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Music listening provides one of the most significant abstract rewards for humans because hearing music activates the dopaminergic mesolimbic system. Given the strong link between reward, dopamine, and memory, we aimed here to investigate the hypothesis that dopamine-dependent musical reward can drive memory improvements. Twenty-nine healthy participants of both sexes provided reward ratings of unfamiliar musical excerpts that had to be remembered following a consolidation period under three separate conditions: after the ingestion of a dopaminergic antagonist, a dopaminergic precursor, or a placebo. Linear mixed modeling of the intervention data showed that the effect of reward on memory-i.e., the greater the reward experienced while listening to the musical excerpts, the better the memory recollection performance-was modulated by both dopaminergic signaling and individual differences in reward processing. Greater pleasure was consistently associated with better memory outcomes in participants with high sensitivity to musical reward, but this effect was lost when dopaminergic signaling was disrupted in participants with average or low musical hedonia. Our work highlights the flexibility of the human dopaminergic system, which can enhance memory formation not only through explicit and/or primary reinforcers but also via abstract and aesthetic rewards such as music.

Many studies suggest that information about past experience, or episodic memory, is divided into discrete units called “events.” Yet we can often remember experiences that span multiple events. Events that occur in close succession might simply be linked because of their proximity to one another, but we can also build links between events that occur farther apart in time. Intuitively, some kind of organizing principle should enable temporally distant events to become bridged in memory. We tested the hypothesis that episodic memory exhibits a narrative-level organization, enabling temporally distant events to be better remembered if they form a coherent narrative. Furthermore, we tested whether post-encoding memory consolidation is necessary to integrate temporally distant events. In three experiments, participants learned and subsequently recalled events from fictional stories, in which pairs of temporally distant events involving side characters (“sideplots”) either formed one coherent narrative or two unrelated narratives. Across participants, we varied whether recall was assessed immediately after learning, or after a delay: 24 hours, 12 hours between morning and evening (“wake”), or 12 hours between evening and morning (“sleep”). Participants recalled more information about coherent than unrelated narrative events, in most delay conditions, including immediate recall and wake conditions, suggesting that post-encoding consolidation was not necessary to integrate temporally distant events into a larger narrative. Furthermore, post hoc modeling across experiments suggested that narrative coherence facilitated recall over and above any effects of sentence-level semantic similarity. This reliable memory benefit for coherent narrative events supports theoretical accounts which propose that narratives provide a high-level architecture for episodic memory.

This experiment tests a newly proposed model of trust (Bellucci, 2022) that formalizes trust attitudes, and investigates memory effects on learning and inferences on partners' trust attitudes. The experiment mimics an interactive trust interaction online. It was implemented by using the jsPsych framework (De Leeuw, 2015).

Older adults experience deficits in associative memory. However, age-related differences are reduced when information is consistent with prior knowledge (i.e., schematic support), suggesting that episodic and semantic memory are interrelated. It is unclear what role metacognitive processes play in schematic support. Prior knowledge may reduce encoding demands, but older adults may allocate cognitive resources to schema-consistent information because it is more meaningful. We examined metacognitive awareness of and control over associative information that was consistent or inconsistent with prior knowledge. In Experiment 1, participants self-paced their study of grocery items paired with either market prices or unusually high prices and were tested on the exact price of each item over four study-test lists with new items on each list. In Experiment 2, participants studied items for a fixed time but made judgments of learning (JOLs) at encoding. Older adults better remembered the prices of market-value items than overpriced items. In Experiment 1, younger and older adults studied overpriced items longer than market-priced items, consistent with a discrepancy reduction model of self-regulated learning, but study time did not relate to later recall accuracy, suggesting a labor-in-vain effect. In Experiment 2, participants gave higher JOLs to market-priced items than overpriced items and were generally metacognitively aware of the benefits of schematic support. Together, these results suggest that the benefits of schematic support may not be dependent on or influenced by metacognitive control processes, supporting the hypothesis that episodic memory may be less distinct from semantic memory in younger and older adults.

Similarity between memories is a primary cause of interference and forgetting. Exaggerating subtle differences between memories is therefore a potential mechanism for reducing interference. Here, we report a human fMRI study (n= 29, 19 female) that tested whether behavioral and neural expressions of memories are adaptively distorted to reduce interference. Participants learned and repeatedly retrieved object images, some of which were identical except for subtle color differences. Behavioral measures of color memory revealed exaggeration of differences between similar objects. Importantly, greater memory exaggeration was associated with lower memory interference. fMRI pattern analyses revealed that color information in parietal cortex was stronger during memory recall when color information was critical for discriminating competing memories. Moreover, greater representational distance between competing memories in parietal cortex predicted greater color memory exaggeration and lower memory interference. Together, these findings reveal that competition between memories induces adaptive, feature-specific distortions in parietal representations and corresponding behavioral expressions.SIGNIFICANCE STATEMENTSimilarity between memories is a primary cause of interference and forgetting. Here, we show that, when remembering highly similar objects, subtle differences in the features of these objects are exaggerated in memory to reduce interference. These memory distortions are reflected in, and predicted by, overlap of activity patterns in lateral parietal cortex. These findings provide unique insight into how memory interference is resolved and specifically implicate lateral parietal cortex in representing feature-specific memory distortions.

