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Bridging neuroscience, immunology, and pharmacology, and bringing together the foremost authorities, Neuroimmune Pharmacology and Therapeutics, 3rd edition, is an invaluable reference and textbook. The text discusses the immunology of the nervous system. New chapters are offered on innate, humoral, and cellular immune responses (innate and adaptive immunity). The additions join each component of the immune response in descriptions for how each affects nervous system function in both health and disease. Next, discussions of neuropharmacology now include both drug development and delivery into brain subregions to optimize clinical responses. This edition features greatly expanded coverage of therapeutics. The new extensions have blossomed into focused therapies engaging the immune system directly, deploying it for drug delivery, attracting the newly evolving field of genetics, vaccinations, and bioengineering, ultimately leading to improved therapeutic disease outcomes. All of the revisions in this edition are designed to bring an early trainee together with a skilled clinical and translational scientist to discuss the state of the art in each part of the emerging field of immunity as it affects the nervous system during steady state and disease and how it can be harnessed for therapeutics and clinical benefit.

Dieses essential klärt darüber auf, wie von der Parkinson-Krankheit Betroffene bereits vor der klinischen Diagnose, in der Prodromalphase, identifiziert werden können und welche ethischen Aspekte dabei zu beachten sind. Bereits vor Manifestation der typischen motorischen Kardinalsymptome breitet sich die α-Synucleinopathie schon einige Jahre im Körper aus und eine Reihe von Symptomen kann auftreten, insbesondere die isolierte REM-Schlaf-Verhaltensstörung. Das Buch für Neurologen in Weiterbildung, Klinik und Praxis beschreibt die jüngsten Fortschritte insbesondere auf dem Gebiet der Biomarker und zeigt die besondere Relevanz eines frühzeitigen individuellen symptomatischen Therapieangebots sowie die Bedeutung präventiver nicht-medikamentöser Maßnahmen auf.

This book bridges the gap between biomechanics and engineering and presents advanced concepts and techniques for the analysis of motion in biological systems. Advanced theoretical and computational concepts applied to motion analysis of biological systems are presented, as well as how these concepts can assist in identifying strategies and developing methodologies for effective rehabilitation, and even detecting movement-related disorders. This is an ideal book for biomedical engineers, physical therapists, and researchers and students studying motion analysis of biological systems.

This practical, case-based book offers an approach to diagnosis and treatment of movement disorders in the outpatient setting. The major hypokinetic and hyperkinetic disorders are considered in turn, with more than 1,000 videos illustrating the role of phenomenology in the diagnosis and treatment of these conditions. Discussion of the role of ancillary testing (imaging, genetic testing) and treatment options with medications, botulinum toxin injections, and surgical intervention are woven in to the discussion of cases throughout the book. Special attention is directed to pitfalls and perils of office-based practice. This volume will be of interest to movement disorders neurologists and trainees, general neurologists, neurology residents, and any healthcare professional with an interest in exploring the application of the many treatments that have transformed movement disorders into a therapeutic field. Rather than a textbook of movement disorders, thisvolume will help the practicing clinician in guiding the thought process for evaluation and management of patients in the clinic.

This book gathers outstanding papers presented at the International Conference on Data Science and Applications (ICDSA 2023), organized by Soft Computing Research Society (SCRS) and Malaviya National Institute of Technology Jaipur, India, from 14 to 15 July 2023. The book is divided into four volumes, and it covers theoretical and empirical developments in various areas of big data analytics, big data technologies, decision tree learning, wireless communication, wireless sensor networking, bioinformatics and systems, artificial neural networks, deep learning, genetic algorithms, data mining, fuzzy logic, optimization algorithms, image processing, computational intelligence in civil engineering, and creative computing.

​Das Gebiet der funktionellen Störungen hat in der Neurologie inzwischen einen festen Platz eingenommen. Um Behandelnden Sicherheit bei der Diagnostik und handfeste Unterstützung bei der Therapie zu bieten, erläutert dieses Buch praxisnah und evidenzbasiert Untersuchungstechniken und klinische Zeichen, die eine frühe und sichere Diagnosestellung jenseits des Ausschlussprinzips möglich machen. Der Autor erklärt die Wirkungsweise verschiedener Therapien und gibt Tipps zur ärztlichen Gesprächsführung sowie konkrete Behandlungsempfehlungen aus der Physiotherapie und Psychotherapie, um die interdisziplinäre Patientenversorgung zu erleichtern. Die überarbeitete Auflage berücksichtigt aktuelle Entwicklungen aus der klinischen Forschung mit einem Akzent auf praktisch relevanten Aspekten. Neue Kapitel behandeln das pragmatische Management funktioneller neurologischer Störungen in der Notaufnahme und Besonderheiten bei Kindern und Jugendlichen.

