1. The effect of antioxidant vitamins E and C on cognitive performance of the elderly with mild cognitive impairment in Isfahan, Iran: a double-blind, randomized, placebo-controlled trial.
- Author
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Alavi Naeini, A., Elmadfa, I., Djazayery, A., Barekatain, M., Aghaye Ghazvini, M., Djalali, M., and Feizi, A.
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COGNITION disorders treatment , *GERIATRIC nutrition , *ANALYSIS of variance , *ANTHROPOMETRY , *CHI-squared test , *DIETARY supplements , *GLUTATHIONE , *LONGITUDINAL method , *NEUROPSYCHOLOGICAL tests , *NUTRITIONAL assessment , *HEALTH outcome assessment , *RESEARCH funding , *STATISTICAL sampling , *T-test (Statistics) , *VITAMIN C , *VITAMIN E , *MALONDIALDEHYDE , *OXIDATIVE stress , *BODY mass index , *RANDOMIZED controlled trials , *TREATMENT effectiveness , *REPEATED measures design , *BLIND experiment , *DATA analysis software , *DESCRIPTIVE statistics , *OLD age - Abstract
Purpose: This study was carried out to investigate the effect of vitamins E and C on cognitive performance among the elderly in Iran. Methods: About 256 elderly with mild cognitive impairment, aged 60-75 years, received 300 mg of vitamin E plus 400 mg of vitamin C or placebo daily just for 1 year. Background: Demographic characteristics, anthropometric variables food consumption, cognitive function by Mini-Mental State Examination (MMSE), and some of the oxidative stress biomarkers were examined. Results: Antioxidant supplementation reduced malondialdehyde level ( P < 0.001) and raised total antioxidant capacity ( P < 0.001) and glutathione ( P < 0.01). The serum 8-hydroxydeoxyguanosine remained unchanged ( P < 0.4). After adjusting for the covariates effects, MMSE scores following 6- (25.88 ± 0.17) and 12-month antioxidant supplementation (26.8 ± 0.17) did not differ from control group (25.86 ± 0.18 and 26.59 ± 0.18, respectively). Conclusion: Despite significant improvement in most of the oxidative stress biomarkers, antioxidants' supplementation was not observed to enhance cognitive performance. A large number of kinetic and/or dynamic factors could be suspected. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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