1. Evolution of the Clinical Profile and Outcomes of Unvaccinated Patients Affected by Critical COVID-19 Pneumonia from the Pre-Vaccination to the Post-Vaccination Waves in Italy.
- Author
-
Calabrese, Cecilia, Annunziata, Anna, Mariniello, Domenica Francesca, Coppola, Antonietta, Mirizzi, Angela Irene, Simioli, Francesca, Pelaia, Corrado, Atripaldi, Lidia, Pugliese, Gaia, Guarino, Salvatore, and Fiorentino, Giuseppe
- Subjects
SARS-CoV-2 ,COVID-19 ,TREATMENT effectiveness ,PNEUMONIA ,RESPIRATORY insufficiency - Abstract
The vaccination campaign and the new SARS-CoV-2 variants may have changed the clinical profile and outcomes of patients admitted to sub-intensive unit care. We conducted a retrospective study aimed to compare the clinical and radiological features of unvaccinated critical COVID-19 patients hospitalized during the last pandemic wave (December 2021–February 2022, No-Vax group) and before starting the vaccination campaign (March–December 2020, Pre-Vax group). The No-Vax group was also compared with vaccinated patients of the same pandemic wave (Vax group). With respect to the Pre-Vax group, the No-Vax group contained a higher percentage of smokers (p = 0.0007) and a lower prevalence of males (p = 0.0003). At admission, the No-Vax patients showed both a higher CT score of pneumonia and a worse severe respiratory failure (p < 0.0001). In the No-Vax group, a higher percentage of deaths occurred, though this was not significant. In comparison with the No-Vax group, the Vax patients were older (p = 0.0097), with a higher Charlson comorbidity index (p < 0.0001) and a significantly lower HRCT score (p = 0.0015). The percentage of deaths was not different between the two groups. The No-Vax patients showed a more severe disease in comparison with the Pre-Vax patients, and were younger and had fewer comorbidities than the Vax patients. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF