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Your search keyword '"Hansen, Henrik"' showing total 2 results
2 results on '"Hansen, Henrik"'

1. Comparison of Durable-Polymer Zotarolimus-Eluting and Biodegradable-Polymer Biolimus-Eluting Coronary Stents in Patients With Coronary Artery Disease:3-Year Clinical Outcomes in the Randomized SORT OUT VI Trial

Author

Raungaard, Bent, Christiansen, Evald H, Bøtker, Hans Erik, Hansen, Henrik S, Ravkilde, Jan, Thuesen, Leif, Aarøe, Jens, Villadsen, Anton B, Terkelsen, Christian J, Krusell, Lars R, Maeng, Michael, Kristensen, Steen D, Veien, Karsten T, Hansen, Knud N, Junker, Anders, Madsen, Morten, Andersen, Søren, Jensen, Svend E, and Jensen, Lisette O

Subjects
Male, Time Factors, Polymers, Denmark, Myocardial Infarction, Coronary Artery Disease, Prosthesis Design, Percutaneous Coronary Intervention, Risk Factors, Absorbable Implants, Journal Article, Humans, Comparative Study, cardiovascular diseases, Aged, Proportional Hazards Models, Sirolimus, Coronary Thrombosis, Cardiovascular Agents, Drug-Eluting Stents, Middle Aged, equipment and supplies, Multicenter Study, Treatment Outcome, Randomized Controlled Trial, Female
Abstract

OBJECTIVES: The authors sought to compare the safety and efficacy of the biocompatible durable-polymer zotarolimus-eluting stent with the biodegradable-polymer biolimus-eluting stent in unselected coronary patients.BACKGROUND: Biodegradable-polymer biolimus-eluting stents are superior to first-generation durable-polymer drug-eluting stents in long-term randomized all-comer trials. Long-term data comparing them to second-generation durable-polymer drug-eluting stents are lacking.METHODS: The study was a randomized, multicenter, all-comer, noninferiority trial in patients with chronic stable coronary artery disease or acute coronary syndromes and at least 1 coronary artery lesion requiring treatment with a drug-eluting stent. Endpoints included major adverse cardiac events (MACE), a composite of safety (cardiac death and myocardial infarction not clearly attributable to a non-target lesion) and efficacy (target lesion revascularization); the individual endpoints of MACE; all-cause mortality; any myocardial infarction; target vessel revascularization; and definite or probable stent thrombosis at 36 months.RESULTS: From March 2011 to August 2012, 2,999 patients were randomly assigned (1:1) to receive either the zotarolimus-eluting (1,502 patients) or the biolimus-eluting (1,497 patients) stent. At 3-year follow-up, MACE occurred in 128 (8.6%) patients assigned to the durable-polymer zotarolimus-eluting stent and in 144 (9.6%) assigned to the biodegradable-polymer biolimus-eluting stent (p = 0.36). Occurrence of cardiac death (2.7% vs. 3.4%), myocardial infarction not clearly attributable to a non-target lesion (2.7% vs. 2.5%), and target lesion revascularization (5.4% vs. 5.5%) did not differ significantly between the 2 groups. Definite very late stent thrombosis occurred in 6 (0.4%) patients assigned to the durable-polymer zotarolimus-eluting stent and in 10 (0.7%) assigned to the biodegradable-polymer biolimus-eluting stent (p = 0.33).CONCLUSIONS: At 3-year follow-up, the durable-polymer zotarolimus-eluting stent and the biodegradable-polymer biolimus-eluting stent were similar in clinical outcome, with no significant difference in safety and efficacy outcomes, including stent thrombosis.

Published
2017

2. Time trends in leisure time physical activity, smoking, alcohol consumption and body mass index in Danish adults with and without COPD.

Author

Hansen, Henrik, Johnsen, Nina Føns, and Molsted, Stig

Subjects
OBSTRUCTIVE lung disease treatment, LIFESTYLES & health, PHYSICAL activity, HEALTH, SMOKING, ALCOHOL drinking & health, BODY mass index, ALCOHOL drinking, EXERCISE, FORECASTING, OBSTRUCTIVE lung diseases, OBESITY, REGRESSION analysis, SURVEYS, LOGISTIC regression analysis, LIFESTYLES, CROSS-sectional method, ODDS ratio, DISEASE complications
Abstract

Background: Promotion of a healthy lifestyle and non-pharmacological interventions in the treatment of chronic obstructive pulmonary disease (COPD) has received great attention in recent decades. The aim of this study was to investigate trends in leisure time physical activity (PA), smoking, alcohol consumption and body mass index (BMI) from 2000 to 2010 in Danish individuals with and without COPD.Methods: Analyses were based on data provided by The Danish Health and Morbidity's three cross-sectional surveys from 2000, 2005 and 2010. Data compromised level of leisure time PA, smoking, alcohol consumption, BMI and sociodemographic characteristics. Participants aged 25 years or older with and without COPD were included in the analyses.Results: In multiple logistic regression analyses, odds ratio (OR) of being physically active in the leisure time in 2010 compared to 2000 was 1.70 (95 % CI: 1.28-2.26), p < 0.001, and 1.32 (1.22-1.43), p < 0.001, in participants with and without COPD, respectively. Being a non-smoker in 2010 compared to 2000 was associated with an OR of 1.41 (1.07-1.85), p = 0.015, and 1.73 (1.63-1.85), p < 0.001, in participants with and without COPD. The OR of not exceeding national recommended alcohol limits was 0.64 (0.45-0.93), p = 0.020, and 1.19 (1.09-1.29), p < 0.001, in participants with and without COPD. In a multiple linear regression analysis, the time frame from 2000 to 2010 was associated with an increased BMI of 1.18 kg · m(-2) (0.52-1.84), p < 0.001, and 0.74 kg · m(-2) (0.63-0.86), p < 0.001, in participants with and without COPD. The COPD participants with higher levels of education and/or living in a marriage or a relationship were more likely to be physically active, non-smoking and not exceeding the recommended alcohol limits.Conclusion: From the 2000 to 2010, Danish individuals aged 25 years with and without COPD, increased their leisure time PA level and reduced smoking. Lower socioeconomic status was associated with a reduced level of PA, smoking and an increased alcohol intake. Future national health campaigns and treatment strategies need to target this socioeconomic impact. The reported increased PA level and reduced smoking may have important implications in relation to a reduced morbidity and mortality risk in Danish patients with COPD. [ABSTRACT FROM AUTHOR]

Published
2016
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