This book reviews the role of trace elements in brain development, function, metabolism, and neurodegenerative disorders. It explores the molecular mechanisms of the effects of trace elements on metabolic pathways, mitochondrial nutrients, neurodegeneration, Central Nervous System (CNS) disorders, cell signaling, and neuronal functions. The book also discusses transport mechanisms of trace elements within CNS and their impact on neurotransmitter biology. Further, it examines the deleterious effects due to dyshomeostasis of trace elements in the central nervous system (CNS), resulting in damage to neurons and glial cells through the generation of reactive oxygen species and oxidative stress turn leading to neurodegeneration and neurological dysfunction. The book also explores the putative role of trace element deficiency in psychiatric disorders, including depression, and the imbalance of trace elements on neuronal genomic stability.

This monograph, now in its 2nd edition with 31 new chapters and significant updates, is the first book of its kind written specifically for graduate students and clinicians. The monograph is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013; 2nd edition: 2022), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology and related areas. There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. Essentials of the Cerebellum and Cerebellar Disorders makes this large and expanding body of knowledge readily accessible to trainees and clinicians alike. It is organized into easy to read and short chapters that are ideal for students and clinicians. The most common cerebellar disorders encountered in the clinic are covered. The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from cerebellar laboratories and ataxia clinics throughout North America, Europe and Asia. Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar cellular biology and circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. This book is an indispensable resource for students and practitioners navigating the evolving field of cerebellar motor and cognitive neurology. It also links to the more expansive Handbook for those who need to explore the topics in this monograph in greater depth.

Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society. New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.

This book provides a detailed practically focused guide on the latest diagnostic and treatment techniques available for normal pressure hydrocephalus (NPH). Chapters in this work cover the latest developments related to this condition. It introduces how to use a range of diagnostic modalities including magnetic resonance scanning along with how artificial intelligence and machine learning methodologies can be applied. Cases are presented to reinforce how the methods covered can be appropriately applied and guiding principles are also given to assist the reader in developing a thorough understanding of the topic. Potential complications and means of mitigating these are also described. Normal Pressure Hydrocephalus is a detailed practically applicable resource on NPH with insightful contributions covering relevant aspects of pathophysiology, diagnostic modalities and treatment strategies, making it an ideal resource for all medical practitioners whoencounter these patients.

This book is a collection of thoroughly well-researched studies presented at the Eighth Future Technologies Conference. This annual conference aims to seek submissions from the wide arena of studies like Computing, Communication, Machine Vision, Artificial Intelligence, Ambient Intelligence, Security, and e-Learning. With an impressive 490 paper submissions, FTC emerged as a hybrid event of unparalleled success, where visionary minds explored groundbreaking solutions to the most pressing challenges across diverse fields. These groundbreaking findings open a window for vital conversation on information technologies in our community especially to foster future collaboration with one another. We hope that the readers find this book interesting and inspiring and render their enthusiastic support toward it.

This book explores the molecular mechanisms of iron hemostasis in the brain and discusses the cognitive and behavioral implications of iron deficiency. It presents the effect of iron dysregulation on neurophysiological mechanisms. The book provides an overview of iron metabolism and homeostasis at the cellular level and its regulation at the mRNA translation level. It emphasizes the importance of iron for brain development in fetal and early life in preterm infants. Further, it presents iron metabolism as a therapeutic target for novel pharmacological treatment against neurodevelopmental diseases and neurodegenerative disorders. It discusses the role of iron deficiency in sleep disorders and offers diagnosis and treatment of iron-related CNS diseases. Finally, it relates dysregulated expression of iron-related genes in brain tumors. ​​

The goal of this book is to provide brief-but-comprehensive information that can aid in rapid differential diagnosis and allow for more thorough follow-up if needed. This guide is intended to fit easily into the pocket of a lab coat or on your desk, giving readers an efficient way to find information about a specific disease or disorder to prepare for an upcoming case. The book is divided into two parts: Part 1 involves general psychometric and reference information including score classifications, formulas for score conversion, likelihood chaining, and reliable change, psychometric data for stand-alone and embedded PVTs, and the effects of common medications on cognition. Part 2 of the book is organized alphabetically by disease or disorder to promote quick searching, and each chapter provides straightforward information including definitions, subtypes, etiology, epidemiology, course, diagnostic criteria, expectations for test results, and links to more comprehensive sources. Wheneverpossible, information is gathered through up-to-date literature and high quality pubilcations such as systematic reviews or meta-analyses. Helpful references are provided for more extensive follow-up or further reading.

