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Start Over Author "Mei, Zhendong" Topic mendelian randomization Publication Year Range Last 10 years
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4. Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

Author

Zheng, Yan, Huang, Tao, Wang, Tiange, Mei, Zhendong, Sun, Zhonghan, Zhang, Tao, Ellervik, Christina, Chai, Jin-Fang, Sim, Xueling, van Dam, Rob M., Tai, E-Shyong, Koh, Woon-Puay, Dorajoo, Rajkumar, Saw, Seang-Mei, Sabanayagam, Charumathi, Wong, Tien Yin, Gupta, Preeti, Rossing, Peter, Ahluwalia, Tarunveer S., Vinding, Rebecca K., Bisgaard, Hans, Bønnelykke, Klaus, Wang, Yujie, Graff, Mariaelisa, Voortman, Trudy, van Rooij, Frank J. A., Hofman, Albert, van Heemst, Diana, Noordam, Raymond, Estampador, Angela C., Varga, Tibor V., Enzenbach, Cornelia, Scholz, Markus, Thiery, Joachim, Burkhardt, Ralph, Orho-Melander, Marju, Schulz, Christina-Alexandra, Ericson, Ulrika, Sonestedt, Emily, Kubo, Michiaki, Akiyama, Masato, Zhou, Ang, Kilpeläinen, Tuomas O., Hansen, Torben, Kleber, Marcus E., Delgado, Graciela, McCarthy, Mark, Lemaitre, Rozenn N., Felix, Janine F., Jaddoe, Vincent W. V., Wu, Ying, Mohlke, Karen L., Lehtimäki, Terho, Wang, Carol A., Pennell, Craig E., Schunkert, Heribert, Kessler, Thorsten, Zeng, Lingyao, Willenborg, Christina, Peters, Annette, Lieb, Wolfgang, Grote, Veit, Rzehak, Peter, Koletzko, Berthold, Erdmann, Jeanette, Munz, Matthias, Wu, Tangchun, He, Meian, Yu, Caizheng, Lecoeur, Cécile, Froguel, Philippe, Corella, Dolores, Moreno, Luis A., Lai, Chao-Qiang, Pitkänen, Niina, Boreham, Colin A., Ridker, Paul M., Rosendaal, Frits R., de Mutsert, Renée, Power, Chris, Paternoster, Lavinia, Sørensen, Thorkild I. A., Tjønneland, Anne, Overvad, Kim, Djousse, Luc, Rivadeneira, Fernando, Lee, Nanette R., Raitakari, Olli T., Kähönen, Mika, Viikari, Jorma, Langhendries, Jean-Paul, Escribano, Joaquin, Verduci, Elvira, Dedoussis, George, König, Inke, Balkau, Beverley, Coltell, Oscar, Dallongeville, Jean, Meirhaeghe, Aline, Amouyel, Philippe, Gottrand, Frédéric, Pahkala, Katja, Niinikoski, Harri, Hyppönen, Elina, März, Winfried, Mackey, David A., Gruszfeld, Dariusz, Tucker, Katherine L., Fumeron, Frédéric, Estruch, Ramon, Ordovas, Jose M., Arnett, Donna K., Mook-Kanamori, Dennis O., Mozaffarian, Dariush, Psaty, Bruce M., North, Kari E., Chasman, Daniel I., and Qi, Lu

Published
2020
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5. Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

