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This is a great book to explore the science underlying the Food Biotechnology, which explores and presents current biotechnological advances and approaches to improving the nutritional value of modern-foods. Novel fermentation and enzyme technological processes, protein engineering, genetic engineering, metabolic engineering, bioengineering, quorum sensing and nanobiotechnology have been incorporated to fetch into new dimensions in current food biotechnology research and this book provides a deep insight on all these aspects as a comprehensive resource for anybody interested in all the types of foods, latest processing, preservation technology and safety. Written by leading scientists in the field, the book will be a valuable resource for students and researchers in the fields of food chemistry, nutritional science, taste physiology, and neuroscience, as well as for professionals in the food industry.

Patients with chronic visceral pain present a challenge for medical providers because of their vague presenting symptoms and frequent lack of identifiable pathology. Despite this, chronic visceral pain can be a debilitating medical condition that increases morbidity and decreases quality of life; the long-term consequences of which cause significant socioeconomic burden and debility. Covering the newest trends, studies, diagnosis and treatments in visceral pain care, as well as the pain treatment strategies that have been successfully employed in the past, this book brings readers fully up to date with effective recognitions and treatments for visceral pain. The clinical evaluation and presentation of common chronic visceral pain conditions and multimodal treatment options that can be used to assist patients and providers are focused.

The Plant-based and Vegan Handbook is the first of its kind to bring together interlocking – and sometimes conflicting – perspectives focused on veganism and plant-based living. As an interdisciplinary volume the noted contributors are from the fields of medicine, psychiatry, environmental studies, sociology, marine ecology, philosophy, agriculture, psychology, animal studies, religion, economics, literature, business, and law. Despite a range of individual preferences, these authors advance a scientific argument for a societal move away from the current model of human and nonhuman animal relationships. In our Anthropocene era experts not only debate about how human beings will, survive on Earth, but more particularly are more concerned with how they will thrive. As evidenced by the authors in this collection, it will involve a reconsideration of the way our species relates to the planet and to other species. This volume can serve as a critical reference work, especially for students and scholars working in both emerging and established fields such as psychology, medicine, animal studies, food studies, environmental studies, philosophy, animal ethics, and marine ecology.

This book provides an in-depth exploration of microbial biodiversity and its crucial role in diverse biotechnological and industrial sectors. It covers topics such as the integration of molecular approaches for identifying industrially significant strains, omics roles in the production of bioproducts, and modern genetic engineering techniques. It discusses biostatistical investigations and the impact of microbial biotechnology on healthcare and emerging contaminants. It highlights the significance of food microbiology, fermentation, and the latest technologies in improving human health. Additionally, the book delves into emerging trends in oligosaccharide production, biobased approaches for a sustainable future, and the importance of microbial biomolecules and secondary metabolites. It also explores the identification and production of industrially significant biocatalysts/enzymes, the valorization of agro-industrial waste using microorganisms for green energy generation, and the development of bioreactor systems for the biobased economy. The book covers advancements in solid-gaseous biofuels production, impact assessment of synthetic microfiber pollution, sustainable management strategies for waste management, and the impact of emerging technologies in medical microbiology. The book also discusses the development of healthcare products using nano-biotechnological advancements, the impact of novel remediation technology, and the utilization of microbial products in biomaterial development. It further explores microbial regulatory systems, gene expression studies, and the significance of mutations in microbial technology. This book serves as a great reference for researchers, environmentalists, microbiologists, biotechnologists, and graduate, post-graduate students, and doctoral students working on microbial biotechnology and industrial microbiology.

This dictionary of toxicology provides curated and authentic information on the terminologies used with their description as per modern toxicology and associated declines. It aims to have a collection of over 3500 terminologies with their basic information and roles with relevance in toxicology and associated disciplines in alphabetical order. This book has a flow of information in alphabetical order starting from word A to Z. The contents cover all the possible facets of contemporary. It is an unparalleled reservoir of information with a practical understanding of the subject for undergraduates, post-graduate, doctorate and post-doctorate, researchers of toxicology, medical and dental sciences, veterinary sciences, pharmacy sciences, life sciences, forensic sciences, etc. Besides this, target readers would also be personnel working in academia, pharma industries, contract research organizations involved in regulatory studies, regulatory agencies and implementing agencies, and people having an interest in toxicological sciences.

Textbook of Industrial Microbiology is a groundbreaking book encompassing the entire spectrum of industrial microbiology, filling a significant void in the field. From tracing its historical roots to exploring primary and secondary metabolites, down to downstream processing and product recovery, this book offers a cohesive narrative previously unavailable in a single resource. The meticulously structured chapters discuss the systematic journey of metabolites, covering the screening of microorganisms, preservation techniques, fermentation media, fermenters, and the significance of industrially vital secondary metabolites. It provides insights for industrialists, elucidating crucial process parameters essential for comprehending and optimizing microbial processes. This textbook serves as a great resource for undergraduate, and postgraduate students, researchers, industrialists, and technologists

