Search

Immunosensors are promising diagnostics for the next-generation healthcare systems and are evolving constantly with technological advancements. In recent days, immunosensors have found wide attention in the field of healthcare/clinical diagnostics due to their excellent capabilities of detecting various causative agents for diseases/disorders. Unlike the conventional immuno-technologies, immunosensors support ASSURED criteria for the diagnostics provided by the World Health Organization, and hence it has found wider commercial attention globally. In this chapter, we have summarized such immunosensors fabricated using paper substrates in comprehensive details and pictorial illustrations. First section of this chapter describes the conventional immuno-technologies used in biomedical/clinical applications and their associated limitations. In the next section, the chapter describes the transformations of clinical diagnostic technologies to the adoption of inexpensive paper-based solutions. Followed by this, the chapter also describes different types of paper-based immunosensors used for biomedical/clinical applications. Further, the recent trends and advancements have been summarized and concluded with detailed discussions in the next section.

Animals frequently compete over limited resources such as food, territories or mating opportunities. Contest behaviour varies based on factors such as the value of the contested resources and the agonistic ability of rivals. Much work on animal contests has examined aggression, but vigilance, or a state of heightened alertness directed towards specific stimuli, may also be an important component of competition in many species. In this study, we measure the relationships among social vigilance, aggression, agonistic ability and resource value during staged contests over nest ownership in Polistes dominula nest-founding wasps. Our results show that both social vigilance and aggression are involved in mediating social risk during contests. Nest owner vigilance towards a rival increased with the time of season, a measure of nest value. Owner vigilance was also positively associated with aggression such that more aggressive owners were more vigilant. During contests, aggression of owners and rivals was influenced by different factors. Owner aggression was positively associated with nest size, another measure of nest value, while rival aggression was unrelated to nest size. Instead, rival aggression was associated with facial patterns that function as signals of agonistic ability; rivals were less aggressive to owners that signalled high agonistic ability than they were to owners that signalled low agonistic ability. The distinct predictors of contest behaviour between owners and rivals indicate that competitive role has a surprisingly strong influence on cues used to inform contest behaviour. Differences may occur because owners and rivals have different information and/or motivation. These results also suggest that social vigilance and aggression may be complementary behaviours that animals use to mitigate social threat.

In paper dryer section of the paper machine, paper dehydration is small, but the steam consumption for the process of dehydration is very large, this steam consumption has a great influence to the total steam consumption of the whole papermaking process. A method optimization of the dryer section based on genetic algorithm is proposed to reduce the dryer section steam consumption, which can reduce the total steam consumption of the papermaking process. After analyzing steam consumption of the whole drying process, the result is that the temperature of dryer section air is the key factor that influences the steam consumption. The model of paper machine dryer section is build with supply air temperature as a variable and steam consumption as the objective function, then using the genetic algorithm to optimize the supply air temperature. Simulation results show that after optimizing air temperature by genetic algorithm steam consumption of papermaking process is further reduced.

Prepared for the Victorian Department of Education and Training, this paper provides advice on a proposed conceptual framework for the Enhanced Maternal and Child Health service.

Un elevado porcentaje de las personas que han padecido COVID refieren, tras la recuperación de la fase aguda de la enfermedad, una serie de manifestaciones clínicas tanto subjetivas como objetivas que se prolongan más allá de 3 semanas e incluso de 3 meses del cuadro clínico original. No existe todavía una nomenclatura consensuada para referirse a este cuadro, pero quizá la más usada es la de síndrome post-COVID. El Comité Científico sobre COVID del Colegio de Médicos de Madrid ha discutido este problema con una aproximación multidisciplinar en la que han participado, internistas, infectólogos, psiquiatras, neumólogos, cirujanos, geriatras, pediatras, microbiólogos, médicos de familia y otros especialistas, tratando de acopiar la información existente y discutiéndola en el grupo. Las manifestaciones clínicas son muy variables y oscilan entre cuadros de simple cansancio y persistencia de lesiones pulmonares fibrosantes con alteraciones objetivas de la función pulmonar. El síndrome post-COVID parece particularmente frecuente y grave en aquellos adultos que han precisado ingreso en Unidades de Cuidados Intensivos y tiene un comportamiento peculiar en un grupo muy reducido de niños. El síndrome post-COVID, de existencia indudable, no es, a primera vista, claramente diferenciable del que se produce tras otras enfermedades víricas agudas y tras estancias prolongadas en UCI por enfermedades de otra naturaleza. Por tanto, ofrece oportunidades excelentes de investigación para clarificar su patogenia y posiblemente la de otras entidades afines. Es posible que progresivamente se produzca una demanda asistencial incrementada entre los millones de personas que han sufrido y superado el COVID agudo para la cuál las autoridades sanitarias debieran diseñar mecanismos de gestión ágil de una asistencia que posiblemente requerirá de grupos multidisciplinares bien coordinados. Este documento, estructurado en preguntas sobre distintos aspectos del síndrome post-COVID, intenta poner en escena el estado actual de este problema. A high proportion of people who have suffered from COVID-19 report, after recovery from the acute phase of the disease, clinical manifestations, both subjective and objective, that continue beyond 3 weeks or even 3 months after the original clinical disease. There is still no agreed nomenclature to refer to this condition, but perhaps the most commonly used is post-COVID syndrome. The Scientific Committee on COVID of the Madrid College of Physicians (ICOMEM) has discussed this problem with a multidisciplinary approach in which internists, infectious disease specialists, psychiatrists, pneumologists, surgeons, geriatricians, pediatricians, microbiologists, family physicians and other specialists have participated, trying to gather the existing information and discussing it in the group. The clinical manifestations are very variable and range from simple fatigue to persistent fibrosing lung lesions with objective alterations of pulmonary function. Post-COVID syndrome seems to be particularly frequent and severe in adults who have required admission to Intensive Care Units and has a peculiar behavior in a very small group of children. The post-COVID syndrome, which undoubtedly exists, is at first sight not clearly distinguishable from clinical manifestations that which occur after other acute viral diseases and after prolonged stays in ICUs due to other diseases. Therefore, it offers excellent research opportunities to clarify its pathogenesis and possibly that of other related entities. It is possible that progressively there will be an increased demand for care among the millions of people who have suffered and overcome acute COVID for which the health authorities should design mechanisms for the agile management of care that will possibly require well-coordinated multidisciplinary groups. This paper, structured in questions on different aspects of the post-COVID syndrome, attempts to stage the current state of this problem. Sin financiación 2.515 JCR (2021) Q3, 206/279 Pharmacology & Pharmacy 0.440 SJR (2021) Q3, 1353/2489 Medicine (miscellaneous) No data IDR 2020 UEM

