1. In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2.
- Author
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Villalobos-Sánchez, Erendira, García-Ruiz, Daniel, Camacho-Villegas, Tanya A., Canales-Aguirre, Alejandro A., Gutiérrez-Ortega, Abel, Muñoz-Medina, José E., and Elizondo-Quiroga, Darwin E.
- Subjects
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SARS-CoV-2 , *COVID-19 , *ANTIVIRAL agents - Abstract
The coronavirus infectious disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been spreading rapidly worldwide, creating a pandemic. This article describes the evaluation of the antiviral activity of nordihydroguaiaretic acid (NDGA), a molecule found in Creosote bush (Larrea tridentata) leaves, against SARS-CoV-2 in vitro. A 35 µM concentration of NDGA was not toxic to Vero cells and exhibited a remarkable inhibitory effect on the SARS-CoV-2 cytopathic effect, viral plaque formation, RNA replication, and expression of the SARS-CoV-2 spike glycoprotein. The 50% effective concentration for NDGA was as low as 16.97 µM. Our results show that NDGA could be a promising therapeutic candidate against SARS-CoV-2. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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