Traditional foods can be defined as foods that have been consumed for several generations by a specific community in a particular locality, region or country. Many of these plant- and animal-based foods have traditionally been consumed for generations in different corners of the world, without proper understanding or knowledge of their beneficial properties. Apart from the basic nutritional attributes provided by these foods, they contribute to the prevention of several diseases, including hypertension, hyperglycemia and gastrointestinal disorders. The way traditional foods are prepared also plays a key role in naturally preserving the therapeutic potential of the food ingredients. In the present age of globalization, where food habits and food preferences are constantly being challenged, the reinvention of the therapeutic potential of traditional foods can provide a viable alternative. Measures have been initiated to gain an understanding of the beneficial attributes of traditional foods. Traditional Foods: The Reinvented Superfoods focuses on the health benefits of traditional foods in the light of recent evidence. This book also presents a fundamental overview of food-based therapy and the traditional methods that contribute to the preservation of the nutraceutical properties of food ingredients. This text comprehensively presents the background, history and prospects of traditional foods for a broad range of readers, presenting a balanced understanding of the present knowledge and technical advances in the field of traditional foods. Readers will find photographs of all the major traditional foods, along with illustrative schemes and sketches highlighting their preparation and future commercialization strategies.

This open access book examines a rapidly'datafied'society, reminding us that it is crucial to know what data is about and where it originates. This insight has led to an embryonic stage of new theorizing, empirical research, and the formation of new technologies, standards, practices, and concepts to ensure the availability of adequate'paradata'– data on the making and processing of data. This edited volume aims to provide a cross-disciplinary overview of perspectives on the concept and phenomenon of paradata and its implications for research and practice.

This book is a comprehensive guide on microbiome research, from the fundamentals of to the latest advancements in microbiome-based therapeutics. The initial chapters introduce the concept of the human microbiome delving into the intricate relationship between the human host and its microbiome. The chapter also examines the various tools and techniques used in microbiome research and the role of computational biology in analyzing vast amounts of microbiome data. The subsequent chapters review the role of the microbiome in various health conditions, including metabolic disorders, immunological disorders, gastrointestinal tract disorders, management of cancers, metabolic disorders, and mental health disorders. Towards the end, the book examines the regulatory considerations surrounding microbiome-based therapeutics, and ethical considerations surrounding microbiome-based therapeutics. This book is a comprehensive and cutting-edge guide for researchers, healthcare professionals, and students interested in the field of microbiome research and its potential for transforming healthcare.

The book delves into the multifaceted world of migraine pain, offering a profound understanding of its underlying pathophysiology and presenting established treatment strategies for its effective management. It discusses the intricate world of migraine pain, offering valuable insights into its diverse aspects. Starting with an exploration of migraine's epidemiology and etiology and the complex factors contributing to this debilitating headache disorder. This book explores the significance of lifestyle changes and offers practical strategies for incorporation. Furthermore, the impact of diet and nutrients on migraine management is extensively covered, shedding light on their role in alleviating symptoms. This book serves as a comprehensive guide, blending scientific insights with practical approaches, making it an indispensable resource for healthcare professionals, researchers, and individuals seeking a deeper understanding of migraine pain. By addressing both established practices and cutting-edge advancements, it bridges the gap between knowledge and effective management, offering a holistic perspective on this challenging condition.

The book aims to be a handy compendium to the very voluminous texts of gastroenterology and hepatology existing in the knowledge market and provides the reader with an easy understanding of the bench knowledge (basic sciences) as they apply to bedside practice (clinical gastroenterology). With introduction and contributions from Prof Eamon Quigley, Former president of World Gastroenterology Organization and American College of Gastroenterology, the book covers the recent advances in the basic sciences that form an important pillar of the knowledge, thereby linking basic sciences such as anatomy, physiology, biochemistry, molecular medicine, etc. to clinical conditions, diseases and new therapeutic approaches in gastroenterology and hepatology. The book is written in a simple easy to read format, with a lot of diagrams and flowcharts, making it a handy guide. It also discusses in-depth about very common clinical conditions encountered in hospital settings such as ulcerative colitis, pseudomembranous colitis, colonic cancer, amebiasis, and various other syndromes and diseases. This book is a useful read for fellows and trainees in Gastroenterology and Hepatology, as well as gastroenterologists, hepatologists and physicians interested in digestive disorders.

This Volume 1 of a two-volume work provides an up-to-date overview of the latest advances in live biotherapeutics research. It focuses on key areas within probiotics and microbiome studies from the veterinary sciences including their translation into commercial applications. The book is divided into three sections, comprising (I) fundamentals about probiotic resources, (II) probiotics for veterinary health, with chapters on farm animals, pets, wildlife and aquaculture, and (III) industrial applications of probiotics. The broad spectrum of industry-relevant contributions makes this work a valuable resource for industry professionals as well as researchers in functional feed and food biotechnology, applied veterinary microbiology and gastroenterology. Presenting novel and evidence-based research, this volume will drive the commercial enterprise and meets the great demand for good probiotic products in the veterinary medical sector.

