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Background: COVID-19 is an emerging infectious disease caused by a novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In Malaysia, first few cases of COVID-19 were detected in January 2020, among Chinese nationals and the cases keep increasing day by day. Methods: This self-administered web based cross sectional study using Google forms was conducted among 400 Malaysian adults to explore their level of knowledge, attitude and practice towards COVID-19, as well as factors associated with the variables. Descriptive and binary logistic regression were performed using SPSS version 22. Results: Knowledge and practice among Malaysian adults towards COVID-19 were low. Gender (p = 0.030, OR:0.616, 95% CI 0.398-0.955) and occupation (p = 0.002, OR:2.489, 95% CI 1.485-4.172) were found as significant predictors of practice towards COVID-19. Conclusions: In conclusion, proper mass public health messages should be conducted by the higher authorities to improve knowledge and practice towards COVID-19. [ABSTRACT FROM AUTHOR]

Introduction: Invasive Candida infections cause significant mortality and morbidity worldwide. Information on recent trends in species distribution and antifungal resistance in local settings is essential. Methodology: Yeast isolates identified through standard culture methods throughout 2014 and 2015 from Hospital Ampang, Malaysia were retrospectively studied. The antifungal susceptibility of Candida species was determined using colorimetric broth microdilution method and MIC values interpreted according to CLSI breakpoints. Results: Out of all the 149 yeast cultures collected, most were from blood (55.7%) and respiratory specimens (33.6%). Candida tropicalis was the most common (28.9%), followed by C. albicans (26.2%), C. parapsilosis (15.4%), C. glabrata (14.1%), Crytococcus neoformans (6.7%), Trichosporon asahi (3.4%), C. krusei (2.0%), C. famata, C. rugose, C. guilliermondii, C. dublinensis and Trichosporon spp. (0.7% each). Occurrence of C. tropicalis in candidaemia cases was significantly associated to presence of an underlying haematological disorder, while C. albicans isolates in blood were significantly found in absence of such disorders. The four most common Candida species isolated showed high susceptibility to amphotericin B (100%), anidulafungin (100%), micafungin (100%), caspofungin (98.4%), flucytosine (98.4%) and voriconazole (84.1%). However, drug susceptibility to itraconazole and fluconazole was comparatively lower (57.9% and 72.2%, respectively). C. glabrata and C. tropicalis were the least susceptible to these azoles. Conclusion: Prevalence of the high number of non-albicans Candida species with slight predominance of C. tropicalis over C. albicans was observed. Low susceptibility to itraconazole among C. glabrata and C. tropicalis isolates and to fluconazole among C. glabrata isolates warrants for continued surveillance to monitor emerging antifungal resistance. [ABSTRACT FROM AUTHOR]