A study conducted at the University Hospital Center in Porto, Portugal, aimed to assess the diagnostic accuracy of different synovial fluid biomarkers for the diagnosis of periprosthetic joint infection (PJI). The study found that four biomarkers, including alpha-defensin, leukocyte esterase, synovial fluid C-reactive protein, and calprotectin, showed good specificity and sensitivity in diagnosing PJI. However, the diagnostic performance of these biomarkers varied depending on the PJI definition used. The research concluded that biomarkers perform differently according to the selected PJI definitions. [Extracted from the article]