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379 results on '"Puzik A"'

356. Über die Häufigkeit der Hypophysenvorderlappeninsuffizienz bei angeborenen Herzfehlern mit Blausucht

Author

K. Kopetz, A. Puzik, and K. Schwarz

Abstract

Patienten mit angeborenen Herzfehlern und fruhkindlicher Blausucht fallen haufig als Erwachsene schon im Aspekt durch einen Minderwuchs, Hypogonadismus und infantile Zuge auf, deren Symptomatik an eine Storung des endokrinen Systems denken lassen. Die Cyanose als Folge des „Rechts-Links-Shunts“ fuhrt bei diesem Krankheitsbild zu einer kompensatorischen Polyglobulie, erhohten Blutviscositat, Stase und Thromboseneigung und schlieslich bei Blutdruckabfall zu Zirkulationsstorungen an den empfindlichsten Organen, z. B. am Gehirn und vielleicht auch an der Hypophyse.

Published
1962
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360. Lef1 regulates caveolin expression and caveolin dependent endocytosis, a process necessary for Wnt5a/Ror2 signaling during Xenopus gastrulation.

Author

Puzik, Katharina, Tonnier, Veronika, Opper, Isabell, Eckert, Antonia, Zhou, Lu, Kratzer, Marie-Claire, Noble, Ferdinand le, Nienhaus, Gerd Ulrich, and Gradl, Dietmar

Subjects
*CAVEOLINS, *ENDOCYTOSIS, *XENOPUS, *WNT signal transduction, *GASTRULATION
Abstract

The activation of distinct branches of the Wnt signaling network is essential for regulating early vertebrate development. Activation of the canonical Wnt/β-catenin pathway stimulates expression of β-catenin-Lef/Tcf regulated Wnt target genes and a regulatory network giving rise to the formation of the Spemann organizer. Non-canonical pathways, by contrast, mainly regulate cell polarization and migration, in particular convergent extension movements of the trunk mesoderm during gastrulation. By transcriptome analyses, we found caveolin1, caveolin3 and cavin1 to be regulated by Lef1 in the involuting mesoderm of Xenopus embryos at gastrula stages. We show that caveolins and caveolin dependent endocytosis are necessary for proper gastrulation, most likely by interfering with Wnt5a/Ror2 signaling. Wnt5a regulates the subcellular localization of receptor complexes, including Ror2 homodimers, Ror2/Fzd7 and Ror2/dsh heterodimers in an endocytosis dependent manner. Live-cell imaging revealed endocytosis of Ror2/caveolin1 complexes. In Xenopus explants, in the presence of Wnt5a, these receptor clusters remain stable exclusively at the basolateral side, suggesting that endocytosis of non-canonical Wnt/receptor complexes preferentially takes place at the apical membrane. In support of this blocking endocytosis with inhibitors prevents the effects of Wnt5a. Thus, target genes of Lef1 interfere with Wnt5a/Ror2 signaling to coordinate gastrulation movements. [ABSTRACT FROM AUTHOR]

Published
2019
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363. НЕІНВАЗИВНА ОЦІНКА ФУНКЦІОНАЛЬНОГО СТАНУ СЕРЦЯ, СУДИН І ОРГАНІВ ТРАВЛЕННЯ ПРИ ПРИЙОМІ ЗМІШАНОЇ ЇЖІ В ПРАКТИЦІ СІМЕЙНИХ ЛІКАРІВ

Author

Reshetilov, U. І., Dmitrieva, S. M., Kuznetsova, L. P., Vasilchenko, O. U., Bohoslav, T. V., Puzik, S. H., Kurhan, A. P., Statsenko, O. M., Tsaprika, O. F., Taranjuk, L. V., Zuevich, L. H., Reshetilov, U. І., Dmitrieva, S. M., Kuznetsova, L. P., Vasilchenko, O. U., Bohoslav, T. V., Puzik, S. H., Kurhan, A. P., Statsenko, O. M., Tsaprika, O. F., Taranjuk, L. V., and Zuevich, L. H.

365. Artificial enhancement of sturgeon stock in freshwater reservoirs: A case study on sterlet Acipenser ruthenus of the Kama reservoir.

Author

Mikheev, Pavel B., Kazarinov, Semyon N., Melnikova, Alla G., Ponosov, Stanislav V., Petrenko, Nikolai G., Nikiforov, Andrei I., Yu Puzik, Alexey, and Elchenkova, Olga N.

