8 results
Search Results
2. Long-Term Exposure to Low-Level PM2.5 and Mortality: Investigation of Heterogeneity by Harmonizing Analyses in Large Cohort Studies in Canada, United States, and Europe.
- Author
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Jie Chen, Braun, Danielle, Christidis, Tanya, Cork, Michael, Rodopoulou, Sophia, Samoli, Evangelia, Stafoggia, Massimo, Wolf, Kathrin, Xiao Wu, Weiran Yuchi, Andersen, Zorana J., Atkinson, Richard, Bauwelinck, Mariska, de Hoogh, Kees, Janssen, Nicole A. H., Katsouyanni, Klea, Klompmaker, Jochem O., Kristoffersen, Doris Tove, Youn-Hee Lim, and Oftedal, Bente
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MORTALITY risk factors ,PARTICULATE matter ,AERODYNAMICS ,RELATIVE medical risk ,CONFIDENCE intervals ,NOSOLOGY ,META-analysis ,RISK assessment ,SOCIAL classes ,DESCRIPTIVE statistics ,DATA analysis software ,ENVIRONMENTAL exposure ,LONGITUDINAL method ,PROPORTIONAL hazards models ,MEDICARE ,POISSON distribution - Abstract
BACKGROUND: Studies across the globe generally reported increased mortality risks associated with particulate matter with aerodynamic diameter ≤2.5 μm (PM
2.5 ) exposure with large heterogeneity in the magnitude of reported associations and the shape of concentration-response functions (CRFs). We aimed to evaluate the impact of key study design factors (including confounders, applied exposure model, population age, and outcome definition) on PM2.5 effect estimates by harmonizing analyses on three previously published large studies in Canada [Mortality-Air Pollution Associations in Low Exposure Environments (MAPLE), 1991-2016], the United States (Medicare, 2000-2016), and Europe [Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), 2000-2016] as much as possible. METHODS: We harmonized the study populations to individuals 65+ years of age, applied the same satellite-derived PM2.5 exposure estimates, and selected the same sets of potential confounders and the same outcome. We evaluated whether differences in previously published effect estimates across cohorts were reduced after harmonization among these factors. Additional analyses were conducted to assess the influence of key design features on estimated risks, including adjusted covariates and exposure assessment method. A combined CRF was assessed with meta-analysis based on the extended shape-constrained health impact function (eSCHIF). RESULTS: More than 81 million participants were included, contributing 692 million person-years of follow-up. Hazard ratios and 95% confidence intervals (CIs) for all-cause mortality associated with a 5-μg/m³ increase in PM2.5 were 1.039 (1.032, 1.046) in MAPLE, 1.025 (1.021, 1.029) in Medicare, and 1.041 (1.014, 1.069) in ELAPSE. Applying a harmonized analytical approach marginally reduced difference in the observed associations across the three studies. Magnitude of the association was affected by the adjusted covariates, exposure assessment methodology, age of the population, and marginally by outcome definition. Shape of the CRFs differed across cohorts but generally showed associations down to the lowest observed PM2.5 levels. A common CRF suggested a monotonically increased risk down to the lowest exposure level. [ABSTRACT FROM AUTHOR]- Published
- 2023
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3. Patient-Identified Solutions to Primary Care Access Barriers in Canada: The Viewpoints of Nepalese Immigrant Community Members.
- Author
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Dahal, Rudra, Naidu, Jessica, Bajgain, Bishnu Bahadur, Thapa Bajgain, Kalpana, Adhikari, Kamala, Chowdhury, Nashit, and Turin, Tanvir C.
