1. Review of methods and applications of attenuation coefficient measurements with optical coherence tomography
- Author
-
Shuang Chang and Audrey K. Bowden
- Subjects
Paper ,Male ,Materials science ,Light ,Optical Phenomena ,genetic structures ,Biomedical Engineering ,tissue differentiation ,Diagnostic Techniques, Ophthalmological ,01 natural sciences ,Retina ,Light scattering ,010309 optics ,Biomaterials ,Optical coherence tomography ,Neoplasms ,0103 physical sciences ,medicine ,Humans ,Scattering, Radiation ,Review Papers ,light attenuation coefficient ,optical coherence tomography ,Models, Statistical ,medicine.diagnostic_test ,Choroid ,Phantoms, Imaging ,Scattering ,Glaucoma ,Benign lesion ,Ray ,Plaque, Atherosclerotic ,eye diseases ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Visualization ,Tissue Differentiation ,Brain Injuries ,Attenuation coefficient ,Female ,Neoplasm Grading ,Tomography, Optical Coherence ,Biomedical engineering - Abstract
The optical attenuation coefficient (AC), an important tissue parameter that measures how quickly incident light is attenuated when passing through a medium, has been shown to enable quantitative analysis of tissue properties from optical coherence tomography (OCT) signals. Successful extraction of this parameter would facilitate tissue differentiation and enhance the diagnostic value of OCT. In this review, we discuss the physical and mathematical basis of AC extraction from OCT data, including current approaches used in modeling light scattering in tissue and in AC estimation. We also report on demonstrated clinical applications of the AC, such as for atherosclerotic tissue characterization, malignant lesion detection, and brain injury visualization. With current studies showing AC analysis as a promising technique, further efforts in the development of methods to accurately extract the AC and to explore its potential use for more extensive clinical applications are desired.
- Published
- 2019