Subjects
*STURGEON fishing, *FRESHWATER fishes, *STERLET, *FISHING catch effort, *RESERVOIRS
Abstract

The paper presents the results of the sterlet sturgeon Acipenser ruthenus reintroduction into the Kama Reservoir (Perm Krai, Russia) by sterlet fry from hatcheries into the reservoir since 2001. The effectiveness of hatchery releases was evaluated by monitoring gillnet sampling 2014-2020. The results showed that the species was reported throughout entire Kama Reservoir, which contrasts with 1988-1994 data, when the species was registered only at the upper part of the reservoir near the Kama River mouth. The highest number and biomass values of catch per unit effort (CPUE) of the sterlet were found in submerged river channels - the deepest habitats with flow conditions which are close to the ecological requirements of the species. The distribution of the sterlet within the channel biotopes of the reservoir is defined by reduced variability. The biggest individuals and the widest size range of the sterlet were typical for the upper area of the reservoir and Chusovskoy Bay, which have the greatest flow. The smallest sizes were typical for fish from catches near the dam of the reservoir, which is consistent with the published data on the distribution of sterlet in reservoir conditions. The presented results may indicate the artificial formation of the sterlet stock in the Kama Reservoir maintained by hatchery releases. The revealed distribution of the sterlet in the reservoir determines the direction of further research on natural reproduction and thus formation of an artificially formed population. Also, future studies are required to assess the possibility of hybridization of the sterlet of artificial origin with natural populations of the species, since the low genetic diversity of the sterlet released into the Kama Reservoir which can lead to irreversible loss of genetic individuality of the natural stocks of the species in the catchment of upper course of the Kama River. [ABSTRACT FROM AUTHOR]

Published
2024
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366. [Erythema migrans disease. A contribution to its clinical features and relation to Lyme disease].

Author

Weber K, Puzik A, and Becker T

Subjects
Adolescent, Adult, Anti-Bacterial Agents therapeutic use, Arrhythmia, Sinus etiology, Child, Child, Preschool, Depression etiology, Elbow pathology, Female, Fever etiology, Humans, Hypertension etiology, Infant, Knee pathology, Larva Migrans drug therapy, Laryngitis etiology, Male, Middle Aged, Prospective Studies, Shoulder pathology, Arthritis, Infectious pathology, Larva Migrans pathology
Abstract

A largely prospective study averaging 33 months was undertaken in 30 patients with and one without (chronic) erythema migrans. In one case erythema migrans disappeared spontaneously, in the 29 others it persisted up to six months, but quickly responded to antibiotic treatment. Measured from the tick bite in 9 patients or from onset of the erythema migrans, arthritis and arthralgia appeared in ten patients on average 6.5 months (0.7-36), and persisted for eight months (0.2-42). In seven of these patients sensory disturbances appeared three weeks (1-10) later and (or) signs of meningitis which lasted for four months (0.5-16), while in three patients cardiac symptoms appeared a few weeks later, persisting for 4.5 months (0.3-12). In one patient tracheolaryngitis developed two months later, persisting for three months. These manifestations occurred in seven patients despite antibiotic treatment. Extradermal manifestations in two patients were successfully treated with high parenteral penicillin doses, in one instance followed by tetracyclin. "Erythema migrans disease", differing from Lyme disease described in the U.S.A. in only a few aspects, apparently cannot be successfully treated with low oral doses of penicillin, but can in certain circumstances be favourably influenced by high parenteral doses of penicillin G.

Published
1983
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369. The identification of individuals with hatchery and natural origin in a mixed sample of Amur River chum salmon by Otolith microchemistry.

Author

Mikheev, Pavel B., Kotsyuk, Denis V., Podorozhnyuk, Elena V., Koshelev, Vsesolod N., Nikiforov, Atbkyh I., Sheina, Tatiana A., Puzik, Alexey Yu., and Baklanov, Mikhail A.

Subjects
*CHUM salmon, *FISH spawning, *MICROCHEMISTRY, *RAW materials
Abstract

We estimated the proportion of hatchery and natural fall spawning chum salmon returning to the Amur River using chemical markers specific to hatchery-origin fry. We used otolith microchemistry technique to identify fish with artificial origin among returning spawners. First, we found that juveniles of artificial origin had higher values of the Sr:Ca molar ratio of the otoliths' edge zone compared with juveniles of natural origin, what can be related to the use of rearing feed produced from raw materials of marine origin rich in strontium. Then we observed that most of the spawners from Anyuisky Hatchery and from the Amur River mouth at the start of the spawning migration has also the higher value of Sr:Ca molar ratio of the juvenile zone of otoliths. Also, adults with higher values of the Sr:Ca molar ratio are characterized by a skewed right in the peak of the age distribution. Both, the age structure and phenological shift in the time of spawning migration of individuals with higher value of the used chemical marker corresponds to results of studies on hatchery-produced chum salmon completed at different parts on Northern Pacific. The results of this study will be used in the management of Amur fall chum salmon fisheries, and also demonstrates the necessity of the development of specific measures for increasing the survival of juvenile anadromous salmonids released at large rivers and exposed to prolonged freshwater migration to the ocean. As a further application of the methodology, we plan to identify the markers specific to each of the hatcheries and main spawning tributaries belonging to Amur River catchments. This will be an important step in the evaluation of the contribution of different stocks in mixed fisheries and also in the estimation of the effect of hatchery releases on naturally spawning stocks of Amur fall chum. Following to, our results may indicate the applicability of this approach for the determination of artificialorigin fish in a mixed sample of the Amur fall chum salmon. [ABSTRACT FROM AUTHOR]

Published
2023
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371. Prussian Blue Nanozymes with Enhanced Catalytic Activity: Size Tuning and Application in ELISA-like Immunoassay.

