1. precision medicine trial in psoriatic arthritis—first jump in the deep end.
- Author
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Leijten, Emmerik F A
- Subjects
- *
THERAPEUTIC use of monoclonal antibodies , *ANTIRHEUMATIC agents , *BIOMARKERS , *FLOW cytometry , *SERIAL publications , *PSORIATIC arthritis , *T cells , *PHENOTYPES , *TUMOR necrosis factors , *TREATMENT effectiveness , *INDIVIDUALIZED medicine , *CHEMICAL inhibitors , *GENETICS , *DIAGNOSIS , *THERAPEUTICS - Abstract
The article discusses a study on the immunologic heterogeneity within the overall group of patients classified as having psoriatic arthritis. The authors examined the efficacy of steering the choice of biologic on a per-patient immunologic basis in the strategic arm as compared with a standard-of-care approach. The authors have addressed recent calls for novel trial design. Slight caution is warranted as the strategic arm and standard-of-care arm were different in some key factors.
- Published
- 2019
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