The hippocampus supports episodic memory via interaction with a distributed brain network. Previous experiments using network-targeted noninvasive brain stimulation have identified episodic memory enhancements and modulation of activity within the hippocampal network. However, mechanistic insights were limited because these effects were measured long after stimulation and therefore could have reflected various neuroplastic aftereffects with extended timecourses. In this experiment with human subjects of both sexes, we tested for immediate stimulation impact on encoding-related activity of the hippocampus and immediately adjacent medial-temporal cortex by delivering theta-burst transcranial magnetic stimulation (TBS) concurrent with fMRI, as an immediate impact of stimulation would suggest an influence on neural activity. We reasoned that TBS would be particularly effective for influencing the hippocampus because rhythmic neural activity in the theta band is associated with hippocampal memory processing. First, we demonstrated that it is possible to obtain robust fMRI correlates of task-related activity during concurrent TBS. We then identified immediate effects of TBS on encoding of visual scenes. Brief volleys of TBS targeting the hippocampal network increased activity of the targeted (left) hippocampus during scene encoding and increased subsequent recollection. Stimulation did not influence activity during an intermixed numerical task with no memory demand. Control conditions using beta-band and out-of-network stimulation also did not influence hippocampal activity or recollection. TBS targeting the hippocampal network therefore immediately impacted hippocampal memory processing. This suggests direct, beneficial influence of stimulation on hippocampal neural activity related to memory and supports the role of theta-band activity in human episodic memory.Significance StatementCan noninvasive stimulation directly impact function of indirect, deep-brain targets such as the hippocampus? We tested this by targeting an accessible region of the hippocampal network via transcranial magnetic stimulation during concurrent fMRI. We reasoned that theta-burst stimulation would be particularly effective for impacting hippocampal function, as this stimulation rhythm should resonate with the endogenous theta-nested-gamma activity prominent in hippocampus. Indeed, theta-burst stimulation targeting the hippocampal network immediately impacted hippocampal activity during encoding, improving memory formation as indicated by enhanced later recollection. Rhythm- and location-control stimulation conditions had no such effects. These findings suggest a direct influence of noninvasive stimulation on hippocampal neural activity and highlight that the theta-burst rhythm is relatively privileged in its ability to influence hippocampal memory function.

Retroactive interference refers to the impairing effects of new learning on earlier memories. The memory-for-change framework posits that being reminded of earlier information when learning new information can alleviate such retroactive interference and lead to facilitation. Such effects have been shown in younger adults, but the extent to which remindings play a role in retroactive effects of memory for older adults has not been examined. We address this issue here in two experiments using variants of an A-B, A-C paired associate paradigm. Participants studied two lists containing associated word pairs that: repeated across lists (A-B, A-B), included the same cue with a changed response in List 2 (A-B, A-C), or only appeared in List 1 (A-B), and then completed a cued-recall test of List 1. Participants reported List 1 reminding during List 2 study and recollection of reminding at test. Neither age group showed retroactive interference in overall List 1 recall, but younger adults showed poorer source monitoring by producing more List 2 intrusions onto List 1 recall than older adults. For both age groups, reminding was associated with retroactive facilitation for List 1 recall, whereas the absence of reminding was associated with retroactive interference. The benefits associated with reminding and recollection of reminding were greater for younger than older adults, partly because younger adults were able to recollect remindings more often than older adults. Together these results implicate a role for reminding in retroactive effects of memory that is more facilitative for younger than older adults. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

After experiencing the same episode, some people can recall certain details about it, whereas others cannot. We investigate how common (intersubject) neural patterns during memory encoding influence whether an episode will be subsequently remembered, and how divergence from a common organization is associated with encoding failure. Using functional magnetic resonance imaging with intersubject multivariate analyses, we measured brain activity as people viewed episodes within wildlife videos and then assessed their memory for these episodes. During encoding, greater neural similarity was observed between the people who later remembered an episode (compared with those who did not) within the regions of the declarative memory network (hippocampus, posterior medial cortex [PMC], and dorsal Default Mode Network [dDMN]). The intersubject similarity of the PMC and dDMN was episode-specific. Hippocampal encoding patterns were also more similar between subjects for memory success that was defined after one day, compared with immediately after retrieval. The neural encoding patterns were sufficiently robust and generalizable to train machine learning classifiers to predict future recall success in held-out subjects, and a subset of decodable regions formed a network of shared classifier predictions of subsequent memory success. This work suggests that common neural patterns reflect successful, rather than unsuccessful, encoding across individuals.

