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Our paper advances a subcategory of influencers who mobilise their audiences towards consumption-driven change; we label them 'ethical influencers'. Using netnography and an archival dataset on ten ethical influencers, we delineate their unique challenges and positioning. Ethical influencers legitimate their accounts via a close-up of personal practices, as opposed to an articulated persona, and connect with divergent audiences to advocate for the needed change. Our paper describes the divergent audience groups and engagement styles: allies, inquisitives, detractors, and enigmatics. We also identify the ethical influencers' linking strategies to connect these audiences with other market actors (e.g. ethical businesses and other ethical influencers) which include acting, humanising, framing, pivoting, and evangelising. This research advances influencer marketing literature and offers important managerial and public policy implications. [ABSTRACT FROM AUTHOR]

This document discusses the feasibility of using CD19 CAR T-cell therapy in patients with cardiac lymphoma. The article highlights that cardiac non-Hodgkin lymphoma is not well-represented in medical literature, and the exact incidence is unknown. The authors present three cases of patients with cardiac lymphoma who received CAR T-cell therapy. The first two patients had successful outcomes with no significant cardiac events, while the third patient experienced severe cardiotoxicity after CAR T infusion. The authors suggest that a multidisciplinary approach and preventive measures for severe cytokine release syndrome are important in optimizing the safety and efficacy of CAR T-cell therapy in patients with cardiac lymphoma. [Extracted from the article]

Since the 1990s, many countries have implemented healthcare reforms underlined by New Public Management principles and technological transformations. Although studies have examined these reforms from different viewpoints, the spatial implications of healthcare reforms have received limited attention. Scholarship focused predominantly on regional variations of healthcare provision overlooking the sharp contrasts between cities where most healthcare facilities are de facto located. Addressing this research gap, we investigate the long-term dynamics of healthcare provision on the urban level, tracing the differences (if any) between cities of different sizes and administrative statuses. The study adopts a comparative approach. We draw our data from two countries: France and Russia (mainland France and European Russia). Findings indicate that, despite some variations, healthcare reforms in both countries follow similar paths, resulting in fewer hospital beds that have been partially replaced by places in day hospitals. At the same time, we also observe diverging country-specific trends in terms of redistribution of healthcare provision. In France, some cities completely lost their hospital equipment but those cities that remained equipped tend to a uniform distribution. In European Russia, on the contrary, all cities remain equipped but there is a drastic polarization depending on size and administrative status. [ABSTRACT FROM AUTHOR]

This article discusses non-conventional diplomatic tools. It does so by focussing on the Conference on Security and Co-operation in Europe (CSCE) and the Multilateral Balanced Force Reduction (MBFR) talks and suggests that individuals and individual creativity to make use of non-conventional tools, in combination with attention to working conditions, impact the outcome. CSCE ventured in entirely new territory and promoted such novel concepts as the indivisibility of security, and the free flow of individuals, information, and ideas. As such it appealed to negotiatiors' creativity; by contrast, MBFR was about reducing conventional forces in the given constellation of a divided Europe -- it treated this division as a fact of life; as such it may have offered far less opportunities for individual diplomats' creativity to fully blossom. Taken together a discussion of these tools also contribute to the structure -- agency debate: they provide additional evidence that individual diplomats -- though often simply seen as tools of their respective governments and merely acting within a certain constellation -- and close attention to the conditions they have to work in, do matter, even when, of course, it is governments, not diplomats, that will have to sanction the results they achieve. [ABSTRACT FROM AUTHOR]

