1. Antifungal Amide Alkaloids from the Aerial Parts of Piper flaviflorum and Piper sarmentosum.
- Author
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Yan-Ni Shi, Fang-Fang Liu, Jacob, Melissa R., Xing-Cong Li, Hong-Tao Zhu, Dong Wang, Rong-Rong Cheng, Chong-Ren Yang, Min Xu, and Ying-Jun Zhang
- Subjects
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ALKALOIDS , *AMIDES , *CANDIDA , *CRYPTOCOCCUS , *CHINESE medicine , *MOLECULAR structure , *X-rays , *PLANT extracts - Abstract
Sixty-three amide alkaloids, including three new, piperflaviflorine A (1), piperflaviflorine B (2), and sarmentamide D (4), and two previously synthesized ones, (1 E,3S)-1-cinnamoyl-3-hydroxypyrrolidine (3) and N-[7'-(4'-methoxyphenyl)ethyl]-2-methoxybenzamide (5), were isolated from the aerial parts of Piper flaviflorum and Piper sarmentosum. Their structures were elucidated by detailed spectroscopic analysis and, in case of 3, by single-crystal X-ray diffraction. Most of the isolates were tested for their antifungal and antibacterial activities. Ten amides (6-15) showed antifungal activity against Cryptococcus neoformans ATCC 90113 with IC50 values in the range between 4.7 and 20.0 µg/mL. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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