Background The degree to which individuals with autism spectrum disorder (ASD) evidence impairments in episodic memory relative to their typically developing (TD) counterparts remains unclear. According to a prominent view, ASD is associated with deficits in encoding associations between items and recollecting precise context details. Here, we evaluated behavioral and neural evidence for this impaired relational binding hypothesis using a task involving relational encoding and recollection during functional magnetic resonance imaging. Methods Adolescents and young adults (nASD = 47, nTD = 60) performed the Relational and Item-Specific Encoding task during functional magnetic resonance imaging, including item and associative recognition testing. We modeled functional recruitment within the medial temporal lobes (MTLs), and connectivity between MTL and the posterior medial (PM) network thought to underlie relational memory. The impaired relational binding model would predict a behavioral deficit driven by aberrant recruitment and connectivity of MTL and the PM network. Results The ASD and TD groups showed indistinguishable item and associative recognition performance. During relational encoding, the ASD group demonstrated increased hippocampal recruitment, and decreased connectivity between MTL and PM regions relative to the TD group. Within ASD, hippocampal recruitment and MTL-PM connectivity were inversely correlated. Conclusions The lack of a behavioral deficit in ASD does not support the impaired relational binding hypothesis. Instead, the current data suggest that increased recruitment of the hippocampus compensates for decreased MTL-PM connectivity to support preserved episodic memory in ASD. These findings suggest a compensatory neurodevelopmental mechanism that may support preserved cognitive domains in ASD: local hyperrecruitment may offset connectivity aberrations in individuals with ASD relative to TD subjects.

Keturių tyrimų metu pažvelgta į dviejų kalbų žodžių santykį dvikalbio asmens atmintyje. Dviejų kalbų žodžių santykis buvo tikrinamas, atliekant nuorodų ir tikslinių žodžių užduotį, kai, naudojantis žodžių (angliškų ar lietuviškų, pavyzdžiui, chair ar kėdė) nuorodomis, dalyviams tekdavo atkurti įsimintus tikslinius žodžius (angliškus ar lietuviškus, pavyzdžiui, TABLE ar STALAS). Vienu atveju dalyviai pirma turėjo įsiminti pavienių tikslinių žodžių (TABLE) sąrašą, o paskui dar kartą juos prisiminti padedami tapačios ar skirtingos kalbos nuorodų (chair ar kėdė). Atrasta, kad, nesvarbu, ar nuorodos buvo tos pačiõs, ar skirtingos kalbos, jos lygiai veiksmingai padėdavo prisiminti anksčiau matytus tikslinius žodžius. Taigi skirtingų kalbų žodžiai peržengia kalbos ribas ir kalbiniu atžvilgiu yra nepriklausomi. Išeitų, kad dvikalbiam asmeniui atskirų kalbų žodžiai yra betarpiškai susiję ir lygiai prieinami. Kitu atveju dalyviai pirma turėjo įsiminti nuorodų ir tikslinių žodžių poras (pavyzdžiui, chair-STALAS). Vėliau tikslinių žodžių (STALAS) prisiminimas buvo patikrintas dalyviams pateikiant arba kartu buvusias nuorodas (chair), arba jų vertimus (kėdė). Aptikta, kad tiesiogiai matytos nuorodos, palyginti su jų verstiniais atitikmenimis, kur kas geriau padėdavo prisiminti tikslinius žodžius. Šiuo atveju atrodytų, kad kalba ir žodžiai yra vienas nuo kito priklausomi. Susidaro įspūdis, kad žodžiai yra užsklęsti kalbos rėmuose. Kaip paaiškinti šiuos skirtingų kalbų žodžių santykius, susijusius su pavieniui ir poromis pateiktais žodžiais? Bandyta šiuos skirtingus duomenis aiškinti žodžių reikšme. Manyta, kad pavieniai tapačios kalbos žodžiai reikšmės atžvilgiu yra labai panašūs ir todėl nesunkiai vienas kitą atliepiantys. O žodžiai, esantys poroje, gali lengvai įgauti savitą reikšmės atspalvį ir todėl tapti nelengvai sukeičiami su kitos kalbos verstiniais žodžiais. Aiškinant šiuos duomenis platesniu mastu, jiems buvo pritaikyta Don Dulany (1997) sąmonės sampratos teorija, kuria remiantis, yra skirtumas tarp sukeliančiojo (angl. evocative) versus svarstomojo (angl. deliberative) žodžių apdorojimo. In a series of four experiments, the cued-recall task was used to explore bilingual word representation in episodic memory. When target words were encoded singly, their recall to same-language and to crossed-language extralist cues was found not to be different. These results appear to support a language independent view of bilingual word representation in which words of different languages are mutually accessible. When target words were encoded in a cue-target relational fashion, recall of target words was much higher to original-language than to translated-language intralist cues, thus supporting a language dependent view. In this case information seems to be bound by the language in which it was originally encountered. This difference in results of cross-language cuing of singly and relationally encoded words was assumed to result from shifts in meaning brought about by contrasting word experiences. More broadly, the findings were interpreted within the context of Don Dulany’s (1997) mentalistic theory of evocative versus deliberative processing of words.

One important feature of episodic memory is that it contains fine-grained and vividly recollected details. How to improve and maintain detailed information over time has been one of the central issues in memory research. Previous studies have inconsistent findings on whether detailed memory is forgotten more rapidly than gist memory. In this study, we investigated to what extent different encoding tasks modulated forgetting of gist and detailed information. In three experiments, participants were presented pictures of common objects and were asked to name them (Experiment 1), describe the details about them (Experiment 2) or imagine scenes associated with them (Experiment 3). After intervals of 10 minutes, one day, one week and one month, gist and detailed memories of the pictures were tested and assessed using a remember/know/guess judgement. The results showed that after the naming task, gist and detailed memories were forgotten at a similar rate, but after the description and the imagination tasks, detailed memory was forgotten at a slower rate than gist memory. The forgetting rate of gist memory was the slowest after the naming task, while that of detailed memory was the slowest after the description task. In addition, when three experiments were compared, the naming task enhanced the contributions of recollection and familiarity for gist memory, while the description task enhanced the contribution of familiarity for detailed memory. These results reveal the importance of the encoding task in the forgetting of gist and detailed information, and suggest a possible way to maintain perceptual details of objects at longer intervals.

