1. Deep learning based method for predicting DNA N6-methyladenosine sites.
- Author
-
Han K, Wang J, Chu Y, Liao Q, Ding Y, Zheng D, Wan J, Guo X, and Zou Q
- Subjects
- Humans, DNA chemistry, DNA genetics, Computational Biology methods, Deep Learning, Adenosine analogs & derivatives, Adenosine chemistry, Adenosine genetics, DNA Methylation
- Abstract
DNA N6 methyladenine (6mA) plays an important role in many biological processes, and accurately identifying its sites helps one to understand its biological effects more comprehensively. Previous traditional experimental methods are very labor-intensive and traditional machine learning methods also seem to be somewhat insufficient as the database of 6mA methylation groups becomes progressively larger, so we propose a deep learning-based method called multi-scale convolutional model based on global response normalization (CG6mA) to solve the prediction problem of 6mA site. This method is tested with other methods on three different kinds of benchmark datasets, and the results show that our model can get more excellent prediction results., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
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