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The reliability of pumping units at nuclear power plants (NPPs) is critical in terms of their energy efficiency and safety. Remarkably, WWER-1000 reactors at Ukrainian NPPs are equipped with outdated pumping units that have already served their full-service life. This fact leads to an urgent need to develop a new, more efficient pump. In the article, a promising pump, ACNA 600-35, was developed. It was designed to increase the energy efficiency of pumps TX 800/70/8-K-2E, applied at the holding pool and the industrial circuit of the nuclear reactor. Since these pumps should be imported from the monopoly suppliers, this affects both the energy efficiency of pumping equipment and the energy independence of Eastern Europe. The proposed pump ACNA 600-35 is characterized by an increased efficiency of up to 0.12–0.13 compared with the TX 800/70/8-K-2E pump. In general, the life cycle cost of the proposed pump is 15–20% lower than for the analog TX 800/70/8-K-2E. The design of the developed pump ACNA 600-35 and the related pumping unit based on its production at industrial facilities allows for further development of the industrial and fuel-energy complex, increasing the state's energy independence and employment. According to expert estimates, the average economic effect from supplying the developed pump can reach 10 mln USD/year. [ABSTRACT FROM AUTHOR]