The validity and applicability of tactile battery tests for the diagnosis and medical follow-up of patients with Alzheimer’s disease and other dementia syndromes do not have their usefulness well understood in clinical practice. While haptic abilities in older individuals receive less attention, in earlier stages of human life they are well focused on. There are even fewer studies on tactile memory, including episodic memory of demented individuals with or without sensorial limitations. The applicability of a new haptic memory battery was evaluated in patients with Alzheimer’s disease with mild or moderate commitment. Objective: The aim of this study is to apply a battery based on tactile perception, recognition, and recollection of everyday objects in patients with Alzheimer’s disease, testing tactile delayed recall memory discrimination and late recognition to compare validated visual and verbal tests. Methods: Tactile-, visual-, and verbal-based memory performance was registered in 21 patients diagnosed with Alzheimer’s disease. Results: Except for tactile identification, it showed that there was a close relationship between the three sensory modalities of memory, with an apparent better performance of tactile incidental memory and recognition compared with the test with pictures. Conclusions: The haptic evaluation of memory demonstrated applicability in the evaluation of memory dysfunction in patients with Alzheimer’s disease. Further studies are needed to establish the sensibility and specificity of the proposed test that had a small sample size and many limitations. RESUMO A aplicação de baterias baseadas em informações táteis para diagnóstico e acompanhamento de pacientes com doença de Alzheimer e outras demências não é muito difundida na prática clínica. Ao passo que a capacidade de reconhecimento tátil de objetos em crianças recebe bastante atenção dos pesquisadores, o mesmo não ocorre com indivíduos mais idosos. Existem ainda menos estudos abordando avaliação de memória episódica em pacientes idosos, com ou sem limitações sensoriais, como cegueira e surdez. O presente estudo propõe avaliar aplicabilidade de teste para avaliação de memória tátil em paciente com doença de Alzheimer. Objetivo: Aplicar em pacientes com doença de Alzheimer uma bateria baseada na percepção e reconhecimento táctil de objetos de uso cotidiano, avaliando a memória e reconhecimento tardio, comparado com testes visuais e verbais validados. Métodos: Foi avaliado o desempenho de baterias baseadas em informação táteis, visuais e verbais em 21 pacientes diagnosticados com a doença de Alzheimer. Resultados: Com a exceção da percepção tátil, foi demonstrada uma boa correlação entre as três modalidades de apresentação das informações a serem resgatadas tardiamente. Houve um desempenho aparentemente melhor do reconhecimento tátil quando comparado com apresentação de figuras impressas. Conclusões: A determinação da memória tátil em pacientes com doença de Alzheimer demonstrou ser aplicável como instrumento de avaliação dos distúrbios de memória presentes em portadores de doença de Alzheimer com comprometimento leve a moderado. As limitações do estudo, com reduzido tamanho da amostra, aponta para a necessidade de novos estudos com a devida validação, incluindo determinação de sensibilidade e especificidade, assim como pareamento, de acordo com sexo e idade com grupo controle.

As we comprehend narratives, our attentional engagement fluctuates over time. Despite theoretical conceptions of narrative engagement as emotion-laden attention, little empirical work has characterized the cognitive and neural processes that comprise subjective engagement in naturalistic contexts or its consequences for memory. Here, we relate fluctuations in narrative engagement to patterns of brain coactivation, and test whether neural signatures of engagement predict later recall. In behavioral studies, participants continuously rated how engaged they were as they watched a television episode or listened to a story. Self-reported engagement was synchronized across individuals and driven by the emotional content of the narratives. During fMRI, we observed highly synchronized activity in the default mode network when people were, on average, more engaged in the same narratives. Models based on time-varying whole-brain functional connectivity predicted evolving states of engagement across participants and even across different datasets. The same functional connections also predicted post-scan event recall, suggesting that engagement during encoding impacts subsequent memory. Finally, group-average engagement was related to fluctuations of an independent functional connectivity index of sustained attention. Together, our findings characterize the neural signatures of engagement dynamics and elucidate relationships between narrative engagement, sustained attention, and event memory.

