, 差异有统计学意义 (P=0. 024); 试验组患 者住院时间为(12. 24±5. 38)d, 明显短于对照组的 (15. 97±8. 21)d, 差异有统计学意义 (P=0. 025)。结论 早期 定量营养干预方式可以使寻常型天疱疮患者血清蛋白水平稳定在正常水平, 从而促进皮损愈合, 缩短住院时间。 [ABSTRACT FROM AUTHOR]

Objective To explore the clinical efficacy of ozone hydrotherapy combined with ozone dressings in the adjuvant treatment of pemphigus. Methods A total of 50 patients with pemphigus who were hospitalized in the dermatology department of the hospital from January 2020 to July 2021 were selected and randomly divided into the control group and the observation group using medical interval randomization method, with 25 cases in each group. The control group was washed with potassium permanganate diluent and treated with Kangfuxin liquid wet compress. The observation group was soaked in ozone hydrotherapy and applied with ozone oil. The clinical efficacy, pemphigus disease area index (PDAI) score, dermatology life quality index (DLQI) score, length of hospital stay, and treatment satisfaction between the two groups were compared. Results The difference in clinical efficacy between the two groups was statistically significant (P＜0.05) .After treatment, the PDAI and DLQI scores of the observation group were lower than those of the control group, and the hospital stay was shorter than that of the control group, with statistical significance (P＜0.05) .There was significant difference in treatment satisfaction between the two groups (P＜0.05) .Conclusion The combination of ozone hydrotherapy and ozone dressings is a safe and effective adjuvant treatment method for pemphigus, with high treatment satisfaction. [ABSTRACT FROM AUTHOR]

Objective To investigate the expression levels of type 2 inflammatory cytokines, IL-4 and IL-13, in the serum and blister fluid of patients w让h bullous pemphigoid (BP)・ Methods The serum or blister fluid was collected from BP patients (49 cases) and healthy individuals (33 cases)・ ELISA was used to measure the concentrations of IL-4 and IL・13・ The expression levels of IL-4 and IL-13 were compared between the BP patients and healthy controls・ The correlations of IL-4 and IL-13 with total serum IgE levels, eosinophils, skin erythema score and pruritus severity (NRS) in BP patients were analyzed・ Moreover, the associations of BP180 and BP230 IgG antibodies w让h IL-4, IL-13 and total serum IgE levels, and eosinophils were determined・ Results The concentrations of IL-4 and IL-13 in the blister fluid, but not in the serum, were signif-icantly higher in the BP patients than in the healthy controls (P <0・ 01)・ Serum levels of either IL-4 or IL-13 were not significantly correlated with total serum IgE levels, eosinophils, erythema score and NRS in BP patients・ However, IL-4 levels in blister fluid were positively correlated with total serum IgE levels in BP patients (r = 0. 98, P 二 0. 021)・ The IL-13 levels in blister fluid were associated with serum BP180 positive, but BP230 negative (厂二0. 58, P = 0. 009)・ Conclusions Elevated IL-4 and IL-13 levels in the involved skin site of bullous pemphigoid suggest the present of local type 2 inflammation・ Total IgE levels may reflect the severity of local type 2 inflammation. BP180 complex may affect the development of type 2 inflammation through increasing local IL-13 levels・ These findings might be helpful in the target therapy in the future. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Dermatovenereology is the property of Xi'an Jiaotong University Periodicals Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Dermatovenereology is the property of Xi'an Jiaotong University Periodicals Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Dermatovenereology is the property of Xi'an Jiaotong University Periodicals Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

A case of Wolf's isotopic response is reported. A 68-year-old-female presented with vesicles and bullae on the scars of the left chest and the back for 2 months. Dermatological examination revealed five vesicles and bullae of various sizes on the edge of a 10 cm×5 cm scar, with a deep central ulcer sized 5 cm×5 cm, under the left armpit. Ulcer was with little discharge and dark crusts. The vesicles were with clear fluid and negative for Nikolsky's sign. Two bullae were seen on a 3 cm×2 cm hypertrophic scar at T2 to T4 of the left anterior chest. One hypertrophic scar with a bulla sized 1.5 cm and another one with 1 cm erosion and pustular secretion were on the left back. Patient had no mucosal involvement. Histology of skin lesion showed subepidermal blister and perivascular infiltrates of a few lymphohistiocytes, neutrophils and plasma cells in the superficial dermis. Direct immunofluorescence showed linear deposition of C3 in the basement membrane zone. The diagnosis was isotopic response: bullous pemphigoid secondary to herpes zoster. After the treatment with oral prednisone acetate, the blisters resolved in 2 weeks. No recurrence was observed during 15-months follow-up. The follow-up is still ongoing. [ABSTRACT FROM AUTHOR]