Author

George Dedoussis, Frédéric Fumeron, Zhonghan Sun, E-Shyong Tai, Bruce M. Psaty, Paul M. Ridker, Kim Overvad, Marcus E. Kleber, Wolfgang Lieb, Marju Orho-Melander, Xueling Sim, Philippe Froguel, Mark I. McCarthy, Tiange Wang, Diana van Heemst, Emily Sonestedt, Veit Grote, Karen L. Mohlke, Inke R. König, Tibor V. Varga, Chris Power, Matthias Munz, Ulrika Ericson, Luc Djoussé, Dariush Mozaffarian, Tuomas O. Kilpeläinen, Jorma Viikari, Ralph Burkhardt, Chao-Qiang Lai, Klaus Bønnelykke, Mariaelisa Graff, Woon-Puay Koh, Jin-Fang Chai, Nanette R. Lee, Harri Niinikoski, Torben Hansen, Christina-Alexandra Schulz, Caizheng Yu, Renée de Mutsert, Colin Boreham, Jean Dallongeville, Anne Tjønneland, Philippe Amouyel, Tao Zhang, Markus Scholz, Elina Hyppönen, Tarunveer S. Ahluwalia, Niina Pitkänen, Fernando Rivadeneira, Rebecca K. Vinding, Donna K. Arnett, Craig E. Pennell, Joachim Thiery, Jose M. Ordovas, Thorkild I. A. Sørensen, Lu Qi, Oscar Coltell, Daniel I. Chasman, Olli T. Raitakari, Preeti Gupta, Dariusz Gruszfeld, Rajkumar Dorajoo, Berthold Koletzko, Seang-Mei Saw, Tangchun Wu, Charumathi Sabanayagam, Rozenn N. Lemaitre, Meian He, Tao Huang, Carol A. Wang, Graciela E. Delgado, Rob M. van Dam, Luis A. Moreno, Peter Rossing, Mika Kähönen, Aline Meirhaeghe, Christina Ellervik, Frédéric Gottrand, Yan Zheng, Katherine L. Tucker, Ying Wu, Lavinia Paternoster, Lingyao Zeng, Joaquin Escribano, David A. Mackey, Raymond Noordam, Masato Akiyama, Dolores Corella, Thorsten Kessler, Frank J. A. van Rooij, Terho Lehtimäki, Jeanette Erdmann, Ang Zhou, Michiaki Kubo, Winfried März, Frits R. Rosendaal, Kari E. North, Cécile Lecoeur, Cornelia Enzenbach, Albert Hofman, Elvira Verduci, Tien Yin Wong, Hans Bisgaard, Zhendong Mei, Trudy Voortman, Yujie Wang, Heribert Schunkert, Beverley Balkau, Annette Peters, Dennis O. Mook-Kanamori, Vincent W. V. Jaddoe, Peter Rzehak, Christina Willenborg, Katja Pahkala, Jean-Paul Langhendries, Janine F. Felix, Angela C. Estampador, Ramon Estruch, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning National Basic Research Program of China (973 Program): 2016YFC1304801 2017SHZDZX01, This work was supported by Shanghai Municipal Science and Technology Major Project (Grant No. 2017SHZDZX01) and the National Key Research and Development Program of China (Grant No. 2016YFC1304801). YZ was supported by the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning. For the funding information of each study within CHARGE-BIG consortium, please see Supplemental Table 8., CHU Lille, CNRS, Inserm, Université de Lille, Génomique Intégrative et Modélisation des Maladies Métaboliques (EGID) - UMR 8199, Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 [EGENODIA (GI3M)], Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167, Lille Inflammation Research International Center (LIRIC) - U995, Epidemiology, Erasmus MC other, Pediatrics, Internal Medicine, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Zheng, Yan, Huang, Tao, Wang, Tiange, Mei, Zhendong, Zhou, A, Hypponen, E, and Qi, L

Subjects
Adult, Male, medicine.medical_specialty, Epidemiology, Birth weight, [SDV]Life Sciences [q-bio], Birthweight, 030204 cardiovascular system & hematology, Polymorphism, Single Nucleotide, Article, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Mendelian randomization, medicine, Birth Weight, Humans, Hypertension, Blood pressure, Causal association, Genetic Predisposition to Disease, 030212 general & internal medicine, business.industry, Infant, Newborn, Mendelian Randomization Analysis, Odds ratio, Infant, Low Birth Weight, 3. Good health, Pulse pressure, Cohort, Female, business, Genome-Wide Association Study
Abstract

International audience; Epidemiology studies suggested that low birthweight was associated with a higher risk of hypertension in later life. However, little is known about the causality of such associations. In our study, we evaluated the causal association of low birthweight with adulthood hypertension following a standard analytic protocol using the study-level data of 183,433 participants from 60 studies (CHARGE-BIG consortium), as well as that with blood pressure using publicly available summary-level genome-wide association data from EGG consortium of 153,781 participants, ICBP consortium and UK Biobank cohort together of 757,601 participants. We used seven SNPs as the instrumental variable in the study-level analysis and 47 SNPs in the summary-level analysis. In the study-level analyses, decreased birthweight was associated with a higher risk of hypertension in adults (the odds ratio per 1 standard deviation (SD) lower birthweight, 1.22; 95% CI 1.16 to 1.28), while no association was found between genetically instrumented birthweight and hypertension risk (instrumental odds ratio for causal effect per 1 SD lower birthweight, 0.97; 95% CI 0.68 to 1.41). Such results were consistent with that from the summary-level analyses, where the genetically determined low birthweight was not associated with blood pressure measurements either. One SD lower genetically determined birthweight was not associated with systolic blood pressure (β = − 0.76, 95% CI − 2.45 to 1.08 mmHg), 0.06 mmHg lower diastolic blood pressure (β = − 0.06, 95% CI − 0.93 to 0.87 mmHg), or pulse pressure (β = − 0.65, 95% CI − 1.38 to 0.69 mmHg, all p > 0.05). Our findings suggest that the inverse association of birthweight with hypertension risk from observational studies was not supported by large Mendelian randomization analyses.

Published
2020

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