1. Two new compounds from Atractylodes macrocephala with neuroprotective activity.
- Author
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Zhang, Na, Liu, Chao, Sun, Tie-Min, Ran, Xiao-Ku, Kang, Ting-Guo, and Dou, De-Qiang
- Subjects
BIOLOGICAL assay ,CHROMATOGRAPHIC analysis ,COLORIMETRY ,MEDICINAL plants ,MOLECULAR structure ,NUCLEAR magnetic resonance spectroscopy ,RESEARCH funding ,PHYTOCHEMICALS ,QUANTITATIVE research - Abstract
In the present study, two new compounds, together with six known compounds, were isolated from rhizome ofAtractylodes macrocephalaKoidz by a series of silica gel, ODS column chromatography, and preparative HPLC. Their structures were characterized as atractylenolide II (1), atractylenolide I (2), biepiasterolid (3), isoatractylenolide I (4), atractylenolide III (5), 3β-acetoxyl atractylenolide I (6), (4E,6E,12E)-tetradeca-4,6,12-triene-8,10-diyne-13,14-triol (7), (3S,4E,6E,12E)-1-acetoxy-tetradeca-4,6,12-triene-8,10-diyne-3,14-diol (8) on the basis of 1D, 2D NMR, and circular dichroism analyses. Among them, compounds6and8were novel compounds. In addition, their neuroprotective activity against MPP+-induced SH-SY5Y cells was evaluated by MTT colorimetry. The results showed that all these compounds have definite protective effect on MPP+-induced SH-SY5Y cells. [ABSTRACT FROM PUBLISHER]
- Published
- 2017
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