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The basic combined test (CRL+NT+blood test) and NIPT (non-invasive prenatal testing) do not have the ability to identify morphological anomalies. New ultrasound machines with improved resolution that provide a good 2D image allow the visualization of the smallest details and together with experienced sonographers increase the detection rate of first trimester anomalies. The 11-13+6-week scan is an accessible investigation that allows preventive and therapeutic measures in certain cases. A normal scan is important for reassurance, especially for patients having an increased risk. We analyzed cases from 2016 to 2019 that had an NIPT performed followed by an ultrasound scan at 11-13+6 weeks. A special attention was given to cases with negative NIPT and chromosomal anomalies diagnosed invasively/ postaborum after ultrasound. Between 2016 and 2019, we had 323 patients who had a NIPT screening at 10 weeks and presented for an anomaly scan at 11-13+6 weeks. Among these, we encountered three cases of chromosomal anomalies diagnosed after termination of pregnancy – due to multiple anomalies, one case of spina bifida, and four cases of single umbilical artery. NIPT has become a widely used tool in both high- and low-risk pregnancies and it is obvious that parents expect an honest and complete answer regarding their fetus. Studies available so far show that about 50% of major fetal anomalies can be detected at the 11-13+6-week scan and a complete anatomy scan – for this gestational age – is possible in most cases. [ABSTRACT FROM AUTHOR]