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目的探究不同浓度双氢睾酮（DHT）对毛囊生长和毛囊细胞增殖的影响及其与miR-133b表达的关系，然后进一步探究miR-133b对毛乳头细胞的增殖和诱导能力的影响。方法体外显微分离人毛囊，选取生长期的毛囊进行培养，显微镜下每日测量并拍摄不同浓度的DHT处理组（10-8、10-7、10-6 和10-5 mol/L）和对照组各组毛囊的生长长度，免疫荧光检测各组毛母质细胞Ki-67表达量评估毛囊增殖能力，qRT-PCR检测各组毛囊中miR-133b的表达量。通过Lipofectamine 2000转染miR-133b mimics及miR-133b NC至人毛乳头细胞中，CCK-8检测各组人毛乳头细胞增殖能力，qRT-PCR及Western Blot检测毛乳头细胞诱导能力指标Versican、ALP、β-catenin的mRNA及蛋白水平的相对表达量。结果与对照组相比，DHT 10-5 mol/L实验组对毛囊的生长的抑制作用有统计学意义（P-5 mol/L实验组进入退行期的时间提前；其他组生长长度与对照组相比无统计学意义。免疫荧光及qRT-PCR显示，与对照组相比，DHT 10-5 mol/L实验组毛母质细胞中Ki-67阳性细胞较少且毛囊中miR-133b的相对表达量明显升高，相当于对照组的（3.17±0.26）倍（PPPPPPPP

Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effects of exercise preconditioning with different durations on the expression of cerebral neovascularization related proteins HIF-lα. VEGF and HO-1 in rats with vascular dementia (VD). Method: One hundred and twenty SD male rats were randomly divided into sham group, model group. 2- week exercise preconditioning sham and model group, 4- week exercise preconditioning sham and model group, with 20 rats in each group. The 4-week exercise preconditioning rats received 30 minutes of non-weight-bearing swimming training 5 times a week for 4 weeks before modeling, while the 2-week exercise pre conditioning rats lasted for 2 weeks. After training, in the model group. 2-week and 4-week exercise precondi tioning model groups, the bilateral carotid artery was ligated to establish the VD model, whereas in the sham group. 2-week and 4-week exercise preconditioning sham group, only bilateral carotid artery was separated without ligation. At 14 days after modeling. Morris water maze was performed, immunohistochemical stain technique was used to detect the hippocampus microvessel density. Nissl's stain method was used to detect the damage of hippocampus neurons. Western Blot was used to detect the expression of hypoxia-inducible factor a (HIF-In), vascular endothelial growth factor (VEGF) and heme oxygenase 1(HO-1)protein in the hippocampus of VD rats at 3. 7 and 14 days after modeling Result: At 14 days after modeling, compared with the sham group, the escape latency was prolonged and the times of crossing the platform was reduced in the model group P < 0.001 P = 0.018 ) Compared with the model group, the escape latency of the 4-week exercise preconditioning model group was decreased (P 0.023). The number of neurons in hippocampal CAI region decreased in the model group compared with the sham group ( P r0.001). Compared with the model group, the number of neurons in hippocampal CAI region in the 2-week and 4-week exercise preconditioning model groups increased ( P 0.011. P < 1) . Compared. with the 2-week exercise preconditioning model group, the number of neurons in the hippocampus CAI region was increased in the 4-week exercise preconditioning model group (P-0.046). Compared with the sham group, HIF-14. VEGF and HO-1 proteins in the hippocampus of the model group were increased after modeling (P 0.013. P = 0.037 P sim 0.044 ) Compared with the model group, the expressions of HIF-1n, VEGF, HO-1 proteins in the hippocampus of the 4- week exercise preconditioning model group were increased after modeling ( P = 0.013, P = 0.012 P = 0.002 ) . Compared with 3 and 14 days after modeling. the expression of VEGF pro tein increased at 7 days after modeling (P = 0.001) P r0.001). Compared with 3 days after modeling, the ex-pression of HO-1 protein was increased at 7 days after modeling (P = 0.001) Compared with sham group, the MVD in hippocampal CAI region was increased in model group (P - 0.002) Compared with the model group and 2-week exercise preconditioning model group, the MVD hippocampal CAI region of the 4 week exercise preconditioning model group was increased (P<0.001,P=0.003). Conclusion: Exercise preconditioning for 4 weeks can promote angiogenesis, increase microvacular density, re-duce neuron damage, and delay the development of cognitive impairment in VD rats by regulating the expres sion of hippocampal angiogenesis related proteins. The effect of exercise preconditioning on the expression of cerebral angiogenesis proteins in VD rats may have a certain time rule. [ABSTRACT FROM AUTHOR]

Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Coal Geology & Exploration is the property of Xian Research Institute of China Coal Research Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Water Conservancy & Electric Power Technology & Application is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To develop a nomogram for predicting the successful implementation of radical surgery for gallbladder cancer (GBC). Methods A total of 320 patients with GBC who underwent surgical procedures including radical surgery, palliative excision, abdominal exploration, and biopsy were enrolled in this study. Patients were divided into the training set (235 cases) and the verification set (85 cases) according to the time of inclusion. By comparing the clinical data of patients undergoing radical surgery and patients with non-radical surgery, multivariate Logistic regression analysis was conducted to analyze the prediction model affecting the successful implementation of radical surgery in GBC patients, and a column graph was drawn. Receiver operating characteristic (ROC) curve and calibration curve were used to evaluate the differentiation and calibration of the prediction model. Clinical decision curve (DCA) was used to evaluate the practical utility of the nomogram prediction model. Results Univariate analysis showed that there were significant differences in weight loss, jaundice, hypertension, lymph node metastasis, body mass index (BMI), hemoglobin (HB), albumin (ALB), CA19-9, CA125, total bilirubin and direct bilirubin between the radical surgery group and the non-radical surgery group (P＜0.05). These 11 potential predictors were included in the multivariate Logistic regression analysis in the training set, and results showed that no jaundice, hypertension, lymph node metastasis, elevated HB and ALB, and decreased CA19-9 were predictive factors for the successful implementation of radical GBC surgery. A nomogram was established based on 6 independent risk factors obtained by Logistic regression. In the training group and the verification group, the area under the curve of the nomogram was 0.901 and 0.822, respectively, and the model has good differentiation. Hosmer-Lemeshow test showed that the model was well calibrated (χ² =5.740, P=0.676). The calibration curve of the model was close to ideal curve, indicating that the observed results were in good agreement with the actual results. The DCA curve showed that the model had a net benefit and good clinical practicability for clinical application. Conclusion The nomogram can effectively screen patients with GBC suitable for radical surgery, thus reducing the chance of conversion of anticipated radical surgery to palliative resection or exploratory laparotomy and increasing the likelihood of surgical benefits for patients. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Guangxi Normal University - Natural Science Edition is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Multipurpose Utilization of Mineral Resources / Kuangchan Zonghe Liyong is the property of Multipurpose Utilization of Mineral Resources Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Chinese Journal of Pathophysiology is the property of Jinan University, School of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Science & Biotechnology is the property of Journal of Food Science & Biotechnology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the effects of different duration of exercise preconditioning on changes in cerebral blood flow and microglia activation related proteins in rats with vascular dementia. Method: Sixty SPF SD male rats were used to prepare vascular dementia rat models by permanent ligation of bilateral common carotid arteries. They were randomly divided into the model group, sham-operated group, exercise preconditioning 4-week model group, exercise preconditioning 4-week sham-operated group, exercise preconditioning 2week model group and exercise preconditioning 2week shamoperated group, with 10 rats in each group. The exercise preconditioning 4-week rats received 30 minutes of moderate intensity non-weight-bearing swimming training 5 times a week for 4 weeks before modeling, while the exercise preconditioning 2week rats received the same training for 2 weeks. Morris water maze was used to detect the spatial learning and memory ability of rats, laser speckle imaging technique was used to observe the changes of cerebral blood flow and the opening of collateral circulation of rats at different time point before and after the modeling, and Western Blotting was used to detect the expression of TLR4 and Iba 1 protein in hippocampus. Result: Compared with the sham-operated group and the exercise preconditioning 2-week sham-operated group, the average escape latency time of rats in the exercise preconditioning 4-week sham-operated group, the model group, the exercise preconditioning 4-week model group and the exercise preconditioning 2-week model group was significantly prolonged (P<0.05).Compared with the exercise preconditioning 4week