This fully updated second edition demonstrates the major impact that the gut microbiota has on human gastrointestinal health, with a special focus on children. The book also explores the potential use of probiotic microorganisms to protect or improve gastrointestinal health in children. Humans are not a single organism: We are a multi-organic structure composed of ourselves and our microbiota, living in close symbiosis since birth and even before. The enormous impact that the billions of microscopic cells in our gut have on our gastrointestinal and systemic health cannot be overstated. The tremendous progress that has been made in the last decade in our still very incomplete understanding of the gut microbiota opens the door to potential applications in human health that were simply unthinkable before. One of the most interesting aspects of this new scientific horizon is the fact that we can identify (or even create in the lab) many of these'friendly bacteria'and use themto protect or improve our health. Thus, strains of probiotic microorganisms are being identified and studied in a variety of clinical scenarios. One of the most studied areas for probiotics is pediatric gastrointestinal health. Topics covered in this book range from the development of the intestinal microbiota in the fetus and neonate to current and potential applications in various conditions such as necrotizing enterocolitis or infectious or inflammatory diseases of the child. Written by an international group of preeminent experts in these fields in a rigorous, evidence-based manner, the book is intended for pediatric gastroenterologists, pediatricians, and medical scientists alike.

The book provides an introduction to the differential diagnosis and decision-making in pediatric rheumatological diseases through typical and real cases. One of the aspects in the discussion of various case scenarios is the avoidance of errors and error management. The casebook is useful for specialists and trainees in pediatrics, young doctors, and anyone on the path to specialization in pediatric rheumatology.The translation was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content.

This textbook for graduate veterinary students provides basic concepts of veterinary immunopathology with particular reference to immunopathogenesis. The initial chapters provide up-to-date knowledge on important aspects of immunology, immunodeficiency disorders, hypersensitivity reactions, and autoimmune disorders of various animal species. The book examines different natural and synthetic immunomodulatory products that can modulate the immune system of animals. It discusses the immunopathogenesis and immunopathology of multiple diseases and immunopathological disorders in diverse animal species, including cattle, buffalo, sheep, goat, swine, equine, and laboratory animals. The book also covers the immunopathology of various body systems, including lungs, reproductive system, enteric system, mammary gland, joints, kidneys, and skin. It provides clinical manifestations that are useful in diagnosing immunopathological conditions. The book presents a highly informative text with highquality gross and microscopic photographs, diagrammatic presentations of immunopathological disorders and techniques, making it useful in both classrooms and professional training courses for students, researchers, and professionals alike.

Ten years have elapsed since the printing of the second edition of this book. Since then there's been a veritable explosion of information coming mainly from the field of molecular diagnostics, which bear particular importance in the classification and treatment of Infantile enteropathies, disorders associated with immunodeficiencies, the classification of intestinal polyps and polyposis syndromes in childhood, cholestatic and metabolic disorders of childhood, liver tumors and transplantation pathology, all of which were major subjects explored in our previous editions. In this updated third edition, most of the chapters have been extensively revised to incorporate updated understanding in pathogenesis and terminology. For example, the widespread use of genetic panels and next generation sequencing in the diagnosis of cholestatic disorders of infancy and childhood, not widely available when the last edition was being prepared, prompted the writing of an entirely new chapter reflecting these advances by a new set of authors. Similarly, progress in diagnosis and classification of liver tumors justified an entirely new chapter on liver tumors that incorporates newer patient stratification in treatment protocols and reflects the new WHO classification of liver tumors. Pathology of Pediatric Gastrointestinal and Liver Disease 3rd Edition provides the pediatric pathologist, the GI or general pathologist, and the pediatric gastroenterologist with the most complete and current reference on the subject. It includes in-depth discussions on disorders and issues that are frequently encountered but for which up-to-date information is often not readily available, as well as infrequent disorders unique or specific to children that are not covered in standard texts.

This reference book discusses the role of synbiotics in a wide range of disease states, including cardiovascular, reproductive, metabolic, neurodegenerative, gastrointestinal, thrombotic, skin, and inflammatory disorders. It reviews the functions of probiotics in the diagnosis, prevention, or treatment of various disease states. The book further covers improving the targeting efficiency of synbiotics through advanced drug delivery systems such as nanoparticles, microparticles, liposomes, microemulsion, solid lipid nanoparticles, and nano lipid carriers. The chapter addresses the implications of oral and topical delivery of synbiotics in different diseases and presents the safety assessment of synbiotics and clinical trials associated with synbiotics containing drug delivery systems for the treatment of diseases. The book also explores the synergistic welfare of synbiotics nutraceuticals in various conditions such as chronic respiratory diseases, gut health, and neurological functions and examines the toxicological profile, and regulatory aspects of nutraceutical supplements. As such, this book is a valuable resource for academics, research and industry professionals working in Pharmaceutical Sciences, Food Biotechnology, Immunology, and Health Sciences.​

This book focuses on novel technologies related to food processing technology and engineering. It also focuses on food safety, quality and management, the scope of the Internet of Things (IoT) in food processing and its management, bioengineering tools for crop improvement in agriculture, recent innovations in food packaging, nanotechnology in food processing, and the nutritional health benefits of food. 3D printed food, an interesting and increasingly popular concept among the public today, is a meal prepared through an automated additive process using 3D food printers. This book is a ready reference for food researchers, students, and industry professionals. The book updates the current scenario of food processing technology and engineering for readers from agriculture and its allied fields including students and researchers of food science and technology, dairy science and technology, packaging industry, people working in food safety organisations, and researchers in the field of nanotechnology.