This book discusses anger in psychology, its mechanisms, predisposing factors, precipitating factors, its impacts on brain structure. Anger in psychology is considered from two perspectives – function, and its impacts on physical health. This book is compiled of cutting-edge research, presenting anger in a new, modern and educational way. It presents a mathematical expression for the law of anger, allowing us to understand anger before it truly occurs and to control the anger to prevent its occurrence.The book is highly specialized with anger and considers various perspectives, such as race, historical origin and how these theories align with the modern psychology and neurosciences.

Tremor represents one of the most common movement disorders worldwide. It affects both sexes and may occur at any age. In most cases, tremor is disabling and causes social difficulties, resulting in poorer quality of life. Tremor is now recognized as a public health issue given the aging of the population. Tremor is a complex phenomenon that has attracted the attention of scientists from various disciplines. Tremor results from dynamic interactions between multiple synaptically coupled neuronal systems and the biomechanical, physical, and electrical properties of the external effectors. There have been major advances in our understanding of tremor pathogenesis these last three decades, thanks to new imaging techniques and genetic discoveries. Moreover, significant progress in computer technologies, developments of reliable and unobtrusive wearable sensors, improvements in miniaturization, and advances in signal processing have opened new perspectives for the accurate characterization and daily monitoring of tremor. New therapies are emerging. In this book, we provide an overview of tremor from pathogenesis to therapeutic aspects. We review the definitions, the classification of the varieties of tremor, and the contribution of central versus peripheral mechanisms. Neuroanatomical, neurophysiological, neurochemical, and pharmacological topics related to tremor are pointed out. Our goals are to explain the fundamental basis of tremor generation, to show the recent technological developments, especially in instrumentation, which are reshaping research and clinical practice, and to provide up-to-date information related to emerging therapies. The integrative transdisciplinary approach has been used, combining engineering and physiological principles to diagnose, monitor, and treat tremor. Guidelines for evaluation of tremor are explained. This book has been written for biomedical engineering students, engineers, researchers, medical students, biologists, neurologists, and biomedical professionals of any discipline looking for an updated and multidisciplinary overview of tremor. It can be used for biomedical courses. Table of Contents: Introduction / Anatomical Overview of the Central and Peripheral Nervous System / Physiology of the Nervous System / Characterization of Tremor / Prinipal Disorders Associated with Tremor / Quantification of Tremor / Mechanisms of Tremor / Treatments

This book reviews the role of glial cells (astrocytes, microglia, oligodendroglia, satellite cells, and Schwann cells) in neuronal health and diseases. It discusses the latest advances in understanding their origin, differentiation, and hemostasis. The book also examines the role of microglial cells in central nervous system (CNS) development, maintenance, and synaptic plasticity. Further, the book presents the functions of astrocytes in healthy CNS and their critical role in CNS disorders, including Parkinson's and Alzheimer's diseases. Notably, the book describes the pathobiology, molecular pathogenesis, stem cells, and imaging characteristics of gliomas. It defines the role of glial cells in regulating iron homeostasis and their effect on the neurodegeneration of neurons. Lastly, it covers the structure, function, and pathology of oligodendrocytes and their role in neuronal health and disease. ​

This book serves as a reference and comprehensive guide for PET/MR neuroimaging. The field of PET/MR is rapidly evolving, however, there is no standard resource summarizing the vast information and its potential applications. This book will guide neurological molecular imaging applications in both clinical practice and the research setting. Experts from multiple disciplines, including radiologists, researchers, and physicists, have collaborated to bring their knowledge and expertise together. Sections begin by covering general considerations, including public health and economic implications, the physics of PET/MR systems, an overview of hot lab and cyclotron, and radiotracers used in neurologic PET/MRI. There is then coverage of each major disease/systemic category, including dementia and neurodegenerative disease, epilepsy localization, brain tumors, inflammatory and infectious CNS disorders, head and neck imaging, as well as vascular hybrid imaging. Together, we have created a thorough, concise and up-to-date textbook in a unique, user-friendly format. This is an ideal guide for neuroradiologists, nuclear medicine specialists, medical physicists, clinical trainees and researchers.