shamoperated group, the average escape latency time of rats in the model group and the exercise preconditioning 4week model group was significantly prolonged (P<0.05). Compared with the model group and exercise preconditioning 4week model group, the average escape latency time of rats in exercise preconditioning 2week model group was significantly decreased (P<0.05). The simple effect of repetitive measurement deviation analysis suggested that the average cerebral blood flow before modeling, 2h after modeling, 3d after modeling and 7d after modeling was statistically significant between the groups (P<0.05). The simple effect of time factor on average cerebral blood flow of the model group, the exercise preconditioning 4-week model group and the exercise preconditioning 2-week model group was statistically significant (P<0.01). The opening of collateral circulation of rats in each group was observed. Compared with the model group, less reduction in microvessel diameter was observed in the exercise preconditioning 2-week model group (P<0.05). Compared with the sham-operated group, the exercise preconditioning 4-week sham-operated group and the exercise preconditioning 2-week sham-operated group, Iba1 and TLR4 protein expressions in the model group were significantly increased (P<0.01). Compared with the model group, Iba1 and TLR4 protein expressions in the exercise preconditioning 2-week model group were decreased (P<0.05). Conclusion: Moderate intensity exercise preconditioning for 2 weeks can improve the learning and memory ability of vascular dementia rats, but exercise preconditioning for 4 weeks has no obvious effect on the improvement of learning and memory ability. The mechanism may be related to the improvement of cerebral blood flow status and the inhibition of microglia activation. [ABSTRACT FROM AUTHOR]

Copyright of Geology & Exploration is the property of Geology & Exploration Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Thidiazuron (TDZ) is used for the expansion of fruits, but excessive levels of TDZ lead to a decline in fruit quality. The appropriate concentration of TDZ for mango expansion without a decline in quality is not clear. In the present study, four different concentrations (5, 10, 15, and 20 mg/L) of TDZ were applied via spraying on mango plants, and several physiological and biochemical indicators were measured. The results showed that TDZ treatment significantly increased mango fruit size and single-fruit weight. In mango fruit, TDZ treatment decreased the disease index, delayed the increase in the malondialdehyde and H2O2 content, and maintained firmness and antioxidant capacities at a relatively high level during postharvest storage. At the same time, TDZ treatment delayed the decrease in the giberellin, indoleacetic acid and jasmonic acid content in mango, and reduced the accumulation of abscisic acid and ethylene. These trends are consistent with TDZ treatment leading to extension of the shelf life of mango. Furthermore, ethylene biosynthesis, signal transduction, and cell wall dismantling-related genes were investigated. The results indicated that the expression of the MiACS , MiETR2 , MiERF113 , MiERF010 , MiERF054 , MiEXP , MiPG14 , MiPG21 , MiCEL , and MiPEL genes in mango was inhibited under TDZ treatment compared with the control. In summary, TDZ treatment can significantly increase the size and weight of mango fruit and can extend its shelf life. The most suitable concentration is 10–15 mg/L TDZ, which will not affect the quality of mango fruit. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of South China University of Technology (Natural Science Edition) is the property of South China University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to study the shear strength characteristics of cohesive soil of Ge-Hu Formation in Suzhou-Wuxi-Changzhou area and establish a prediction model of shear strength parameters, the principal component analysis (PCA) method was used to extract the principal components affecting the target variables from 11 indicators of the sample based on 711 sets of physical and mechanical test data of cohesive soil in Gehu Formation in the area. After the selected principal components being used as the input layer of the back propagation neural network (BPNN) model, the prediction model based on PCA-BPNN algorithm was established. Results show that when the number of principal components is 3, the cumulative contribution rate of principal components reaches 93. 4% . The contribution rates of the first and second principal components are 52. 1% and 36. 