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5 results on '"Tocchetti, C. Gabriele"'

1. Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications

Author

Omerovic, Elmir, Citro, Rodolfo, Bossone, Eduardo, Redfors, Bjorn, Backs, Johannes, Bruns, Bastian, Ciccarelli, Michele, Couch, Liam S, Dawson, Dana, Grassi, Guido, Iacoviello, Massimo, Parodi, Guido, Schneider, Birke, Templin, Christian; https://orcid.org/0000-0003-0287-4193, Ghadri, Jelena R, Thum, Thomas, Chioncel, Ovidiu, Tocchetti, C Gabriele, Van Der Velden, Jolanda, Heymans, Stephane, Lyon, Alexander R, Omerovic, Elmir, Citro, Rodolfo, Bossone, Eduardo, Redfors, Bjorn, Backs, Johannes, Bruns, Bastian, Ciccarelli, Michele, Couch, Liam S, Dawson, Dana, Grassi, Guido, Iacoviello, Massimo, Parodi, Guido, Schneider, Birke, Templin, Christian; https://orcid.org/0000-0003-0287-4193, Ghadri, Jelena R, Thum, Thomas, Chioncel, Ovidiu, Tocchetti, C Gabriele, Van Der Velden, Jolanda, Heymans, Stephane, and Lyon, Alexander R

Abstract

While the first part of the scientific statement on the pathophysiology of Takotsubo syndrome was focused on catecholamines and the sympathetic nervous system, in the second part we focus on the vascular pathophysiology including coronary and systemic vascular responses, the role of the central and peripheral nervous systems during the acute phase and abnormalities in the subacute phase, the gender differences and integrated effects of sex hormones, genetics of Takotsubo syndrome including insights from microRNA studies and inducible pluripotent stem cell models of Takotsubo syndrome. We then discuss the chronic abnormalities of cardiovascular physiology in survivors, the limitations of current clinical and preclinical studies, the implications of the knowledge of pathophysiology for clinical management and future perspectives and directions of research.

Published
2022

2. Pathophysiology of Takotsubo syndrome – a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology – Part 1: overview and the central role for catecholamines and sympathetic nervous system

Author

Omerovic, Elmir, primary, Citro, Rodolfo, additional, Bossone, Eduardo, additional, Redfors, Bjorn, additional, Backs, Johannes, additional, Bruns, Bastian, additional, Ciccarelli, Michele, additional, Couch, Liam S., additional, Dawson, Dana, additional, Grassi, Guido, additional, Iacoviello, Massimo, additional, Parodi, Guido, additional, Schneider, Birke, additional, Templin, Christian, additional, Ghadri, Jelena R., additional, Thum, Thomas, additional, Chioncel, Ovidiu, additional, Tocchetti, C. Gabriele, additional, van der Velden, Jolanda, additional, Heymans, Stephane, additional, and Lyon, Alexander R., additional

Published
2022
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3. Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC)

Author

de Boer, Rudolf A., primary, Heymans, Stephane, additional, Backs, Johannes, additional, Carrier, Lucie, additional, Coats, Andrew J.S., additional, Dimmeler, Stefanie, additional, Eschenhagen, Thomas, additional, Filippatos, Gerasimos, additional, Gepstein, Lior, additional, Hulot, Jean‐Sebastien, additional, Knöll, Ralph, additional, Kupatt, Christian, additional, Linke, Wolfgang A., additional, Seidman, Christine E., additional, Tocchetti, C. Gabriele, additional, van der Velden, Jolanda, additional, Walsh, Roddy, additional, Seferovic, Petar M., additional, and Thum, Thomas, additional

Published
2022
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4. Pathophysiology of Takotsubo syndrome – a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology – Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications

Author

Omerovic, Elmir, primary, Citro, Rodolfo, additional, Bossone, Eduardo, additional, Redfors, Bjorn, additional, Backs, Johannes, additional, Bruns, Bastian, additional, Ciccarelli, Michele, additional, Couch, Liam S., additional, Dawson, Dana, additional, Grassi, Guido, additional, Iacoviello, Massimo, additional, Parodi, Guido, additional, Schneider, Birke, additional, Templin, Christian, additional, Ghadri, Jelena R., additional, Thum, Thomas, additional, Chioncel, Ovidiu, additional, Tocchetti, C. Gabriele, additional, van der Velden, Jolanda, additional, Heymans, Stephane, additional, and Lyon, Alexander R., additional

Published
2021
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5. Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications.

Author

Omerovic E, Citro R, Bossone E, Redfors B, Backs J, Bruns B, Ciccarelli M, Couch LS, Dawson D, Grassi G, Iacoviello M, Parodi G, Schneider B, Templin C, Ghadri JR, Thum T, Chioncel O, Tocchetti CG, van der Velden J, Heymans S, and Lyon AR

Subjects
Gonadal Steroid Hormones, Humans, Cardiology, Heart Failure genetics, MicroRNAs, Takotsubo Cardiomyopathy genetics
Abstract

While the first part of the scientific statement on the pathophysiology of Takotsubo syndrome was focused on catecholamines and the sympathetic nervous system, in the second part we focus on the vascular pathophysiology including coronary and systemic vascular responses, the role of the central and peripheral nervous systems during the acute phase and abnormalities in the subacute phase, the gender differences and integrated effects of sex hormones, genetics of Takotsubo syndrome including insights from microRNA studies and inducible pluripotent stem cell models of Takotsubo syndrome. We then discuss the chronic abnormalities of cardiovascular physiology in survivors, the limitations of current clinical and preclinical studies, the implications of the knowledge of pathophysiology for clinical management and future perspectives and directions of research., (© 2021 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)

Published
2022
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