This handbook is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments – to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model disease entities. Neuroprotection is approached in different manners including those 1) afforded by therapeutic agents – clinical and preclinical; or 2) by non-drug means, such as exercise. The amorphous term ‘neurotoxin'is discussed in terms of the possible eventuality of a neuroprotectant producing an outcome of excess neuronal survival and a behavioral spectrum that might produce a dysfunction – akin to a neurotoxin's effect. This new edition significantly expands on the information provided in the first edition, providing the latest research in neurotoxicity and highlighting the relationship between specificneurotoxins and the neurodegenerative disorders they can cause. It also includes new sections on the neurotoxicity of heavy metals, fungi, and snake venom. The Handbook of Neurotoxicity is thus an instructive and valuable guide towards understanding the role of neurotoxins/neurotoxicity in the expansive field of Neuroscience, and is an indispensable tool for laboratory investigators, neuroscientists, and clinical researchers.

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.This book series'Cell Biology and Translational Medicine (CBTMED)'as part of Springer Nature's longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 14th volume of a continuing series.

This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds. It is divided up into the three parts: Molecular aspects of KOR, Preclinical research on pharmacology of KOR agonists and antagonists in animals and KOR agonists and antagonists in clinical use and in past and present clinical trials.The chapters'Biosensors monitor ligand-selective effects at kappa opioid receptors'and'The role of dynorphin and the kappa opioid receptor in schizophrenia and major depressive disorder: a translational approach'of this book are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This new volume, a part of the Proteomics, Metabolomics, Interactomics and Systems Biology series, will explain how proteomic studies of post-translational modifications (PTMs) can be applied to neurodegenerative diseases and relevant studies. The goal of the book is to increase awareness among researchers about how PTMs may be helpful in understanding mechanisms in various neurodegenerative diseases through proteomic studies. This book will serve as a tool for those who want to begin work in the proteomics field and explore how to implement PTMs studies into their work. Chapter authors will describe different PTMs enrichment methods developed by experts in the field so that researchers may learn to apply these methods and techniques to new studies. Divided into three sections, chapters will cover sample preparation, data quality, enrichment techniques, guidelines on how to analyze PTMs, and explain the role of PTMs and different brain diseases. Among those topics includes will be brain cancer, SLA disease, Parkinsons disease, muscular dystrophies, and schizophrenia. This volume will be useful for researchers and students studying brain and neurodegenerative diseases who are interested in delving into work with proteomic studies and PTMs.

Under the name of Frontotemporal Dementias (FTD) numerous hereditary and sporadic disorders are listed. FTD may take away speech and language, social skills and ethical judgement, wishes and will, empathy and emotions; it may also impair motor functions. FTD may affect men and women in midlife or during old age leading to the demolition of the uniqueness of the human mind. In the last decade of the 20th century and in the first two decades of the 21st century, progress in the understanding of clinical, neuropathological, biochemical, and genetic aspects of FTD has accelerated. The novel awareness about FTD has directed young generations of researchers toward the study of this complex group of disorders. This Volume has been formulated with the participation of some of the leading scientists who have contributed to the development of knowledge in the clinical and basic science arenas. It captures the current central elements thatare relevant to an up-to-date understanding of causes and pathogenesis of multiple forms of FTD. The volume is an opus that represents a distillation of the work of many scientists and addresses the current directions in the study of one of the most complex groups of diseases. In view of its structure, the book could also be used as a textbook, that offers both a broad and deep analysis of major areas in FTD. This book, planned by the International Society for Frontotemporal Dementias, is distinctive as it opens a window to a wide landscape about the biology of FTD. Thus, the book represents a moment of reflection on the present state of our knowledge of FTD and a collective vision toward scientific progress. The authors of each chapter share their knowledge and vision aimed at reducing the suffering which is caused by FTD.