This textbook for undergraduate students aims at providing an in-depth understanding of the relationship between diet, nutrients, health, diseases, and drug treatment. The book presents a comprehensive but detailed view of the field of Nutritional Biochemistry; balancing the historical with contemporary findings, the descriptive with the experimental, structure with function as well as the mechanistic and the clinical aspects of any particular nutrient. Though the major emphasis of the book is on Nutritional Biochemistry, the book also attempts to provide an insight into other related and relevant areas. Amongst the topics that are covered are: nutraceuticals, food, and nutrient interactions; the newly emerging field of the human microbiome, its interdependence on diet and human health as well as the public health concerns which is a looming burden of non-communicable diseases. Each chapter begins with an insight into the history of discovery and structure of the nutrient, its absorption, and metabolism, physiological functions, ending with diseases associated with nutrient deficiency/toxicity along with a clinical perspective. Apart from this, the book emphasizes the biochemical basis of physiological responses and correlates the same with symptoms identifying the pathophysiology. This textbook caters to students of undergraduate courses like Biochemistry, Biomedical Sciences, Biological Sciences, Life Sciences, Home Science; Nutrition and Dietetics, Clinical Nutrition and Dietetics, and Nursing. ​

This is the second and fully updated edition of the successful volume on intestinal failure in adults and children. The book provides a comprehensive coverage of all aspects of intestinal failure: from acute and chronic intestinal failure management and treatment, to outcomes, consequences and problems of treatment. In addition, 20 new chapters have been added, covering acute and chronic pancreatitis, critical care and abdominal pain among other topics. Each of the chapters contains a section with top tips on the topic, summarizing the essential take-home messages. Highly educational, this book is a must have for gastroenterologists but is of use for all members of a hospital nutrition support team including nurses, dietitians and pharmacists, whom it will serve as a practical guide for management of intestinal failure both in the hospital and in an outpatient setting. Written by a multidisciplinary author team, this book brings this important subject to a wide readership. With extensive referencing the book provides a detailed overview of the topic, discussing the latest research in the subject and how this relates to current clinical practice and potential future treatments.

This textbook explores the fundamental qualitative and quantitative aspects of veterinary physiology. It presents the morphological description of the organs, tissues, and cells involved in the physiological system with species variation. The book provide the most up-to-date information and in depth knowledge in animal physiology. The book addresses a broad range of topics, including the physiology of digestion in, monogastric animals, ruminants, and birds, and cardio vascular and respiratory system in different animals. The chapters contain a wealth of information on the areas related to the endocrine system, excretory system, body fluid homeostasis, hematology, male and female reproductive systems, coordination of body functions, and regulation of brain functions and sense organs. Further, this book acquaints students with advanced topics like immune system, assisted reproductive technology, ovarian dynamics, environmental physiology and thermoregulation, and behavioral physiology. This textbook contains clear illustrations including graphical abstracts and study questions for each chaptermaking this book a valuable learning resource for veterinary sciences and veterinary medicine students.Further to attract students and create interest in them, interesting facts related to animal physiology have also been highlighted in form of “Know more widges”.​

​Das Buch gibt anhand typischer und realer Fälle eine Einführung in die Differenzialdiagnostik und Entscheidungsfindung bei pädiatrisch-rheumatologischen Erkrankungen. Ein Aspekt bei der Diskussion unterschiedlicher Fallszenarien ist die Vermeidung von Fehlern und das Fehlermanagement. Das Fallbuch ist nützlich für Fachärzte und Fachärztinnen in Weiterbildung zur Pädiatrie, junge Fachärztinnen und Fachärzte und alle, die sich auf dem Weg zur Spezialisierung in der pädiatrischen Rheumatologie befinden.

This third edition brings together the latest in research and clinical practice of the expanding field of pediatric neurogastroenterology. In addition to a comprehensive review of the current state of the art, many chapters have been significant revised and updated, covering the latest discoveries of the delicate and detailed mechanisms of the neuroenteric system as well as relationships of the latter with microbiota and metabolites produced by resident intestinal bacteria. The book also covers rapidly-changing techniques to assess clinical problems, along with international diagnostic criteria and recommendations and guidelines for clinical management. The content is supported by ample figures, photographs and selected video segments.Remaining the gold standard text in this up-and-coming field, Pediatric Neurogastroenterology 3e is dedicated to reporting the most accurate and recent knowledge available. Written by international experts in the field, the bookis a comprehensive and up-to-date theoretical review and practical guide to pediatric gastrointestinal motility and functional disorders to pediatricians, pediatric gastroenterologists and all professionals involved in the treatment of children with such disorders.

