1. Concomitant fibromyalgia complicating chronic inflammatory arthritis: a systematic review and meta-analysis.
- Author
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Duffield, Stephen J, Miller, Natasha, Zhao, Sizheng, and Goodson, Nicola J
- Subjects
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ANKYLOSING spondylitis , *ARTHRITIS , *FIBROMYALGIA , *MEDICAL databases , *INFORMATION storage & retrieval systems , *PSYCHOLOGY information storage & retrieval systems , *JOINTS (Anatomy) , *MEDLINE , *META-analysis , *ONLINE information services , *PSORIATIC arthritis , *RHEUMATOID arthritis , *SELF-evaluation , *SYSTEMATIC reviews , *DISEASE management , *VISUAL analog scale , *DISEASE prevalence , *DISEASE complications , *ADULTS - Abstract
Objectives This systematic review and meta-analysis will describe the prevalence of concomitant FM in adults with inflammatory arthritis and quantify the impact of FM on DAS. Methods Cochrane library, MEDLINE, Psychinfo, PubMed, Scopus and Web of Science were searched using key terms and predefined exclusion criteria. As appropriate, proportional and pairwise meta-analysis methods were used to pool results. Results Forty articles were identified. In RA the prevalence of FM ranged from 4.9 to 52.4% (21% pooled). In axSpA the range was 4.11–25.2% (13% pooled in AS only). In PsA the range was 9.6–27.2% (18% pooled). The presence of concomitant FM was related to higher DAS in patients with RA and AS (DAS28 mean difference 1.24, 95% CI: 1.10, 1.37 in RA; BASDAI mean difference 2.22, 95% CI: 1.86, 2.58 in AS). Concomitant FM was also associated with higher DAS in existing PsA studies. Self-reported, rather than objective, components of DAS appear to be raised in the presence of FM (e.g. tender joint count and Visual Analogue Scale (VAS) pain scores). Conclusion FM is common in RA, AxSpA and PsA. Comorbid FM appears to amplify DAS and could therefore influence management of these rheumatic conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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