Author

Khramtsov, Pavel, Kropaneva, Maria, Minin, Artem, Bochkova, Maria, Timganova, Valeria, Maximov, Andrey, Puzik, Alexey, Zamorina, Svetlana, and Rayev, Mikhail

Subjects
*PRUSSIAN blue, *SYNTHETIC enzymes, *CATALYTIC activity, *IMMUNOASSAY, *PROSTATE-specific antigen, *PEROXIDASE
Abstract

Prussian blue nanozymes possessing peroxidase-like activity gather significant attention as alternatives to natural enzymes in therapy, biosensing, and environmental remediation. Recently, Prussian blue nanoparticles with enhanced catalytic activity prepared by reduction of FeCl3/K3[Fe(CN)6] mixture have been reported. These nanoparticles were denoted as 'artificial peroxidase' nanozymes. Our study provides insights into the process of their synthesis. We studied how the size of nanozymes and synthesis yield can be controlled via adjustment of the synthesis conditions. Based on these results, we developed a reproducible and scalable method for the preparation of 'artificial peroxidase' with tunable sizes and enhanced catalytic activity. Nanozymes modified with gelatin shell and functionalized with affine molecules were applied as labels in colorimetric immunoassays of prostate-specific antigen and tetanus antibodies, enabling detection of these analytes in the range of clinically relevant concentrations. Protein coating provides excellent colloidal stability of nanozymes in physiological conditions and stability upon long-term storage. [ABSTRACT FROM AUTHOR]

Published
2022
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372. Hemangioblastoma and von Hippel-Lindau disease: genetic background, spectrum of disease, and neurosurgical treatment.

Author

Klingler, Jan-Helge, Gläsker, Sven, Bausch, Birke, Urbach, Horst, Krauss, Tobias, Jilg, Cordula A., Steiert, Christine, Puzik, Alexander, Neumann-Haefelin, Elke, Kotsis, Fruzsina, Agostini, Hansjürgen, Neumann, Hartmut P.H., and Beck, Jürgen

Subjects
*VON Hippel-Lindau disease, *GENETIC disorders, *CENTRAL nervous system, *VON Willebrand disease, *SYMPTOMS, *TUMOR growth, *PANCREATIC cysts
Abstract

Introduction: Hemangioblastomas are rare, histologically benign, highly vascularized tumors of the brain, the spinal cord, and the retina, occurring sporadically or associated with the autosomal dominant inherited von Hippel-Lindau (VHL) disease. Children or adults with VHL disease have one of > 300 known germline mutations of the VHL gene located on chromosome 3. They are prone to develop hemangioblastomas, extremely rarely starting at age 6, rarely at age 12–18, and, typically and almost all, as adults. There is a plethora of VHL-associated tumors and cysts, mainly in the kidney, pancreas, adrenals, reproductive organs, and central nervous system. Due to a lack of causal treatment, alleviation of symptoms and prevention of permanent neurological deficits as well as malignant transformation are the main task. Paucity of data and the nonlinear course of tumor progression make management of pediatric VHL patients with hemangioblastomas challenging. Methods: The Freiburg surveillance protocol was developed by combining data from the literature and our experience of examinations of > 300 VHL patients per year at our university VHL center. Results: Key recommendations are to start screening of patients at risk by funduscopy with dilated pupils for retinal tumors with admission to school and with MRI of the brain and spinal cord at age 14, then continue biannually until age 18, with emergency MRI in case of neurological symptoms. Indication for surgery remains personalized and should be approved by an experienced VHL board, but we regard neurological symptoms, rapid tumor growth, or critically large tumor/cyst sizes as the key indications to remove hemangioblastomas. Since repeated surgery on hemangioblastomas in VHL patients is not rare, modern neurosurgical techniques should encompass microsurgery, neuronavigation, intraoperative neuromonitoring, fluorescein dye-based intraoperative angiography, intraoperative ultrasound, and minimally invasive approaches, preceded in selected cases by endovascular embolization. Highly specialized neurosurgeons are able to achieve a very low risk of permanent morbidity for the removal of hemangioblastomas from the cerebellum and spinal cord. Small retinal tumors of the peripheral retina can be treated by laser coagulation, larger tumors by cryocoagulation or brachytherapy. Conclusion: We consider management at experienced VHL centers mandatory and careful surveillance and monitoring of asymptomatic lesions are required to prevent unnecessary operations and minimize morbidity. [ABSTRACT FROM AUTHOR]

Published
2020
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373. Dietary Immunomodulators - An Organic Boom in the Management of Chronic Diseases

Author

Anwesha Banerjee1, Divya Pandya1, Arpita Maitra1, Kaushik Dutta1, and Rekha Puttanawar1

Subjects
cancer, immunity, immunomodulator, organic food, probiotics, vitamins
Abstract