This book is a comprehensive reference guide for team physicians to manage common or rare clinical issues that may occur on the sidelines and field of play in recreational, professional or elite sports. Musculoskeletal injuries and health-related clinical issues that may occur on the field of play can directly impact the ability of athletes to safely participate in sport. Indeed, the ability to urgently respond to the myriad of health-related issues is critical during both sideline and event coverage. The variety of challenges may be more prevalent according to the type of sport, the athletes'physical condition, the field of play, the level of competition, as well as the environmental conditions. Initial assessment, proper investigation of athletes'clinical complaints and findings, followed by a well-practiced intervention protocol play an essential role in optimizing the outcome of each case. Written by an international team of experts, and published in partnership with ISAKOS, this book is an excellent source of knowledge for sports physicians, orthopedists and physiotherapists alike.

The book offers a comprehensive and didactic overview of both advanced diagnostic and therapeutic endoscopy imaging techniques, with a clinical impact correspondent in major gastroenterology, hepatology, and pancreatology diseases.It includes state-of-the art techniques like endoscopic ultrasound and confocal laser endomicroscopy, as well as endoscopic retrograde cholangio-pancreatography. Divided into 9 main chapters, the book covers the examination techniques, the sedation and monitoring, and investigates the clinical impact of endoscopy. Specific chapters are dedicated to the upper gastrointestinal tract, the lower gastrointestinal tract, to pancreatico-biliary diseases and to liver diseases. Enriched by more than 400 original images based on 25 years'experience in the field of advanced endoscopy imaging, and accompanied by carefully selected videos, this volume will be a reference guide for residents and trainees in gastroenterology, hepatology, pancreatology,and surgery, with emphasis on endoscopy techniques.

This book focuses on the exploitation of whey through the extensive analysis of its molecular composition. Whey can provide various valuable compounds such as lactose, proteins and peptides. The book covers the biotechnological treatments of whey using biochemical and enzymatic treatment and microbial transformation, various high value products such as bioethanol, glycerol, Bioplastics (PLA), bacteriocins, exopolysaccharides, bacterial polysaccharides (PHA, PHB, Xanthan), single cell proteins, probiotics, bioactive peptides, organic acids (lactic, butyric, acetic acid), enzymes and biogas using microbial conversion of whey. The book also covers the use of whey for the preparation of different food products such as whey powder, condensed whey, spreads and various whey-based beverages including fermented beverages. Recent trends, opportunities and challenges in functional carbonated whey-based beverages are also discussed. Unlike the existing literature describing whey utilization, this book focuses on valorization, technological advancement and sustainable biotransformation of whey. The book also deals with membrane processing, sustainable approaches, biotechnological potential, green technologies and production of bioplastics. In addition, the book provides theoretical and practical information to present the various aspects of valorization of whey as a by-product. This book is a need of the hour for its eco-friendly approach. Whey Valorization: Innovations, Technological Advancements and Sustainable Exploitation will be a great resource for researchers, dairy technologists, food technologists, students and professionals working on sustainable and effective utilization of food as well as dairy wastes and by-products.

This book builds upon the first edition with new and improved chapters. The book explores the rich assemblage of clinical wisdom from expert rheumatologists from a wide range of specialties including Vasculitis and Sjogren's syndrome. It examines the nuggets or ‘pearls'of wisdom gained from collective clinical experience about the diagnosis or treatment of various diseases whilst also aiming to debunk myths that have influenced the practice of rheumatology by many clinicians. The second edition of A Clinician's Pearls and Myths in Rheumatology is a critical resource for both practitioners and students of rheumatology. This book provides a clear guide for those wishing to take a “deep dive” into the diagnostic and therapeutic elements of rheumatology.

Bioactive ingredients, including both bioactive compounds and bioactive live organisms, are present in small amounts in natural sources such as fruits and vegetables. These ingredients have been continuously investigated during the last few decades and the epidemiological data suggest that their intake is associated with significant decreased risk of various disorders and chronic diseases owing to their anti-oxidant, anti-bacterial and anti-inflammatory qualities. Some of these natural ingredients such as catechins, curcumin, resveratrol, oleuropein, quercetin, rutin, hesperidin, sulforaphane, ellagic acid, and anthocyanins, have been studied as factors with possible direct or indirect effect on specific molecular pathways which are playing vital roles in the association with the pathophysiology of the chronic diseases such as cancer. In light of this, natural foods and food-derived products rich in bioactives have received recent growing attention. It has been reported that frequent consumption of fruits, vegetables, and their associated natural products have many health-promoting benefits that protect against degenerative illnesses including heart disease, arthritis, cancer, immune system decline, brain dysfunction, inflammation and cataracts. Functional foods and medicinal supplements containing encapsulated bioactive materials will be the future of new emerging products in the food and pharma industries. Such products present therapeutical and medicinal properties that can prevent and/or cure specific chronic diseases and disorders. Handbook Of Bioactive Ingredients provides a systematic overview of different food bioactive ingredients describing their chemistry, structure, functionality, safety/toxicity, oral delivery and their applications in functional foods. Detailed chapters will describe various bioactive ingredients including polyphenolic compounds such as phenolic acids, flavonoids and anthocyanins, carotenoids, sterols such as non-oxygenated carotenoids, xanthophylls and phytosterols, bioactive peptides such as marine bioactive peptides, animal bioactive peptides, plant bioactive peptides, microbial bioactive peptides, essential fatty acids like fish and marine oils and plant oils, live organisms like probiotics and yeasts, essential oils and oleoresins like monoterpens, sequiterpens and oleoresins, vitamins and minerals including liposoluble vitamins, hydrosoluble vitamins and trace minerals), and other bioactive compounds including prebiotics, oligosaccharides, dietary fibers and beta-glucan. This book is the first comprehensive collection of scientific evidence form published literature on natural bioactive ingredients.

