Dissolving pulp is an important source of cellulose raw material, and its key quality parameter is the Fock reactivity for viscose rayon application. Cellulase treatment is an effective method for improving the Fock reactivity of kraft-based dissolving pulp. In this study, a novel process concept of improving the cellulase treatment for this purpose was developed, and it consists of mechanical pre-refining and PDADMAC-assisted cellulase treatment. The hypothesis is based on: 1) opening up the fiber structures to improve the cellulase accessibility by pulp prerefining, 2) the addition of cationic poly DADMAC to the subsequent cellulase stage enhances the cellulase adsorption onto anionic fibers due to favorable electrostatic interactions. The results showed that the Fock reactivity of the resultant pulp from the combined treatment is much higher than that of the control, yet, achieved at a much lower cellulase dosage., (Copyright © 2018 Elsevier Ltd. All rights reserved.)