This book systematically introduces the Brain in Traditional Chinese Medicine (TCM) and its acupuncture treatments. It discusses the origin and development of the TCM Brain theory, and presents current research on brain and acupuncture, the unique brain related techniques such as scalp acupuncture and Dao-qi technique, the new developing acupuncture treatment methods for brain-related conditions, such as stroke, Parkinson's, dementia, Alzheimer's disease, multiple sclerosis, traumatic brain injury, autism, cerebral palsy and depression, anxiety, bipolar disorder among others. This book is of interest to TCM and acupuncture practitioners in the West, as well as acupuncture researchers and lecturers. It gives a new understanding of the brain and treatments for brain-related conditions from a complementary medicine point of view.

This book discusses the contemporary medico-social, psychological, legal, and therapeutic concerns related to people affected by dementia as a patient or as a caregiver. It provides global emerging responses to dementia. It highlights different dimensions of dementia in terms of issues, concerns, policies, and strategies all around the globe. The contributing authors present issues from cross-cultural education visible in dementia studies and discuss the power of music, art therapy, artistic collaborations, and many innovative practices in dealing with dementia. Written by international specialists from various disciplines, the chapters include challenges and emerging issues related to the role of family caregivers, the concern with vulnerability to elder abuse and neglect, and the role of technology in dementia care. The book provides a diverse perspective to dementia care not covered in such a broad way by any other books on the topic. This book is intended for academics from a wide range of fields such as sociology, geriatrics, community medicine, public health, clinical psychology, social work all of which, collectively, bear on the problem and the solutions for better dementia care.

This book is an invaluable resource for the diagnosis and management of neurological illnesses in the emergency setting. It emphasizes the quality of prognosis to be contingent on the prompt management of these illnesses.Emergency Neurology, Second Edition follows the exemplary format of the previous edition, with comprehensive chapters on every neurological emergency, including stroke, headache, back pain, dizziness, vertigo, syncope, visual loss, diplopia, facial nerve palsy, weakness, altered mental status, coma, meningitis and encephalitis, seizures, and spinal cord disorders. Chapters emphasize the clinical presentation, diagnostic studies and management, and include high-quality images and tables that are invaluable for rapid diagnosis and therapy.Building off its predecessor's success, Emergency Neurology, Second Edition is an excellent reference for neurologists, emergency room physicians, internists, neurology residents, emergency medicine residents, and internal medicine residents.

This book describes the range of technologies that have been developed for diagnosing and assessing Parkinson's disease patients. Also presenting the latest studies providing insights into the changes to the neural system in Parkinson's disease, it is a valuable resource for neurologists, general practitioners and nurses. Further, the book highlights areas that require more research, and as such will appeal to researchers, biomedical engineers and clinicians.

This book highlights the latest advances in the application of artificial intelligence and data science in health care and medicine. Featuring selected papers from the 2020 Health Intelligence Workshop, held as part of the Association for the Advancement of Artificial Intelligence (AAAI) Annual Conference, it offers an overview of the issues, challenges, and opportunities in the field, along with the latest research findings. Discussing a wide range of practical applications, it makes the emerging topics of digital health and explainable AI in health care and medicine accessible to a broad readership. The availability of explainable and interpretable models is a first step toward building a culture of transparency and accountability in health care. As such, this book provides information for scientists, researchers, students, industry professionals, public health agencies, and NGOs interested in the theory and practice of computational models of public and personalized health intelligence.

This book provides concrete scientific basis that we can conceive the possibility of modifying or even completely canceling aging process, despite the fact that aging is commonly regarded as the result of the overall effects of many uncontrollable degenerative phenomena. The authors illustrate in detail the mechanisms by which cells and the whole organism age. Actions by which it is possible, or will be possible within a limited time, to operate for modifying aging are also debated.The discussion is conducted within the frame and the concepts of evolutionary medicine, which is also indispensable for distinguishing between the manifestations of aging and: (i) diseases that worsen with age, and (ii) acceleration of normal aging rates, caused by unhealthy lifestyle habits and other avoidable factors. The book also discusses the impact of aging on overall mortality and the strange situation that, according to official statistics, aging does not exist as cause of death.This book is a turning point between a gerontology and geriatrics conceived as the study and vain treatment of an incurable condition and one in which these disciplines examine the how and why of a physiological phenomenon that can be modified up to a possible total control. This means transforming the medical prevention and treatment of physiological aging from the greatest failure to the greatest success of medicine.