The application of single-cell mRNA sequencing technologies to plant embryos promises to reveal the gene expression dynamics underlying cell-type differentiation. A new paper in Development reports the generation of high-quality transcriptomes from single embryonic nuclei without contamination from maternal tissues. To find out more about the story, we caught up with first author Ping Kao and his supervisor Michael Nodine, who recently moved from the Gregor Mendel Institute in Vienna to become Assistant Professor in the Laboratory of Molecular Biology at Wageningen University in the Netherlands.

o El propósito de este estudio es describir el estado actual de la publicación de investigaciones y las tendencias en el aprendizaje invertido, que se encuentran en "Web of Science" durante el período 2014-2018. Hay 262 artículos investigados, publicados e indexados en "Web of Science" con la palabra clave: "aprendizaje invertido" y "aula invertida". Los resultados del estudio se analizan según la revista de publicación según estos criterios: autor, países, agencias de financiación, tipos de documentos, idiomas, organización, años de publicación y título de la fuente. El aprendizaje invertido cambia la clase tradicional dando la vuelta al aula en el sentido de escuchar las videoconferencias en casa y realizar actividades dinámicas en grupo en el aula. Esto involucra a los estudiantes en el aprendizaje activo, el pensamiento crítico y mejora las habilidades interpersonales.Se recomienda a los autores explorar la posibilidad de utilizar este método, experimentar y publicar los hallazgos que permitan crear mejores prácticas y un marco unificado para instructores líderes que deseen adoptar esta metodología de enseñanza. Palabras clave: aprendizaje invertido, aula invertida, análisis de contenido, The purpose of this study is to describe the current state of research publication and trends in flipped learning, found on ‘Web of Science’ during the period 2014–2018. There are 262 papers investigated, published and indexed on ‘Web of Science’ with the keyword: “flipped learning” and “flipped classroom”. The results of the study are analysed according to the journal of publication by these criteria: author, countries, funding agencies, document types, languages, organisation, publication years and source title. Flipped learning changes the traditional lecturing by flipping the classroom in the sense of listening to the video lectures at home and doing dynamic, group-based activities in the classroom. This engages the students in active learning, critical thinking, and meliorates interpersonal skills.It is recommended to authors to explore the possibility of utilising this method, experimenting and publish the findings which allows to create best practices and a unified framework for leading instructors who want to adopt this teaching methodology. Keywords: Flipped learning, flipped classroom, content analysis

The application of single-cell mRNA sequencing technologies to plant embryos promises to reveal the gene expression dynamics underlying cell-type differentiation. A new paper in Development reports the generation of high-quality transcriptomes from single embryonic nuclei without contamination from maternal tissues. To find out more about the story, we caught up with first author Ping Kao and his supervisor Michael Nodine, who recently moved from the Gregor Mendel Institute in Vienna to become Assistant Professor in the Laboratory of Molecular Biology at Wageningen University in the Netherlands.

In this paper tracing paper was used as the support on which interdigitated graphite electrodes (IGE) were deposited by a line patterning technique (LPT). This substrate was characterized before and after the patterning procedure by thermogravimetric analysis, atomic force microscopy (AFM) and field emission scanning electron microscopy (FE-SEM). The performance of the IGEs prepared by LPT as humidity sensors were evaluated in an electronic nose system, under different humidities (in triplicate) at room pressure and temperature in a closed chamber. The relative humidity (RH) in the chamber was varied from 20 to 70% using dry nitrogen as a carrier gas, which was passed through a bubbler containing water to generate humidity. Slight changes in the morphology of the tracing paper were noted after the processes used to produce the IEG, but these changes did not prevent these sensors performing well under varied environmental conditions, as part of an electronic nose system to detect humidity. The results showed that humidity sensors were sensitive (215% ± 1.02) and provided good repeatability and reversibility (99% ± 0.01) after several cycles of exposure to RH.