A first pass workflow for placing cover sequence materials into four broad lithological groups using A-CNK-FM (Al2O3-CaOþNa2OþK2O-Fe2O3þMgO) and A-CN-K (Al2O3-CaOþNa2O-K2O) ternary diagrams in conjunction with the SiO2 vs Al2O3, Fe2O3 and CaO plus the Ca versus Sr XY diagrams has been derived from lithological logging and laboratory whole-rock geochemistry of 2346 samples. These lithological groups include siliciclastics (quartz sands and clays), weathered material, carbonate lithologies (marine limestone, pedogenic carbonate and compositions intermediate between the two end members) and ferruginous lithologies (including ferricrete and ferruginous sediments). Depositional, weathering and groundwater processes influence sample geochemistry during or after the formation of the material and will influence where the sample will plot on the geochemical diagrams used in this study. Geochemical data for discrete lithologies targeted during sampling (e.g. carbonate lithologies) clusters on diagrams used in the geochemical workflow, whereas data from targeted stratigraphic horizons (e.g. basement-cover interface) are more variable. The ability to characterise rock types that are texturally defined using the geochemical workflow is limited. For instance, the geochemistry of diamictite/conglomerate samples is dependent on the matrix versus clast content and composition as well as the source rock and catchment area. This workflow has the potential to be applied in a mineral exploration environment for rapid interpretation of real-time geochemical (e.g. portable XRF) data to gain an understanding of background geochemistry and geochemical signatures that may be related to underlying mineralisation. [ABSTRACT FROM AUTHOR]

Confronted by the multiscaled ecological crisis, many experience so-called ecological emotions such as ecological grief and eco-anxiety. Visual media can channel and contribute to creating and nurturing ecological emotions. Specifically, eco-documentaries are one of the triggers of ecological emotions. This paper explores the role of images in the generation of emotions regarding the environmental crisis through a case study of five contemporary Swiss eco-documentaries: It All Begins, Citizen Nobel, Lynx, Taming the Garden and The Mushroom Speaks. It analyses the ecological emotions expressed by the characters or the filmmakers, or the expected emotions of the viewers, with regard to the types of images and their framing, editing, narrative and attractiveness. Finally, drawing on interdisciplinary literature from environmental humanities, this paper discusses the variety and intertwinement of ecological emotions and their interrelations to knowledge of the ecological crisis and pro-environmental actions. [ABSTRACT FROM AUTHOR]

While the System Usability Scale (SUS) is probably one of the most widely used questionnaires to measure the perceived ease of use of interactive systems, there is currently no scientific valid translation in French. This article describes the translation and statistical validation of the French version of the SUS, called F-SUS. On the basis of two translations carried out by a committee of bilingual experts, the various psychometric analyses made it possible to select only one translation. Fidelity measurement, factor analysis and sensitivity measurement obtained results very close or similar to the original version of the SUS. Thus, the F-SUS can be used with confidence by French-speaking usability researchers and practitioners. [ABSTRACT FROM AUTHOR]

In many countries, the objective of reducing public spending combined with the introduction of New Public Management reforms have led to changes in the territorial organization of public services and to a withdrawal of public facilities in many places. Our hypothesis is that in France, this territorial process has not occurred in the same way in all cities. We assume that while medium-sized cities are seeing a reduction in some public service facilities, their disappearance usually occurs in small cities. Larger metropolitan areas have not been affected by such territorial retrenchment of public services facilities. These differences could lead to increased territorial inequalities at the level of urban systems and to a marginalization of some small cities. This paper examines these processes through a quantitative analysis of changes in the location of justice courts and hospital beds from 2000 to 2016, within French Functional Urban Areas. It shows that the decrease in the number of justice and hospital facilities was significant and has affected small cities. [ABSTRACT FROM AUTHOR]