This Open access book provides a survey of the economic, health, and somatic progress of Baltic countries during the period 1918–2018, framed by the outline of the historical-sociological theory of modern social restorations, as originally conceived by the Austrian-American comparative historian Robert A. Kann. The author reworks Kann's theory to analyse post-communist transformations in the Baltic region. The book argues that the purpose of modern social restorations is to make restoration societies safe against a recurrence of revolution. There were two waves of modern social restorations: post-Napoleonic and post-communist. Most post-Napoleonic restorations were brief, because they failed to economically and socially outperform the pre-revolutionary and post-revolutionary systems. It considers Baltic restorations as laboratory cases of second-wave modern social restorations, because they encompass a triple restoration of the nation-state, capitalism, and democracy. The bookassesses the performance success of Baltic restorations by comparing economic and social progress of Baltic countries during the periods of original independence (1918–1940), foreign-imposed state socialism (1940–1990), and restored independence (since 1990). It then elaborates the criteria to assess the ultimate performance success of these restorations by 2040, when restored Baltic states may endure longer than their ancestors in 1918–1940 and the complete foreign occupations era (1940–1990). The author, an expert in historical sociology, uses extensive historical-statistical data in cross-time comparisons to develop his analysis and create future projections. This book is of wide interest to sociologists, social demographers, political scientists, and economists studying the Baltic region. This is an open access book.

This book reviews all important aspects of Microbial sustainability in food production and food safety with the aim of shedding new light on these microbes through combined understanding of traditional and novel paradigms. The book is divided into three sections, the first of which reinterprets fundamentals of food microbiology, examining the beneficial aspects of microorganisms in food and microbial responses from food environments and preservation. The second section discusses recent advances in understanding of the sustainable food production, covering, for example, agriculturally important microbes, farming microbes, and fermentation. A wide range of bio-factory issues in food production are also addressed, before turning attention to contemporary food safety approaches in the context of novel assessment methods for microbiological food characterization, improving food safety and food quality, etc. The final section is devoted to public health and its importance of microorganisms in food processing as well as the economic importance of microorganisms as this is also an increasingly important area as we move toward microbial research advances.

This book covers the recent trends on the biological applications of nanomaterials, methods for their preparation, and techniques for their characterization. Further, the book examines the fundamentals of nanotoxicity, methods to assess the toxicity of engineered nanomaterials, approaches to reduce toxicity during synthesis. It also provides an overview of the state of the art in the application of Artificial intelligence-based methodologies for evaluation of toxicity of drugs and nanoparticles. The book further discusses nanocarrier design, routes of various nanoparticle administration, nano based drug delivery systems, and the toxicity challenges associated with each drug delivery method. It presents the latest advances in the interaction of nanoparticles with the cellular environment and assess nanotoxicity of these engineered nanoparticles. The book also explores the comparative and mechanistic genotoxicity assessment of the nanomaterials. This book is useful source of informationfor industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, and drugs.

The latest edition of this essential text provides a comprehensive overview of the unique pediatric issues of inflammatory bowel disease. Through new and thoroughly revised chapters, the volume features updates on all aspects of etiology, diagnosis, and treatment, with an emphasis on recent understanding of pharmacokinetics and the utilization of cutting edge therapeutic monitoring to maximize efficacy of medical management. The new edition also highlights newer, recently approved drugs, emerging therapies, and the most recent recommendations regarding post-operative management for patients who ultimately require surgery. Written by experts in the field, Pediatric Inflammatory Bowel Disease, Fourth Edition is a valuable resource for both pediatric and adult gastroenterologists involved in the care of children with inflammatory bowel disease.

This book provides an overview of the metabolism of dietary compounds by the intestinal microbiota, and on the consequences of such metabolic activity on host metabolism and physiological functions; both in intestinal and peripheral tissues.Over the last years, our understanding of the causal links between microbiota metabolic activity towards dietary and endogenous substrates and human health status has evolved extensively. In this context, the book starts with a comprehensive introduction devoted to the physiological and metabolic functions of the intestinal epithelium, followed by a part dedicated to the way intestine offers board and lodging for microbes being on a short- or long-term stay. The next chapters focus on the utilization of the available substrates from diet by the intestinal bacteria to produce numerous bacterial metabolites, and on the impact of such microbial activity, in the first place for communication between microbes, and for communication between microbes and lodging host. As will be detailed, this latter process of interkingdom communication leads to either beneficial or deleterious effects on intestinal physiology and metabolism. Special attention is given to selected pathophysiological processes namely chronic intestinal inflammation, colorectal carcinogenesis, and diarrhea. Then, the effects of modifications of bacterial metabolites and other bioactive compounds by the host after intestinal absorption, and consequences for peripheral tissue functions are presented.Summarizing the state of the art on what is known about the metabolic crosstalk between gut microbiota and human metabolism, as well as perspectives for further experimental and clinical research, this book provides a useful resource for researchers, professionals, and students with a background in biology, and/or nutrition, medicine, pharmacology, and for those which are involved in the agriculture and food production. By explaining technical terms all along the text, this book should be understandable also for interested non-specialists.

