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Your search keyword '"Schulte-Mecklenbeck A"' showing total 3 results
Start Over Author "Schulte-Mecklenbeck A" Topic encephalopathy Topic flow cytometry Publication Year Range Last 10 years
3 results on '"Schulte-Mecklenbeck A"'

1. Intravenous methadone causes acute toxic and delayed inflammatory encephalopathy with persistent neurocognitive impairments

Author

Jonathan Repple, Svea Haessner, Andreas Johnen, Nils C. Landmeyer, Andreas Schulte-Mecklenbeck, Marc Pawlitzki, Heinz Wiendl, and Gerd Meyer zu Hörste

Subjects
Methadone, Encephalopathy, Cognition, Flow cytometry, Case report, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background The mu-opioid agonist methadone is administered orally and used in opioid detoxification and in the treatment of moderate-to-severe pain. Acute oral methadone–use and –abuse have been associated with inflammatory and toxic central nervous system (CNS) damage in some cases and cognitive deficits can develop in long-term methadone users. In contrast, reports of intravenous methadone adverse effects are rare. Case presentation Here, we report a patient who developed acute bilateral hearing loss, ataxia and paraparesis subsequently to intravenous methadone-abuse. While the patient gradually recovered from these deficits, widespread magnetic resonance imaging changes progressed and delayed-onset encephalopathy with signs of cortical dysfunction persisted. This was associated with changes in the composition of monocyte and natural killer cell subsets in the cerebrospinal fluid. Conclusion This case suggests a potential bi-phasic primary toxic and secondary inflammatory CNS damage induced by intravenous methadone.

Published
2021
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3. Intravenous methadone causes acute toxic and delayed inflammatory encephalopathy with persistent neurocognitive impairments

Author

Repple, Jonathan, Haessner, Svea Elena, Johnen, Andreas, Landmeyer, Nils C., Schulte-Mecklenbeck, Andreas, Pawlitzki, Marc, Wiendl, Heinz, and Meyer zu Hörste, Gerd

Subjects
Male, 610 Medicine and health, Brain Edema, Case Report, Encephalopathy, lcsh:RC346-429, Monocytes, Hearing Loss, Bilateral, Young Adult, Cognition, Paraparesis, Humans, Cognitive Dysfunction, Flow cytometry, Substance Abuse, Intravenous, lcsh:Neurology. Diseases of the nervous system, Inflammation, Brain Diseases, Brain, Magnetic Resonance Imaging, Analgesics, Opioid, Killer Cells, Natural, Diffusion Magnetic Resonance Imaging, Administration, Intravenous, Ataxia, Neurotoxicity Syndromes, Methadone
Abstract

Background: The mu-opioid agonist methadone is administered orally and used in opioid detoxification and in the treatment of moderate-to-severe pain. Acute oral methadone–use and –abuse have been associated with inflammatory and toxic central nervous system (CNS) damage in some cases and cognitive deficits can develop in long-term methadone users. In contrast, reports of intravenous methadone adverse effects are rare. Case presentation: Here, we report a patient who developed acute bilateral hearing loss, ataxia and paraparesis subsequently to intravenous methadone-abuse. While the patient gradually recovered from these deficits, widespread magnetic resonance imaging changes progressed and delayed-onset encephalopathy with signs of cortical dysfunction persisted. This was associated with changes in the composition of monocyte and natural killer cell subsets in the cerebrospinal fluid. Conclusion: This case suggests a potential bi-phasic primary toxic and secondary inflammatory CNS damage induced by intravenous methadone., Finanziert über die DEAL-Vereinbarung mit Wiley 2019-2022.

Published
2020

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