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A detailed overview of the knowledge gaps in our understanding of the heliospheric interaction with the largely unexplored Very Local Interstellar Medium (VLISM) are provided along with predictions of with the scientific discoveries that await. The new measurements required to make progress in this expanding frontier of space physics are discussed and include in-situ plasma and pick-up ion measurements throughout the heliosheath, direct sampling of the VLISM properties such as elemental and isotopic composition, densities, flows, and temperatures of neutral gas, dust and plasma, and remote energetic neutral atom (ENA) and Lyman-alpha (LYA) imaging from vantage points that can uniquely discern the heliospheric shape and bring new information on the interaction with interstellar hydrogen. The implementation of a pragmatic Interstellar Probe mission with a nominal design life to reach 375 Astronomical Units (au) with likely operation out to 550 au are reported as a result of a 4-year NASA funded mission study. [ABSTRACT FROM AUTHOR]

Exo-zodiacal dust, exozodi for short, is warm (∼300 K) or hot (up to ∼2000 K) dust found in the inner regions of planetary systems around main sequence stars. In analogy to our own zodiacal dust, it may be located in or near the habitable zone or closer in, down to the dust sublimation distance. The study of the properties, distribution, and evolution of exozodis can inform about the architecture and dynamics of the innermost regions of planetary systems, close to their habitable zones. On the other hand, the presence of large amounts of exo-zodiacal dust may be an obstacle for future space missions aiming to image Earth-like exoplanets. The dust can be the most luminous component of extrasolar planetary systems, but predominantly emits in the near- to mid-infrared where it is outshone by the host star. Interferometry provides a unique method of separating the dusty from the stellar emission. We discuss the prospects of exozodi observations with the next generation VLTI instruments and summarize critical instrument specifications. [ABSTRACT FROM AUTHOR]