Since the publication of the 7th edition of this book, there has been a remarkable increase in information in several clinical areas, including cardiology, immunology and oncology. This rapid knowledge expansion has led to practice changes for family physicians and other primary care providers. Patients are now discharged from tertiary care hospitals to their home communities with life sustaining left ventricular assist “heart pumps”. Hepatitis C, once an incurable illness, is now routinely cured. Oncology treatment regimens are increasingly becoming ambulatory and individualized. The decreased cost and increasing availability of health monitoring devices will make it possible for physicians to remotely check on the health status of their patients in their homes. With the ongoing and worsening shortage of family physicians across the US, the practice model for family medicine in the future may tend toward a family physician supervising a cast of mid-level providers as they care for a panel of patients, versus the physician providing the majority of care. All of these changes will require practice pattern changes and a need for up to date sources of information for the family physician. In addition, the “family” of family medicine academic organizations is undertaking a major review of the practice, training, funding and evaluation of all aspects of family medicine. Eight family medicine organizations have launched the “Family Medicine for America's Health” (FMAHealth) with the expressed purpose “to strategically align work to improve practice models, payment, technology, workforce and education, and research to support the triple aim”. This project has moved past the study phase and will soon move to the implementation phased. This book is organized into short, focused chapters almost exclusively dedicated to topics relevant to daily practice. All lead authors are themselves accomplished family physicianswho can specifically address the needs, concerns, and interests of this crucial profession. As one of the key reference textbooks for family medicine, it is very important to provide the most up-to-date knowledge to support learners and practitioners of family medicine in the face of rapidly expanding clinical knowledge and the extensive self-examination of family medicine. Family Medicine: Principles and Practice, 8th Edition, is a must-have reference for medical students, residents, practicing physicians, nurse practitioners and physician assistants with an active role in patient care.

This 7th edition is a milestone in the series of Inborn Metabolic Diseases (IMD), recognised as the standard textbook for professionals involved in the diagnosis and management of IMD.Within the last 5 years a Copernican revolution in our understanding of IMD has changed the definition, concepts, paradigms, and classification. This new edition now extends the concept of IMD to include those disturbances in molecular machinery diagnosed by molecular techniques but currently without measurable metabolic markers.The book presents a clinical and biochemical approach to the diagnosis and management of IEM with many diagnostic algorithms for patients of all ages and with a particular focus on neurological presentations. It includes separate, comprehensive sections on IEM classified in 3 major pathophysiological categories: disorders of energy metabolism, both mitochondrial and non-mitochondrial; small molecule disorders, mostly diagnosed with metabolic markers; and complex molecules disorders, mostly diagnosed with molecular techniques.Two new chapters were added, describing around 600 disorders of nucleic acid metabolism, tRNA metabolism, ribosomal biogenesis, and cellular trafficking.

The Advanced Dairy Chemistry series was first published in four volumes in the 1980s (under the title Developments in Dairy Chemistry) and revised in three volumes in the late 1990s and again in the 2000s and 2010s. For nearly four decades, the series has been the leading reference source on dairy chemistry and is now in its fourth edition. Advanced Dairy Chemistry Volume 3: Lactose, Water, Salts, and Minor Constituents, fourth edition, reviews the extensive literature on lactose and its significance in milk products. This volume also reviews the literature on milk salts, vitamins, and the behaviour of water in dairy products and the physical properties of milk. Most topics covered in the third edition are retained in the current edition, which has been updated and expanded considerably. New chapters cover chemically and enzymatically prepared derivatives of lactose and oligosaccharides indigenous to milk and some chapters from earlier editions are consolidated.

This book provides an overview of bidirectional communication between gut-microbiome-brain, pathways, nutrients, and metabolites that are involved in microbiota gut-brain axis (MGBA) interactions. Further it reviews the relevance of this axis in the neurological disorders and potential therapeutic interventions, involving gut microbiome or probiotics and prebiotics which can ameliorate the neurological disorders. The book examines the role of gut microbiota in the establishment and hemostasis of innate immune response and explores the possibility of development of microbiome-targeted therapeutic interventions. Notably, the book discusses the role of the gut microbiota and immune system on the maintenance of brain functions and the development of neurological disorders. It also highlights the recent advances in improving neurological diseases by phytochemicals, prebiotics and probiotics. This book is useful for researchers working in neuropharmacology, Clinical Research, toxicology, neurodegeneration, and stroke biology.

This encyclopedia, representing one of the most multi-disciplinary areas of research, is a comprehensive examination of the key areas in animal cognition and behavior. It will serve as a complementary resource to the handbooks and journals that have emerged in the last decade on this topic, and will be a useful resource for student and researcher alike. With comprehensive coverage of this field, key concepts will be explored. These include social cognition, prey and predator detection, habitat selection, mating and parenting, development, genetics, physiology, memory, learning and perception. Attention is also given to animal-human co-evolution and interaction, and animal welfare. All entries are under the purview of acknowledged experts in the field.