Immunology involves all the defence mechanisms occurring in the body after the invasion of any infectious agent and the ability to resist this infection. The micronutrients like essential proteins, essential amino acids, vitamins (A, B6, B12, C, D, E and folic acid), fatty acids, minerals (iron, selenium, zinc and copper) and certain phytochemicals are of prime importance towards healthy immune system. In addition to these nutritional components, intestinal microflora and certain bacteria (probiotic bacteria) also play an important role in the modulation of healthy immune system. There is an ongoing trend of usage of immunomodulators to combat various chronic diseases like viral diseases, cancers, inflammatory and autoimmune diseases. 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Planta Medica. 2002;68:97-100 72. Cos P, Ying L, Calomme M, Hu JP, Cimanga K, Van Poel B, et al. Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers. J Natural Products.1998;61:71-6. 73. Sangwan NS, Shanker S, Sangwan RS, Kumar S. Plant derived products as antimutagens. Phytotherapy Res.1998;12:389-99. 7 4 . D i x o n R A , F e r r e i r a D . G e n i s t e i n . Phytochemistry.2002;60:205-11. 7 5 . Ya m a z a k i K , M u r r a y J A , K i t a H . I n n a t e immunomodulatory effects of cereal grains through i n d u c t i o n o f I L - 1 0 . J A l l e r g y C l i n Immunol.2008;121:172-8. 76. Ye M, Liu JK, Lu ZX, Zhao Y, Liu SF, Li LL, et al. Grifolin, a potential antitumor natural product from the mushroom Albatrellusconfluens, inhibits tumor cell growth by inducing apoptosis in vitro. FEBS Letters.2005;579:3437-43. 77. Kohno K, Okamoto I, Sano O, Arai N, Iwaki K, Ikeda M, et al. Royal jelly inhibits the production of proinflammatory cytokines by activated macrophages. BiosciBiotechnolBiochem. 2004;68:138-45. 78. Okamoto I, Taniguchi Y, Kunikata T, Kohno K, Iwaki K, Ikeda M, et al. Major royal jelly protein 3 modulates","immune responses in vitro and in vivo. Life Sci.2003;73:2029-45. 79. Meydani SN, Ha WK. Immunologic effects of yogurt. Am J Clin Nutr.2000;71:861-72. 80. Yamauchi A, Bloom ET. Requirement of thiol compounds as reducing agents for IL-2-mediated induction of LAK activity and proliferation of human NK cells. J Immunol.1993;151:5535-44. 81. Durrieu C, Degraeve P, Chappaz S, MartialGros A. Immunomodulating effects of watersoluble extracts of traditional French Alps cheeses on a human Tlymphocyte cell line. Int Dairy J.2006;16:1505-14. 82. Meisel H, Gunther S. Food proteins as precursors of p e p t i d e s m o d u l a t i n g h u m a n c e l l a c t i v i t y. Nahrung.1998;42:175-6. 83. Meisel H, Gunther S. Food proteins as precursors of p e p t i d e s m o d u l a t i n g h u m a n c e l l a c t i v i t y. Nahrung.1998;42:175-6. 84. Green TD, LaBelle VS, Steele PH, Kim EH, Lee LA, Mankad VS, et al. Clinical Characteristics of Peanut- Allergic Children: Recent Changes. Pediatrics. 2007;120:1304-10. 85. Sicherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol.2006;117:470-5."]}

Published
2023
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374. [Tuberculosis in adolescents: diagnosis, clinical picture, and treatment]

Author

V A, Firsova

Subjects
Diabetes Complications, Diagnosis, Differential, Time Factors, Adolescent, Drug Resistance, Multiple, Bacterial, Antitubercular Agents, Humans, Drug Therapy, Combination, Respiratory Tract Infections, Tuberculosis, Pulmonary
Abstract

The paper is dedicated to the anniversary of Professor V. I. Puzik, Honored Science Worker. It gives the data of morphological studies from her dissertation and some sections of the dissertations supervised by V. I. Puzik. The paper also presents data on the diagnosis, clinical picture, and treatment of tuberculosis in adolescents. The problems of early detection, differential diagnosis, the significance of concomitant diseases and social factors in the course of tuberculosis are discussed. Emphasis is placed on the importance of drug resistance in adolescent patients with tuberculosis, which has been revealed in 63.3% of cases. Complex treatment with essential, reserve, and combined antituberculous drugs is recommended in relation to the sensitivity of Mycobacterium tuberculosis. It is also advisable to treat concomitant diseases and to prescribe pathogenetic agents enhancing the body's overall resistance.

