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Many healthcare workers (HCWs) have been confirmed to be infected with SARS‐CoV‐2 in China. A retrospective, single‐center study was conducted. The median age of the 132 HCWs with COVID‐19 was 32 years, with 92 (69.7%) being females. There were 47 (35.6%) doctors, 72 (54.6%) nurses, and 13 (9.9%) other HCWs. Ten of the 132 patients (7.6%) had underlying diseases. The most common symptoms of illness onset were fever (70, 53.0%), cough (66, 50.0%), and fatigue (58, 43.9%). All patients were categorized into mild or moderate COVID‐19 type on admission to hospital, and five (3.8%) progressed to the severe COVID‐19 type. Sixty‐six HCWs patients were included in both the early and later discharged group. In the logistic analysis, the later discharged patients had a longer time for illness onset to hospital admission (per 1 day; OR, 1.10; 95% CI, 1.03–1.18; p =.006), a higher proportion of >3 onset symptoms clustering (OR, 3.11; 95% CI, 1.27–7.62; p =.01), and a higher percentage of other HCWs (OR, 6.20; 95% CI, 1.49–25.80; p =.01). HCW patients were young female nurses with fewer comorbidities, and most were mild or moderate COVID‐19 type. The later discharged patients exhibited characteristics of longer time for illness onset to hospitalization and clustering of onset symptoms. [ABSTRACT FROM AUTHOR]