1. Global treatment patterns and outcomes among patients with recurrent and/or metastatic head and neck squamous cell carcinoma: Results of the GLANCE H&N study.
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Grünwald, Viktor, Chirovsky, Diana, Cheung, Winson Y., Bertolini, Federica, Ahn, Myung-Ju, Yang, Muh-Hwa, Castro, Gilberto, Berrocal, Alfonso, Sjoquist, Katrin, Kuyas, Hélène, Auclair, Valérie, Guillaume, Xavier, Joo, Seongjung, Shah, Roshani, Harrington, Kevin, and GLANCE H&N STUDY Investigators
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SQUAMOUS cell carcinoma , *TREATMENT effectiveness , *HEAD & neck cancer , *OROPHARYNGEAL cancer , *THERAPEUTIC use of antineoplastic agents , *HEAD tumors , *PLATINUM compounds , *RESEARCH , *CONFIDENCE intervals , *RESEARCH methodology , *CANCER relapse , *RETROSPECTIVE studies , *MEDICAL cooperation , *EVALUATION research , *FLUOROURACIL , *METHOTREXATE , *HYDROCARBONS , *COMPARATIVE studies , *KAPLAN-Meier estimator , *NECK tumors - Abstract
Objectives: Given a lack of universally-accepted standard-of-care treatment for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), study objectives were to assess treatment utilization and survival outcomes for R/M HNSCC in the real-world setting.Materials and Methods: A multi-site retrospective chart review was conducted in Europe (Germany, United Kingdom, Italy, Spain), Asia Pacific (Australia, South Korea, Taiwan), and Latin/North America (Brazil and Canada) to identify patients who initiated first-line systemic therapy for R/M HNSCC between January 2011 and December 2013. Patients were followed through December 2015 to collect clinical characteristics, treatment and survival data.Results: Among 733 R/M HNSCC patients across 71 sites, median age was 60 years (inter-quartile range 54-67), 84% male, and 70% Eastern Cooperative Oncology Group performance status 0-1; 32% had oral cavity and 30% oropharyngeal cancers. The most common first-line regimen across all countries consisted of platinum-based combinations (73%), including platinum + 5-fluorouracil (5-FU) (26%), cetuximab + platinum ± 5-FU (22%), or taxane + platinum ± 5-FU (16%). However, use of different platinum-based combinations varied substantially; administration of cetuximab + platinum ± 5-FU was frequent in Italy (81%), Germany (46%) and Spain (38%), whereas use in other countries was limited. Median follow-up was 22.6 months (95% confidence interval [CI]: 21.5-24.6 months). Median real-world overall survival was only 8.0 months (95% CI: 7.0-8.0), with one-year survival reaching only 30.9% (95% CI: 27.5-34.3).Conclusion: Systemic therapies used in clinical practice for patients with R/M HNSCC vary substantially across countries. Prognosis remains poor in this patient population, highlighting the need for newer, more efficacious treatments. [ABSTRACT FROM AUTHOR]- Published
- 2020
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