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A low noise, high gain, stable radiometer front-end is presented for non-invasive tissue thermometry using custom designed narrow band low noise amplifiers (LNAs) and band pass filter (BPF) with 1.3 GHz centre frequency and − 20 dB pass band of 332 MHz. The fabricated LNAs have >15 dB gain, unconditional gain stability and noise figure (NF) < 1.45 dB in the pass band. The maximum insertion loss of the BPF is <1 dB over 1.2-1.4 GHz with 50 dB suppression in the surrounding communication bands. The cascaded radiometer front-end has measured gain of 45-50 dB, NF < 1.75 dB in the pass band and > 30 dB suppression in the adjacent personal communication bands. The Allan deviation of the total power radiometer indicates long term system stability and presence of Gaussian thermal noise for integration time, . Radiometer measurements of a matched load at room temperature for indicate acceptably low influence of external electromagnetic interference (EMI) and system noise equivalent temperature of 145 K. The brightness temperature measured by the total power radiometer using a resonant slot antenna demonstrates the ability to detect a 0.3°C change in the test load temperature with better than 0.1°C accuracy. [ABSTRACT FROM AUTHOR]