1. A New Sperm Concentration Threshold for Y Chromosome Microdeletion Analysis in Infertile Men: Could It Be Azoopermia?
- Author
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Ali Çift, Can Benlioğlu, Mehmet Özgür Yücel, Muhammer Özgür Çevik, Bedreddin Kalyenci, Alper Gök, Sait Sever, Hasan Sulhan, Haydar Bağış, and Ali Ayyıldız
- Subjects
Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Objective: We aimed to assess the frequency of Y-chromosome microdeletions (YCMs) in a non-multiethnic urban population in our region, define predictive factors, and determine a new clinical threshold for YCMs in infertile men. Materials and Methods: A total of 281 patients with a sperm concentration ≤5 million/mL were retrospectively evaluated. Oligozoospermic and/or azoospermic patients with a sperm concentration of ≤5 million/mL were screened for the YCM analysis. Results: Y-chromosome microdeletion was detected in 9 (3.2%) of the 281 patients. All patients with YCM were azoospermic. The presence of azoospermia, a high folliclestimulating hormone level, and a high luteinizing hormone level were found to be important determinants for the identification of a microdeletion (P = .002, P = .002, and P=.021, respectively). If the presence of azoospermia and a sperm concentration threshold of more...
- Published
- 2024
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