Almost self-fulfilling, commonly held negative stereotypes about old age and memory can impair older adults’ episodic memory performance, due to age-based stereotype threat or self-stereotyping effects. Research studies demonstrating detrimental impacts of age stereotypes on memory performance are generally conducted in research laboratories or medical settings, which often underestimate memory abilities of older adults. To better understand the “real world” impact of negative age and memory stereotypes on episodic memory, the present research tested story recall performance of late middle-aged and older adults (N = 51) following a naturalistic age stereotype manipulation, wherein every day, newspaper-style materials (comics and puzzles) were either embedded with negative age and memory stereotype stimuli (stereotype group) or neutral stimuli (control group). Furthermore, all participants were tested in favorable, familiar environments. Potential moderators of the stereotype effects, e.g., metamemory beliefs, were assessed at baseline. Current memory evaluation and subjective age, as well as perceived stereotype threat and task-related anxiety, were assessed following the stereotype manipulation as potential mechanisms of the expected stereotype effects. Results suggested a contrast effect, as the stereotype group demonstrated superior story recall performance compared to the control group. Marginally significant moderation effects by age and perceived stereotype threat indicated that stereotype rejection was present for late middle-aged adults but not older adults, indicative of stereotype lift, and for individuals who reported low and average, but not high, levels of perceived stereotype threat. Additionally, a trend suggested more positive memory evaluation for those in the stereotype group who reported awareness of the stereotype stimuli than those who did not notice the stimuli. These results are consistent with other research demonstrating benefits to memory performance in adulthood based on motivational and contextual factors, such as using relevant memory materials and testing in favorable conditions. Moreover, the results of this study contribute to our understanding of individuals’ responses to different types of stereotype stimuli, and the differential impact of stereotype manipulations that are subtle versus blatant. Individuals were motivated to counteract negative stereotype effects when conditions were supportive, stereotype presentations were naturalistic, and personal beliefs were positive.

Episodic memory has a dynamic nature: when we recall past episodes, we retrieve not only their content, but also their temporal structure. The phenomenon of replay, in the hippocampus of mammals, offers a remarkable example of this temporal dynamics. However, most quantitative models of memory treat memories as static configurations, neglecting the temporal unfolding of the retrieval process. Here, we introduce a continuous attractor network model with a memory-dependent asymmetric component in the synaptic connectivity, which spontaneously breaks the equilibrium of the memory configurations and produces dynamic retrieval. The detailed analysis of the model with analytical calculations and numerical simulations shows that it can robustly retrieve multiple dynamical memories, and that this feature is largely independent of the details of its implementation. By calculating the storage capacity, we show that the dynamic component does not impair memory capacity, and can even enhance it in certain regimes., eLife digest When we recall a past experience, accessing what is known as an ‘episodic memory’, it usually does not appear as a still image or a snapshot of what occurred. Instead, our memories tend to be dynamic: we remember how a sequence of events unfolded, and when we do this, we often re-experience at least part of that same sequence. If the memory includes physical movement, the sequence combines space and time to remember a trajectory. For example, a mouse might remember how it went down a hole and found cheese there. However, mathematical models of how past experiences are stored in our brains and retrieved when we remember them have so far focused on snapshot memories. ‘Attractor network models’ are one type of mathematical model that neuroscientists use to represent how neurons communicate with each other to store memories. These models can provide insights into how circuits of neurons, for example those in the hippocampus (a part of the brain crucial for memory), may have evolved to remember the past, but so far they have only focused on how single moments, rather than sequences of events, are represented by populations of neurons. Spalla et al. found a way to extend these models, so they could analyse how networks of neurons can store and retrieve dynamic memories. These memories are represented in the brain as ‘continuous attractors’, which can be thought of as arrows that attract mental trajectories first to the arrow itself, and once on the arrow, to the arrowhead. Each recalled event elicits the next one on the arrow, as the mental trajectory advances towards the arrowhead. Spalla et al. determined that memory networks in the hippocampus of mammals can store large numbers of these ‘arrows’, up to the same amount of ‘snapshot’ memories predicted to be stored with similar models. Spalla et al.’s results may allow researchers to better understand memory storage and recall, since they allow for the modelling of complex and realistic aspects of episodic memories. This could provide insights into processes such as why our minds wander, as well as having implications for the study of how neurons physically interact with each other to transmit information.

Although it is understood that episodic memories of everyday events involve encoding a wide array of perceptual and non-perceptual information, it is unclear how these distinct types of information are recalled. To address this knowledge gap, we examine how perceptual (visual versus auditory) and non-perceptual details described within a narrative, a proxy for everyday event memories, were retrieved. Based on previous work indicating a bias for visual content, we hypothesized that participants would be most accurate at recalling visually described details and would tend to falsely recall non-visual details with visual descriptors. In Study 1, participants watched videos of a protagonist telling narratives of everyday events under three conditions: with visual, auditory, or audiovisual details. All narratives contained the same non-perceptual content. Participants’ free recall of these narratives under each condition were scored for the type of details recalled (perceptual, non-perceptual) and whether the detail was recalled with gist or verbatim memory. We found that participants were more accurate at gist and verbatim recall for visual perceptual details. This visual bias was also evident when we examined the errors made during recall such that participants tended to incorrectly recall details with visual information, but not with auditory information. Study 2 tested for this pattern of results when the narratives were presented in auditory only format. Results conceptually replicated Study 1 in that there was still a persistent visual bias in what was recollected from the complex narratives. Together, these findings indicate a bias for recruiting visualizable content to construct complex multi-detail memories.

