1. Physical exercise, cognition, and brain health in aging.
- Author
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Boa Sorte Silva NC, Barha CK, Erickson KI, Kramer AF, and Liu-Ambrose T
- Subjects
- Humans, Neuronal Plasticity physiology, Cognitive Dysfunction physiopathology, Exercise physiology, Brain physiology, Aging physiology, Cognition physiology
- Abstract
Exercise training is an important strategy to counteract cognitive and brain health decline during aging. Evidence from systematic reviews and meta-analyses supports the notion of beneficial effects of exercise in cognitively unimpaired and impaired older individuals. However, the effects are often modest, and likely influenced by moderators such as exercise training parameters, sample characteristics, outcome assessments, and control conditions. Here, we discuss evidence on the impact of exercise on cognitive and brain health outcomes in healthy aging and in individuals with or at risk for cognitive impairment and neurodegeneration. We also review neuroplastic adaptations in response to exercise and their potential neurobiological mechanisms. We conclude by highlighting goals for future studies, including addressing unexplored neurobiological mechanisms and the inclusion of under-represented populations., Competing Interests: Declaration of interests The authors declare no competing interests in relation to this work., (Copyright © 2024. Published by Elsevier Ltd.)
- Published
- 2024
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