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IMMIGRANTS ,CULTURE ,HEALTH policy ,HEALTH services accessibility ,NEPALI people ,FOCUS groups ,GOVERNMENT regulation ,COMMUNITIES ,LANGUAGE & languages ,PRIMARY health care ,PATIENTS' attitudes ,SOCIAL classes ,COMMUNICATION ,THEMATIC analysis ,HEALTH equity ,PATIENT-professional relations - Abstract
Background: Accessing healthcare for immigrants in Canada is complicated by many difficulties. With the continued and upward trend of immigration to Canada, it is crucial to identify the solutions to the barriers from the perspectives of different immigrant communities as they encounter them including the relatively smaller and less studied population groups of immigrants. As such, Nepalese immigrants in Canada are a South Asian ethnic group who have their own distinct language, culture, and socio-economic backgrounds, however, their experience with accessing healthcare in Canada is scarce in the literature. Methods: We conducted 12 focus group discussions with first-generation Nepalese immigrants who had experiences with primary care use in Canada. Informed consent and demographic information were obtained before each focus group discussion. The verbatim transcription of the focus groups was analyzed using thematic analysis. Results: The participants expressed a range of potential solutions to overcome the barriers, which we presented using the socio-ecological framework into 4 different levels. This includes individual-, community-, service provider-, and government/policy-levels. Individual-level actions included improving self-awareness and knowledge of health in general and navigating the healthcare system and proactively improving the language skills and assimilating into the Canadian culture. Examples of community-level actions included community events to share health information with immigrants, health literacy programs, and driving/carpooling to clinics or hospitals. Actions at the service provider level were mainly focused on enhancing communications, cultural competency training for providers, and ensuring to hire primary care workforce representing various ethnocultural backgrounds. Overall, focus group participants believed that the provincial and federal government, as appropriate, should increase support for dental and vision care support and take actions to increase the healthcare capacity, particularly by employing internationally graduated health professionals. Conclusions: Access to primary care is essential for the health of immigrant populations in Canada. Individuals, community organizations, health service providers, and governments need to work both individually and collaboratively to improve immigrants' primary care access. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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4. Association between pre-pregnancy multimorbidity and adverse maternal outcomes: A systematic review.
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Brown, Hilary K, McKnight, Anthony, and Aker, Amira
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CINAHL database ,HYPERTENSION in pregnancy ,OBESITY ,MEDICAL information storage & retrieval systems ,CONFIDENCE intervals ,CHRONIC diseases ,SYSTEMATIC reviews ,AGE distribution ,RACE ,PREGNANCY outcomes ,RISK assessment ,MEDICAL care use ,PREGNANCY complications ,PUERPERIUM ,CRITICAL care medicine ,SOCIAL classes ,HEALTH behavior ,DESCRIPTIVE statistics ,RESEARCH funding ,MEDLINE ,MATERNAL mortality ,SMOKING ,ODDS ratio ,COMORBIDITY ,DISEASE risk factors - Abstract
Objective: We reviewed the literature on the association between pre-pregnancy multimorbidity (co-occurrence of two or more chronic conditions) and adverse maternal outcomes in pregnancy and postpartum. Data sources: Medline, EMBASE, and CINAHL were searched from inception to September, 2021. Study selection: Observational studies were eligible if they reported on the association between ≥ 2 co-occurring chronic conditions diagnosed before conception and any adverse maternal outcome in pregnancy or within 365 days of childbirth, had a comparison group, were peer-reviewed, and were written in English. Data extraction and synthesis: Two reviewers used standardized instruments to extract data and rate study quality and the certainty of evidence. A narrative synthesis was performed. Results: Of 6,381 studies retrieved, seven met our criteria. There were two prospective cohort studies, two retrospective cohort studies, and 3 cross-sectional studies, conducted in the United States (n=6) and Canada (n=1), and ranging in size from n=3,110 to n=57,326,681. Studies showed a dose-response relation between the number of co-occurring chronic conditions and risk of adverse maternal outcomes, including severe maternal morbidity or mortality, hypertensive disorders of pregnancy, and acute health care use in the perinatal period. Study quality was rated as strong (n=1), moderate (n=4), or weak (n=2), and the certainty of evidence was very low to moderate. Conclusion: Given the increasing prevalence of chronic disease risk factors such as advanced maternal age and obesity, more research is needed to understand the impact of pre-pregnancy multimorbidity on maternal health so that appropriate preconception and perinatal supports can be developed. [ABSTRACT FROM AUTHOR]
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- 2022
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5. AN URBAN NATION: THE SHIFTING FORTUNES OF CANADIAN CITIES.