Published
2003

375. 'Ne riday Mene, Mati' ('Do not mourn Me, Mother'): poetics, liturgics, hymnography

Author

Olena Sadovnikova

Subjects
biology, Poetics, Mene, media_common.quotation_subject, Liturgics, General Medicine, Art, Theology, biology.organism_classification, media_common
Abstract

Introduction. The meaning of the Holy Saturday is a transition from Passion week to the Easter, from the greatest grief to jubilation, from death to life. It focuses different ontological extremities in a single point: death of the Immortal and resurrection of mortal body. This engenders maximal concentration of liturgical events, exceptional saturation of the services, revealing ample hymnographic material, diversity of stylistics, ways of incarnating of different senses, approaches to the events happening. One of the most interesting chants of the Passion Cycle is “Ne riday Mene, Mati” (“Do not mourn Me, Mother”), with its wonderful poetics, profound images and lapidary structure. Vividness and theological deepness of this chant provide inexhaustible material for research. Theoretical Background. In modern theological literature “Ne riday Mene, Mati” is mention in the context of special traits of the Holy Saturday services (I. Karabinova (1910), A. Kashkin (2010), M. Krasovitskaya (2014), G. Shimanskiy (2002) etc. It was characterised in more details in the researches on the Byzantine singers, among them the most important are works by archbishop Filaret (Gumilevskiy) and nun Ignatia (Puzik). Describing the personality and works of St. Kosma Mayumski, archbishop Filaret notes concentration of his style. Nun Ignatia studies images of this author’s works, their foundation in creed, links with dogmas of the Church; stresses features of poetics as well as dissects canons for Epiphany and Christmas. She pays special attention to the canons dedicated to Holy Mother, and she mentions “Ne riday Mene, Mati” as one of the most touching work by St. Kosma. Unfortunately, detailed analysis doesn’t follow this statement, that makes given paper relevant. Objective of this article is to study location of chant “Ne riday Mene, Mati” in service, specifics of its content, influence on later hymnography and iconography. Methods. Given that this research addresses theology, corresponding terminological system has been used, including special concepts as well as Church Slavonic words and expressions. Results. “Ne riday Mene, Mati” is an irmos of the ninth chant of the canon sung at the morning service on the Holy Saturday and devoted to suffering and death of Jesus Christ, interpreted as a culmination of the salvation of humanity. It has a distinctive feature of personal appeal of the Son to the Mother, answering her grief and closing a dialogical form in a spacetime of the whole service and Passion week, defining specifics of the poetics of its services. Several levels of content can be defined in a chant: 1) personal, describing relations between the Mother and the Son; 2) soteriological, revealing Lord’s plan of the salvation of humanity; 3) dogmatic, presenting dogmas of Christ and Holy Mother; 4) celebratory, establishing praise of the Mother of God. The structure of the irmos is defined by a triad thesis – antithesis – synthesis. Thesis is imperative expression (addressing “Ne riday Mene, Mati”), antithesis is justification of this reaction (“zrjashhi vo grobe, Ego zhe rodila esi Syna”). Not only does the synthesis resolve appearing contradiction, but also transfers the relations between the Son and the Mother into sphere of God-man relations. In this context the initial imperative can be understood as a demand for silence and tranquillity of soul, for absolute concentration in the situation of the contact with Godly essence. The same demand is situated in one of the crucial moments of liturgy of the Holy Saturday, in the time of The Great Entrance: “Da molchit vsjakaja plot chelovecha”. For the second time “Ne riday Mene, Mati” is sung in the final part of Eucharistic canon of the liturgy. In this context it brings out completely different facet, reincarnation of the God in a human through Resurrection. Thus, due to changes of context and place in the service, “Ne riday Mene, Mati” undergoes modulation of meaning. For the third and last time, “Ne riday…” appears in the Eastern Midnight office, that is a threshold between the Holy Saturday and The Easter, accompanying appearance of the shroud with the image of Jesus Christ. Thus, “Ne riday…” ends all the Passion cycle of the service. The profoundness of the images and dogmas as well as structure exceptionality of “Ne riday Mene, Mati” is reflected in later hymnography. Irmoses of the canons sung on Eves of Epiphany and Christmas are constituted in a way, similar to irmoses of the Holy Saturday. They preserve images, poetic devices, genre traits (irmos of the canon), glas (voice), usage of acrostic, thesis – antithesis – synthesis principle of composition. Besides for hymnography, “Ne riday Mene, Mati” influenced iconography of the stated image. All the most vital aspects of it have found their incarnation in iconography: Birth from the Virgin (iconography “Eleusa”), Crucifixion (the Cross, pierced rib), death and burial (crossed hands, closed eyes of Christ, stone tomb), Resurrection, appeal to the Mother (leaning of the Saviour’s head) as a sign of a dialogue; and every aspect from the abovementioned is a separate edge of multidimensional meaning of the Holy Saturday. Conclusions. Through analysis specifics of content and composition of “Ne riday Mene, Mati” is revealed. Dialogue is defined as a crucial principle, causing peculiar poetics of this chant and all the services of the Holy Saturday. Role of silence as one of the factors of the reception of the content is stated. Logical principle of structure thesis – antithesis – synthesis is brought out. Connections are drawn between this chant and its “podobnas” in texts of Menaion and Octoechos. Perspective of the further research lies in studying of dialogue in service of the Holy Saturday on micro- and macrolevels. Specifics of influence of chants on the iconography seems to be worthy of attention.