Providing a subset of previously studied items as retrieval cues can both impair and improve memory for the remaining items. Here, we investigated such part-list cuing effects in younger and older adults' episodic recall, using listwise directed forgetting to manipulate study context access at test. When context access was maintained, part-list cuing impaired recall regardless of age. In contrast, when context access was impaired, part-list cuing improved recall in younger but not in older adults. The results are consistent with the proposal that older adults show intact inhibition and blocking of competing information, but reduced capability for episodic context reactivation. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Alexithymia is a deficit in the recognition, expression and regulation of emotions, which has the following features: difficulty in identifying or describing feelings, difficulty distinguishing between feelings and bodily sensations, stringent imaginal processes, and externally oriented cognitive style. This personality trait is associated with many psychiatric and psychosomatic disorders, as well as with risky behaviors. Objective: To investigate whether this trait is also associated with reduced memory for emotional information. Methods: A review of articles investigating the possible damage caused by alexithymia to implicit and explicit memory for emotional information was conducted. Results: Although the studies concerning implicit memory presented divergent results, most studies on explicit memory suggested a deficit for emotional information retention in high-alexithymia individuals. Conclusion: The reviewed data support the notion that the typical increase in episodic memory for emotional information is reduced in high-alexithymia individuals. RESUMO. A alexitimia é um déficit no reconhecimento, expressão e regulação das emoções, que possui as seguintes características: dificuldade em identificar sentimentos, dificuldade em descrever sentimentos, dificuldade em distinguir sentimentos e sensações corporais, processos de imaginação dificultados e estilo de cognição externamente orientado. Este traço de personalidade está associado a muitos transtornos psiquiátricos e psicossomáticos, bem como a comportamentos de risco aumentados. Objetivo: Investigar se este traço também está associado a redução de memória para informações emocionais. Métodos: Artigos que investigam os possíveis danos causados pela alexitimia na memória implícita e explícita para informações emocionais foram revisados. Resultados: Embora os estudos sobre memória implícita tenham apresentado resultados divergentes, a maioria dos estudos sobre memória explícita sugeriu déficits na retenção de informação emocional em indivíduos com altos índices de alexitimia. Conclusion: Os dados revisados sugerem que o aumento típico na memória episódica para informações emocionais é reduzido em indivíduos com alta alexitimia.

Encoding of episodic memories relies on stimulus-specific information processing and involves the left prefrontal cortex. We here present an incidental finding from a simultaneous EEG-TMS experiment as well as a replication of this unexpected effect. Our results reveal that stimulating the left dorsolateral prefrontal cortex (DLPFC) with slow repetitive transcranial magnetic stimulation (rTMS) leads to enhanced word memory performance. A total of 40 healthy human participants engaged in a list learning paradigm. Half of the participants (N = 20) received 1 Hz rTMS to the left DLPFC, while the other half (N = 20) received 1 Hz rTMS to the vertex and served as a control group. Participants receiving left DLPFC stimulation demonstrated enhanced memory performance compared to the control group. This effect was replicated in a within-subjects experiment where 24 participants received 1 Hz rTMS to the left DLPFC and vertex. In this second experiment, DLPFC stimulation also induced better memory performance compared to vertex stimulation. In addition to these behavioural effects, we found that 1 Hz rTMS to DLPFC induced stronger beta power modulation in posterior areas, a state that is known to be beneficial for memory encoding. Further analysis indicated that beta modulations did not have an oscillatory origin. Instead, the observed beta modulations were a result of a spectral tilt, suggesting inhibition of these parietal regions. These results show that applying 1 Hz rTMS to DLPFC, an area involved in episodic memory formation, improves memory performance via modulating neural activity in parietal regions., Encoding of episodic memories relies on stimulus-specific information processing and involves the left prefrontal cortex. An incidental finding from a simultaneous EEG-TMS experiment reveals that applying 1-Hz repetitive transcranial magnetic stimulation to this area of the brain improves memory performance by modulating neural activity in parietal regions.

There is disagreement in the literature as to whether episodic memory maintains an inherent temporal organisation, that is, whether learned items are necessarily organised along some temporal dimension or whether temporal organisation is a task-specific occurrence. The current series of experiments explored this issue. In Experiment 1, we tested whether temporal or spatial contiguity was present in an incidental encoding task where either strategy (but not both together) could be employed at test. In Experiment 2, we attempted to facilitate the use of a spatial retrieval strategy at test by asking participants to recall the location where target items had been displayed at study, after incidental encoding. Experiment 3 explored the role of study-test congruency by informing participants at encoding that they would be tested on either their memory for the temporal sequence or spatial locations, and then testing both at retrieval. Finally, Experiment 4 employed a masking task at encoding to ensure participants could not predict the true nature of the task, despite it being incidental, and a surprise free recall task. Predominantly, participants displayed recall performance consistent with temporal contiguity, although there was evidence for spatial contiguity under certain conditions. These results are consistent with the notion that episodic memory has a stable and predictable temporal organisation.

Characterizing episodic memory abilities is highly important in the diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI), and usually includes wordlist learning and recall tasks. Clinical evaluations typically focus on the number of words recalled, ignoring additional information, like serial position. Here, we tested the potential value of two serial positioning measures for clinical diagnosis – how retrieval is initiated, as measured by the first word recalled, and how it proceeds – using data from patients with AD and MCI that completed a wordlist learning and recall task. Our results show that during the early stages of learning, patients with AD are less prone to retrieve the first word from the wordlist, manifested as lower primacy effect in the first word recalled, compared with MCI patients. The first word recalled measure adds to the differentiation between the groups over and above the total number of words learned. Thus, the first word recalled during word list learning and recall tasks may be used as a simple complementary measure to distinguish between MCI and AD during standard neuropsychological evaluations.