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McQuillan, Kevin and Laszlo, Michael
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SMALL cities ,METROPOLIS ,MUNICIPAL services ,CITIES & towns ,LABOR supply ,SOCIAL classes ,FORTUNE ,POPULATION aging - Abstract
Canada is not immune to the dramatic economic changes that are transforming society in other industrialized countries, where once-thriving factory and resource towns are dying, while educated knowledge workers in more cosmopolitan centres prosper. Where this growing inequality between communities and social classes takes root, worrisome social and political developments can develop, such as the polarization occurring in the U.S. and parts of Europe. Canada's 10 largest cities have been the primary driver of economic growth in recent years, and Canada is unusual in the degree to which its population is concentrated in a relatively small number of cities. To date, Canada's largest cities have been doing well and Canada has not so far seen the contrast so evident in the United States between highly successful cities and large cities in decline, such as Detroit and Cleveland. However, a ranking of national cities using "vitality" scores highlights a growing inequality between Canada's largest cities and its midsize and smaller cities. In many communities in the Atlantic region, in Quebec beyond its two major cities, and in the northern regions of B.C. and Ontario, harder times may lie ahead. Their populations are stagnating, their employment rates for people of prime working age are distressingly low, and their proportion of lowincome families is high. Urban decline can lead to further poverty, significant population aging and more pressure on higher levels of government to provide services that these communities can no longer afford. The strength of cities primarily revolves today around human capital and the ability of a community to develop or attract a highly skilled labour force. If Canada is to avoid a future where just a few cities are economic and demographic "winners" and the rest are "losers," policy-makers will need to consider how to help keep midsized cities from being increasingly left behind, whether that be through diversifying immigration patterns, targeted investment outside large urban areas, or other approaches. The pandemic, which has led some employers to rethink the need to keep workers in expensive big-city downtown offices, could create new opportunities to reinvigorate smaller, lower-cost centres. However, without a change in the pattern of divergence between Canada's dynamic cities and the rest, the societal and political strife that has unfolded elsewhere could someday happen here. [ABSTRACT FROM AUTHOR]
- Published
- 2021
6. Naturalistic development of trait mindfulness: A longitudinal examination of victimization and supportive relationships in early adolescence.
- Author
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Warren, Michael T., Schonert-Reichl, Kimberly A., Gill, Randip, Gadermann, Anne M., and Oberle, Eva
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MINDFULNESS ,SOCIAL ecology ,SOCIAL classes ,SCHOOL districts ,ENGLISH language ,ADOLESCENCE - Abstract
Scholars have only just begun to examine elements of young adolescents' social ecologies that explain naturalistic variation in trait mindfulness and its development over time. We argue that trait mindfulness develops as a function of chronically encountered ecologies that are likely to foster or thwart the repeated enactment of mindful states over time. Using data from 4,593 fourth and seventh grade students (50% female; M
ageG4 = 9.02; 71% English first language) from 32 public school districts in British Columbia (BC), Canada, we examined links from peer belonging, connectedness with adults at home, and peer victimization to mindfulness over time. Variable-centered analyses indicated that young adolescents with lower victimization in fourth grade reported higher mindfulness in seventh grade, and that cross-sectionally within seventh grade victimization, peer belonging, and connectedness with adults at home were each associated with mindfulness. Contrary to our hypothesis, connectedness with adults at home moderated the longitudinal association between victimization and mindfulness such that the negative association was stronger among young adolescents with high (vs. low) levels of connectedness with adults at home. Person-centered analysis of the fourth graders' data confirmed our variable-centered findings, yielding four latent classes of social ecology whose mindfulness levels in seventh grade largely tracked with their victimization levels (from highest to lowest mindfulness): (1) flourishing relationships, (2) unvictimized but weak relationships with adults, (3) moderately victimized but strong relationships, and (4) victimized but strong relationships. Overall, our findings contribute to a growing body of evidence indicating that trait mindfulness may develop as a function of ecologically normative experiences in young adolescents' everyday lives. [ABSTRACT FROM AUTHOR]- Published
- 2021
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7. Using self-reported data on the social determinants of health in primary care to identify cancer screening disparities: opportunities and challenges.
- Author
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Lofters, A. K., Schuler, A., Slater, M., Baxter, N. N., Persaud, N., Pinto, A. D., Kucharski, E., Davie, S., Nisenbaum, R., and Kiran, T.