6% respectively. PCA algorithm not only retains most of the information of the sample, but also reduces the dimension of multidimensional variables. The first principal component can be summarized as soil pore characteristics, which are negatively correlated with cohesion and internal friction angle. The second principal component can be summarized as soil water stability, which is positively correlated with cohesion and internal friction angle. Therefore, the more significant the pore characteristics of the soil, the weaker the water stability and the lower the shear strength. PCA-BPNN model was established for predicting the shear strength parameters of cohesive soil in Gehu Formation. The goodness of fit of the model for cohesion is 0. 85 and the goodness of fit for internal friction angle is 0. 72. The prediction accuracy and reliability of the model are generally high. In summary, the PCA-BPNN prediction model can not only reduce the multicollinearity between explanatory variables, simplify the model, but also improve the generalization ability of the model. It provides a reference for using mathematical methods to study soil engineering geological parameters. [ABSTRACT FROM AUTHOR]

Copyright of Industrial Water Treatment is the property of CNOOC Tianjin Chemical Research & Design Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Nonferrous Metals (Mineral Processing Section) is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Beijing University of Civil Engineering & Architecture is the property of Journal of Beijing University of Civil Engineering & Architecture Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agro-Environment Science is the property of Journal of Agro-Environment Science Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To change the large fluctuation of fluid pressure and production in the early and late stages of shale gas field production, the problem of poor adaptability to changes in working conditions during the production process of the gathering and transportation pipeline network. Based on the operation status and working conditions of the gathering and transportation pipeline network in a shale gas field in a block in Changning, the three aspects of pipeline network layout, transportation technology, and pressure boosting technology are selected respectively to select the optimal evaluation indicators for adaptability analysis and evaluation. The results show that the overall reliability of the gathering and transportation pipeline network in the Changning block is high, and the pressurization process is large in scale but low in pressurization efficiency. Under the maximum design scale of the rolling combined supercharging mode, try to increase the supercharging ratio as much as possible. The evaluation results aim to provide technical support for the safe and stable operation of the gathering and transportation pipeline network in the Changning block shale gas field. [ABSTRACT FROM AUTHOR]

Most existing vertical handoff algorithms cannot realize seamless handoff and provide stable communication services for mobile users in heterogeneous wireless networks. In order to solve the above problem, this paper proposed a vertical handoff algorithm based on mobile user location prediction to realize seamless handoff. Firstly, using the similar regular characteristics of the mobile trajectories of each user, the algorithm trained the Long Short Term Memory (LSTM) model offline and used it to predict the location of each mobile user at the next moment online, and estimated the multiattribute parameters of the future networks. After that, the algorithm used fuzzy logic to analyze the return set of all optional networks under the condition of multi-attribute parameters, and selected the network with the highest return in order to complete the handoff decision. The experimental results show that the proposed algorithm has better handover performance than the existing handover algorithms in terms of the number of handoff and the number of handoff failures under different mobile speeds and the scale of users, and is superior to other methods in terms of switching time and memory resource consumption. In conclusion, it can realize seamless handoff in heterogeneous wireless networks. [ABSTRACT FROM AUTHOR]

Copyright of New Building Materials / Xinxing Jianzhu Cailiao is the property of New Building Materials Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Changzhou University (Natural Science Edition) / Changzhou Daxue Xuebao (Ziran Kexue Ban) is the property of Editorial Department of Journal of Changzhou University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)