Published
2019
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376. Theoretical aspects of increasing the quality of project management

Author

Gerasimova, Lyudmyla

Subjects
project, project quality, project management, project management quality, TQM
Abstract

The article is about theoretical approaches to the definition of the concepts "quality of the project", "quality of project management" from the perspective of the practice of managing innovative projects. The term "project" should be viewed as a specific type of economic system and, in accordance with this, as a basic property of project management. The project is a collegially designed and implemented a unique plan of changes of an intensive nature with established requirements for quality (result), timing and budget. The main parameters of the project are a) satisfaction of requirements (quality); b) implementation costs; c) duration of implementation. There are two closely related, but separate aspects in project management: project quality management and quality of project management. The quality of management of an innovative project involves not only obtaining the necessary result in terms of its characteristics, but also achieving this result within a certain time frame within a certain budget., {"references":["Voropaev, V.I. (Eds). (2010). Project Management: Fundamentals of professional knowledge, National requirements for the competence of specialists . (NCB – SOVNET National Competence Baseline Version 3.0). M .: CJSC \"Project PRACTICE\" [in Russian].","Baguli, F. (2002). Project Management. M.: FAIR-PRESS [in Russian].","Geizler, P.S., & Zavyalova, O.V. (2005). Project management. Minsk: BSEU [in Russian].","Gray, K.F. & Larson, E.W. (2003). Project Management: A Practical Guide. M.: Business and Service [in Russian].","Kerzner, G. (2003). Strategic planning for project management using the maturity model. M .: IT Co.; M.: DMK Press [in Russian].","Lokir, K., Gordon, J. (2008). Project Management: Grades of Excellence. Minsk: Grevtsov Publisher [in Russian].","Resin, V.I., Vladimirova, I.L., &Symonenko, A.N. (2011). Formation of a strategy for centralized provision of construction projects with resources. Vestnik Rossiyskoy ekonomicheskoy akademii im. G.V. Plekhanova, 6 (42),102-106 [in Russian].","Tovb, A.S., & Tsipes, G.L. (2003). Project Management: Standards, Methods, Experience. М.: ZAO \"Olimp-business\" [in Russian].","ICB-IPMA Competence Baseline, Version 3.0. IPMA, International Project Management Association [in English].","Chizhova, E.N., & Shumilova, E.Yu. (2006). Improving the technology for assessing the target effectiveness of project management: a monograph. Belgorod: Publishing House of BSTU [in Russian].","Brezhnev, A. (2015). Quality management tools for an innovative project. Application of new technologies in management (ANTiM 2012): materialy Mezhdunarodnoy nauchnoy konferentsii (pp. 27-34). Serbia, Belgrade [in Russian].","Kleiner, G. (2011). Systemic resource of economics. Voprosy ekonomiki, 1, 89-100 [in Russian].","Woodward, X. (2005). Within budget and deadlines: so what? Upravleniye proyektami,1 (1), 10-13 [in Russian].","Harrington, J., & McNellis T. (2007). Perfection of Project Management. M.: RIO \"Standards and Quality\" [in Russian].","Salimova, T.A. (2008). Quality management. M.: Omega-L [in Russian].","Mazur, I.I., Shapiro V.D., & Olderogge N.G. (2001). Project management: studies, manual. M.: CJSC \"Publishing Economy\" [in Russian].","Heldman, K. (2005). Professional project management. M.: BINOM, Laboratory of knowledge [in Russian].","Turner, J.R. (2007). A Guide to Project-Oriented Management. M.: Grebennikov Publishing House [in Russian].","O'Connell, F. (2003). How to successfully manage projects. Silver Bullet. M.: KUDITS-IMAGE [in Russian].","Bychkov, V. (2010). Innovations in project management technologies Upravleniye proyektami, 2 (19), 42-45 [in Russian].","Project Management. Practical Guide. (2003). M.: \"YURK-NIGA\", [in Russian].","Pounds, V.N. (2008). Basics of project management in companies. (2nd ed.). SPb.: Peter, [in Russian].","Semechkin, A.Ye., & Pazyuk, Yu.V. (2007). Strategic Management: Theory and Practice. M.: SvR-Argus [in Russian].","Purba, S., & Zukkero, Dzh. (2007). How to avoid a disaster when managing a project. Express course for novice top managers. M.: NT Press [in Russian].","Puzik, L.M. (2017). The quality problem at the present stage. Kharkiv KHNAU. Retrieved from: http://dspace.knau.kharkov.ua/jspui/bitstream/123456789/537/4/%D1%80%D0%BE%D0%B7%D0%B4%D1%96%D0%BB%201.pdf [in Ukrainian]."]}

Published
2019
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377. Milling Simulations With A 3-Dof Flexible Planar Robot