Objective Using bioinformatic technique to identify key genes and pathways involved in the pathogenesis of pemphigus foliaceus (PF), in order to elucidate the pathogenesis of PF. Methods Gene microarray dataset GSE53873 of peripheral blood CD4+ T cells from PF patients was obtained from Gene Expression Omnibus database, and various bioinformatics methods such as Limma difference analysis, gene function and pathway enrichment analysis, and protein-protein interaction network analysis were integrated to determine the key genes and pathways associated with PF. Results A total of 121 significantly upregulated genes and 48 significantly downregulated genes were identified in PF patients compared with healthy controls. The differentially expressed genes in PF patients were involved in multiple functions such as T cell differentiation, T cell activation, leukocyte differentiation and metabolism. CXCL10 and OAS1 were identified as key genes in the pathogenesis of PF. Receiver operating characteristic (ROC) results suggested that CXCL10 (AUC=0.86) and OAS1 (AUC=0.86) had high diagnostic efficacy for PF. Gene function and pathway enrichment analysis indicated that CXCL10 was mainly associated with TOLL-like receptor signaling pathway, COVID-19 infection, and cytokine interaction, while OSA1 was mainly associated with viral infection and type I interferon signaling pathway. Conclusions CXCL10 and OAS1 are the key genes associated with PF. The pathogenesis of pemphigus is associated with pathways such as T cell differentiation and activation, leukocyte differentiation and metabolism. [ABSTRACT FROM AUTHOR]

High amylase level is a typical sign of acute pancreatitis. However， it can also be found in other diseases. In the article， a case of persistent elevation of amylase level for over 1 year was reported. A 66-year-old male patient suffered from bullous pemphigoid complicated with diabetes mellitus for 3 years. After bullous pemphigoid treatment 8 months ago， he presented with elevated amylase level ranging from 556 to 1106 U/L， serum lipase level between 62 U/L and 73 U/L and urine amylase level between 553 U/L and 1162 U/L， respectively. The renal amylase clearance rate /creatinine clearance ratio was 0.8% （<1%）. The patient had no gastrointestinal discomforts. Abdominal color Doppler ultrasound（ color ultrasound） and enhanced CT scan revealed that the pancreas was normal. Color ultrasound showed no abnormality in the thyroid and salivary gland. The possibility of salivary gland disease was excluded by stomatologist consultation. The patient was diagnosed with macroamylasemia. The patient reported no discomfort during the 8-month follow-up. The serum amylase level was gradually decreased but still higher than the normal range. This case suggested macroamylasemia should be considered when a patient present with persistent elevation of amylase level， without dynamic changes， gastrointestinal symptoms or elevated serum lipase level. [ABSTRACT FROM AUTHOR]

目的 探讨基于损害评分标准的静脉滴注糖皮质激素联合免疫球蛋白治疗天疱疮的疗效评 估,总结天疱疮住院患者的护理经验. 方法 在2013年10月至 2018 年11月该院收治的重症天疱疮患者中, 选取65例按照随机法分为观察组 (40例)与对照组 (25例). 观察组患者在常规糖皮质激素治疗的基础上联合 静脉滴注免疫球蛋白治疗,同时给予综合护理干预,对照组常规给予糖皮质激素治疗及常规护理. 比较两组患 者治疗前、后的天疱疮损害的评分来分析临床疗效。结果 治疗前,两组患者天疱疮损害评分比较,差异无统 计学意义 (P>0.05). 治疗后 1, 2, 3周后,观察组患者天疱疮损害的评分显著优于对照组,差异均有统计学意 义 (P<0.01). 结论 联合应用静脉滴注糖皮质激素与免疫球蛋白治疗难治性天疱疮,同时给予综合护理干 预,可减轻患者焦虑情绪,显著减轻天疱疮的损害程度,适宜临床推广. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Prevention & Treatment For Stomatological Diseases is the property of Journal of Prevention & Treatment For Stomatological Diseases Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)