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BREAST tumor diagnosis ,ASIANS ,BLACK people ,MAMMOGRAMS ,FAMILY medicine ,HEALTH services accessibility ,HEALTH status indicators ,HISPANIC Americans ,IMMIGRANTS ,INCOME ,EVALUATION of medical care ,METROPOLITAN areas ,POVERTY ,PRIMARY health care ,RESEARCH funding ,SELF-evaluation ,SOCIAL classes ,SURVEYS ,WHITE people ,CERVIX uteri tumors ,RESIDENTIAL patterns ,SOCIOECONOMIC factors ,HUMAN research subjects ,PATIENT selection ,DATA analysis software ,HEALTH & social status ,EARLY detection of cancer - Abstract
Background: Data on the social determinants of health can help primary care practices target improvement efforts, yet relevant data are rarely available. Our family practice located in Toronto, Ontario routinely collects patient-level sociodemographic data via a pilot-tested survey developed by a multi-organizational steering committee. We sought to use these data to assess the relationship between the social determinants and colorectal, cervical and breast cancer screening, and to describe the opportunities and challenges of using data on social determinants from a self-administered patient survey. Methods: Patients of the family practice eligible for at least one of the three cancer screening types, based on age and screening guidelines as of June 30, 2015 and who had answered at least one question on a socio-demographic survey were included in the study. We linked self-reported data from the sociodemographic survey conducted in the waiting room with patients' electronic medical record data and cancer screening records. We created an individual-level income variable (low-income cut-off) that defined a poverty threshold and took household size into account. The sociodemographic characteristics of patients who were overdue for screening were compared to those who were up-to-date for screening for each cancer type using chi-squared tests. Results: We analysed data for 5766 patients for whom we had survey data. Survey participants had significantly higher screening rates (72.9, 78.7, 74.4% for colorectal, cervical and breast cancer screening respectively) than the 13, 036 patients for whom we did not have survey data (59.2, 65.3, 58.9% respectively). Foreign-born patients were significantly more likely to be up-to-date on colorectal screening than their Canadian-born peers but showed no significant differences in breast or cervical cancer screening. We found a significant association between the low-income cut-off variable and cancer screening; neighbourhood income quintile was not significantly associated with cancer screening. Housing status was also significantly associated with colorectal, cervical and breast cancer screening. There was a large amount of missing data for the low-income cut-off variable, approximately 25% across the three cohorts. Conclusion: While we were able to show that neighbourhood income might under-estimate income-related disparities in screening, individual-level income was also the most challenging variable to collect. Future work in this area should target the income disparity in cancer screening and simultaneously explore how best to collect measures of poverty. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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8. Utility of linking primary care electronic medical records with Canadian census data to study the determinants of chronic disease: an example based on socioeconomic status and obesity.
- Author
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Biro, Suzanne, Williamson, Tyler, Leggett, Jannet Ann, Barber, David, Morkem, Rachael, Moore, Kieran, Belanger, Paul, Mosley, Brian, and Janssen, Ian
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ELECTRONIC health records ,MEDICAL care ,HOSPITAL care ,PUBLIC health ,MEDICAL records ,CHRONIC diseases ,CENSUS ,MEDICAL record linkage ,OBESITY ,PRIMARY health care ,SOCIAL classes ,PILOT projects - Abstract
Background: Electronic medical records (EMRs) used in primary care contain a breadth of data that can be used in public health research. Patient data from EMRs could be linked with other data sources, such as a postal code linkage with Census data, to obtain additional information on environmental determinants of health. While promising, successful linkages between primary care EMRs with geographic measures is limited due to ethics review board concerns. This study tested the feasibility of extracting full postal code from primary care EMRs and linking this with area-level measures of the environment to demonstrate how such a linkage could be used to examine the determinants of disease. The association between obesity and area-level deprivation was used as an example to illustrate inequalities of obesity in adults.Methods: The analysis included EMRs of 7153 patients aged 20 years and older who visited a single, primary care site in 2011. Extracted patient information included demographics (date of birth, sex, postal code) and weight status (height, weight). Information extraction and management procedures were designed to mitigate the risk of individual re-identification when extracting full postal code from source EMRs. Based on patients' postal codes, area-based deprivation indexes were created using the smallest area unit used in Canadian censuses. Descriptive statistics and socioeconomic disparity summary measures of linked census and adult patients were calculated.Results: The data extraction of full postal code met technological requirements for rendering health information extracted from local EMRs into anonymized data. The prevalence of obesity was 31.6 %. There was variation of obesity between deprivation quintiles; adults in the most deprived areas were 35 % more likely to be obese compared with adults in the least deprived areas (Chi-Square = 20.24(1), p < 0.0001). Maps depicting spatial representation of regional deprivation and obesity were created to highlight high risk areas.Conclusions: An area based socio-economic measure was linked with EMR-derived objective measures of height and weight to show a positive association between area-level deprivation and obesity. The linked dataset demonstrates a promising model for assessing health disparities and ecological factors associated with the development of chronic diseases with far reaching implications for informing public health and primary health care interventions and services. [ABSTRACT FROM AUTHOR]- Published
- 2016
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