Many motor skills require rapidly choosing a movement goal and preparing a movement to that goal, such as in sports where circumstances often change quickly and many actions are possible. Humans can benefit from learning the perceptual cues that predict the requirements of movement so that the choice of a movement goal and movement preparation can occur earlier. However, there remains uncertainty about how these perceptual cues are learned. Here we investigate the use and learning of these perceptual-motor associations. First, we ask if episodic memory for associations can support learning. In Experiment 1, participants first memorized associations between symbols and movement goals. When these symbols were subsequently presented as cues, reaching movements were prepared as efficiently as if the goals themselves were previewed, without the need for additional practice. Next, we ask whether statistical learning can be used to learn the associations. In Experiment 2, participants had to learn the associations during the movement task itself. This learning enabled efficient movement preparation, and the rate of improvement scaled with the number and complexity of associations. These findings suggest that movement preparation can be facilitated by perceptual cues via statistical learning and memory recall, highlighting a potential role for learning and memory systems not conventionally implicated in motor behavior. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Ironically, the presentation of a subset of studied material as retrieval cues at test often impairs recall of the remaining (target) material—an effect known as part-list cuing impairment. Part-list cues are typically provided at the beginning of the recall period, a time when nearly all individuals would be able to recall at least some studied items on their own. Across two experiments, we examined the effects of part-list cuing when student participants could decide on their own when the cues were presented during the recall period. Results showed that participants activated the cues relatively late in the recall period, when recall was already close to asymptote. Critically, such delayed cuing no longer impaired recall performance. The detrimental effect of part-list cuing, as it has been demonstrated numerous times in the memory literature, thus seems to depend on presentating the cue items (too) early in the recall period.

Studies examining age effects in autobiographical memory have produced inconsistent results. This study examined whether a set of typical autobiographical memory measures produced equivalent results in a single participant sample. Five memory tests (everyday memory, autobiographical memory from the past year, autobiographical memory from age 11–17, word-cued autobiographical memory, and word-list recall) were administered in a single sample of young and older adults. There was significant variance in the tests’ sensitivity to age: word-cued autobiographical memory produced the largest deficit in older adults, similar in magnitude to word-list recall. In contrast, older adults performed comparatively well on the other measures. The pattern of findings was broadly consistent with the results of previous investigations, suggesting that (1) the results of the different AM tasks are reliable, and (2) variable age effects in the autobiographical memory literature are at least partly due to the use of different tasks, which cannot be considered interchangeable measures of autobiographical memory ability. The results are also consistent with recent work dissociating measures of specificity and detail in autobiographical memory, and suggest that specificity is particularly sensitive to ageing. In contrast, detail is less sensitive to ageing, but is influenced by retention interval and event type. The extent to which retention interval and event type interact with age remains unclear; further research using specially designed autobiographical memory tasks could resolve this issue.

Memory for complex content is severely impaired in patients with schizophrenia spectrum disorders, which might make processing of daily information such as news and commercials particularly challenging. The goal of the present study was to assess the impairment of everyday memory in patients with schizophrenia. Healthy controls (HC) and patients with schizophrenia (SZ) were asked to watch a selection of six news segments and six commercials and complete a recognition task on the content of these video clips. All participants completed a neuropsychological test battery comprising measures of attention, working and episodic memory, and executive function. The total number of correctly recognized items was significantly lower in the SZ group. In contrast, the number of false recognitions was alike in both news and commercials paradigm. We conclude that memory in patients with schizophrenia is more prone to omissions than distortions for complex everyday stimuli. The results offer further support for impaired binding in SZ patients. Memory in SZ suffices to reject false multi-feature items on grounds of identifying at least one feature as incorrect but does not suffice to recall all features of a complex item and affirm it as correct.

To examine episodic memory in rats, we trained rats to perform two tasks and tested them for memory of past self-behavior without making them expect to be asked about the memory later when encoding. One of the trained tasks was a delayed matching-to-position task in which the rats were required to remember the location of a presented lever. The other was a tone discrimination task in which the rats were required to discriminate between two pure tones. After learning both tasks, the rats were unexpectedly asked the location of the pressed lever after responding to the cue tone in probe trials during test sessions. The rats demonstrated a response bias that suggests that they have the ability to retrospectively recollect their self-behavior, i.e., episodic memory. We next made excitotoxic lesions in the retrosplenial cortex (RSC) and investigated the effects of the lesions on the unexpected recollection. In the rats with lesions of the RSC, the response bias disappeared. This suggests that the RSC has a role in retrospectively answering unexpected questions about self-behavior.

