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激活蛋白1(AP-1)是机体内一种重要的转录因子。近年来研究表明,AP-1活性失调与肿瘤、哮喘、自身免疫性疾病、肾脏疾病等多种疾病的发生、发展有关。AP-1在前列腺癌、甲状腺癌、子宫内膜癌、胃癌等肿瘤中表达失调,其表达失调可导致肿瘤进展,且与预后相关。AP-1在自身免疫性疾病如类风湿关节炎中过表达,而在系统性红斑狼疮患者中AP-1的表达降低。AP-1高表达参与了支气管哮喘的发病,且与糖皮质激素抵抗有关。AP-1可调节糖尿病肾病发生发展中起重要作用的基因的表达,还可介导糖尿病肾病标志蛋白纤连蛋白的合成。另外,AP-1表达升高还与肾病综合征的发病有关。 [ABSTRACT FROM AUTHOR]

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Copyright of Southwest China Journal of Agricultural Sciences is the property of Editorial Department of Southwest China Journal of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Southwest China Journal of Agricultural Sciences is the property of Editorial Department of Southwest China Journal of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)