AbstractBackgroundMethodsResultsConclusionThis study aimed to assess the prognostic value of cardiac magnetic resonance (CMR) variables and compare them with biological and echocardiographic markers in patients with AL cardiac amyloidosis (CA).We conducted a prospective study across three tertiary centres, where patients underwent clinical examination, blood tests, echocardiography, and CMR. The primary endpoint was all-cause mortality.A total of 176 patients with AL CA were included, with a median age of 68 years (IQR 58-75). According to the 2004 Mayo Clinic staging, 121 patients (69%) were in stage 3. During a median follow-up of 22 months (IQR 8–48), 45 patients died, and 55 were hospitalized for heart failure. Patients who died had higher NT-proBNP and troponin levels, and lower LVEF, cardiac output, and longitudinal strain. Among CMR variables, extracellular volume (ECV) was most strongly associated with all-cause mortality. In multivariate Cox models, including Mayo Clinic staging, ECV ≥ 0.45 was independently associated with mortality (HR 2.36, CI 95% 1.47–5.60) and also with heart failure hospitalizations (HR 4.10, 95%CI 2.15–8.8).ECV is a powerful predictor of outcomes in AL CA, providing additional prognostic value on top of Mayo Clinic staging. [ABSTRACT FROM AUTHOR]

This study presents new geochemical and mineralogical data collected on 13 drill holes across the South Australian part of the Eromanga Basin, with a focus on the Lower Cretaceous Cadna-owie Formation, Bulldog Shale, Coorikiana Sandstone and Oodnadatta Formation. Mineralogical and geochemical data are used to determine the provenance of the sediments along with the paleoenvironments at the time of deposition. The dominant clay species across the formations are kaolinite and montmorillonite, although each drill hole shows individual mineralogical assemblages. The Cadna-owie Formation is mainly composed of quartz and kaolinite; montmorillonite is the dominant clay species in the other formations. Differences in major-element chemistry are best shown on the K–Na–Ca ternary diagram and display a strong relationship with mineralogy. Trace and rare earth elements are preserved at similar average concentrations between formations and are depleted relative to the upper continental crust. The signature of the sediments is interpreted to be derived from a mix of felsic and mafic igneous rocks with almost no sedimentary recycling. Sources of the sediments are likely to be from exposed basement packages surrounding the study area such as the Gawler Range Volcanics, the Musgrave Province, the Benagerie Volcanic Suite, the Mount Painter Inlier and the Arunta Block. The variations in dominant clay species between the formations could have been driven by an increase in temperature and a decrease in rainfall during the Early Cretaceous along with seasonal variations, and/or by the input in volcanogenic sediments from the active volcanoes located along the eastern margin of Australia. Lower Cretaceous formations in the South Australian Eromanga Basin show limited regional lateral and vertical geochemical and mineralogical variations. Sediments are a mix of mafic through felsic igneous rocks derived from basement terranes exposed in the Early Cretaceous. The paleoclimate during deposition evolved from cold and humid to warm and arid. [ABSTRACT FROM AUTHOR]

The detection of molecules dissolved in liquid medium can be envisaged by means of an optical integrated sensor operating in middle infrared range. The intended sensor is composed of a cladding and a guiding selenide sputtered layers transparent in middle infrared. Hence, Ge-Sb-Se thin films were selected in view of tailored refractive index contrast, successfully deposited by radio frequency magnetron sputtering and characterized. To maximize the evanescent field at a wavelength of 7.7 µm, a suitable selenide waveguide allowing measuring the optical transmitted power was designed by performing computer simulations based on the effective index method enabling single-mode propagation for a waveguide width between 8 and 12 µm. Selenide sputtered films were micro-patterned using reactive ion etching with inductively coupled plasma process. Finally, optical waveguide surface was functionalized by the deposition of a hydrophobic polymer, which will permit detection of organic molecules in water. [ABSTRACT FROM PUBLISHER]

This article discusses scholarly views on the rise of the human rights paradigm. Based on a case study of the Netherlands it argues that the appeal of human rights cannot simply be attributed to the memory of the Holocaust, or the rise of post-war generations disillusioned with traditional ideologies in the 1960s and especially, the 1970s. Instead, it proposes that human rights primarily owe their popularity to the ideological contest of the Early Cold War, even though means to convey the message all over the world were only available in the decades that followed. [ABSTRACT FROM AUTHOR]