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The patent application by Oxford Nanopore Technologies PLC discusses a new mutant lysenin monomer that enhances the performance of nanopore sensors in interacting with polynucleotides and determining their characteristics. The mutant lysenin monomer improves nucleotide discrimination, widens the current range, reduces variability, and decreases the number of nucleotides affecting the observed current. The application also includes different embodiments, such as constructs, pores, methods, and apparatuses for analyzing target analytes and polynucleotides using the mutant lysenin monomer. The patent application was filed by a team of researchers from Oxford Nanopore Technologies PLC. [Extracted from the article]

A patent has been issued to Oxford Nanopore Technologies PLC for a mutant lysenin monomer that can form a pore and interact with polynucleotides. The mutant pores have improved nucleotide discrimination, an increased current range, reduced variance of states, and a decreased number of nucleotides contributing to the current. The patent describes the amino acid substitutions and modifications made to the lysenin monomer to enhance its interaction with polynucleotides. This technology has the potential to provide rapid and cost-effective nucleic acid sequencing. [Extracted from the article]