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Combined piled raft foundation (CPRF) is an effective solution for supporting high-rise constructions. The traditional design philosophy of CPRF does not consider the capacity of foundation based on combined vertical (V), horizontal (H), and moment (M) load. However, V-M-H load acts on the CPRF system concurrently due to the action of wind, wave, earth pressure, and earthquake loading in addition to gravity loading. In this context, the present investigation deals with the effect of combined V-M-H load interaction on the behavior of CPRF in sand and clay, respectively. The response of CPRF under combined loading is obtained using a 3D finite element analysis. First, validation of the numerical model is performed considering the model test results conducted in Agartala sand and another based on the available field test result of Messeturm Tower in Frankfurt clay obtained from the literature. Further, failure and design envelopes for the validated CPRF system are developed considering V-M-H load in both sand and clay deposits attributing a variety of influential system parameters. Simplified expressions for design lateral and moment capacities are proposed based on multiple linear regression analysis. Finally, the implication in design based on the findings of the present study is illustrated using a prototype case study structure. [ABSTRACT FROM AUTHOR]