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Purpose: Type 2 diabetes mellitus (T2DM) is known to produce diabetic retinopathy (DR). Pulse wave analysis (PWA) provides arterial stiffness (AS) and central hemodynamic (CH) parameters. We studied the effect of DR on AS and CH parameters in type 2 diabetics (T2D). Methods: We performed a cross-sectional study on 47 T2Ds attending a private ophthalmology clinic screened for DR by optical coherence tomography angiography and divided into NDR (non-DR), NPDR (non-proliferative DR), and PDR (proliferative DR). Mobil-o-graph (IEM, Germany) based oscillometric PWA yielded AS and CH parameters. They were further compared between groups stratified by DR with P value set at 0.05. Results: Participants had a mean age 62, mean diabetes duration 9 years, high mean BMI, and high prevalence of physical inactivity, hypertension, and poor diseases control. Significant differences were lacking in NPDR, NDR, and PDR in rate pressure product (mean 112.71 vs 116.06 vs 119.57), central pulse pressure (mean 46.50 vs 43.09 vs 42.72), stroke work (mean 153.36 vs 132.36 vs 146.08), augmentation index (mean 29.43 vs 33.14 vs 31.64), and aortic pulse wave velocity (mean 10.06 vs 9.08 vs 9.06). There was no clear pattern of distribution of most parameters among the three subgroups. Conclusion: We found a lack of association between DR and cardiovascular ageing studied by AS and hemodynamic parameters. It suggests a possible difference in risk factors for both of these aftermaths of T2DM and calls for further prospective studies with a large sample size. [ABSTRACT FROM AUTHOR]

Introduction: Type 1 Diabetes is an early onset disease that imposes significant cardiovascular risk. Arterial stiffness and central haemodynamics are immediate and discrete parameters but studied scarcely. Pulse wave analysis (PWA) allows non-invasive measurement of them which we undertook in diabetics. Methodology: We performed a case control study on 36 treated type 1 diabetics and 36 nondiabetic, normotensive, matched controls. Oscillometric pulse wave analysis (PWA) was performed by Mobil-o-Graph (IEM, Germany). Parameters were compared between case and controls. Multiple linear regressions were accomplished to find significant predictors. P < 0.05 was taken as statistical significance. Results: - Cases showed significantly raised brachial haemodynamics (blood pressure, heart rate, rate pressure product); arterial stiffness (augmentation pressure, augmentation index, pulse wave velocity, total arterial stiffness, pulse pressure amplification) and central haemodynamics (central blood pressure, cardiac output, stroke work) than controls, with statistical significance for not all. Most outcome parameters were predicted by age, HR, BP to lesser extents. Genders, presence of hypertension, glycemic control, blood pressure control, physical activity were not significantly affecting study outcomes in case group. Conclusion: Gujarati type 1 diabetics had beyond brachial blood pressure, adverse profile of discrete cardiovascular parameters; independent of conventional confounders; suggesting vascular progeria. This baseline work hints further study of these PWA parameters. [ABSTRACT FROM AUTHOR]