Author

Hoai Nam Huynh, Edouard Rivière-Lorphèvre, and Olivier Verlinden

Subjects
robotic, Control, simulation, multibody, machining
Abstract

Manufacturing technologies are becoming continuously more diversified over the years. The increasing use of robots for various applications such as assembling, painting, welding has also affected the field of machining. Machining robots can deal with larger workspaces than conventional machine-tools at a lower cost and thus represent a very promising alternative for machining applications. Furthermore, their inherent structure ensures them a great flexibility of motion to reach any location on the workpiece with the desired orientation. Nevertheless, machining robots suffer from a lack of stiffness at their joints restricting their use to applications involving low cutting forces especially finishing operations. Vibratory instabilities may also happen while machining and deteriorate the precision leading to scrap parts. Some researchers are therefore concerned with the identification of optimal parameters in robotic machining. This paper continues the development of a virtual robotic machining simulator in order to find optimized cutting parameters in terms of depth of cut or feed per tooth for example. The simulation environment combines an in-house milling routine (DyStaMill) achieving the computation of cutting forces and material removal with an in-house multibody library (EasyDyn) which is used to build a dynamic model of a 3-DOF planar robot with flexible links. The position of the robot end-effector submitted to milling forces is controlled through an inverse kinematics scheme while controlling the position of its joints separately. Each joint is actuated through a servomotor for which the transfer function has been computed in order to tune the corresponding controller. The output results feature the evolution of the cutting forces when the robot structure is deformable or not and the tracking errors of the end-effector. Illustrations of the resulting machined surfaces are also presented. The consideration of the links flexibility has highlighted an increase of the cutting forces magnitude. This proof of concept will aim to enrich the database of results in robotic machining for potential improvements in production., {"references":["A. Abele, M. Weigold, S. Rothenb¨ucher, \"Model and identification of an\nindustrial robot for machining applications,\" Annals of CIRP, vol. 56-1,\npp. 387–390, 2007.","S. Caro, C. Dumas, S. Garnier, B. Furet, \"Workpiece placement\noptimization for machining operations with a kuka kr270-2 robot,\"\nIEEE International Conference on Robotics and Automation (ICRA),\npp. 2921–2926, May, 2013.","C. Dumas, A. Boudelier, S. Caro, S. Garnier, M. Ritou, B. Furet,\n\"D´eveloppement d'une cellule robotis´ee de d´etourage des composites,\"\nM´ecanique et industries, vol. 12, pp. 487–494, 2011.","H. Zhang, J. Wang, G. Zhang, Z. Gan, Z. Pan, H. Cui, Z. Zhu,\n\"Machining with flexible manipulator: Toward improving robotic\nmachining performance,\" Proc. IEEE-ASME International Conference\non Advanced Intelligent Mechatronics, pp. 1127–1132, USA, July, 2005.","Z. Pan, H. Zhang, Z. Zhu, J. Wang, \"Chatter analysis of robotic\nmachining process,\" Journal of Material Processing Technology,\nvol. 173, pp. 301–309, 2006.","J. Tlusty, M. Polacek, \"The stability of the machine tool against\nself-excited vibration in machining,\" ASME International Research in\nProduction Engineering, pp. 465–474, 1963.","S. G. Mousavi, V. Gagnol, B.C. Bouzgarou, P. Ray, \"Dynamic behaviour\nmodel of a machining robot,\" ECCOMAS Multibody Dynamics,\npp. 771–779, July, 2013.","U. Schneider, M. Drust, A. Puzik, A. Verl, \"Compensation of errors\nin robot machining with a parallel 3d-piezo compensation mechanism,\"\nProcedia CIRP, vol. 7, pp. 305–310, 2013.","N.R. Slavkovic, D.S. Milutinovic, M.M. Glavonjic, \"A method for\noff-line compensation of cutting force-induced errors in robotic\nmachining by tool path modification,\" Int J Adv Manuf Technol,\nSpringer, vol. 70, pp. 2083–2096, 2014. [10] C. Dumas, S. Caro, S. Garnier, B. Furet, \"Joint stiffness identification of\nsix-revolute industrial serial robots,\" Robotics and Computer-Integrated\nManufacturing, vol. 27, pp. 881–888, 2011.\n[11] O. Verlinden, G. Kouroussis, C. Conti, \"EasyDyn: a framework based\non free symbolic and numerical tool for teaching multibody systems,\" in\nMultibody Dynamics 2005, ECCOMAS Thematic Conference, Madrid,\nSpain, 21-24 June 2005.\n[12] O. Verlinden, L. Ben F´ekih and G. Kouroussis, \"Symbolic generation\nof the kinematics of multibody systems in EasyDyn: From MuPAD to\nXcas/Giac,\" Theoretical and Applied Mechanics Letters, vol. 3, no. 1,\npp. 013012, doi: 10.1063/2.13013012, 2013.\n[13] H.N. Huynh, E. Rivi`ere, O. Verlinden, \"Integration of machining\nsimulation within a multibody framework: application to milling,\"\nIMSD: The 4th Joint International Conference on Multibody System\nDynamics, Canada, June, 2016.\n[14] S. Mousavi, V. Gagnol, B. C. Bouzgarrou, P. Ray, \"Dynamic model\nand stability prediction in robotic machining,\" Int J Adv Manuf Technol\n(2016), Springer, pp. 1–13, June 2016.\n[15] A. Cardona, \"Superelements modelling in flexible multibody dynamics,\"\nMultibody System Dynamics, vol. 4, pp. 245–266, 2000.\n[16] O. Verlinden, H.N. Huynh, E. Rivi`ere, \"Modelling of flexible bodies\nwith minimal coordinates by means of the co-rotational formulation,\"\nThe 4th Joint International Conference on Multibody System Dynamics,\nCanada, June, 2016.\n[17] E. Rivi`ere, E. Filippi, P. Dehombreux, \"Forces, vibrations and roughness\nprediction in milling using dynamic simulation,\" Proceedings, (Fifth\nInternational Conference on High Speed Machining (HSM 2006)), Mars,\nMetz, France 2006.\n[18] E. Rivi`ere, E. Filippi, P. Dehombreux, \"Chatter prediction using\ndynamic simulation,\" International Review of Mechanical Engineering\n(I.RE.M.E.), vol. 1, pp. 78–86, 2007.\n[19] G. Peign´e, H. Paris, D. Brissaud, \"A model of milled surface generation\nfor time domain simulation of high-speed cutting,\" Proceedings of the\nInstitution of Mechanical Engineers, vol. 217, pp. 919–930, 2003.\n[20] S. Engin, Y. Altintas, \"Mechanics and dynamics of general milling\ncutters. Part I: helical end mills,\" International Journal of Machine Tools\nand Manufacture, vol. 41, pp. 2195–2212, 2001.\n[21] John J. Craig, Introduction to Robotic: Mechanics and Control. Pearson,\nPrentice Hall, 2005.\n[22] C. Renotte, A. VandeWouwer, M. Remy, \"A simple frequency domain\napproach to the tuning of pid control: design of an interactive software\ntool,\" Journal A. Benelux Quaterly Journal on Automatic Control,\nvol. 42-3, pp. 23–27, 2001.\n[23] T. Insperger, B.P. Mann, G. St´ep´an, P.V. Bayly, \"Stability of up-milling\nand down-milling, part I: alternative analytical methods,\" International\nJournal of Machine Tools and Manufacture, vol. 43, pp. 25–34, 2003.\n[24] B. Siciliano, L. Sciavicco, L. Villani, G. Oriolo, Robotics: Modelling,\nPlanning and Control. Springer, 2010.\n[25] M.H. Raibert, J.J. Craig, \"Hybrid position/force control of\nmanipulators,\" Journal of Dynamic Systems, Measurement and\nControl, vol. 103-2, pp. 126–133, 1981."]}

