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Off-site research institutes serve as crucial platforms for universities to facilitate the translation and application of their scientific research outcomes. Additionally, these institutes act as vital intermediaries for local governments to harmonize scientific inputs with economic development and play a key role in the industrial transformation and elevation of regional science and innovation levels. Drawing on the triple helix theory, this paper outlines strategic planning for off-site research institutes and develops a multi-objective linear programming model aimed at optimizing resource allocation. This model focuses on enhancing both the efficiency of resource utilization and the efficiency of resource allocation at these institutes. To address the issue of local minima commonly encountered in optimization algorithms, this study employs a simulated annealing algorithm to refine the performance of the particle swarm optimization algorithm. The resulting hybrid algorithm termed the simulated annealing particle swarm algorithm, is applied to solve the proposed model and investigate the determinants of optimal resource allocation. The findings indicate a significant improvement in resource allocation efficiency, with the coefficient for heterogeneous research institutes decreasing from an average of 0.84 in 2020 to 0.68. This optimization has led to a more effective and rational distribution of resources, better meeting the needs of the institutes. Furthermore, the analysis reveals that financial support and talent introduction and development account for approximately 69.7% of the variance in the optimized development of resource allocation at these institutes. The study provides actionable insights that could guide the optimal development of off-site research institutes, offering valuable references for future applications.

Aims: To investigate the efficacy of pre‐emptive remifentanil in alleviating pain during tracheal suctioning in patients under mechanical ventilation. Background: Goal‐directed sedation is recommended for patients under mechanical ventilation by the current guidelines. Whether goal‐directed sedation can prevent pain during tracheal suctioning in these patients is unknown. Design: This was a two‐centre, randomized, crossover, single‐blind trial conducted between August and October 2019. Methods: Patients under mechanical ventilation received low‐dose remifentanil, high‐dose remifentanil or placebo prior to each tracheal suctioning in a random order. The primary outcomes were evaluated using the critical‐care pain observation tool and Richmond agitation–sedation scale after tracheal suctioning. Adverse events were also documented. Results: A total of 39 patients who underwent 117 tracheal suctions were enrolled. After the tracheal suction, changes in the critical‐care pain observation tool and Richmond agitation–sedation scale scores were significantly lower in the low‐dose and high‐dose groups than in the placebo group (P < 0.001). A non‐significant increase in the absence of spontaneous breathing was observed in the high‐dose group compared to that in the placebo group. Conclusion: A pre‐emptive remifentanil bolus of 0.5 μg/kg can mitigate the pain associated with tracheal suctioning. SUMMARY STATEMENT: What is already known about this topic? Pre‐emptive analgesia is recommended by several guidelines to alleviate the pain associated with invasive and potentially painful procedures in ICU patients.Goal‐directed sedation can shorten the length of hospital stay and is recommended for patients in the ICU by several clinical practice guidelines.Literature regarding whether goal‐directed sedation management or pre‐emptive remifentanil can prevent the pain associated with tracheal suctioning in patients under mechanical ventilation is scarce. What this paper adds? A pre‐emptive remifentanil bolus of 0.5 μg/kg can mitigate the pain associated with tracheal suctioning. The implications of this paper: Normal opioid doses administered for goal‐directed sedation management might be insufficient to prevent the pain associated with tracheal suctioningPre‐emptive analgesia can alleviate the pain without increasing the risk of opioid‐related adverse events in ICU patients under mechanical ventilation. [ABSTRACT FROM AUTHOR]