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6 results on '"Falkard, Brie"'

2. Bivalent oral cholera vaccination induces a memory B cell response to the V. cholerae O1-polysaccharide antigen in Haitian adults

Author

Falkard, Brie, primary, Charles, Richelle C., additional, Matias, Wilfredo R., additional, Mayo-Smith, Leslie M., additional, Jerome, J. Gregory, additional, Offord, Evan S., additional, Xu, Peng, additional, Kováč, Pavol, additional, Ryan, Edward T., additional, Qadri, Firdausi, additional, Franke, Molly F., additional, Ivers, Louise C., additional, and Harris, Jason B., additional

Published
2019
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3. Bivalent oral cholera vaccination induces a memory B cell response to the V. cholerae O1-polysacchide in Haitian adults.

Author

Falkard, Brie, Charles, Richelle C., Matias, Wilfredo R., Mayo-Smith, Leslie M., Jerome, J. Gregory, Offord, Evan S., Xu, Peng, Kováč, Pavol, Ryan, Edward T., Qadri, Firdausi, Franke, Molly F., Ivers, Louise C., and Harris, Jason B.

Subjects
*B cells, *ORAL vaccines, *ANTIBODY formation, *MEMORY, *CHOLERA vaccines, *IMMUNOGLOBULIN producing cells
Abstract

The bivalent killed whole-cell oral cholera vaccine (BivWC) is being increasingly used to prevent cholera. The presence of O-antigen-specific memory B cells (MBC) has been associated with protective immunity against cholera, yet MBC responses have not been evaluated after BivWC vaccination. To address this knowledge gap, we measured V. cholerae O1-antigen MBC responses following BivWC vaccination. Adults in St. Marc, Haiti, received 2 doses of the BivWC vaccine, Shanchol, two weeks apart. Participants were invited to return at days 7, 21, 44, 90, 180 and 360 after the initial vaccination. Serum antibody and MBC responses were assessed at each time-point before and following vaccination. We observed that vaccination with BivWC resulted in significant O-antigen specific MBC responses to both Ogawa and Inaba serotypes that were detected by day 21 and remained significantly elevated over baseline for up to 12 months following vaccination. The BivWC oral cholera vaccine induces durable MBC responses to the V. cholerae O1-antigen. This suggests that long-term protection observed following vaccination with BivWC could be mediated or maintained by MBC responses. [ABSTRACT FROM AUTHOR]

Published
2019
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4. Antibody Secreting Cell Responses following Vaccination with Bivalent Oral Cholera Vaccine among Haitian Adults

Author

Matias, Wilfredo R., primary, Falkard, Brie, additional, Charles, Richelle C., additional, Mayo-Smith, Leslie M., additional, Teng, Jessica E., additional, Xu, Peng, additional, Kováč, Pavol, additional, Ryan, Edward T., additional, Qadri, Firdausi, additional, Franke, Molly F., additional, Ivers, Louise C., additional, and Harris, Jason B., additional

Published
2016
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5. Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh

Author

Falkard, Brie, primary, Uddin, Taher, additional, Rahman, M. Arifur, additional, Franke, Molly F., additional, Aktar, Amena, additional, Uddin, Muhammad Ikhtear, additional, Bhuiyan, Taufiqur Rahman, additional, Leung, Daniel T., additional, Charles, Richelle C., additional, Larocque, Regina C., additional, Harris, Jason B., additional, Calderwood, Stephen B., additional, Qadri, Firdausi, additional, and Ryan, Edward T., additional

Published
2015
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