This book covers all aspects of small intestinal disease with the aim of providing an up-to-date reference of the highest quality that will assist in everyday clinical practice. After introductory chapters on anatomy, pathophysiology, epidemiology, and signs and symptoms, the roles of different imaging modalities in the diagnosis of small intestinal disease are clearly explained, focusing particularly on capsule endoscopy, device-assisted enteroscopy, CT and MR enterography, and nuclear medicine techniques. A series of chapters then address each of the diseases and conditions that may be encountered. The coverage is wide ranging, including, for example, obscure gastrointestinal bleeding, Crohn's disease and other inflammatory conditions, celiac disease, Behçet's disease, Meckel's diverticulum, intestinal tuberculosis, and various malignancies. Numerous informative clinical cases are presented to identify characteristic imaging findings and assist in treatment decision making. Small intestinal disease continues to represent a significant challenge. The scope and detail of this book will make it an invaluable asset for gastroenterologists and other clinicians.

This book serves as a definitive nutritional reference for medical practitioners who care for patients with digestive diseases. This first-of-its-kind title explores the critical link between nutrition and weight and digestive health and organizes the necessary information for easy use for clinicians across specialties. The book is divided into four sections; the first section outlines basic nutritional concepts that lay a foundation for future chapters. This includes discussion of the gastrointestinal tract's role in digestion and metabolism, an outline of dietary composition and associated deficiencies, and a review of nutritional assessment and general therapeutic principles. Next, the second section outlines dietary and nutritional implications of specific digestive diseases organized by affected gastrointestinal organs. Following this, the third section discusses appetite regulation, weight management, and obesity's association with gastrointestinal diseases. It also discusses the importance of comprehensive, multi-disciplinary obesity care including a review of dietary, pharmacological, endoscopic, and surgical options that promote weight loss. In concluding the book, the fourth section discusses foundational nutritional support concepts. Nutrition, Weight, and Digestive Health is an invaluable reference for medical practitioners seeking a title that explores important and revolutionary elements to the medical care of those with digestive diseases.

This book is a collection of full papers based on the peer-reviewed submissions accepted for the ERIDOB 2020 conference (which was cancelled due to COVID-19). ERIDOB brings together researchers in Biology Education from around the world to share and discuss their research work and results. It is the only major international conference on biology education research, and all the papers therefore are written by international researchers from across Europe (and beyond), which present the findings from a range of contemporary biology education research projects. They are all entirely new papers describing new research in the field. The papers are peer-reviewed by experienced international researchers selected by the ERIDOB Academic Committee. The papers reflect the ERIDOB conference strands by covering topics on: Socioscientific issues, Nature of Science and scientific thinkingTeaching and learning in biologyPerceptions of biology and biology educationTextbook analysisOutdoor and environmental education By providing a collection of new research findings from many countries, this book is a great resource for researchers and practitioners such as school, college and university biology teachers'around the world. It is useful for training biology teachers and therefore valuable to teacher training institutions.

This book serves as a valuable resource for surgeons and health care providers at all stages of their career caring for patients with colorectal disease. This edition provides all newly written chapters, organized around the “pillars” of colorectal disease: perioperative (including endoscopy); anorectal disease; benign disease (including inflammatory bowel disease); malignancy; pelvic floor disorders; and a “miscellaneous” section that covers aspects both inside and beyond the operating room. Chapters are formatted to follow that of a “how to” manual as well as an algorithm-based guide to allow the reader to understand the thought process behind a proposed treatment strategy. By making use of evidence-based recommendations, each chapter includes not only background information and diagnostic/therapeutic guidelines, but also provides operative technical details and perioperative “tips and tricks” that are utilized in the management of these complex surgical challenges. Chapters also include the assessment of risk and methods utilized to minimize perioperative complications. In addition, the book incorporates sections covering the medical and surgical therapies for abdominal, pelvic and anorectal disease. Written by experts in the field from around the world, The ASCRS Textbook of Colon and Rectal Surgery 4th Edition exposes the many critical gaps in our knowledge base and inspires the next generation to answer them through thoughtful and high level scientific inquiry.

The fully updated fifth edition of this highly successful textbook provides an integrated symptom- and issue-based approach to internal medicine with easily accessible, high-yield clinical information. For each topic, carefully organized sections on different diagnoses, investigations, and treatments are designed to facilitate patient care and examination preparation. Numerous clinical pearls and comparison tables are provided to help enhance learning, and international units (US and metric) are used to facilitate application in everyday clinical practice. In addition to the central tenets of internal medicine, the book covers many highly important, rarely discussed topics in medicine, including: palliative care, obstetrical medicine, transfusion reactions, needle stick injuries, interpretation of gram stain, depression and code status discussion. This fifth edition additionally includes new coverage of the coronavirus-19 and cancer survivorship while being fully updated throughout. Authors present this information in a streamlined fashion, preserving the book's pocket-sized, quick reference format. Approach to Internal Medicine continues to serve as an essential reference primarily for medical students, residents, and fellows -- with practicing physicians, nurses, and advanced practice providers also finding the text of value as a point of care reference.