Published
2016
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378. [The scientific path of a laboratory of pathomorphology and electron microscopy]

Author

Z S, Zemskova and L E, Gedymin

Subjects
Microscopy, Electron, Pathology, Clinical, Humans, Tuberculosis, History, 20th Century, Laboratories, Hospital, History, 21st Century, Russia, USSR
Abstract

The paper shows the research directions of the staff of the laboratory of pathomorphology and electron microscopy, which cover the period from 1924 to the present time, which can be conventionally divided into 4 stages associated with the leading role of the laboratory's heads: Prof. V.G. Shtefko (1924-1945), Prof. V.I. Puzik (1945-1974), Prof. O.A. Uvarova (1974-1980), and Prof. V.V. Yerokhin (1980 up to the present time). The laboratory's researches are the productive path of phthisiomorphology. The tasks of the laboratory have been associated with the problems to be solved by the institute. This applies the morphology, pathogenesis, classification of tuberculosis, and changes in inflammatory reactions in response to the altered Mycobacterium tuberculosis and to specific and pathogenetic actions on tuberculosis. New living conditions give the laboratory's researchers new tasks that require their solution at a new technological level.

Published
2007

379. [To the problem of abacillary caverns in patients with pulmonary tuberculosis]

Author

T A, Khudushina and E P, Voloshina

Subjects
Liver, Guinea Pigs, Antitubercular Agents, Sputum, Animals, Humans, Lymph Nodes, Mycobacterium tuberculosis, Lung, Tuberculosis, Pulmonary, Spleen
Abstract

Less interest has been recently shown in the so-called openly negative syndrome in patients with pulmonary tuberculosis, which occasionally results in healing of tuberculous caverns to form a cystoid cavity. The materials presented in this paper suggest that in the 1960s the openly negative syndrome occurred after chemotherapy in 8.7% of the patients registered at a tuberculosis facility for destructive pulmonary tuberculosis. This syndrome persists for 3 years or more (according to the data of bacterioscopy, sputum inoculation and biological test on guinea pigs). Of great interest are the data of histological study made under the head of Prof. V. I. Puzik on experimental animals. The absence of specific reactions in response to a biological test and the presence of significant lymphoid focal and diffuse infiltration in the lungs, hyperplasia of follicles of the spleen and lymph nodes allow them to be regarded as immunomorphological reactions in response to the protein components of destroyed Mycobacterium tuberculosis (MBT). The long existing openly negative syndrome is also presented observed in patients with pulmonary tuberculosis but only in those who isolate MBT sensitive to antituberculous agents. In this connection, it is not inconceivable that special reparative processes that do not result in the long (3 years or more) existing openly negative syndrome in patients with destructive pulmonary tuberculosis who isolate resistant MBT forms.

Published
2003

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