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Background: Asthma is a major global public health issue worldwide. It's the most frequent chronic disease in children and one of the primary causes of morbidity. Hemoglobin, myoglobin, and a number of enzymes all include iron, which is an essential mineral. Objective: It was to evaluate iron deficiency as a risk factor affected children with bronchial asthma in order to back up the clinical findings at Mansoura University Children Hospital. Patients and Methods: In this study, 50 asthmatic patients and 50 control participants, ranging in age from 6 to 18, were matched. We investigated the effects of iron deficiency on children with bronchial asthma by analysing laboratory results for the following tests and parameters; 1) Pulmonary function tests (FEV1, FVC, PEF, FEV1/FVC), 2) Complete blood count (HB, MCV, MCH, MCHC, RBC, RDW, HCT), 3) Serum iron, 4) Serum ferritin level, 5) Total iron binding capacity, and 6) Transferrin saturation. Results: Both FEV1/FVC and FEV1/FVC percent had statistically significant relationships with RBCs. Among the cases analysed, there was no statistically significant association between ferritin and pulmonary function tests or between TIBC and pulmonary function tests. All lung function tests had no statistically significant link with transferrin saturation (Tsat). Conclusion: Iron deficiency anaemia may have a negative impact on spirometry in asthmatic children, resulting to an increase in the severity of asthmatic attacks. Iron supplementation in infants may show to be a safe and successful technique for reducing the incidence of asthma, but further research is needed to determine the causality. [ABSTRACT FROM AUTHOR]