This book constitutes the refereed proceedings of the 17th IFIP WG 12.5 International Conference on Artificial Intelligence Applications and Innovations, AIAI 2021, held virtually and in Hersonissos, Crete, Greece, in June 2021.The 50 full papers and 11 short papers presented were carefully reviewed and selected from 113 submissions. They cover a broad range of topics related to technical, legal, and ethical aspects of artificial intelligence systems and their applications and are organized in the following sections: adaptive modeling/ neuroscience; AI in biomedical applications; AI impacts/ big data; automated machine learning; autonomous agents; clustering; convolutional NN; data mining/ word counts; deep learning; fuzzy modeling; hyperdimensional computing; Internet of Things/ Internet of energy; machine learning; multi-agent systems; natural language; recommendation systems; sentiment analysis; and smart blockchain applications/ cybersecurity. Chapter “Improving the Flexibility of Production Scheduling in Flat Steel Production Through Standard and AI-based Approaches: Challenges and Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This comprehensive book addresses all elements of the autonomic nervous system (ANS) and sleep interaction, as well as ANS alterations in sleep and how these impact primary and comorbid sleep dysfunction. It meets the market need for a comprehensive text that deals with ANS changes in sleep and how these impact various neurological, medical, and primary sleep disorders. Organized into three parts, the book begins with a review of the foundational bodily systems that participate in coordination of ANS activity with other homeostatic responses such as respiration, cardiovascular reflexes, and responses to stress. Part two then examines methods of laboratory evaluation and the “why, when, how” of interpreting heart rate variability in sleep. To conclude, the final section of the book broadly covers the many clinical aspects of ANS, including insomnia, restless leg syndrome, sleep apnea, sleep related epilepsy, and acute autonomic neuropathy. Autonomic Nervous System and Sleep enhances the reader's understanding of the pathophysiology of various disorders, and explains how to apply this profound understanding is important to new lines of therapy to improve morbidity.

This book provides a comprehensive and practical guide to orthostatic hypotension (OH) for doctors and nurses involved in the care of older adults, together with a state-of-the-art update on OH, covering its epidemiology, pathophysiology, assessment, diagnosis, causes, prevention, management, and relevance for geriatric practice. In addition, it addresses mechanisms of orthostatic tolerance and other orthostasis related conditions, as well as drugs, comorbidities and geriatric syndromes related to OH. The homeostatic ability to maintain blood pressure while standing requires an adequate blood volume and the integrity of the nervous system, heart, blood vessels and muscle pump. However, in older adults, some age-related factors can contribute to the development of OH. For example, decreased baroreflex sensitivity, α-1-adrenergic vasoconstrictor response to sympathetic stimuli, parasympathetic activity, renal salt and water conservation, increased vascular stiffness and decreased ventricular diastolic filling, as well as concentrated capacities of the kidney may be associated with changes in postural blood pressure. It has also been shown that OH is associated with falls, cardiac events, heart failure, stroke, reduced quality of life, and increased risk of overall mortality in these patients. “Orthostatic Hypotension in Older Adults” will be of considerable interest to all professionals working in the fields of geriatrics, geriatric psychiatry, neurology, internal medicine, cardiology, and emergency medicine, or working with older people in hospitals or in their community.

This book provides a comprehensive overview of the use of PET and SPECT in not only classic neurodegenerative disorders but also cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders, and inflammatory and infectious diseases of the CNS. The new edition has been revised and updated to reflect recent advances and includes additional chapters, for example on the use of artificial intelligence and machine learning in imaging data analysis, the study of brain connectivity using PET and SPECT images, and the role of PET imaging in modulation of brain functioning by deep brain stimulation. The authors are renowned experts whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state of the art compendium will be invaluable for neurologists and radiologists/nuclear medicine specialists and will also be informative for interested general practitioners and geriatricians. Companion volumes on PET and SPECT in psychiatry and in neurobiological systems complete a trilogy.

The purpose of this book is to educate readers regarding the efficacy of cognitive rehabilitation across a variety of neurological conditions, with specific emphasis on rehabilitation-related change detectable via neuroimaging. For ease of reference, this information is divided into separate chapters by neurological condition, since the nature of cognitive impairment and mechanism of rehabilitation may differ across populations. Also included are discussions of the use of neuroimaging in cognitive rehabilitation trials, rigorous design of cognitive rehabilitation trials to have greater scientific impact (e.g., obtaining Class I evidence), and future directions for the field. As such, the book is designed to be useful to both clinicians and researchers involved in the rehabilitation of such conditions so that they can make informed decisions regarding evidence-based treatment to deploy in clinical settings or to further study in research endeavors.