Binge-drinking in adolescents and young adults is a widespread problem, however, an often unreported consequence of binge-drinking behaviour is an alcohol-induced memory blackout (MBO). An MBO is a transient amnesic event resulting from rapid, excessive alcohol consumption. Here, we examine the short-term impact of an alcohol-induced MBO event (testing

Intentionality to remember is associated with better performances in episodic memory retrieval. The practice effect has better performance in memory retrieval. However, little is known about the effect of intentionality on memory over days and the influence of age, gender, and level of education on it as well as on practice effect.To verify the effect of intentionality and practice effect on memory performance over days, using an ecological approach.One hundred and twenty subjects from 18 to 81 years of age and free of psychiatric and neurological disorders were evaluated. They were randomized into a "testing effect group" and a "intentionality group" and then were asked to read a text on the FIFA World Cup. The "intentionality group" was instructed to pay careful attention to the text because they would answer a questionnaire with 10 factual items from the text after 2 and 7 days. The "testing effect group" had the same procedure at the same time as the first group but were not instructed about the intentionality, and answered the questionnaire immediately after reading the text.Memory performance was better 2 days after the exposure session than 7 days later in the "intentionality group". On the other hand, there was no difference in memory performance from the "testing effect group" 2 and 7 days later.Intention to recall may enhance memory over a short period of days, while retaining similar amount of information over days to what was acquired immediately after text exposure.A intencionalidade de lembrar associa-se a melhores desempenhos na recuperação da memória episódica. O efeito da prática também apresenta melhores desempenhos na recuperação da memória. Entretanto, pouco se sabe sobre a intencionalidade na memória ao longo dos dias sob influência da idade, sexo e escolaridade, assim como sob efeito da prática.Verificar o efeito da intencionalidade e de testes no desempenho da memória ao longo dos dias, utilizando abordagem ecológica.Foram avaliados 120 sujeitos (idade 18-81 anos) e a ausência de distúrbios psiquiátricos e neurológicos. Eles foram randomizados para o “grupo de efeito de testes” ou para o “grupo de intencionalidade” e expostos ao texto da Copa do Mundo de Futebol. O “grupo de intencionalidade” foi instruído a prestar muita atenção ao texto, pois seria aplicado um questionário com 10 itens factuais do texto 2 e 7 dias depois. O “grupo de efeito de testes” realizou o mesmo procedimento no mesmo tempo que o primeiro grupo, mas não foi instruído em relação à intencionalidade e responderam ao questionário imediatamente após a leitura do texto.O desempenho da memória foi melhor 2 dias após a exposição do que 7 dias depois no “grupo de intencionalidade”. Por outro lado, não houve diferença no desempenho de memória no “grupo de efeito de testes” 2 e 7 dias depois.A intenção de recordar pode melhorar a memória por um curto período de dias. Enquanto o efeito de teste pode reter ao longo de dias quantidade similar de informação que foi adquirida imediatamente após a exposição do texto.

Fewer studies have focused on the independent association between mean corpuscular volume (MCV) and cognitive performance. This study was designed to characterize the cross-sectional association between MCV and cognitive performance in a large sample of Chinese residents (age≥45 years) from the China Health and Retirement Longitudinal Study (CHARLS). A total of 4023 male and 4173 female adults with MCV ≥ 80 fl were included for analysis. By multivariable linear regression analysis, for the total subjects, MCV level was significantly negatively associated with global cognitive function and episodic memory. When adjusted by sex, only in male subjects, higher MCV level was associated with reduced scores for global cognitive function, episodic memory and mental status. Via binary logistic regression analysis, the higher MCV level (MCV>100 fl) was associated with poor global cognitive function (OR = 1.601; 95% CI = 1.198–2.139; p = 0.001), episodic memory (OR = 1.679; 95% CI = 1.281–2.201; p

Objectives To study the brain lateralization of the verbal emotional memory and the influence of the emotional valence, we investigated a sample composed of patients with medial temporal lobe refractory epilepsy (MTLE) treated with unilateral amygdalohippocampectomy compared to a control group. Materials & Methods A new task (Verbal Association) was designed and implemented to assess emotional memory performance. It was applied to 62 patients with MTLE of whom 31 have been subjected to right amygdalohippocampectomy and 31 to left amygdalohippocampectomy. These patients were compared with 31 participants with no cerebral pathology, as a control group. Results (a) The control group obtained a higher number of recalled words than the rest of the groups, while the MTLE‐right group obtained better results than the MTLE‐left group. (b) In the case of positive emotional valence words, the MTLE‐left group performed significantly worse than the rest of the groups; whereas for negative emotional words, the MTLE‐left group presented the lowest average performance and the control group obtained a higher number of recalled words compared to MTLE‐right group. In the case of neutral emotional words, no significant differences were found among the groups. (c) The MTLE‐left group showed poorer performance on positive and negative words than neutral; the control group demonstrated lower average performance on positive and neutral words compared to negative; the MTLE‐right group did not show any significant differences on the recall of different emotional valences. Conclusions Patients with MTLE show a deficit in the verbal recall which is exacerbated for information with an affective component. This deficit is more prominent in the case of patients with left unilateral resection (MTLE‐left group) since they lose the benefits of the emotional information for the recall., We studied the lateralization of verbal emotional memory depending on the emotional valence using a sample composed of subjects with medial temporal lobe epilepsy (MTLE) who received an amygdalohippocampectomy and a control group. Patients with MTLE show a deficit in the verbal recall which is exacerbated for information with an affective component. This deficit is more prominent in the case of patients with left unilateral resection (MTLE‐left group) since they lose the benefits of the emotional information for the recall.